Details of the Target

General Information of Target

Target ID LDTP00337
Target Name Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)
Gene Name PIK3C2B
Gene ID 5287
Synonyms
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta; EC 2.7.1.137; EC 2.7.1.154; C2-PI3K; Phosphoinositide 3-kinase-C2-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW
DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK
GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS
SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL
KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT
PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY
VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD
VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS
PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC
NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY
CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH
GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS
SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI
LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW
EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR
RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD
GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR
TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV
IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK
IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN
IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL
CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI
ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH
PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE
AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP
VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV
ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK
TGWFALGSRSHGTL
Target Bioclass
Enzyme
Family
PI3/PI4-kinase family
Subcellular location
Microsome
Function Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
Uniprot ID
O00750
Ensemble ID
ENST00000367187.7
HGNC ID
HGNC:8972
ChEMBL ID
CHEMBL5554

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1054(45.87)  LDD0209  [1]
HHS-465
 Probe Info  		Y1056(1.94)  LDD2237  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [5]
TFBX
 Probe Info  		C1119(0.00); C1373(0.00)  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C384(1.00); C1373(1.07)  LDD1507  [7]
 LDCM0215  AC10 HCT 116 C994(0.92)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C994(0.59)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C994(0.66)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C994(0.62)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C994(0.62)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C994(0.68)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C994(0.63)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C994(0.61)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C994(0.16)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C994(0.66)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C994(0.62)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C994(0.87)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C994(0.48)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C994(0.44)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C994(0.18)  LDD0546  [8]
 LDCM0237  AC12 HCT 116 C994(0.88)  LDD0554  [8]
 LDCM0259  AC14 HCT 116 C994(0.97)  LDD0576  [8]
 LDCM0270  AC15 HCT 116 C994(0.93)  LDD0587  [8]
 LDCM0276  AC17 HCT 116 C994(0.95)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C994(1.03)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C994(0.91)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C384(1.06); C1373(0.85); C429(1.11)  LDD1518  [7]
 LDCM0280  AC20 HCT 116 C994(0.89)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C994(0.92)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C994(0.82)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C994(0.90)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C994(1.10)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C994(0.97)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C994(0.92)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C994(0.99)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C994(0.97)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C994(1.00)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C1373(0.94); C429(0.93)  LDD1529  [7]
 LDCM0291  AC30 HCT 116 C994(0.98)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C994(0.99)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C994(1.09)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C994(1.00)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C994(1.11)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C994(1.05)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C994(0.96)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C994(0.99)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C994(1.03)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C994(0.93)  LDD0617  [8]
 LDCM0301  AC4 HEK-293T C384(0.98); C1373(0.93)  LDD1540  [7]
 LDCM0302  AC40 HCT 116 C994(1.05)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C994(0.95)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C994(0.94)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C994(0.94)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C994(1.01)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C994(0.93)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C994(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C994(1.09)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C994(1.02)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C994(0.74)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C1373(1.00)  LDD1551  [7]
 LDCM0313  AC50 HCT 116 C994(0.94)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C994(1.02)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C994(0.93)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C994(1.02)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C994(1.17)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C994(0.98)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C994(1.25)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C994(1.00)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C994(0.94)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C994(1.10)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C994(1.05)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C994(0.94)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C994(0.97)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C994(1.32)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C994(0.99)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C994(1.04)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C994(1.22)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C994(1.16)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C994(1.19)  LDD0648  [8]
 LDCM0334  AC7 HCT 116 C994(1.00)  LDD0651  [8]
 LDCM0345  AC8 HCT 116 C994(0.91)  LDD0662  [8]
 LDCM0349  AC83 HCT 116 C994(0.84)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C994(1.09)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C994(1.05)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C994(1.00)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C994(1.05)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C994(1.02)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C994(0.94)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C994(0.96)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C994(1.02)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C994(1.08)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C994(0.99)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C994(1.04)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C994(0.98)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C994(1.12)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C994(0.94)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C994(0.52)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C994(0.57)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C994(0.88)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C994(0.91)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C994(0.99)  LDD0592  [8]
 LDCM0367  CL1 HEK-293T C691(0.98); C384(0.98); C1373(1.33)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C1373(0.90)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C384(0.94); C1373(1.20); C429(1.12)  LDD1573  [7]
 LDCM0370  CL101 HCT 116 C994(1.02)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C994(0.87)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C994(0.99)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C994(1.02)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C994(0.96)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C994(1.00)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C994(1.01)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C994(1.12)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C994(0.99)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C384(1.09); C1373(1.17); C429(1.02)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C994(0.92)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C994(0.93)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C994(0.96)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C994(1.04)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C994(1.14)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C994(1.00)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C994(1.04)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C994(1.12)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C994(0.99)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C994(1.00)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C1373(1.12); C749(0.99)  LDD1594  [7]
 LDCM0391  CL120 HCT 116 C994(0.96)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C994(0.98)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C994(1.15)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C994(1.28)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C994(1.10)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C994(0.89)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C994(1.15)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C994(1.01)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C994(1.08)  LDD0716  [8]
 LDCM0400  CL13 HEK-293T C691(0.98); C384(1.08); C1373(1.05)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C384(1.12); C1373(1.01); C429(1.25)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C384(0.82); C1373(0.88)  LDD1606  [7]
 LDCM0403  CL16 HCT 116 C994(1.03)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C994(1.08)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C994(0.94)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C994(1.01)  LDD0723  [8]
 LDCM0407  CL2 HEK-293T C384(1.00); C1373(0.83); C429(1.09)  LDD1611  [7]
 LDCM0408  CL20 HCT 116 C994(1.11)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C994(1.09)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C994(1.12)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C994(1.04)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C994(1.04)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C994(1.03)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C994(0.96)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C994(0.95)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C994(1.00)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C994(0.98)  LDD0734  [8]
 LDCM0418  CL3 HEK-293T C384(1.01); C1373(1.04)  LDD1622  [7]
 LDCM0419  CL30 HCT 116 C994(1.01)  LDD0736  [8]
 LDCM0420  CL31 HEK-293T C1373(1.13); C429(1.05)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C384(1.10); C1373(0.94)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C1373(0.91)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C1373(1.12)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C384(1.23); C1373(1.08); C429(1.04)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C1373(1.14); C749(0.99)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C691(0.86); C384(0.93); C1373(0.79)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C384(0.89); C1373(1.00)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C384(0.95); C1373(1.08); C429(1.27)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C384(1.03); C1373(1.22); C429(0.94)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C384(0.97); C1373(0.97)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C384(0.96); C1373(1.15); C429(0.90)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C1373(1.08); C429(0.86)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C384(0.97); C1373(0.95)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C1373(0.97)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C994(0.80)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C994(0.83)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C994(0.83)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C994(0.86)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C384(0.91); C1373(1.15)  LDD1644  [7]
 LDCM0441  CL50 HCT 116 C994(0.88)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C994(0.81)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C994(0.77)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C994(0.91)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C994(0.87)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C994(0.79)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C994(0.80)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C994(0.83)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C994(0.80)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C994(0.88)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C384(1.31); C1373(0.77); C429(1.02)  LDD1654  [7]
 LDCM0452  CL60 HCT 116 C994(0.93)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C691(0.86); C384(1.25); C1373(1.18)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C384(0.96); C1373(0.97); C429(1.19)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C384(0.83); C1373(0.95)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C384(0.99); C1373(0.88); C429(1.06)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C384(0.91); C1373(0.98)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C384(0.94); C1373(1.17); C429(1.10)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C1373(1.06); C429(0.98)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C384(1.17); C1373(0.98)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C1373(1.04)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C1373(1.12); C429(1.10)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C1373(1.11)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C384(1.16); C1373(1.19); C429(1.04)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C1373(1.11); C749(1.09)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C691(0.75); C384(1.07); C1373(1.16)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C384(1.00); C1373(0.87); C429(1.07)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C384(1.01); C1373(1.11); C429(1.27)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C384(0.90); C1373(0.85)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C384(1.07); C1373(1.47); C429(1.10)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C1373(1.04); C429(0.88)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C384(1.02); C1373(0.85)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C384(0.94); C1373(1.13)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C1373(0.99)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C1373(1.24)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C384(1.00); C1373(1.03); C429(0.98)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C1373(1.06); C749(1.10)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C691(0.92); C384(1.09); C1373(1.10)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C384(1.02); C1373(1.01); C429(1.37)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C384(0.96); C1373(1.01)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C384(1.02); C1373(1.18); C429(1.32)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C384(0.91); C1373(1.02)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C1373(1.06)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C384(1.03); C1373(1.01); C429(0.93)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C1373(1.03); C429(0.90)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C384(0.97); C1373(0.98)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C1373(1.05)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C1373(0.79)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C384(1.13); C1373(0.99); C429(1.33)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C1373(1.00); C749(1.02)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C691(0.95); C384(0.84); C1373(0.99)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C384(0.91); C1373(0.88); C429(0.98)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C384(0.94); C1373(0.98)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C384(0.84); C1373(1.00)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C384(0.76); C1373(1.01)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C384(1.20); C1373(1.03); C429(0.91)  LDD1631  [7]
 LDCM0022  KB02 T cell-activated C561(8.02)  LDD1704  [9]
 LDCM0023  KB03 Jurkat C1054(45.87)  LDD0209  [1]
 LDCM0024  KB05 RVH421 C749(1.82)  LDD3320  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840