Details of the Target

General Information of Target

Target ID LDTP01212
Target Name DNA polymerase theta (POLQ)
Gene Name POLQ
Gene ID 10721
Synonyms
POLH; DNA polymerase theta; DNA polymerase eta) [Includes: Helicase POLQ; EC 3.6.4.12; DNA polymerase POLQ; EC 2.7.7.7; RNA-directed DNA polymerase POLQ; EC 2.7.7.49)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
SWGELKDFDV
Target Bioclass
Enzyme
Family
DNA polymerase type-A family
Subcellular location
Nucleus
Function
Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase. Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis. The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ. The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates. When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step. Also shows endonuclease activity, which is required to trim the 3' ends before synthesis can occur, thereby preventing non-paired tails. Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ. Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway. Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo. May also have lyase activity. Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs. POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers.
Uniprot ID
O75417
Ensemble ID
ENST00000264233.6
HGNC ID
HGNC:9186
ChEMBL ID
CHEMBL6025

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.S1789I .
AN3CA SNV: p.S530N; p.R808G .
CAL27 SNV: p.S306L .
CAL62 SNV: p.R455C .
DU145 SNV: p.V124M .
HCT116 SNV: p.K2571N .
HCT15 SNV: p.E2493G .
HT115 SNV: p.A819T; p.D1059Y; p.T1717P .
HT29 SNV: p.S1819Ter .
ICC12 SNV: p.Q2537Ter .
IGROV1 Deletion: p.L1430Ter
SNV: p.L45I		 .
IPC298 SNV: p.Q2474Ter .
JURKAT SNV: p.K1958E .
KURAMOCHI SNV: p.N1093K .
LS180 SNV: p.A29V; p.F2318S .
MCC13 SNV: p.Y1772Ter .
MDAMB453 SNV: p.W1760C .
MFE296 SNV: p.P1027H .
MSTO211H SNV: p.R288L DBIA    Probe Info 
NCIH358 Substitution: p.R10L .
NCIH661 SNV: p.E2100Q .
NUGC3 SNV: p.G1908D .
RH30 SNV: p.D727Y DBIA    Probe Info 
SH4 SNV: p.D286N .
SKMEL2 SNV: p.Q1807Ter .
SKMM2 SNV: p.P1075S .
SNGM SNV: p.C909R .
SSP25 SNV: p.S1628L .
SW620 SNV: p.P1817A .
SW837 SNV: p.E386Q; p.S403F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C2411(2.04)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C2295(0.75)  LDD0812  [1]
 LDCM0215  AC10 PaTu 8988t C671(1.26)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C671(1.16)  LDD1105  [1]
 LDCM0230  AC113 PaTu 8988t C671(0.89)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C671(1.00)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C671(0.99)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C671(1.02)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C671(0.91)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C671(0.91)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C671(1.05)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C671(1.14)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C671(0.97)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C671(1.17)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C671(0.95)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C671(0.99)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C671(1.08)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C671(0.91)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C671(1.01)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C671(1.25)  LDD1124  [1]
 LDCM0246  AC128 HEK-293T C2295(1.01)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C2295(1.30)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C2295(0.86)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C2295(0.91)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C2295(0.68)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C2295(1.15)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C2295(0.70)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C2295(0.82)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C2295(0.49)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C2295(1.37)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C2295(0.75)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C2295(0.99)  LDD0856  [1]
 LDCM0259  AC14 PaTu 8988t C671(1.07)  LDD1138  [1]
 LDCM0260  AC140 HEK-293T C2295(0.65)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C2295(0.80)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C2295(0.88)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C2295(0.66)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C2295(0.45)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C2295(0.59)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C2295(0.94)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C2295(0.46)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C2295(0.39)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C2295(0.35)  LDD0867  [1]
 LDCM0270  AC15 PaTu 8988t C671(1.20)  LDD1149  [1]
 LDCM0271  AC150 HEK-293T C2295(0.48)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C2295(0.73)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C2295(0.60)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C2295(0.55)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C2295(0.70)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C2295(0.69)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C2295(0.48)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C2295(0.70)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C1951(1.07)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C1951(0.91)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C1951(0.92)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C2295(0.81)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C1951(1.03)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C1951(0.87)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C1951(1.05)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C1951(0.97)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C1951(0.99)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C2295(2.09); C1951(1.04)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C2295(1.09); C1951(1.10)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C2295(1.08); C1951(1.20)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C2295(1.57); C1951(0.88)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C2295(2.43); C1951(1.08)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C2295(1.05)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C2295(1.56); C1951(1.08)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C2295(1.63); C1951(0.89)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C2295(1.54); C1951(1.01)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C2295(1.48); C1951(1.29)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C2295(3.98); C1951(1.14)  LDD0893  [1]
 LDCM0296  AC35 PaTu 8988t C671(1.05)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C671(1.20)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C671(1.33)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C671(1.41)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C671(1.34)  LDD1179  [1]
 LDCM0301  AC4 HEK-293T C2295(1.09)  LDD0899  [1]
 LDCM0302  AC40 PaTu 8988t C671(1.43)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C671(1.10)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C671(1.47)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C671(1.19)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C671(1.77)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C671(1.45)  LDD1186  [1]
 LDCM0312  AC5 HEK-293T C2295(0.97)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C1148(1.02)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C794(0.98)  LDD1553  [2]
 LDCM0320  AC57 HEK-293T C2295(1.16); C1951(0.80)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C2295(1.09); C1951(0.72)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C2295(1.08); C1951(0.75)  LDD0920  [1]
 LDCM0323  AC6 PaTu 8988t C671(0.99)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C2295(1.52); C1951(0.68)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C2295(0.92); C1951(0.95)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C2295(0.95); C1951(0.72)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C2295(0.69); C1951(0.75)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C2295(0.73); C1951(0.73)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C2295(0.67); C1951(0.87)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C2295(1.06); C1951(0.75)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C2295(0.68); C1951(0.83)  LDD0929  [1]
 LDCM0334  AC7 PaTu 8988t C671(0.79)  LDD1213  [1]
 LDCM0345  AC8 PaTu 8988t C671(0.93)  LDD1224  [1]
 LDCM0349  AC83 HEK-293T C2295(1.04); C1951(1.29)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C2295(0.74); C1951(1.41)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C2295(0.88); C1951(1.10)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C2295(0.78); C1951(1.05)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C2295(0.77); C1951(1.30)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C2295(0.55); C1951(1.27)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C2295(0.63); C1951(1.31)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C2295(0.90); C1951(1.47)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C2295(0.62); C1951(1.21)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C2295(0.86); C1951(1.20)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C2295(0.88); C1951(1.13)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C2295(0.55); C1951(1.06)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C2295(0.64); C1951(1.31)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C2295(2.15); C1951(1.43)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C2295(0.95); C1951(1.75)  LDD0962  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C671(1.20)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C671(1.21)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C671(1.16)  LDD1154  [1]
 LDCM0367  CL1 HEK-293T C1951(0.92)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C1951(1.52)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C2295(0.69)  LDD0967  [1]
 LDCM0370  CL101 PaTu 8988t C671(1.01)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C671(1.12)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C671(1.36)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C671(1.01)  LDD1252  [1]
 LDCM0374  CL105 HEK-293T C1951(0.91)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C1951(0.85)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C1951(0.84)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C1951(0.93)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C1951(0.93)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C1951(1.25)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C1951(0.94)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C1951(0.83)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C2295(1.53); C1951(0.96)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C2295(2.05); C1951(1.03)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C2295(1.01); C1951(1.17)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C2295(1.66); C1951(1.19)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C2295(1.12); C1951(1.26)  LDD0984  [1]
 LDCM0387  CL117 PaTu 8988t C671(1.22)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C671(1.42)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C671(1.27)  LDD1268  [1]
 LDCM0390  CL12 HEK-293T C1951(0.90)  LDD0988  [1]
 LDCM0391  CL120 PaTu 8988t C671(1.08)  LDD1270  [1]
 LDCM0393  CL122 HEK-293T C671(1.33)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C2295(1.00); C1951(0.84)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C2295(0.70); C1951(0.67)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C2295(0.77); C1951(0.71)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C2295(0.89); C1951(0.76)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C1951(1.00)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C1951(1.00)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C1951(1.11)  LDD1000  [1]
 LDCM0405  CL18 HEK-293T C1148(0.95)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C794(1.44)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C1951(0.99)  LDD1005  [1]
 LDCM0414  CL26 HEK-293T C671(1.03)  LDD1618  [2]
 LDCM0418  CL3 HEK-293T C1951(0.96)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C1148(0.84)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C2295(3.59)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C2295(1.36)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C2295(1.33)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C2295(1.56)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C2295(1.45)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C2295(1.11)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C2295(1.54)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C2295(0.95)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C1951(0.99)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C2295(0.90)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C2295(1.04)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C2295(1.05)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C2295(0.93)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C2295(1.53)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C2295(1.34)  LDD1033  [1]
 LDCM0436  CL46 PaTu 8988t C2295(1.44); C671(1.15)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C2295(1.55); C671(1.10)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C2295(1.62); C671(1.09)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C2295(1.43); C671(1.14)  LDD1318  [1]
 LDCM0440  CL5 HEK-293T C1951(1.04)  LDD1038  [1]
 LDCM0441  CL50 PaTu 8988t C2295(1.16); C671(1.40)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C2295(1.44); C671(1.18)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C2295(1.74); C671(1.21)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C2295(1.73); C671(1.48)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C2295(1.80); C671(1.23)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C2295(1.35); C671(1.24)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C2295(0.66); C671(0.88)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C2295(1.76); C671(1.66)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C2295(1.79); C671(1.30)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C2295(1.90); C671(1.63)  LDD1329  [1]
 LDCM0451  CL6 HEK-293T C1951(0.95)  LDD1049  [1]
 LDCM0452  CL60 PaTu 8988t C2295(1.81); C671(1.42)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C2295(1.06); C671(1.13)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C2295(1.06); C671(0.92)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C2295(1.00); C671(0.88)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C2295(1.19); C671(1.03)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C2295(1.27); C671(1.07)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C2295(0.97); C671(1.14)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C2295(1.30); C671(1.29)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C2295(2.89); C671(1.50)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C2295(1.13); C671(1.46)  LDD1340  [1]
 LDCM0462  CL7 HEK-293T C1951(1.07)  LDD1060  [1]
 LDCM0463  CL70 PaTu 8988t C2295(1.28); C671(1.35)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C2295(1.68); C671(1.13)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C2295(1.29); C671(0.95)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C2295(1.26); C671(1.36)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C2295(1.04); C671(1.10)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C2295(1.03); C671(1.31)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C2295(1.63); C671(1.19)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C2295(1.49); C671(1.23)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C2295(1.56); C671(1.13)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C2295(1.72); C671(1.39)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C2295(1.21); C671(1.38)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C2295(1.71); C671(1.24)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C2295(1.79); C671(1.23)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C2295(1.98); C671(1.48)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C2295(1.15); C671(1.10)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C2295(1.61); C671(1.49)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C2295(1.99); C671(1.61)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C2295(1.80); C671(1.35)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C2295(1.38); C671(1.48)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C2295(2.06); C671(1.73)  LDD1364  [1]
 LDCM0486  CL91 HEK-293T C2295(20.00)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C2295(1.17)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C2295(0.85)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C2295(0.95)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C2295(0.61)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C2295(0.76)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C2295(0.94)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C2295(0.82)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C2295(0.76)  LDD1092  [1]
 LDCM0468  Fragment33 PaTu 8988t C2295(1.27); C671(1.13)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C2295(1.28)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C2411(2.04)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C2411(1.63)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C2411(1.70)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402