Details of the Target

General Information of Target

Target ID LDTP17621
Target Name L-seryl-tRNA(Sec) kinase (PSTK)
Gene Name PSTK
Gene ID 118672
Synonyms
C10orf89; L-seryl-tRNA(Sec) kinase; EC 2.7.1.164; O-phosphoseryl-tRNA(Sec) kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDENGMTPLMHAAYKGKLD
MCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMA
AFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVM
LVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVLAMKMHYISCIFQKCINFLKDGE
NKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTA
FSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNL
KDIYEKQQLEAAKEKRQEENHGKLDVNSNCVNEEQPEAEVGISQKDSNPEDSGEGKKESL
ESEAELEGLQDAPAGPQVSEE
Target Bioclass
Enzyme
Family
L-seryl-tRNA(Sec) kinase family
Function Specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
Uniprot ID
Q8IV42
Ensemble ID
ENST00000368887.7
HGNC ID
HGNC:28578

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C21(2.41); C24(2.41)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C21(1.03); C24(1.03)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C21(1.20)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C21(1.09)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C21(1.32)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C21(1.29)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C21(1.15)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C21(0.93)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C21(0.71)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C21(1.07)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C21(0.96)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C21(0.91)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C21(0.96); C24(0.96)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C21(1.89)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C21(2.37)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C21(1.77)  LDD0827  [1]
 LDCM0237  AC12 HEK-293T C21(1.03); C24(1.03)  LDD0835  [1]
 LDCM0246  AC128 HEK-293T C21(1.31)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C21(1.70)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C21(1.49)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C21(0.96)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C21(1.00)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C21(1.33)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C21(1.23)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C21(1.36)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C21(1.47)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C21(1.66)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C21(1.94)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C21(1.67)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C21(1.14); C24(1.14)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C21(1.33)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C21(2.38)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C21(1.42)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C21(1.08); C24(0.97)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C21(1.82); C24(1.11)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C21(1.51); C24(1.11)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C21(1.97); C24(1.00)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C21(1.88); C24(0.96)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C21(2.22); C24(1.04)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C21(1.31); C24(1.15)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C21(1.13); C24(1.13)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C21(1.79); C24(0.98)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C21(1.57); C24(1.07)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C21(1.37); C24(0.81)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C21(1.69); C24(1.25)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C21(1.56); C24(1.11)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C21(1.43); C24(1.05)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C21(2.17); C24(1.42)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C21(2.30); C24(1.17)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C21(0.95); C24(0.95)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C21(1.20); C24(1.20)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C21(1.04); C24(1.04)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C21(1.12); C24(1.12)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C21(0.91); C24(0.91)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C21(0.92); C24(0.92)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C21(1.08); C24(1.08)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C21(1.02); C24(1.02)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C21(0.99)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C21(1.09)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C21(1.11)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C21(1.19)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C21(1.32)  LDD0887  [1]
 LDCM0291  AC30 HEK-293T C21(1.13)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C21(0.83)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C21(1.07)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C21(1.14)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C21(0.92)  LDD0893  [1]
 LDCM0308  AC46 HEK-293T C21(0.85); C24(0.85)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C21(0.79); C24(0.79)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C21(0.90); C24(0.90)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C21(0.96); C24(0.96)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C21(0.98); C24(0.98)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C21(0.83); C24(0.83)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C21(0.92); C24(0.92)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C21(0.97); C24(0.97)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C21(0.92); C24(0.92)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C21(1.01); C24(1.01)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C21(0.81); C24(0.81)  LDD0917  [1]
 LDCM0323  AC6 HEK-293T C21(0.98); C24(0.98)  LDD0921  [1]
 LDCM0332  AC68 HEK-293T C21(0.95)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C21(1.28)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C21(0.84); C24(0.84)  LDD0932  [1]
 LDCM0335  AC70 HEK-293T C21(1.07)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C21(0.71)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C21(0.94)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C21(0.95)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C21(0.51)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C21(0.98)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C21(1.01)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C21(1.25)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C21(1.00)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C21(0.90)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C21(0.96); C24(0.96)  LDD0943  [1]
 LDCM0346  AC80 HEK-293T C21(1.10)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C21(1.03)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C21(2.29)  LDD0946  [1]
 LDCM0365  AC98 HEK-293T C21(1.07)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C21(0.83)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C21(1.10); C24(1.10)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C21(1.08); C24(1.08)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C21(1.20); C24(1.20)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C21(1.10)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C21(2.78)  LDD0966  [1]
 LDCM0370  CL101 HEK-293T C21(1.09); C24(1.09)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C21(1.28); C24(1.28)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C21(0.95); C24(0.95)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C21(0.95); C24(0.95)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C21(1.12); C24(1.12)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C21(1.32); C24(1.32)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C21(1.05); C24(1.05)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C21(1.04); C24(1.04)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C21(1.32); C24(1.32)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C21(2.90)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C21(1.09); C24(1.09)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C21(1.14); C24(1.14)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C21(1.46)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C21(1.08)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C21(1.38)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C21(1.05)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C21(1.43)  LDD0984  [1]
 LDCM0390  CL12 HEK-293T C21(1.33)  LDD0988  [1]
 LDCM0392  CL121 HEK-293T C21(0.96); C24(0.96)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C21(0.84); C24(0.84)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C21(1.17); C24(1.17)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C21(0.92); C24(0.92)  LDD0993  [1]
 LDCM0400  CL13 HEK-293T C21(1.63)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C21(1.53)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C21(1.41)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C21(0.94); C24(0.96)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C21(1.17); C24(0.98)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C21(1.06); C24(1.04)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C21(1.29); C24(0.97)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C21(1.08)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C21(1.20); C24(1.01)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C21(1.43); C24(1.46)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C21(1.09); C24(1.00)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C21(0.97); C24(0.98)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C21(1.35); C24(1.32)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C21(1.34); C24(1.28)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C21(1.04); C24(0.91)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C21(1.05); C24(1.12)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C21(1.21); C24(1.28)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C21(1.03); C24(1.04)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C21(1.23)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C21(1.60); C24(1.07)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C21(0.86); C24(0.86)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C21(0.90); C24(0.90)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C21(1.19); C24(1.19)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C21(1.19); C24(1.19)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C21(1.22); C24(1.22)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C21(0.94); C24(0.94)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C21(1.01); C24(1.01)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C21(1.10); C24(1.10)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C21(1.24)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C21(1.10); C24(1.10)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C21(1.07); C24(1.07)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C21(0.91); C24(0.91)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C21(0.99); C24(0.99)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C21(1.06); C24(1.06)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C21(1.12); C24(1.12)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C21(1.42); C24(1.33)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C21(1.12); C24(0.78)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C21(1.05); C24(0.91)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C21(1.43); C24(1.19)  LDD1037  [1]
 LDCM0440  CL5 HEK-293T C21(1.96)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C21(1.36); C24(1.00)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C21(1.25); C24(1.19)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C21(0.99); C24(0.90)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C21(0.91); C24(1.02)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C21(1.14); C24(1.08)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C21(1.15); C24(0.95)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C21(0.90); C24(0.72)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C21(1.25); C24(0.95)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C21(1.05); C24(0.93)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C21(1.07); C24(0.91)  LDD1048  [1]
 LDCM0451  CL6 HEK-293T C21(1.11)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C21(1.49); C24(0.89)  LDD1050  [1]
 LDCM0462  CL7 HEK-293T C21(1.38)  LDD1060  [1]
 LDCM0469  CL76 HEK-293T C21(1.10); C24(1.10)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C21(1.08); C24(1.08)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C21(1.06); C24(1.06)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C21(1.17); C24(1.17)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C21(0.94)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C21(1.17); C24(1.17)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C21(1.01); C24(1.01)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C21(1.15); C24(1.15)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C21(1.06); C24(1.06)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C21(1.02); C24(1.02)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C21(1.12); C24(1.12)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C21(0.98); C24(0.98)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C21(1.02); C24(1.02)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C21(1.17); C24(1.17)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C21(1.06); C24(1.06)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C21(1.13)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C21(1.23); C24(1.23)  LDD1083  [1]
 LDCM0427  Fragment51 HEK-293T C21(0.96); C24(0.96)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C21(2.41); C24(2.41)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C21(6.50); C24(6.50)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C21(3.50); C24(3.50)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060