Details of the Target

General Information of Target

Target ID LDTP00324
Target Name Peroxisome assembly protein 12 (PEX12)
Gene Name PEX12
Gene ID 5193
Synonyms
PAF3; Peroxisome assembly protein 12; Peroxin-12; Peroxisome assembly factor 3; PAF-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEHGAHFTAASVADDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPTHYGFLWRWFD
EIFTLLDLLLQQHYLSRTSASFSENFYGLKRIVMGDTHKSQRLASAGLPKQQLWKSIMFL
VLLPYLKVKLEKLVSSLREEDEYSIHPPSSRWKRFYRAFLAAYPFVNMAWEGWFLVQQLR
YILGKAQHHSPLLRLAGVQLGRLTVQDIQALEHKPAKASMMQQPARSVSEKINSALKKAV
GGVALSLSTGLSVGVFFLQFLDWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKM
KTVCPLCRKTRVNDTVLATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLYSPEN
Target Bioclass
Transporter and channel
Family
Pex2/pex10/pex12 family
Subcellular location
Peroxisome membrane
Function
Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10. When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation.
Uniprot ID
O00623
Ensemble ID
ENST00000225873.9
HGNC ID
HGNC:8854

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C304(1.25); C307(1.25)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C304(1.06); C307(1.06)  LDD0812  [1]
 LDCM0215  AC10 HEK-293T C304(1.01); C307(1.01)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C304(1.11)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C304(0.96)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C304(1.13)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C304(1.21)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C304(1.14)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C304(1.15)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C304(1.13)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C304(1.23)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C304(0.96)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C304(1.18)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C304(0.95); C307(0.95)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C304(1.33)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C304(1.58)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C304(1.27)  LDD0827  [1]
 LDCM0237  AC12 HEK-293T C304(1.17); C307(1.17)  LDD0835  [1]
 LDCM0259  AC14 HEK-293T C304(0.83); C307(0.83)  LDD0857  [1]
 LDCM0263  AC143 HEK-293T C325(1.10)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C325(1.25)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C325(1.27)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C325(1.26)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C325(1.41)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C325(1.35)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C325(1.12)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C304(0.94); C307(0.94)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C325(1.15)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C325(1.11)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C325(1.08)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C325(1.16)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C325(1.20)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C325(1.15)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C325(1.51)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C325(1.73)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C328(0.97); C325(0.85)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C328(0.99); C325(0.87)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C328(0.92); C325(0.92)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C304(1.05); C307(1.05)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C328(1.06); C325(1.09); C339(0.94)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C328(0.98); C325(1.08); C339(0.99)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C339(0.90)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C328(0.93); C325(0.98)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C325(1.04); C339(1.12)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C328(0.96); C325(0.91)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C328(0.98); C325(0.97)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C328(0.96); C325(0.98)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C328(1.06); C325(1.31); C339(0.92)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C328(0.94); C325(0.94); C339(0.94)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C304(1.10); C307(1.10)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C339(0.96)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C328(0.99); C325(0.89)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C325(1.09); C339(0.88)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C328(0.91); C325(0.83)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C328(1.05); C325(0.98)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C304(0.94); C307(0.94)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C304(1.08); C307(1.08)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C304(1.08); C307(1.08)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C304(0.88); C307(0.88)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C304(0.72); C307(0.72)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C304(1.04); C307(1.04)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C304(0.90); C307(0.90)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C304(0.95); C307(0.95)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C304(1.02); C307(1.02)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C304(0.81); C307(0.81)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C304(0.97); C307(0.97)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C304(0.90); C307(0.90)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C304(1.22); C307(1.39); C325(0.95)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C304(0.98); C307(0.88); C325(0.90)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C304(0.96); C307(0.95); C325(0.90)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C304(1.13); C307(1.22); C325(0.73)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C304(1.11); C307(1.11)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C304(1.22); C307(1.47); C325(0.78)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C304(1.04); C307(1.00); C325(0.73)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C304(1.07); C307(1.18); C325(0.66)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C304(0.95); C307(0.88); C325(0.81)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C304(1.07); C307(1.09); C325(0.70)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C304(1.14); C307(1.29); C325(0.87)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C304(1.16); C307(1.29); C325(0.80)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C328(0.86); C325(0.92)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C328(1.00); C325(0.96)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C328(0.97); C325(1.09)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C304(1.02); C307(1.02)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C328(1.04); C325(1.29); C339(0.96)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C328(0.94); C325(1.03); C339(1.05)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C339(1.02)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C328(0.89); C325(1.04)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C325(0.94); C339(1.12)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C304(1.07); C307(1.07)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C304(1.04); C307(1.04)  LDD0943  [1]
 LDCM0349  AC83 HEK-293T C304(1.29)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C304(0.83)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C304(0.97)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C304(1.02)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C304(0.94)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C304(0.91)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C304(1.21)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C304(0.94)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C304(0.91)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C304(0.84)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C304(0.79)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C304(0.89)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C304(0.91)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C304(0.90)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C304(1.27)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C304(1.06)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C304(1.13)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C304(0.81); C307(0.81)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C304(1.07); C307(1.07)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C304(0.85); C307(0.85)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C304(1.25); C307(1.25)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C304(0.80); C307(0.73)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C304(0.96); C307(0.69)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C304(1.11); C307(1.11)  LDD0967  [1]
 LDCM0370  CL101 HEK-293T C304(0.83); C307(0.83)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C304(0.78); C307(0.78)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C304(1.02); C307(1.02)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C304(1.00); C307(1.00)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C328(0.92); C325(1.03); C339(1.09)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C328(1.11); C325(1.03); C339(1.33)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C328(1.09); C325(1.14); C339(1.06)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C328(0.96); C325(0.98)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C328(1.03); C325(1.08); C339(1.09)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C304(0.90); C307(0.80)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C328(0.96); C325(0.91); C339(1.42)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C328(1.01); C325(1.02); C339(1.17)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C328(0.97); C325(0.89)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C328(0.99); C325(1.03); C339(0.94)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C328(0.99); C325(0.81); C339(1.57)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C328(0.98); C325(1.11); C339(1.05)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C328(1.08); C325(1.20)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C304(0.87); C307(0.87)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C304(1.13); C307(1.13)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C304(1.29); C307(1.29)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C304(0.98); C307(1.00)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C304(0.92); C307(0.92)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C304(1.11); C307(1.24); C325(0.74)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C304(1.07); C307(1.07); C325(0.71)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C304(0.93); C307(0.78); C325(0.93)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C304(1.15); C307(1.19); C325(0.83)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C328(1.01); C325(1.26); C339(1.10)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C328(1.01); C325(1.00); C339(1.12)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C328(1.04); C325(0.97); C339(1.07)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C328(1.02); C325(1.00)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C304(0.95); C307(0.95)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C304(0.87); C307(0.80)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C304(0.87); C307(0.69)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C328(1.08); C325(1.24)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C328(0.91); C325(1.11)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C328(1.07); C325(1.04)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C328(1.11); C325(1.17)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C304(0.83); C307(0.90)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C328(1.14); C325(1.22); C339(1.17)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C328(1.05); C325(1.03); C339(1.90)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C339(1.16)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C328(1.00); C325(1.07)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C325(1.30); C339(1.29)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C328(0.92); C325(1.33); C339(1.08)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C328(0.99); C325(0.93); C339(1.16)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C328(1.13); C325(1.00); C339(0.99)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C328(0.98); C325(0.93)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C328(1.04); C325(1.10)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C304(0.88); C307(0.84)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C328(1.07); C325(0.93)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C304(0.96); C307(1.00); C325(0.72)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C304(1.05); C307(0.94); C325(0.76)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C304(0.74); C307(0.75); C325(0.75)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C304(0.99); C307(0.91); C325(0.98)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C304(0.95); C307(0.85); C325(0.68)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C304(1.04); C307(0.88); C325(0.72)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C304(0.90); C307(0.83); C325(0.68)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C304(0.89); C307(0.83); C325(0.67)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C304(0.93); C307(0.84)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C304(0.97); C307(0.84); C325(0.77)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C304(0.91); C307(0.75); C325(0.69)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C304(1.02); C307(0.87); C325(0.66)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C304(1.05); C307(0.85); C325(0.74)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C304(0.96); C307(0.85); C325(0.69)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C304(0.86); C307(0.73); C325(0.66)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C307(1.17)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C307(1.18)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C307(1.17)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C307(1.03)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C304(0.95); C307(0.98)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C307(1.03)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C307(1.19)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C307(1.39)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C307(1.13)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C307(0.83)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C307(1.03)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C307(1.05)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C307(1.00)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C307(0.88)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C307(1.05)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C304(0.89); C307(0.80)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C307(1.14)  LDD1050  [1]
 LDCM0453  CL61 HEK-293T C304(1.02); C307(1.12); C325(0.60)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C304(0.95); C307(0.93); C325(0.82)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C304(1.03); C307(1.05); C325(0.81)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C304(0.99); C307(0.93); C325(0.97)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C304(1.09); C307(1.16); C325(1.00)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C304(1.07); C307(1.02); C325(0.91)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C304(1.06); C307(0.97); C325(0.99)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C304(1.11); C307(0.96); C325(0.89)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C304(1.06); C307(0.95); C325(0.91)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C304(0.92); C307(0.90)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C304(1.17); C307(0.99); C325(0.86)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C304(1.20); C307(1.09); C325(0.72)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C304(1.14); C307(1.06); C325(0.72)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C304(1.07); C307(0.93); C325(0.89)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C304(1.20); C307(1.05); C325(0.93)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C328(1.04); C325(0.94)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C328(0.99); C325(0.91)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C328(1.13); C325(0.90)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C328(1.03); C325(0.94)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C304(0.94); C307(1.07)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C328(1.16); C325(1.37); C339(1.07)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C328(1.02); C325(1.03); C339(1.12)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C339(1.12)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C328(1.07); C325(1.12)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C325(1.09); C339(1.32)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C328(1.02); C325(1.16); C339(1.03)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C328(1.10); C325(1.02); C339(1.21)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C328(1.06); C325(0.97); C339(1.19)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C328(1.08); C325(1.33)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C328(0.97); C325(1.10)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C304(1.13); C307(0.72)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C328(1.09); C325(1.09)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C304(1.04); C307(1.04)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C304(0.89); C307(0.89)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C304(1.02); C307(1.02)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C304(0.97); C307(0.97)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C304(0.78); C307(0.78)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C304(1.02); C307(1.02)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C304(0.92); C307(0.92)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C304(0.96); C307(0.96)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C304(0.92); C307(0.92)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C328(1.08); C325(1.23); C339(1.18)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C304(1.06); C307(0.94); C325(0.84)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C304(1.00); C307(0.84); C325(0.64)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C328(1.30)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C328(1.82)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C328(1.66)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C304(1.37); C307(1.37)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive pancreatic lipase-related protein 1 (PNLIPRP1) Lipase family P54315
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) ATP-dependent AMP-binding enzyme family Q9ULC5
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
E3 ubiquitin-protein ligase MARCHF2 (MARCHF2) . Q9P0N8
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction beta-2 protein (GJB2) Connexin family P29033
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Protein transport protein Sec61 subunit gamma (SEC61G) SecE/SEC61-gamma family P60059
Adiponectin (ADIPOQ) . Q15848
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-10 (CLDN10) Claudin family P78369
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Nurim (NRM) Nurim family Q8IXM6
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Putative ribosome-binding factor A, mitochondrial (RBFA) RbfA family Q8N0V3
Serglycin (SRGN) Serglycin family P10124
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transmembrane protein 11, mitochondrial (TMEM11) TMEM11 family P17152
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
Alpha-tocopherol transfer protein (TTPA) . P49638
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4
Transmembrane protein 222 (TMEM222) . Q9H0R3
Uncharacterized protein C5orf46 (C5orf46) . Q6UWT4

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402