Details of the Target

General Information of Target

Target ID LDTP02111
Target Name Transcription factor Jun (JUN)
Gene Name JUN
Gene ID 3725
Synonyms
Transcription factor Jun; Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
BZIP family, Jun subfamily
Subcellular location
Nucleus
Function
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity. Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells.; (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.
TTD ID
T68227
Uniprot ID
P05412
DrugMap ID
TTN3GBV
Ensemble ID
ENST00000371222.4
HGNC ID
HGNC:6204
ChEMBL ID
CHEMBL4977

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K309(7.68)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C99(6.40)  LDD0169  [3]
IA-alkyne
 Probe Info  		C99 (4.73)  LDD0194  [4]
DBIA
 Probe Info  		C99(1.05)  LDD1492  [5]
1d-yne
 Probe Info  		N.A.  LDD0358  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C99(2.32)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C99(6.40)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C99(0.91)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C99(0.85); C320(1.31)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C99(0.85)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C99(0.97); C320(1.04)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C99(0.95); C320(0.90)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C99(0.95); C320(0.95)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C99(1.00)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C99(0.92); C320(1.02)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C99(0.74)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C99(0.90); C320(1.07)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C99(1.17); C320(1.03)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C99(0.89)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C99(1.09); C320(1.27)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C99(1.00); C320(0.98)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C99(1.00); C320(1.01)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C99(0.93)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C99(0.87); C320(1.01)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C99(0.89)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C99(1.05); C320(0.98)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C99(0.97)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C99(0.99)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C99(1.03); C320(1.26)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C99(0.92); C320(1.12)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C99(1.03); C320(1.00)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C99(0.90)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C99(0.91); C320(1.44)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C99(1.06)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C99(1.10); C320(0.81)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C99(0.95)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C99(0.92); C320(1.03)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C99(0.99); C320(0.98)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C99(1.18); C320(1.09)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C99(0.89); C320(0.94)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C99(1.15)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C99(1.03); C320(1.46)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C99(0.93)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C99(1.10); C320(1.07)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C99(1.00)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C99(0.91); C320(1.14)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C99(0.99); C320(0.89)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C99(0.99); C320(0.92)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C99(0.81)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C99(1.04)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C99(0.83); C320(1.16)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C99(0.94)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C99(1.03); C320(1.01)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C99(0.98)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C99(0.85); C320(1.04)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C99(0.81); C320(0.97)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C99(0.88); C320(0.93)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C99(0.82)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C99(0.87); C320(1.08)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C99(0.86)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C99(0.99); C320(1.07)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C99(1.21); C320(1.01)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C99(0.93)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C99(0.88); C320(0.96)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C99(0.94); C320(1.12)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C99(0.92); C320(1.12)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C99(0.91); C320(1.08)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C99(0.84); C320(0.93)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C99(0.83)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C99(0.97)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C99(0.87); C320(0.95)  LDD1514  [5]
 LDCM0156  Aniline NCI-H1299 12.67  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C99(0.83); C320(0.95)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C99(1.09); C320(1.00)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C99(0.94)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C99(0.91); C320(0.90)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C99(0.92)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C99(0.95); C320(0.94)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C99(0.85)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C99(0.94); C320(0.86)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C99(0.99)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C99(0.97); C320(0.81)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C99(0.95)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C99(0.88); C320(1.15)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C99(0.97); C320(0.98)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C99(0.97)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C99(0.97); C320(0.83)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C99(1.10)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C99(1.04); C320(0.94)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C99(1.01)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C99(1.05); C320(0.80)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C99(0.93)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C99(0.99); C320(0.96)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C99(0.92)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C99(1.07); C320(0.93)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C99(0.79); C320(0.90)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C99(0.97)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C99(0.77); C320(1.03)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C99(0.81)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C99(0.86); C320(0.93)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C99(0.71)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C99(0.59); C320(1.12)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C99(0.75)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C99(0.79); C320(0.89)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C99(0.73)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C99(0.72); C320(1.18)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C99(0.99)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C99(0.85); C320(0.68)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C99(0.84)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C99(0.81)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C99(0.76); C320(1.13)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C99(0.72)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C99(0.82)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C99(0.85); C320(0.89)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C99(0.91)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C99(0.91); C320(1.17)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C99(0.83); C320(1.00)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C99(0.82); C320(0.88)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C99(0.61); C320(0.87)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C99(1.05)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C99(0.92); C320(0.90)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C99(0.81)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C99(0.98)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C99(1.00); C320(1.05)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C99(0.80); C320(1.11)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C99(0.71)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C99(0.79); C320(0.90)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C99(0.77)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C99(0.82); C320(1.01)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C99(0.79); C320(0.94)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C99(0.86); C320(0.94)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C99(0.71); C320(0.90)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C99(1.08); C320(0.90)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C99(0.73)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C99(0.90)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C99(0.87)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C99(0.78); C320(0.91)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C99(0.85)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C99(1.06); C320(0.87)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C99(0.85)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C99(0.80); C320(1.14)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C99(0.94); C320(0.96)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C99(0.76); C320(1.03)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C99(0.61); C320(1.01)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C99(0.76)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C99(0.90)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C99(0.87)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C99(0.88)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C99(0.66); C320(1.06)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C99(0.86)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C99(1.02); C320(0.78)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C99(0.82)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C99(0.81); C320(0.94)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C99(0.70); C320(0.95)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C99(0.69); C320(1.00)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C99(0.85); C320(1.04)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C99(0.76); C320(0.94)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C99(0.99)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C99(1.02); C320(1.13)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C99(0.90)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C99(0.89)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C99(0.80); C320(1.25)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C99(0.93)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C99(0.76); C320(0.76)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C99(0.74)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C99(0.67)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C99(0.92); C320(1.10)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C99(0.78); C320(0.96)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C99(0.70); C320(0.95)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C99(0.79); C320(1.13)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C99(0.82)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C99(0.81)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C99(0.83)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C99(0.88); C320(1.08)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C99(0.73)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C99(0.71); C320(0.90)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C99(0.88); C320(0.83)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C99(0.82)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C99(0.83); C320(1.03)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C99(0.79); C320(0.96)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C99(0.69); C320(0.88)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C99(0.62); C320(1.12)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C99(0.59)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C99(0.74); C320(0.87)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C99(0.65)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C99(0.68)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C99(0.81)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C99(0.65); C320(0.91)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C99(0.60)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C99(0.83); C320(0.92)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C99(0.67)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C99(0.97); C320(1.05)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C99(0.77); C320(0.76)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C99(0.56); C320(0.82)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C99(0.83); C320(1.00)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C99(1.07)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C99(1.11); C320(0.96)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C99(1.11); C320(0.97)  LDD1698  [5]
 LDCM0086  EN4 231MFP C99 (4.73)  LDD0194  [4]
 LDCM0468  Fragment33 HEK-293T C99(0.92); C320(1.00)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C99(1.06)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C99(1.05)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C99(1.02)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C99(1.07)  LDD1502  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
60 kDa heat shock protein, mitochondrial (HSPD1) Chaperonin (HSP60) family P10809
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Serine/threonine-protein kinase VRK1 (VRK1) CK1 Ser/Thr protein kinase family Q99986
Mitogen-activated protein kinase 10 (MAPK10) CMGC Ser/Thr protein kinase family P53779
Mitogen-activated protein kinase 8 (MAPK8) CMGC Ser/Thr protein kinase family P45983
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Tubulin alpha-1A chain (TUBA1A) Tubulin family Q71U36
Double-stranded RNA-specific editase 1 (ADARB1) . P78563
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Scavenger receptor class B member 1 (SCARB1) CD36 family Q8WTV0
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Bardet-Biedl syndrome 7 protein (BBS7) . Q8IWZ6
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) . Q9HD26
Transcription factor
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Basic leucine zipper transcriptional factor ATF-like 2 (BATF2) BZIP family Q8N1L9
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Cyclic AMP-dependent transcription factor ATF-7 (ATF7) BZIP family P17544
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) BZIP family P18846
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
Cyclic AMP-responsive element-binding protein 3 (CREB3) BZIP family O43889
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Fos-related antigen 1 (FOSL1) BZIP family P15407
Fos-related antigen 2 (FOSL2) BZIP family P15408
Protein c-Fos (FOS) BZIP family P01100
Transcription factor Jun (JUN) BZIP family P05412
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Protein C-ets-1 (ETS1) ETS family P14921
Metastasis-associated protein MTA1 (MTA1) . Q13330
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) . O95644
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid beta precursor like protein 2 (APLP2) APP family Q06481
Cbp/p300-interacting transactivator 1 (CITED1) CITED family Q99966
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) EIF-2-beta/eIF-5 family P20042
P antigen family member 4 (PAGE4) GAGE family O60829
Neurofilament medium polypeptide (NEFM) Intermediate filament family P07197
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Tubulin beta chain (TUBB) Tubulin family P07437
Tubulin beta-2A chain (TUBB2A) Tubulin family Q13885
Gelsolin (GSN) Villin/gelsolin family P06396
Striatin-4 (STRN4) WD repeat striatin family Q9NRL3
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
Protein PRRC2A (PRRC2A) . P48634
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adapalene Small molecular drug DB00210
Arsenic Trioxide Small molecular drug DB01169
Irbesartan Small molecular drug DB01029
Pseudoephedrine Small molecular drug DB00852
Vinblastine Small molecular drug DB00570
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pnri-299 Small molecular drug D06OWM
Tam-67 Small molecular drug D0AH5T
Tws-119 Small molecular drug D0T8KR
Lgd-1550 . DB05785
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
T-5224 Small molecular drug D02LCL

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.