Details of the Target

General Information of Target

Target ID LDTP01116
Target Name Disintegrin and metalloproteinase domain-containing protein 11 (ADAM11)
Gene Name ADAM11
Gene ID 4185
Synonyms
MDC; Disintegrin and metalloproteinase domain-containing protein 11; ADAM 11; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein; MDC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG
EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE
GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP
QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY
VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ
VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY
GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID
EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT
HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG
RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF
LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML
CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP
TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA
Target Bioclass
Transporter and channel
Subcellular location
Presynaptic cell membrane
Function
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation.
Uniprot ID
O75078
Ensemble ID
ENST00000200557.11
HGNC ID
HGNC:189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.H664Y .
AN3CA Deletion: p.G78AfsTer9 .
HELA SNV: p.V368M .
HS936T SNV: p.G162E .
LS180 SNV: p.Y625S .
MEC1 SNV: p.K495M .
MEWO SNV: p.P719L .
NCIH1155 SNV: p.R140Q .
RH30 SNV: p.L3M .
SNGM SNV: p.E46D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C392(1.31)  LDD1507  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
aONE
 Probe Info  		N.A.  LDD0002  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C392(1.31)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C392(0.96)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C392(0.91)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C392(0.88)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C392(1.31)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C392(0.91)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C392(1.16)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C392(0.85)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C392(0.92)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C392(0.75)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C392(1.26)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C392(0.89)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C392(0.99)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C392(0.96)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C392(1.03)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C392(0.90)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C392(1.38)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C392(0.94)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C392(1.07)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C392(0.85)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C392(0.94)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C392(0.96)  LDD1540  [1]
 LDCM0302  AC40 HEK-293T C392(0.96)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C392(1.13)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C392(0.96)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C392(1.08)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C392(0.97)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C392(0.99)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C392(0.95)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C392(1.21)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C392(1.15)  LDD1551  [1]
 LDCM0315  AC52 HEK-293T C392(1.06)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C392(0.95)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C392(0.75)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C392(0.88)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C392(0.98)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C392(1.03)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C392(0.92)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C392(1.07)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C392(1.15)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C392(0.88)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C392(0.95)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C392(0.90)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C392(0.94)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C392(1.07)  LDD1569  [1]
 LDCM0248  AKOS034007472 HEK-293T C392(1.12)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C392(1.10)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C392(1.04)  LDD1514  [1]
 LDCM0020  ARS-1620 HCC44 C392(1.32)  LDD2171  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0368  CL10 HEK-293T C392(1.24)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C392(1.10)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C392(0.88)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C392(1.07)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C392(0.88)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C392(0.96)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C392(1.32)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C392(0.88)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C392(1.26)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C392(0.91)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C392(1.13)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C392(0.93)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C392(1.56)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C392(1.09)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C392(0.94)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C392(1.25)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C392(1.31)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C392(0.97)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C392(1.13)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C392(1.17)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C392(1.39)  LDD1608  [1]
 LDCM0407  CL2 HEK-293T C392(1.04)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C392(1.07)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C392(1.24)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C392(1.14)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C392(1.12)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C392(1.23)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C392(0.77)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C392(1.00)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C392(1.25)  LDD1621  [1]
 LDCM0421  CL32 HEK-293T C392(1.02)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C392(1.25)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C392(0.91)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C392(0.99)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C392(1.11)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C392(1.27)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C392(1.07)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C392(1.33)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C392(1.20)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C392(1.13)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C392(0.95)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C392(1.09)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C392(0.85)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C392(1.51)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C392(0.94)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C392(1.12)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C392(1.43)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C392(1.13)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C392(1.27)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C392(1.09)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C392(1.08)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C392(1.01)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C392(1.10)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C392(0.88)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C392(1.19)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C392(1.10)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C392(1.10)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C392(0.88)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C392(0.95)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C392(0.80)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C392(1.01)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C392(1.22)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C392(1.22)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C392(1.10)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C392(1.03)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C392(1.29)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C392(1.05)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C392(1.01)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C392(0.94)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C392(0.94)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C392(1.07)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C392(1.19)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C392(1.37)  LDD1687  [1]
 LDCM0487  CL92 HEK-293T C392(0.91)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C392(1.24)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C392(1.02)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C392(1.10)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C392(1.03)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C392(0.83)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C392(0.93)  LDD1631  [1]
 LDCM0021  THZ1 HCT 116 C392(1.32)  LDD2173  [5]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.