Details of the Target

General Information of Target

Target ID LDTP17656
Target Name Protein FAM200C (FAM200C)
Gene Name FAM200C
Gene ID 63920
Synonyms
Buster3; C5orf54; ZBED8; Protein FAM200C; Protein ZBED8; Transposon-derived Buster3 transposase-like protein; Zinc finger BED domain-containing protein 8
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAQPPRPVGERSMGSSREAARAPARSPAWASTQASTPGAALAVQRESPESGLQKHYSNL
CMEKSQKINPFILHILQEVDEEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILK
NCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRT
LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLGMQSVIAFATVLTQNQAIKAI
NLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLD
VSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVS
NNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCIAYSDLIQMGCLKPDNTDVEPFVV
DGRVYLAEVSNGLKKHYYWTSTYGESYDHSSNAGFALVPVGQQP
Target Bioclass
Other
Uniprot ID
Q8IZ13
Ensemble ID
ENST00000408953.4
HGNC ID
HGNC:30804

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C561(17.46)  LDD0209  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]
VSF
 Probe Info  		N.A.  LDD0007  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C561(0.68)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C561(0.77)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C561(0.86)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C561(0.97)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C561(0.87)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C561(1.24)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C561(1.08)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C561(1.08)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C561(1.27)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C561(1.15)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C561(1.08)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C561(0.82)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C561(0.89)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C561(0.76)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C561(0.84)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C561(0.93)  LDD0546  [3]
 LDCM0237  AC12 HCT 116 C561(0.78)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C561(0.80)  LDD0576  [3]
 LDCM0270  AC15 HCT 116 C561(0.65)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C561(0.95)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C561(2.33)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C561(1.25)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C561(0.78)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C561(1.07)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C561(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C561(0.93)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C561(1.05)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C561(0.94)  LDD0601  [3]
 LDCM0285  AC25 HEK-293T C518(0.94); C561(0.97)  LDD1524  [4]
 LDCM0287  AC27 HEK-293T C518(0.93); C561(0.91)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C561(1.05)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C561(1.06)  LDD1528  [4]
 LDCM0290  AC3 HCT 116 C561(0.64)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C561(0.94)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C561(0.94)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C518(0.91)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C518(0.95); C561(1.01)  LDD1533  [4]
 LDCM0296  AC35 HCT 116 C561(1.05)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C561(1.17)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C561(1.05)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C561(1.18)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C561(0.95)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C561(0.69)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C561(0.99)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C561(1.09)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C561(1.21)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C561(1.13)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C561(1.12)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C561(1.10)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C561(1.17)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C561(1.35)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C561(1.21)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C561(1.60)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C561(0.71)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C561(1.20)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C561(1.21)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C561(1.33)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C561(1.10)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C561(1.38)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C561(1.23)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C561(1.21)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C518(1.01); C561(1.03)  LDD1559  [4]
 LDCM0322  AC59 HEK-293T C518(1.04); C561(0.90)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C561(0.75)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C561(0.97)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C561(1.18)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C561(1.05)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C561(1.14)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C518(1.05)  LDD1567  [4]
 LDCM0332  AC68 HCT 116 C561(0.72)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C561(0.78)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C561(0.71)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C561(0.90)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C561(0.67)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C561(0.96)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C561(1.11)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C561(1.31)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C561(1.27)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C561(0.78)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C561(1.01)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C561(0.85)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C561(1.14)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C561(0.88)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C561(0.99)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C561(1.10)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C561(1.21)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C561(1.16)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C561(1.11)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C561(1.11)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C561(1.22)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C561(0.96)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C561(1.04)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C561(1.25)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C561(1.17)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C561(1.04)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C561(1.30)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C561(1.28)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C561(0.99)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C561(1.21)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C561(0.97)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C561(1.08)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C561(1.15)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C561(1.06)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C561(0.80)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C561(0.96)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C561(0.90)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C561(1.09)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C561(1.00)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C561(0.80)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C561(0.85)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C561(0.96)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C561(0.80)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C561(0.77)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C561(1.07)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C561(1.21)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C561(1.17)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C561(1.31)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C561(1.13)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C561(1.17)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C561(1.41)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C561(1.28)  LDD0698  [3]
 LDCM0382  CL112 HEK-293T C207(0.91)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C518(1.03)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C518(0.94); C207(0.91); C561(0.96)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C207(1.19)  LDD1590  [4]
 LDCM0387  CL117 HCT 116 C561(1.10)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C561(1.15)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C561(1.17)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C561(0.98)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C561(1.11)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C561(1.51)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C561(1.73)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C561(1.22)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C561(1.33)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C518(1.14)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C518(0.91); C207(1.20); C561(1.01)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C207(1.02)  LDD1603  [4]
 LDCM0400  CL13 HCT 116 C561(0.75)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C561(0.88)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C561(0.71)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C561(1.13)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C561(1.04)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C561(1.08)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C561(1.03)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C561(1.02)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C561(0.94)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C561(1.11)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C561(0.93)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C561(1.07)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C561(0.82)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C561(0.90)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C561(1.15)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C561(0.81)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C561(0.89)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C561(0.67)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C561(1.12)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C561(0.83)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C518(1.16); C561(1.04)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C561(1.05)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C561(1.41)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C561(1.15)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C561(1.16)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C518(1.14)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C518(1.00)  LDD1630  [4]
 LDCM0429  CL4 HCT 116 C561(0.80)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C207(1.13)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C518(0.90); C561(1.13)  LDD1635  [4]
 LDCM0433  CL43 HEK-293T C518(1.03); C561(1.10)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C561(1.00)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C561(1.15)  LDD1639  [4]
 LDCM0436  CL46 PaTu 8988t C561(1.23)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C561(1.13)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C561(1.49)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C561(1.21)  LDD1318  [3]
 LDCM0440  CL5 HCT 116 C561(0.82)  LDD0757  [3]
 LDCM0441  CL50 PaTu 8988t C561(1.16)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C561(2.09)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C561(1.08)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C561(2.62)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C561(1.41)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C561(1.12)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C561(0.29)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C561(1.64)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C561(1.45)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C561(2.54)  LDD1329  [3]
 LDCM0451  CL6 HCT 116 C561(0.89)  LDD0768  [3]
 LDCM0452  CL60 PaTu 8988t C561(1.44)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C561(1.11)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C561(0.90)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C561(0.85)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C561(1.21)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C561(1.17)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C561(1.02)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C561(1.23)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C561(1.33)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C561(1.36)  LDD1340  [3]
 LDCM0462  CL7 HCT 116 C561(0.88)  LDD0779  [3]
 LDCM0463  CL70 PaTu 8988t C561(1.22)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C561(0.92)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C561(1.07)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C561(1.14)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C561(1.15)  LDD1346  [3]
 LDCM0469  CL76 PaTu 8988t C561(1.16)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C561(1.10)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C561(1.38)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C561(1.04)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C561(0.92)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C561(1.04)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C561(1.16)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C561(1.09)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C561(1.03)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C561(1.53)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C561(1.04)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C561(1.37)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C561(1.11)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C561(1.31)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C561(1.27)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C561(0.92)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C561(1.40)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C561(0.85)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C561(1.01)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C561(0.80)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C561(1.16)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C561(0.93)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C561(0.95)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C561(1.00)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C561(0.98)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C561(0.91)  LDD0811  [3]
 LDCM0468  Fragment33 PaTu 8988t C561(1.08)  LDD1347  [3]
 LDCM0427  Fragment51 HEK-293T C518(0.90); C207(0.93); C561(0.99)  LDD1631  [4]
 LDCM0023  KB03 Jurkat C561(17.46)  LDD0209  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-lysine methyltransferase METTL21A (METTL21A) METTL21 family Q8WXB1
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
NGFI-A-binding protein 2 (NAB2) NAB family Q15742

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402