Details of the Target

General Information of Target

Target ID LDTP01154
Target Name Calcium-responsive transactivator (SS18L1)
Gene Name SS18L1
Gene ID 26039
Synonyms
CREST; KIAA0693; Calcium-responsive transactivator; SS18-like protein 1; SYT homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILEYQSKGKTAECTQYQQILHRNLVY
LATIADSNQNMQSLLPAPPTQNMNLGPGALTQSGSSQGLHSQGSLSDAISTGLPPSSLLQ
GQIGNGPSHVSMQQTAPNTLPTTSMSISGPGYSHAGPASQGVPMQGQGTIGNYVSRTNIN
MQSNPVSMMQQQAATSHYSSAQGGSQHYQGQSSIAMMGQGSQGSSMMGQRPMAPYRPSQQ
GSSQQYLGQEEYYGEQYSHSQGAAEPMGQQYYPDGHGDYAYQQSSYTEQSYDRSFEESTQ
HYYEGGNSQYSQQQAGYQQGAAQQQTYSQQQYPSQQSYPGQQQGYGSAQGAPSQYPGYQQ
GQGQQYGSYRAPQTAPSAQQQRPYGYEQGQYGNYQQ
Target Bioclass
Other
Family
SS18 family
Subcellular location
Nucleus
Function
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
Uniprot ID
O75177
Ensemble ID
ENST00000331758.8
HGNC ID
HGNC:15592

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.Q92H DBIA    Probe Info 
CORL23 SNV: p.P352L .
EFO27 SNV: p.Y355C DBIA    Probe Info 
HCC15 SNV: p.V3M .
RKN SNV: p.G126W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
BTD
 Probe Info  		C47(0.64)  LDD2117  [2]
DBIA
 Probe Info  		C47(0.91)  LDD0547  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_5
 Probe Info  		C47(0.00); C34(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C47(0.44)  LDD2142  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C47(0.64)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C47(0.94); C34(0.96)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C47(0.93)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C47(1.05); C34(1.00)  LDD1509  [7]
 LDCM0230  AC113 HCT 116 C47(0.91)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C47(0.80)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C47(0.80)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C47(0.86)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C47(0.77)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C47(0.78)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C47(0.95)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C47(1.10); C34(0.93)  LDD1510  [7]
 LDCM0238  AC120 HCT 116 C47(0.72)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C47(0.61)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C47(0.77)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C47(0.64)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C47(0.66)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C47(0.66)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C47(0.68)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C47(0.62)  LDD0562  [3]
 LDCM0259  AC14 HEK-293T C47(1.16); C34(1.00)  LDD1512  [7]
 LDCM0263  AC143 HCT 116 C47(1.13)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C47(1.36)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C47(1.31)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C47(1.76)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C47(2.11)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C47(2.44)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C47(1.55)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C34(1.05)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C47(1.31)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C47(1.25)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C47(1.91)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C47(2.60)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C47(2.17)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C47(1.51)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C47(1.25)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C47(1.10)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C47(1.08)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C47(0.67)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C47(0.95)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C47(0.95)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C47(0.66)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C47(0.56)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C47(0.70)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C47(0.59)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C47(0.73)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C47(0.96); C34(0.97)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C47(0.89)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C47(1.01); C34(1.01)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C47(1.16); C34(0.96)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C47(0.97); C34(1.02)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C47(1.10); C34(1.00)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C47(0.89); C34(1.09)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C34(1.08)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C47(1.03); C34(1.02)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C47(1.03); C34(0.98)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C47(1.06)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C47(1.17); C34(0.98)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C47(1.18); C34(1.05)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C47(1.11); C34(1.05)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C47(1.20); C34(0.99)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C34(1.10)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C47(1.08); C34(0.98)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C47(0.98); C34(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C47(0.94); C34(0.97)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C47(0.90)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C47(1.02); C34(1.01)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C47(1.09); C34(1.07)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C47(1.06); C34(1.07)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C47(0.89); C34(1.09)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C34(1.02)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C47(0.91); C34(1.00)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C47(0.96); C34(0.96)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C47(1.02); C34(1.12)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C47(0.96)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C47(1.06); C34(1.07)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C47(1.02); C34(1.02)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C47(1.14); C34(1.02)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C47(1.03); C34(1.09)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C34(0.97)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C47(1.02); C34(1.06)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C47(0.98); C34(1.03)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C47(0.96)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C47(1.08); C34(1.01)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C47(0.85); C34(1.03)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C47(1.01); C34(0.99)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C47(1.02); C34(0.99)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C47(0.90); C34(1.05)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C34(1.10)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C47(1.01); C34(0.98)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C34(1.04)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C47(1.00); C34(1.05)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C47(1.09); C34(1.00)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C47(0.99); C34(0.92)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C47(1.10); C34(1.08)  LDD1514  [7]
 LDCM0632  CL-Sc Hep-G2 C47(20.00); C47(0.71)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C47(0.94)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C47(1.04); C34(0.85)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C47(0.94); C34(1.08)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C47(0.99)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C47(0.82); C34(0.91)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C47(0.97); C34(1.05)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C47(0.97); C34(0.99)  LDD1577  [7]
 LDCM0374  CL105 HCT 116 C47(0.80)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C47(0.88)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C47(0.84)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C47(0.97)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C47(0.57)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C34(0.90)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C47(0.58)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C47(0.65)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C47(0.93); C34(1.03)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C47(0.99)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C47(0.78); C34(0.88)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C47(0.94); C34(1.14)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C47(1.03); C34(0.99)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C47(0.89)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C47(0.97); C34(1.03)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C47(0.89); C34(1.05)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C47(0.89); C34(0.98)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C47(1.05); C34(1.00)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C47(1.02)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C47(0.93); C34(1.07)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C47(0.87); C34(0.64)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C47(1.00); C34(1.00)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C47(1.05)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C47(0.86); C34(0.98)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C47(0.92); C34(1.09)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C47(0.90); C34(0.92)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C47(1.04)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C47(0.87); C34(0.99)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C47(0.98); C34(0.85)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C47(1.02); C34(0.95)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C47(1.04); C34(0.86)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C47(0.90)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C47(1.07); C34(1.03)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C47(0.78); C34(1.03)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C47(1.07); C34(0.99)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C47(1.13); C34(0.84)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C47(1.13); C34(1.07)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C34(1.09)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C47(1.04); C34(0.95)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C47(0.90)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C47(0.91); C34(0.99)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C47(0.80); C34(1.14)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C47(1.04); C34(0.93)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C47(1.02); C34(1.03)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C47(0.85); C34(1.11)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C47(0.95)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C47(1.01); C34(0.97)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C47(1.19); C34(0.95)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C47(0.96); C34(0.84)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C47(1.10); C34(0.99)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C34(1.02)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C47(1.08); C34(0.97)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C47(1.01)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C47(1.10); C34(1.10)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C47(0.99); C34(1.13)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C47(1.11); C34(1.07)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C47(0.88); C34(0.87)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C47(1.04)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C47(0.96); C34(1.08)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C47(1.22); C34(0.93)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C47(1.21); C34(0.81)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C47(1.12); C34(0.97)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C34(1.04)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C47(1.03); C34(1.06)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C47(1.00)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C47(1.09); C34(0.95)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C47(0.87); C34(1.02)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C47(1.01); C34(1.05)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C47(0.97); C34(0.95)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C47(0.84)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C47(0.98); C34(1.02)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C47(1.06); C34(0.99)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C47(0.96); C34(0.78)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C47(1.02); C34(1.04)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C34(1.02)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C47(0.82)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C47(1.05); C34(1.06)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C47(1.15)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C47(1.19)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C47(1.27)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C47(1.07)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C47(1.23)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C47(1.23)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C47(1.01)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C47(1.21)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C47(1.27)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C47(1.14); C34(1.02)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C47(1.40)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C47(1.13)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C47(1.15)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C47(1.32)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C47(1.22)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C47(0.96); C34(1.04)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C47(0.89); C34(0.86)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C47(1.10)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C47(1.06); C34(0.98)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C47(0.84); C34(0.78)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C47(1.15); C34(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C47(1.18); C34(1.05)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C47(1.06); C34(1.05)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C34(1.08)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C47(1.06); C34(0.91)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C47(0.83)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C47(0.82); C34(0.97)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C47(1.06); C34(1.10)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C47(1.06); C34(1.13)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C47(0.88); C34(0.98)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C47(1.22); C34(0.87)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C47(0.76)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C47(1.07); C34(1.05)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C47(1.05); C34(0.93)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C47(0.97); C34(1.04)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C47(1.25); C34(0.94)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C34(0.78)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C47(1.03); C34(1.02)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C47(0.96)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C47(0.96); C34(0.93)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C47(0.94); C34(0.96)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C47(0.99); C34(1.20)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C47(1.45)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C47(0.76); C34(0.97)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C47(0.96); C34(1.07)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C47(6.84)  LDD0315  [4]
 LDCM0024  KB05 HMCB C47(1.00)  LDD3312  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Melanoma inhibitory activity protein 2 (MIA2) MIA/OTOR family Q96PC5
Galectin-3 (LGALS3) . P17931
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Paired box protein Pax-8 (PAX8) . Q06710
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM168A (FAM168A) FAM168 family Q92567
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
BAG family molecular chaperone regulator 4 (BAG4) . O95429
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Single-stranded DNA-binding protein 3 (SSBP3) . Q9BWW4
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840