Details of the Target

General Information of Target

Target ID LDTP01298
Target Name Serine/threonine-protein kinase 16 (STK16)
Gene Name STK16
Gene ID 8576
Synonyms
MPSK1; PKL12; TSF1; Serine/threonine-protein kinase 16; EC 2.7.11.1; Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; EC 2.7.10.2; hPSK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE
EAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFL
TEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGS
RQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ
KGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQ
HTTQI
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular location
Cytoplasm, perinuclear region
Function
Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
TTD ID
T04303
Uniprot ID
O75716
DrugMap ID
TTFGN19
Ensemble ID
ENST00000396738.7
HGNC ID
HGNC:11394
ChEMBL ID
CHEMBL3938

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C84(6.93)  LDD0204  [1]
IA-alkyne
 Probe Info  		C53(1.52)  LDD2182  [2]
IPM
 Probe Info  		C53(2.15)  LDD1701  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C53(1.03); C210(1.02); C174(0.88)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C53(1.52); C210(1.15); C84(0.76)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C53(1.05); C210(0.99)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C53(0.96); C210(1.09); C84(0.91)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C53(0.97); C210(1.21); C84(0.74)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C53(0.95); C210(1.05)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C53(0.99); C210(0.99); C174(0.87)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C53(1.06); C210(0.95); C84(1.07)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C53(1.00); C210(0.86)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C53(1.04); C210(0.81); C84(0.65)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C53(1.17); C210(1.01); C84(0.95)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C53(0.92); C210(0.96); C174(0.83); C84(0.79)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C53(0.96); C210(1.16); C84(0.96)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C53(0.76); C210(1.06)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C53(0.87); C210(0.66); C84(1.00)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C53(1.25); C210(1.05); C174(0.81)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C53(1.18); C210(1.00); C84(0.81)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C53(1.17); C210(0.86)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C53(1.37); C210(0.96); C84(1.98)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C53(0.92); C210(1.23); C174(0.89); C84(0.64)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C53(1.10); C210(0.95)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C53(1.05); C210(1.03); C84(0.93)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C53(0.89); C210(1.07)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C53(0.97); C210(1.07); C84(1.02)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C53(1.17); C210(0.96); C174(0.95)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C53(1.32); C210(0.99); C84(0.95)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C53(1.10); C210(1.05)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C53(1.31); C210(0.82); C84(0.84)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C53(0.90); C210(1.15); C174(0.98); C84(0.79)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C53(1.02); C210(1.13); C84(0.94)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C53(0.98); C210(1.06)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C53(1.19); C210(1.29); C84(0.86)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C53(1.15); C210(1.13); C84(2.74)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C53(0.92); C210(1.13); C174(0.87)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C53(1.10); C210(1.03); C84(0.80)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C53(1.04); C210(1.33)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C53(1.15); C210(0.95); C84(0.79)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C53(0.95); C210(1.08); C174(1.17); C84(0.66)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C53(1.07); C210(1.05); C84(1.08)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C53(0.94); C210(1.04)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C53(0.81); C210(0.87); C84(0.96)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C53(1.16); C210(0.99); C174(1.01)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C53(0.95); C210(1.08); C174(1.10); C84(1.16)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C53(0.99); C210(0.97); C84(1.42)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C53(1.02); C210(1.00)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C53(1.03); C210(1.28); C84(0.92)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C53(0.97); C210(0.86); C174(0.98); C84(0.91)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C53(1.13); C210(1.07); C84(0.99)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C53(0.94); C210(1.07)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C53(0.97); C210(0.95); C84(0.89)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C53(1.09); C210(0.93); C174(1.03)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C53(0.99); C210(0.99); C84(0.81)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C53(1.17); C210(1.11)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C53(0.99); C210(0.90); C84(0.87)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C53(1.25); C210(1.06); C84(1.70)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C53(1.06); C210(1.13); C174(1.00); C84(0.96)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C53(1.11); C210(1.10); C84(0.83)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C53(0.95); C210(1.07)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C53(1.13); C210(0.73); C84(0.95)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C53(0.93); C210(1.22)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C53(1.11); C210(0.95); C84(1.01)  LDD1569  [5]
 LDCM0248  AKOS034007472 HEK-293T C53(0.96); C210(0.96); C174(1.04); C84(0.94)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C53(1.05); C210(1.14); C174(1.08)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C53(0.96); C210(0.84); C84(1.52)  LDD1514  [5]
 LDCM0102  BDHI 8 Jurkat C84(6.93)  LDD0204  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C53(1.06); C174(1.08)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C53(1.01); C210(1.36); C84(0.44)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C53(1.05); C210(1.23)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C53(1.04); C174(1.04)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C53(1.01); C210(1.17); C174(0.92)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C53(1.17)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C53(0.99); C210(1.20)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C53(0.91); C174(1.09)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C53(0.98); C210(0.99); C174(1.05)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C53(0.82)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C53(1.02); C210(0.93)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C53(0.92); C174(1.18)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C53(0.63); C210(0.92)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C53(0.80); C210(0.97); C174(1.08)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C53(0.90)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C53(1.05); C210(0.89)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C53(1.05); C174(1.14)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C53(0.96); C210(1.11); C174(0.87)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C53(1.18)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C53(1.05); C210(1.15)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C53(0.98); C174(1.01)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C53(0.88); C210(1.32); C174(1.00)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C53(1.01)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C53(0.81); C210(1.13); C84(0.80)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C53(0.94); C210(1.14)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C53(1.04); C174(0.87)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C53(0.99); C210(1.00); C174(1.06)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C53(0.93)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C53(1.17); C210(0.93)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C53(0.88); C174(0.82)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C53(1.13); C210(1.04); C174(1.02)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C53(1.00)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C53(1.03); C210(1.40)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C53(1.06); C174(1.17)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C53(1.07); C210(1.01); C174(0.94)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C53(0.82)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C53(1.07); C210(1.73)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C53(0.90); C210(0.85); C174(0.79)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C53(1.90); C210(0.93); C84(0.57)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C53(0.97); C210(0.95)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C53(1.26); C210(1.21); C174(1.12)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C53(0.92); C210(1.09); C84(0.58)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C53(0.80); C210(1.08); C174(1.02); C84(0.21)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C53(0.92); C210(1.36); C84(0.42)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C53(0.78); C210(1.25)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C53(0.88); C210(0.84); C84(0.69)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C53(0.86); C174(0.81)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C53(0.97); C210(1.12); C174(1.26)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C53(0.92)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C53(0.95); C210(1.08)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C53(1.01); C210(0.94); C174(1.02)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C53(1.01)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C53(1.28); C210(0.82); C84(0.58)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C53(0.87); C210(1.00)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C53(0.86); C210(1.27); C84(0.64)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C53(0.79); C210(1.07); C174(0.94); C84(0.19)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C53(0.83); C210(1.31); C84(0.48)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C53(0.85); C210(1.54)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C53(0.89); C210(1.19); C84(0.85)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C53(0.94); C174(0.96)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C53(1.12)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C53(1.12); C210(0.98)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C53(1.01); C210(1.15)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C53(1.01); C210(0.91); C174(0.97)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C53(1.38); C210(0.96); C84(0.83)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C53(0.94); C210(1.08)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C53(0.83); C210(1.02); C84(0.67)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C53(0.84); C210(0.95); C174(0.99); C84(0.23)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C53(0.84); C210(1.17); C84(0.39)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C53(0.77); C210(1.11)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C53(0.91); C210(1.13); C84(0.87)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C53(1.05); C174(1.16)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C53(0.96); C210(0.92); C174(1.08)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C53(0.95); C210(1.03); C174(1.01)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C53(1.11); C210(1.01)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C53(0.93); C210(1.02); C174(0.96)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C53(1.37); C210(0.98); C84(0.89)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C53(1.06); C210(1.13)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C53(1.06); C210(1.06); C84(0.71)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C53(0.92); C210(1.07); C174(1.02); C84(0.30)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C53(0.89); C210(1.40); C84(0.58)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C53(0.79); C210(1.08)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C53(1.23); C210(0.95); C84(0.64)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C53(0.76); C210(1.14); C84(0.93)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C53(0.92); C174(0.98)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C53(1.05); C210(1.19); C174(1.21)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C53(1.23)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C53(0.96); C210(1.21)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C53(1.09); C210(1.11); C174(1.03)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C53(1.45); C210(0.85); C84(0.68)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C53(1.11); C210(0.98)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C53(0.98); C210(0.99); C84(0.69)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C53(0.94); C210(1.14); C174(0.95); C84(0.25)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C53(0.97); C210(0.97)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C53(0.88); C210(1.36); C84(0.52)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C53(0.83); C210(1.00)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C53(0.95); C210(1.45); C84(0.86)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C53(0.98); C174(0.91)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C53(1.40); C210(1.11); C174(1.02)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C53(1.10); C210(0.97)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C53(0.97); C210(0.89); C174(0.71)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C53(0.97); C210(0.91); C84(0.69)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C53(0.95); C210(0.88)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C53(1.22); C210(0.92); C84(0.97)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C53(0.94); C210(1.28); C84(0.74)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C53(0.86); C210(1.15); C174(1.02); C84(0.25)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C53(0.89); C210(1.21); C84(0.55)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C53(0.82); C210(1.12)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C53(0.95); C210(0.86); C84(0.84)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C53(0.87); C174(0.97)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C53(1.40); C210(1.05); C174(0.91)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C53(1.42)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C53(1.08); C210(0.83)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C53(1.10); C210(0.98); C174(0.92)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C53(0.85); C210(1.24); C174(1.24); C84(0.22)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C53(1.99); C210(0.99); C84(1.31)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C53(1.27); C210(1.09)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C53(1.16); C210(1.02); C84(0.80)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C53(0.89); C210(1.00); C174(1.07); C84(0.32)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C53(0.85); C210(1.22); C84(0.59)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C53(0.70); C210(0.94)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C53(0.89); C210(0.91); C84(0.96)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C53(0.95); C174(0.97)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C53(1.19); C210(1.06); C174(0.95)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C53(1.13)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C53(0.98)  LDD1698  [5]
 LDCM0625  F8 Ramos C53(2.06)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C53(0.80)  LDD2189  [2]
 LDCM0575  Fragment13 Ramos C53(0.56)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C53(1.62)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C53(0.64)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C53(1.49)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C53(0.72)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C53(0.24)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C53(1.08)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C53(0.85)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C53(1.26)  LDD2201  [2]
 LDCM0468  Fragment33 HEK-293T C53(1.06)  LDD1671  [5]
 LDCM0596  Fragment38 Ramos C53(1.69)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C53(1.10)  LDD2184  [2]
 LDCM0427  Fragment51 HEK-293T C53(1.01); C210(1.22); C174(0.90)  LDD1631  [5]
 LDCM0610  Fragment52 Ramos C53(0.99)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C53(0.88)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C53(1.29)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C53(1.01)  LDD2188  [2]
 LDCM0022  KB02 HEK-293T C53(0.94)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C53(1.00)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C84(2.14)  LDD3314  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CSKMT) Methyltransferase superfamily A8MUP2
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
Proprotein convertase subtilisin/kexin type 5 (PCSK5) Peptidase S8 family Q92824
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Developmentally-regulated GTP-binding protein 1 (DRG1) OBG GTPase family Q9Y295
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
ADAMTS-like protein 4 (ADAMTSL4) . Q6UY14
E3 ubiquitin ligase TRAF3IP2 (TRAF3IP2) . O43734
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GA-binding protein alpha chain (GABPA) ETS family Q06546
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) . Q9HBZ2
Class A basic helix-loop-helix protein 9 (BHLHA9) . Q7RTU4
Homeobox protein MOX-2 (MEOX2) . P50222
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 12 (TCF12) . Q99081
Transcription factor 4 (TCF4) . P15884
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) G-protein coupled receptor 2 family Q03431
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Stabilizer of axonemal microtubules 1 (SAXO1) FAM154 family Q8IYX7
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
R-spondin-4 (RSPO4) R-spondin family Q2I0M5
Ski-like protein (SKIL) SKI family P12757
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
BTB/POZ domain-containing protein KCTD14 (KCTD14) . Q9BQ13
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Chromobox protein homolog 3 (CBX3) . Q13185
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Flagellum-associated coiled-coil domain-containing protein 1 (FLACC1) . Q96Q35
Keratinocyte proline-rich protein (KPRP) . Q5T749
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Properdin (CFP) . P27918
Suppressor of cytokine signaling 2 (SOCS2) . O14508

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid21123062c27 Small molecular drug D0RO9R

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840