Details of the Target

General Information of Target

Target ID LDTP00595
Target Name Ataxin-7 (ATXN7)
Gene Name ATXN7
Gene ID 6314
Synonyms
SCA7; Ataxin-7; Spinocerebellar ataxia type 7 protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRP
EDGGPGAASTSAAAMATVGERRPLPSPEVMLGQSWNLWVEASKLPGKDGTELDESFKEFG
KNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPPLAV
PPTSVFSFFPSLSKSKGGSASGSNRSSSGGVLSASSSSSKLLKSPKEKLQLRGNTRPMHP
IQQSRVPHGRIMTPSVKVEKIHPKMDGTLLKSAVGPTCPATVSSLVKPGLNCPSIPKPTL
PSPGQILNGKGLPAPPTLEKKPEDNSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTR
SLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPPQPLRDPHPAPPR
TSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPP
LPATEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRW
NRLRCALNLMVEKHLNAQLWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVS
TSPVLLSSTCISPNSKSVPAHGTTLNAQPAASGAMDPVCSMQSRQVSSSSSSPSTPSGLS
SVPSSPMSRKPQKLKSSKSLRPKESSGNSTNCQNASSSTSGGSGKKRKNSSPLLVHSSSS
SSSSSSSSHSMESFRKNCVAHSGPPYPSTVTSSHSIGLNCVTNKANAVNVRHDQSGRGPP
TGSPAESIKRMSVMVNSSDSTLSLGPFIHQSNELPVNSHGSFSHSHTPLDKLIGKKRKCS
PSSSSINNSSSKPTKVAKVPAVNNVHMKHTGTIPGAQGLMNSSLLHQPKARP
Target Bioclass
Other
Family
Ataxin-7 family
Subcellular location
Cytoplasm; Nucleus
Function
Acts as a component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.
Uniprot ID
O15265
Ensemble ID
ENST00000295900.10
HGNC ID
HGNC:10560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU4475 SNV: p.D132G .
HCC44 SNV: p.A546S .
HCT15 SNV: p.A466T .
HGC27 SNV: p.K683M .
HKGZCC SNV: p.K175Ter .
Ishikawa (Heraklio) 02 ER Deletion: p.T781PfsTer11 .
LS180 Deletion: p.T781PfsTer11 .
MDAMB453 SNV: p.C278S .
MEWO SNV: p.P416L .
NCIH1155 SNV: p.Q305Ter; p.A596V .
NCIH23 SNV: p.Q36Ter .
OAW42 SNV: p.E388A .
OVK18 Deletion: p.T781PfsTer11 .
REH SNV: p.P53L .
RKO Deletion: p.T781PfsTer11 .
SNGM SNV: p.S821G .
TCCSUP SNV: p.R542Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C839(3.08)  LDD3416  [2]
AHL-Pu-1
 Probe Info  		C839(7.34)  LDD0169  [3]
Acrolein
 Probe Info  		N.A.  LDD0227  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_4
 Probe Info  		C639(0.00); C692(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		C839(0.00); C692(0.00)  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0147  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C839(7.34)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C839(0.93)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C839(1.23)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C278(1.07)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C839(1.01)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C545(0.93); C839(1.04)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C545(1.04)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C839(0.95)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C839(0.94)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C278(1.46)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C839(0.92)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C839(0.99)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C545(1.02); C839(1.07)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C545(1.03); C839(0.92)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C545(1.02)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C545(0.99); C278(0.99)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C839(0.99)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C839(1.02)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C278(1.00)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C839(0.92)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C545(0.96); C839(1.08)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C278(0.98)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C545(1.02); C839(0.89)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C545(0.99)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C545(0.98); C278(0.86)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C839(0.94)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C839(0.96)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C278(1.04)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C839(0.97)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C545(1.04); C839(0.92)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C545(1.04); C839(1.06)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C545(1.05)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C839(0.96)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C545(1.04); C278(0.97)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C839(1.04)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C839(1.34)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C278(1.13)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C839(0.99)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C545(0.99); C839(1.15)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C545(0.96); C839(1.03)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C545(0.98)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C545(0.97); C278(0.95)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C839(1.08)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C545(0.95); C839(0.99)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C839(1.00)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C278(1.04)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C839(0.99)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C545(1.06); C839(1.01)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C545(1.04); C839(1.04)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C545(1.02)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C545(1.00); C278(0.88)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C839(1.04)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C839(0.87)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C278(0.98)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C545(0.97); C839(0.95)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C839(1.01)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C545(0.98); C839(1.13)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C545(0.99); C839(1.17)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C545(1.10)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C545(0.95); C278(0.95)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C545(0.98)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C545(0.96); C278(0.88)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C545(1.01); C839(1.06)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C839(0.97)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C545(0.95); C278(0.89)  LDD1514  [11]
 LDCM0632  CL-Sc Hep-G2 C839(1.46); C692(1.41); C839(0.84)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C545(1.04); C839(0.90); C278(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C545(1.19); C839(0.89)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C839(1.30)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C545(0.74); C839(1.04); C278(1.03)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C545(1.07); C839(0.93)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C545(1.09)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C839(1.14)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C545(1.04); C839(1.04); C278(0.84)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C545(1.12); C839(1.03)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C545(1.00)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C839(0.90)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C545(0.99); C839(1.00); C278(0.92)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C545(1.09)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C545(1.19); C839(0.91)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C545(1.09)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C839(1.12)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C545(1.22); C839(1.04); C278(0.94)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C545(1.21); C839(0.78)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C545(1.09)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C839(1.21)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C545(1.04); C839(0.97); C278(0.97)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C545(1.13); C839(1.05)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C545(1.04)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C545(1.25); C278(0.94)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C839(1.03)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C545(0.78); C839(0.98); C278(1.10)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C545(1.02); C839(1.16)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C545(1.03)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C839(1.25)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C545(1.01); C839(0.88); C278(1.14)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C545(1.16); C839(0.81)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C545(0.95)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C839(0.97)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C545(1.13); C839(1.34); C278(1.00)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C545(1.14); C839(0.91)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C545(0.90)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C839(1.12)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C839(0.89)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C839(1.09)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C278(1.40)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C545(1.11); C839(1.04)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C839(0.95)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C545(1.03); C839(1.04)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C545(1.09); C839(0.93)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C545(1.05)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C545(1.07); C278(1.11)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C545(0.95); C839(0.94); C278(0.85)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C545(1.16); C839(1.03)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C545(0.92)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C839(1.23)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C839(0.91)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C545(1.03)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C839(1.10)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C278(1.21)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C839(0.95)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C545(1.07); C839(0.87)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C545(1.18); C839(0.90)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C545(1.02)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C545(0.90); C278(1.48)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C545(0.97); C839(0.70); C278(0.93)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C545(0.91)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C839(1.00)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C839(0.95)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C839(0.93)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C839(0.95)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C278(1.08)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C839(0.97)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C545(1.10); C839(0.84)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C545(0.94); C839(0.95)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C545(0.98)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C545(0.97); C278(1.23)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C545(1.02); C839(1.11); C278(0.96)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C839(0.92)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C545(1.09); C839(0.92)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C839(1.07)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C839(1.00)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C839(0.83)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C278(1.22)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C839(1.07)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C545(1.10); C839(1.02)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C545(1.00); C839(1.00)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C545(1.19)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C839(0.88)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C545(1.23); C278(1.06)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C545(1.05); C839(0.91); C278(1.10)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C545(1.00); C839(0.98)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C545(1.06)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C839(1.06)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C839(1.02)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C839(0.89)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C278(1.22)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C839(0.94)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C545(1.13); C839(0.95)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C278(1.09)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C545(1.09); C839(0.99)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C545(1.20)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C545(1.00); C278(1.07)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C545(1.03); C839(0.94); C278(0.99)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C545(1.01); C839(0.92)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C839(0.97)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C839(1.07)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C839(0.86)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C278(1.16)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C839(0.76)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C839(0.89)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C545(1.00); C839(1.04)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C545(1.06); C839(1.02)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C545(0.94)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C545(0.99); C278(1.00)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C545(0.98); C839(0.92); C278(0.96)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C545(1.09); C839(1.01)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C545(1.00)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C839(1.07)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C839(0.94)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C545(1.01); C839(0.94)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C839(0.83)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C278(1.07)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C839(0.92)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C545(1.00); C839(0.87)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C545(0.96); C839(1.00)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C545(1.04)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C545(0.96); C278(0.97)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C545(0.97); C839(0.96); C278(1.06)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C545(0.96); C839(0.98)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C545(0.95)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C545(0.88)  LDD1698  [11]
 LDCM0625  F8 Ramos C839(1.37)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C839(1.62)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C839(20.00)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C839(0.77)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C839(0.97)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C839(0.78)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C839(1.11)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C839(0.86)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C839(0.98)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C839(1.11)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C839(1.13)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C839(1.39)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C839(0.85)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C839(1.67)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C545(1.03)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C839(0.87)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C839(1.01)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C545(1.07); C839(0.95)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C839(1.75)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C839(2.39)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C839(1.23)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C839(1.16)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C839(1.14)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C839(1.04)  LDD1497  [11]
 LDCM0024  KB05 SCC-25 C839(3.08)  LDD3416  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transformation/transcription domain-associated protein (TRRAP) PI3/PI4-kinase family Q9Y4A5
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Agrin (AGRN) . O00468
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Latent-transforming growth factor beta-binding protein 4 (LTBP4) LTBP family Q8N2S1
Nucleolar complex protein 2 homolog (NOC2L) NOC2 family Q9Y3T9
Transcription initiation factor TFIID subunit 10 (TAF10) TAF10 family Q12962
Matrilin-2 (MATN2) . O00339
Multiple epidermal growth factor-like domains protein 6 (MEGF6) . O75095
Multiple epidermal growth factor-like domains protein 8 (MEGF8) . Q7Z7M0
Sorbin and SH3 domain-containing protein 1 (SORBS1) . Q9BX66

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578