Details of the Target

General Information of Target

Target ID LDTP18320
Target Name Meiotic nuclear division protein 1 homolog (MND1)
Gene Name MND1
Gene ID 84057
Synonyms
GAJ; Meiotic nuclear division protein 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVLRDSTSVPVTAEAKLMGFTQGCVTFEDVAIYFSQEEWGLLDEAQRLLYRDVMLEN
FALITALVCWHGMEDEETPEQSVSVEGVPQVRTPEASPSTQKIQSCDMCVPFLTDILHLT
DLPGQELYLTGACAVFHQDQKHHSAEKPLESDMDKASFVQCCLFHESGMPFTSSEVGKDF
LAPLGILQPQAIANYEKPNKISKCEEAFHVGISHYKWSQCRRESSHKHTFFHPRVCTGKR
LYESSKCGKACCCECSLVQLQRVHPGERPYECSECGKSFSQTSHLNDHRRIHTGERPYVC
GQCGKSFSQRATLIKHHRVHTGERPYECGECGKSFSQSSNLIEHCRIHTGERPYECDECG
KAFGSKSTLVRHQRTHTGEKPYECGECGKLFRQSFSLVVHQRIHTTARPYECGQCGKSFS
LKCGLIQHQLIHSGARPFECDECGKSFSQRTTLNKHHKVHTAERPYVCGECGKAFMFKSK
LVRHQRTHTGERPFECSECGKFFRQSYTLVEHQKIHTGLRPYDCGQCGKSFIQKSSLIQH
QVVHTGERPYECGKCGKSFTQHSGLILHRKSHTVERPRDSSKCGKPYSPRSNIV
Target Bioclass
Other
Family
MND1 family
Subcellular location
Nucleus
Function
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Uniprot ID
Q9BWT6
Ensemble ID
ENST00000240488.8
HGNC ID
HGNC:24839

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C115(1.99)  LDD3331  [1]
BTD
 Probe Info  		C115(1.10)  LDD2090  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C115(1.33)  LDD2112  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C115(0.64)  LDD2103  [2]
 LDCM0237  AC12 HEK-293T C147(0.93)  LDD1510  [7]
 LDCM0246  AC128 HEK-293T C147(0.96)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C147(1.12)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C147(0.77)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C147(0.74)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C147(0.96)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C147(0.96)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C147(1.16)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C147(1.04)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C147(1.06)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C147(0.95)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C147(1.21)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C147(1.26)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C147(1.02)  LDD1512  [7]
 LDCM0260  AC140 HEK-293T C147(1.09)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C147(1.20)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C147(1.00)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C147(1.30)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C147(1.41)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C147(1.50)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C147(1.40)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C147(1.56)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C147(1.63)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C147(1.23)  LDD0867  [8]
 LDCM0271  AC150 HEK-293T C147(1.36)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C147(1.33)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C147(1.50)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C147(1.42)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C147(1.34)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C147(1.31)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C147(1.41)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C147(1.79)  LDD2165  [8]
 LDCM0280  AC20 HEK-293T C147(0.92)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C147(0.98)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C147(0.98)  LDD1521  [7]
 LDCM0288  AC28 HEK-293T C147(0.91)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C147(1.01)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C147(1.01)  LDD1530  [7]
 LDCM0297  AC36 HEK-293T C147(1.03)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C147(1.00)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C147(1.03)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C147(0.99)  LDD1540  [7]
 LDCM0306  AC44 HEK-293T C147(0.89)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C147(0.92)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C147(1.01)  LDD1547  [7]
 LDCM0312  AC5 HEK-293T C147(0.98)  LDD1551  [7]
 LDCM0315  AC52 HEK-293T C147(0.96)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C147(0.98)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C147(1.18)  LDD1556  [7]
 LDCM0320  AC57 HEK-293T C147(0.72)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C147(0.90)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C147(0.67)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C147(1.01)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C147(0.76)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C147(1.41)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C147(1.45)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C147(0.90)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C147(0.81)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C147(0.86)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C147(1.19)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C147(0.89)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C147(0.99)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C147(0.96)  LDD0931  [8]
 LDCM0335  AC70 HEK-293T C147(0.90)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C147(0.81)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C147(0.90)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C147(1.00)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C147(1.03)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C147(1.21)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C147(1.04)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C147(1.03)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C147(1.06)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C147(0.93)  LDD0942  [8]
 LDCM0346  AC80 HEK-293T C147(1.04)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C147(0.94)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C147(1.22)  LDD0946  [8]
 LDCM0248  AKOS034007472 HEK-293T C147(1.00)  LDD1511  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C147(1.14)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C147(0.83)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C147(1.01)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C147(1.04)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C147(0.97)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C147(1.10)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C147(1.05)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C147(0.83)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C147(1.01)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C147(1.06)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C147(0.89)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C147(0.99)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C147(0.99)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C147(0.92)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C147(1.01)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C147(1.07)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C147(0.92)  LDD1592  [7]
 LDCM0391  CL120 HEK-293T C147(0.99)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C147(0.99)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C147(0.88)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C147(1.12)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C147(0.76)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C147(0.68)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C147(0.73)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C147(0.69)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C147(1.18)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C147(0.98)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C147(1.09)  LDD1607  [7]
 LDCM0407  CL2 HEK-293T C147(1.00)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C147(0.93)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C147(0.84)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C147(0.95)  LDD1614  [7]
 LDCM0413  CL25 HEK-293T C147(0.98)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C147(0.95)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C147(1.05)  LDD1620  [7]
 LDCM0421  CL32 HEK-293T C147(0.85)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C147(0.89)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C147(1.07)  LDD1627  [7]
 LDCM0426  CL37 HEK-293T C147(0.97)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C147(1.07)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C147(0.96)  LDD1634  [7]
 LDCM0434  CL44 HEK-293T C147(1.00)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C147(0.95)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C147(0.87)  LDD1640  [7]
 LDCM0439  CL49 HEK-293T C147(1.16)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C147(1.06)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C147(1.01)  LDD1646  [7]
 LDCM0447  CL56 HEK-293T C147(1.02)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C147(0.87)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C147(0.98)  LDD1652  [7]
 LDCM0453  CL61 HEK-293T C147(0.97)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C147(0.91)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C147(1.00)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C147(1.50)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C147(0.75)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C147(0.90)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C147(0.78)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C147(0.93)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C147(1.06)  LDD1059  [8]
 LDCM0463  CL70 HEK-293T C147(0.76)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C147(1.09)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C147(0.82)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C147(1.24)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C147(1.06)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C147(1.13)  LDD1672  [7]
 LDCM0473  CL8 HEK-293T C147(0.81)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C147(0.97)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C147(1.08)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C147(0.97)  LDD1679  [7]
 LDCM0479  CL85 HEK-293T C147(1.22)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C147(1.06)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C147(1.00)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C147(0.91)  LDD1687  [7]
 LDCM0487  CL92 HEK-293T C147(1.01)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C147(0.95)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C147(1.03)  LDD1692  [7]
 LDCM0492  CL97 HEK-293T C147(1.00)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C147(1.02)  LDD1696  [7]
 LDCM0468  Fragment33 HEK-293T C147(1.13)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C147(0.97)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C147(0.99)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C147(0.97)  LDD1497  [7]
 LDCM0024  KB05 MKN-1 C115(1.99)  LDD3331  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C115(1.10)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C115(0.72)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C115(1.16)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C115(0.71)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C115(0.99)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C115(0.94)  LDD2106  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C115(2.03)  LDD2110  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C115(0.89)  LDD2114  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C115(0.72)  LDD2141  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C115(0.97)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homologous-pairing protein 2 homolog (PSMC3IP) HOP2 family Q9P2W1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.