Details of the Target

General Information of Target

Target ID LDTP01258
Target Name Jerky protein homolog (JRK)
Gene Name JRK
Gene ID 8629
Synonyms
JH8; Jerky protein homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASKPAAGKSRGEKRKRVVLTLKEKIDICTRLEKGESRKALMQEYNVGMSTLYDIRAHKA
QLLRFFASSDSNKALEQRRTLHTPKLEHLDRVLYEWFLGKRSEGVPVSGPMLIEKAKDFY
EQMQLTEPCVFSGGWLWRFKARHGIKKLDASSEKQSADHQAAEQFCAFFRSLAAEHGLSA
EQVYNADETGLFWRCLPNPTPEGGAVPGPKQGKDRLTVLMCANATGSHRLKPLAIGKCSG
PRAFKGIQHLPVAYKAQGNAWVDKEIFSDWFHHIFVPSVREHFRTIGLPEDSKAVLLLDS
SRAHPQEAELVSSNVFTIFLPASVASLVQPMEQGIRRDFMRNFINPPVPLQGPHARYNMN
DAIFSVACAWNAVPSHVFRRAWRKLWPSVAFAEGSSSEEELEAECFPVKPHNKSFAHILE
LVKEGSSCPGQLRQRQAASWGVAGREAEGGRPPAATSPAEVVWSSEKTPKADQDGRGDPG
EGEEVAWEQAAVAFDAVLRFAERQPCFSAQEVGQLRALRAVFRSQQQETVGLEDVVVTSP
EELAIPKCCLEASTET
Target Bioclass
Other
Family
Tigger transposable element derived protein family
Subcellular location
Nucleus
Function May bind DNA.
Uniprot ID
O75564
Ensemble ID
ENST00000571961.7
HGNC ID
HGNC:6199

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C503(3.06); C513(3.06)  LDD0080  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C380(0.50)  LDD0531  [2]
 LDCM0230  AC113 HCT 116 C380(1.02)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C380(0.65)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C380(1.26)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C380(0.78)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C380(0.78)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C380(0.89)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C380(0.84)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C380(0.64)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C380(0.67)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C380(0.56)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C380(0.48)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C380(0.83)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C380(0.85)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C380(1.11)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C380(0.72)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C428(0.92); C129(0.84)  LDD1512  [3]
 LDCM0263  AC143 HCT 116 C380(1.23)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C380(0.93)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C380(1.05)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C380(1.35)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C380(1.06)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C380(1.05)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C380(1.16)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C428(0.97); C166(0.92)  LDD1513  [3]
 LDCM0271  AC150 HCT 116 C380(1.10)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C380(1.39)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C380(1.20)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C380(1.25)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C380(1.38)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C380(1.13)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C380(1.64)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C380(1.30)  LDD2161  [2]
 LDCM0279  AC2 HCT 116 C380(0.75)  LDD0596  [2]
 LDCM0282  AC22 HEK-293T C428(1.01); C129(1.26)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C428(0.96); C166(0.77)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C368(0.85)  LDD1523  [3]
 LDCM0290  AC3 HCT 116 C380(0.45)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C428(1.11); C129(0.99)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C428(1.01); C166(0.97)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C368(0.96)  LDD1532  [3]
 LDCM0299  AC38 HEK-293T C428(1.01); C129(1.14)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C428(1.10); C166(0.64)  LDD1539  [3]
 LDCM0301  AC4 HCT 116 C380(0.37)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C368(0.99)  LDD1541  [3]
 LDCM0308  AC46 HEK-293T C428(1.01); C129(1.64)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C428(0.92); C166(0.90)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C368(0.80)  LDD1549  [3]
 LDCM0312  AC5 HCT 116 C380(0.41)  LDD0629  [2]
 LDCM0317  AC54 HEK-293T C428(1.02); C129(1.20)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C428(0.96); C166(0.77)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C368(1.01)  LDD1558  [3]
 LDCM0320  AC57 HCT 116 C380(1.12)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C380(1.05)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C380(0.88)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C428(1.04); C129(1.02)  LDD1562  [3]
 LDCM0324  AC60 HCT 116 C380(1.12)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C380(1.34)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C380(1.20)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C380(1.25)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C380(0.74)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C380(1.04)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C380(1.02)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C380(1.12)  LDD0648  [2]
 LDCM0334  AC7 HEK-293T C428(0.90); C166(0.80)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C368(0.94)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C368(0.91)  LDD1514  [3]
 LDCM0367  CL1 HCT 116 C380(0.78)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C380(0.85)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C380(0.46)  LDD0686  [2]
 LDCM0372  CL103 HEK-293T C368(1.12)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C428(1.04)  LDD1577  [3]
 LDCM0376  CL107 HEK-293T C368(1.10)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C428(0.97)  LDD1581  [3]
 LDCM0379  CL11 HCT 116 C380(0.90)  LDD0696  [2]
 LDCM0381  CL111 HEK-293T C368(0.90)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C428(1.19)  LDD1586  [3]
 LDCM0385  CL115 HEK-293T C368(1.00)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C428(1.04)  LDD1590  [3]
 LDCM0389  CL119 HEK-293T C368(1.16)  LDD1593  [3]
 LDCM0390  CL12 HCT 116 C380(0.79)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C428(1.28)  LDD1595  [3]
 LDCM0394  CL123 HEK-293T C368(0.99)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C428(1.00)  LDD1599  [3]
 LDCM0396  CL125 HCT 116 C380(0.88)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C380(1.01)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C380(1.47)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C380(1.00)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C380(1.02)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C380(0.81)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C380(0.96)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C428(0.98)  LDD1607  [3]
 LDCM0404  CL17 HCT 116 C380(0.77)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C380(0.91)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C380(0.91)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C380(0.90)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C380(1.08)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C380(0.81)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C380(1.00)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C380(0.49)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C380(0.80)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C380(0.89)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C380(0.81)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C380(0.69)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C380(1.22)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C380(1.06)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C380(0.83)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C380(0.98)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C380(1.06)  LDD0737  [2]
 LDCM0423  CL34 HEK-293T C428(0.92); C129(1.01)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C428(0.96); C166(0.61)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C368(0.89)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C368(0.89)  LDD1632  [3]
 LDCM0429  CL4 HCT 116 C380(0.76)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C428(1.03)  LDD1634  [3]
 LDCM0436  CL46 HCT 116 C380(1.32)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C380(1.45)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C380(1.36)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C380(1.26)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C380(0.92)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C380(1.40)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C380(1.22)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C380(1.20)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C380(1.23)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C380(1.18)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C380(1.22)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C380(1.17)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C380(1.22)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C380(1.20)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C380(1.36)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C380(1.12)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C380(1.42)  LDD0769  [2]
 LDCM0455  CL63 HEK-293T C368(1.07)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C428(1.16)  LDD1659  [3]
 LDCM0462  CL7 HCT 116 C380(0.97)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C428(1.00); C129(1.00)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C428(0.98); C166(0.70)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C368(0.89)  LDD1668  [3]
 LDCM0469  CL76 HEK-293T C428(0.96)  LDD1672  [3]
 LDCM0473  CL8 HCT 116 C380(1.15)  LDD0790  [2]
 LDCM0476  CL82 HEK-293T C428(1.02); C129(0.89)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C428(1.06); C166(0.79)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C368(0.77)  LDD1681  [3]
 LDCM0481  CL87 HEK-293T C368(0.87)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C428(1.13)  LDD1685  [3]
 LDCM0484  CL9 HCT 116 C380(0.98)  LDD0801  [2]
 LDCM0486  CL91 HCT 116 C380(0.71)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C380(0.73)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C380(0.67)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C380(0.53)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C380(1.02)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C380(0.90)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C380(0.65)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C380(0.68)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C380(0.47)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C368(0.88)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C368(0.96)  LDD1671  [3]
 LDCM0022  KB02 HCT 116 C503(3.06); C513(3.06)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C503(1.59); C513(1.59)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C503(2.72); C513(2.72)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
F-box only protein 17 (FBXO17) . Q96EF6
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Importin subunit alpha-7 (KPNA6) Importin alpha family O60684
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 629 (ZNF629) Krueppel C2H2-type zinc-finger protein family Q9UEG4
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Bystin (BYSL) Bystin family Q13895
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Connector enhancer of kinase suppressor of ras 3 (CNKSR3) CNKSR family Q6P9H4
Protein FAM161A (FAM161A) FAM161 family Q3B820
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein LDOC1 (LDOC1) LDOC1 family O95751
Prickle-like protein 1 (PRICKLE1) Prickle / espinas / testin family Q96MT3
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Tropomyosin alpha-4 chain (TPM4) Tropomyosin family P67936
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Heat shock factor 2-binding protein (HSF2BP) . O75031
Placental protein 13-like (LGALS14) . Q8TCE9
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402