Details of the Target

General Information of Target

Target ID LDTP01437
Target Name TOX high mobility group box family member 4 (TOX4)
Gene Name TOX4
Gene ID 9878
Synonyms
C14orf92; KIAA0737; TOX high mobility group box family member 4; Epidermal Langerhans cell protein LCP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFD
DLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANP
PVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPT
SSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAA
IKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATV
ETVELDPAPPSQTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLSSYVANQASSGAG
GQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVT
RSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKV
RINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPSPETICEM
ITDVVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKH
CRDVFLAWVASRNSNTVVFVK
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation.
Uniprot ID
O94842
Ensemble ID
ENST00000448790.7
HGNC ID
HGNC:20161

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.S345C DBIA    Probe Info 
HCT15 SNV: p.V56I DBIA    Probe Info 
JURKAT SNV: p.M84I .
RKO SNV: p.M84I DBIA    Probe Info 
SNU1 SNV: p.P570S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C592(0.90); C596(0.90)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Phosphinate-6
 Probe Info  		C601(0.00); C577(0.00)  LDD0018  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C592(1.16)  LDD0812  [3]
 LDCM0215  AC10 PaTu 8988t C592(0.76); C596(0.76)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C592(0.85); C596(0.85)  LDD1105  [3]
 LDCM0230  AC113 HCT 116 C592(0.95); C596(0.95)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C592(0.90); C596(0.78)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C592(0.90); C596(0.78)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C592(0.88); C596(0.79)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C592(0.96); C596(0.91)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C592(0.94); C596(0.84)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C592(1.12); C596(0.99)  LDD0553  [3]
 LDCM0237  AC12 PaTu 8988t C592(0.74); C596(0.74)  LDD1116  [3]
 LDCM0238  AC120 HCT 116 C592(0.96); C596(0.81)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C592(1.09); C596(1.05)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C592(1.07); C596(0.92)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C592(0.94); C596(0.76)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C592(0.95); C596(0.83)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C592(0.95); C596(0.88)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C592(1.05); C596(0.88)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C592(0.85); C596(0.85)  LDD0562  [3]
 LDCM0259  AC14 PaTu 8988t C592(0.80); C596(0.80)  LDD1138  [3]
 LDCM0263  AC143 HCT 116 C592(0.82); C596(0.82)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C592(0.72); C596(0.72)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C592(0.68); C596(0.68)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C592(0.58); C596(0.58)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C592(0.55); C596(0.55)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C592(0.55); C596(0.55)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C592(0.60); C596(0.60)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C592(0.76); C596(0.76)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C592(0.82); C596(0.82)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C592(0.85); C596(0.85)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C592(0.82); C596(0.82)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C592(0.69); C596(0.69)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C592(0.79); C596(0.79)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C592(0.80); C596(0.80)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C592(0.84); C596(0.84)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C592(1.10); C596(1.10)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C592(1.53)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C592(1.23)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C592(1.08)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C592(1.19)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C592(1.43)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C592(1.31)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C592(1.37)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C592(1.85)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C592(1.23)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C577(1.10)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C577(1.14)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C577(1.01)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C577(1.12)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C577(1.06)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C592(0.92)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C577(0.98); C596(0.90)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C577(1.09)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C577(1.07)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C577(1.06)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C577(0.97)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C592(1.36); C596(1.36)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C592(1.29); C596(1.29)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C592(1.02); C596(1.02)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C592(1.27); C596(1.27)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C592(1.02); C596(1.02)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C592(1.00)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C592(0.85); C596(0.85)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C592(0.91); C596(0.91)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C592(0.91); C596(0.91)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C592(0.99); C596(0.99)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C592(0.91); C596(0.91)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C592(0.81); C596(0.81)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C592(0.97)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C592(1.22)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C592(1.08)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C592(1.24)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C592(1.06)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C592(1.14)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C592(1.29)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C592(1.33)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C592(1.12)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C592(1.25)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C592(1.35)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C592(1.19)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C592(0.52); C596(0.52)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C592(0.51); C596(0.51)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C592(0.46); C596(0.46)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C592(0.94); C596(0.94)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C592(0.53); C596(0.53)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C592(0.64); C596(0.64)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C592(0.42); C596(0.42)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C592(0.57); C596(0.57)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C592(0.41); C596(0.41)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C592(0.25); C596(0.25)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C592(0.26); C596(0.26)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C592(0.18); C596(0.18)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C592(0.68); C596(0.68)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C592(0.76); C596(0.76)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C592(0.96); C596(0.96)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C592(0.47); C596(0.47)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C592(0.50); C596(0.50)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C592(0.76); C596(0.76)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C592(0.57); C596(0.57)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C592(0.55); C596(0.55)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C592(0.67); C596(0.67)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C592(0.57); C596(0.57)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C592(0.72); C596(0.72)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C592(0.76); C596(0.76)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C592(0.68); C596(0.68)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C592(1.09); C596(1.09)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C592(0.82); C596(0.82)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C592(1.06); C596(1.06)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C592(0.44); C596(0.44)  LDD0665  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C592(0.79); C596(0.79)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C592(0.86); C596(0.86)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C592(0.85); C596(0.85)  LDD1154  [3]
 LDCM0156  Aniline NCI-H1299 14.19  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C592(0.90); C596(0.90)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C577(0.97)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C577(0.80); C596(1.16)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C592(1.26)  LDD0967  [3]
 LDCM0370  CL101 PaTu 8988t C592(1.07); C596(1.07)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C592(1.08); C596(1.08)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C592(0.76); C596(0.76)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C592(0.95); C596(0.95)  LDD1252  [3]
 LDCM0374  CL105 HEK-293T C592(1.10)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C592(1.13)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C592(1.07)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C592(1.34)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C592(1.22)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C577(1.00)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C592(1.16)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C592(1.10)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C577(0.95)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C577(1.19)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C577(0.92); C596(0.95)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C577(1.03)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C577(1.13)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C592(0.77); C596(0.77)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C592(1.20); C596(1.20)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C592(0.93); C596(0.93)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C577(0.90)  LDD1594  [9]
 LDCM0391  CL120 HCT 116 C592(1.07); C596(1.07)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C592(1.39)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C592(1.38)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C592(0.91)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C592(1.05)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C592(0.90); C596(0.90)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C592(0.80); C596(0.80)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C592(0.72); C596(0.72)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C592(0.56); C596(0.56)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C577(1.17)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C577(1.04); C596(1.29)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C577(0.97)  LDD1606  [9]
 LDCM0403  CL16 HCT 116 C592(1.37); C596(1.37)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C592(1.15); C596(1.15)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C592(1.51); C596(1.51)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C592(1.13); C596(1.13)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C577(1.03); C596(1.00)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C592(1.08); C596(1.08)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C592(0.91); C596(0.91)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C592(0.85); C596(0.85)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C592(1.37); C596(1.37)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C592(0.86); C596(0.86)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C592(0.99); C596(0.99)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C592(1.16); C596(1.16)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C592(1.19); C596(1.19)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C592(0.89); C596(0.89)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C592(1.03); C596(1.03)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C577(0.90)  LDD1622  [9]
 LDCM0419  CL30 HCT 116 C592(1.23); C596(1.23)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C577(1.08)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C577(0.99)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C577(0.92)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C577(1.03); C596(1.18)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C577(1.15)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C577(1.09)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C577(1.13)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C577(0.95)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C577(1.03)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C577(0.97)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C577(1.13)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C577(1.16)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C577(1.10)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C577(1.12)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C577(1.05)  LDD1639  [9]
 LDCM0436  CL46 PaTu 8988t C592(1.32); C596(1.32)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C592(0.96); C596(0.96)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C592(0.73); C596(0.73)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C592(0.90); C596(0.90)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C577(1.07)  LDD1644  [9]
 LDCM0441  CL50 PaTu 8988t C592(0.89); C596(0.89)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C592(0.83); C596(0.83)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C592(1.07); C596(1.07)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C592(1.23); C596(1.23)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C592(0.80); C596(0.80)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C592(0.80); C596(0.80)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C592(0.72); C596(0.72)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C592(1.02); C596(1.02)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C592(0.85); C596(0.85)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C592(0.72); C596(0.72)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C577(0.94)  LDD1654  [9]
 LDCM0452  CL60 PaTu 8988t C592(0.82); C596(0.82)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C592(1.33); C596(1.33)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C592(1.29); C596(1.29)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C592(1.09); C596(1.09)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C592(1.29); C596(1.29)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C592(0.98); C596(0.98)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C592(1.20); C596(1.20)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C592(1.13); C596(1.13)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C592(1.05); C596(1.05)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C592(1.10); C596(1.10)  LDD1340  [3]
 LDCM0462  CL7 HEK-293T C577(0.96)  LDD1665  [9]
 LDCM0463  CL70 PaTu 8988t C592(1.00); C596(1.00)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C592(1.03); C596(1.03)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C592(1.33); C596(1.33)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C592(1.12); C596(1.12)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C592(1.49); C596(1.49)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C592(1.00); C596(1.00)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C592(0.74); C596(0.74)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C592(0.96); C596(0.96)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C592(0.81); C596(0.81)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C577(0.80)  LDD1676  [9]
 LDCM0474  CL80 PaTu 8988t C592(0.78); C596(0.78)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C592(0.61); C596(0.61)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C592(0.75); C596(0.75)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C592(1.04); C596(1.04)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C592(0.77); C596(0.77)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C592(1.08); C596(1.08)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C592(0.95); C596(0.95)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C592(0.58); C596(0.58)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C592(0.73); C596(0.73)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C592(0.62); C596(0.62)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C577(0.87)  LDD1687  [9]
 LDCM0485  CL90 PaTu 8988t C592(0.69); C596(0.69)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C592(1.08)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C592(0.94)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C592(0.99)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C592(1.50)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C592(1.60)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C592(1.20)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C592(1.17)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C592(1.19)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C592(1.00)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C577(0.93)  LDD1698  [9]
 LDCM0468  Fragment33 PaTu 8988t C592(1.14); C596(1.14)  LDD1347  [3]
 LDCM0427  Fragment51 HEK-293T C577(1.08); C596(1.13)  LDD1631  [9]
 LDCM0022  KB02 HCT 116 C577(0.99)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C577(1.00)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C577(0.92)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C592(0.95); C596(0.95)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-box transcription factor TBX6 (TBX6) . O95947
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Gem-associated protein 6 (GEMIN6) . Q8WXD5
Myosin regulatory light chain 2, atrial isoform (MYL7) . Q01449
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402