Details of the Target

General Information of Target

Target ID LDTP16949
Target Name Zinc finger protein GLI4 (GLI4)
Gene Name GLI4
Gene ID 2738
Synonyms
HKR4; Zinc finger protein GLI4; Krueppel-related zinc finger protein 4; Protein HKR4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQDPGHLQGPPLALDPPRRQRQERTVYTESQQKVLEFYFQKDQYPNYDQRLNLAEMLSLR
EQQLQVWFKNRRAKLARERRLQQQPQRVPGQRGRGARAAPLVPVAAASFPGGPEFPQGRG
SWISPQPGPWGVLPAAEPKIYSLPRTWGGPECGTQEGLKAVPAPGPGPIPAPIPGPAQIP
GPVPGPAPNLGPMSGPLSVSIPGPIPAPISCPGPIPDPVLGRTLMPGPGSLPTPAPGALW
PQSPYASNLSPDTQLYPDFTKLLPLLDRFEESSLSTTTSQYKEEDGFVDKNHSVPRSLLD
L
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Uniprot ID
P10075
Ensemble ID
ENST00000340042.2
HGNC ID
HGNC:4320

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C113(0.74); C136(0.74)  LDD0533  [1]
IA-alkyne
 Probe Info  		C54(0.00); C1891(0.00); C349(0.00); C639(0.00)  LDD0161  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 HCT 116 C113(0.74); C136(0.74)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C113(0.79); C136(0.79)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C113(0.66); C136(0.66)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C113(1.03); C136(1.03)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C113(0.64); C136(0.64)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C113(0.97); C136(0.97)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C113(1.07); C136(1.07)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C113(0.61); C136(0.72)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C113(0.84); C136(0.80)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C113(0.76); C136(0.73)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C113(0.82); C136(0.81)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C113(0.75); C136(0.74)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C113(0.64); C136(0.75)  LDD0546  [1]
 LDCM0246  AC128 HCT 116 C113(1.23); C136(1.23)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C113(1.73); C136(1.73)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C113(1.87); C136(1.87)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C113(1.14); C136(1.14)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C113(1.34); C136(1.34)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C113(2.08); C136(2.08)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C113(1.66); C136(1.66)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C113(1.41); C136(1.41)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C113(0.96); C136(0.96)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C113(1.16); C136(1.16)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C113(1.41); C136(1.41)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C113(1.62); C136(1.62)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C113(2.27); C136(2.27)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C113(1.36); C136(1.36)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C113(1.15); C136(1.15)  LDD0579  [1]
 LDCM0276  AC17 HCT 116 C113(0.31); C136(0.31)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C113(0.39); C136(0.39)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C113(0.31); C136(0.31)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C113(0.31); C136(0.31)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C113(0.29); C136(0.29)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C113(0.32); C136(0.32)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C113(0.30); C136(0.30)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C113(0.31); C136(0.31)  LDD0601  [1]
 LDCM0320  AC57 HCT 116 C113(0.83); C136(0.83)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C113(1.48); C136(1.48)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C113(1.19); C136(1.19)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C113(1.23); C136(1.23)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C113(1.44); C136(1.44)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C113(1.31); C136(1.31)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C113(1.13); C136(1.13)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C113(1.07); C136(1.07)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C113(0.50); C136(0.50)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C113(0.43); C136(0.43)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C113(0.44); C136(0.44)  LDD0648  [1]
 LDCM0349  AC83 HCT 116 C113(1.33); C136(1.33)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C113(1.17); C136(1.17)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C113(0.80); C136(0.80)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C113(1.12); C136(1.12)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C113(1.50); C136(1.50)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C113(1.25); C136(1.25)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C113(1.46); C136(1.46)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C113(0.84); C136(0.84)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C113(1.43); C136(1.43)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C113(1.42); C136(1.42)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C113(0.89); C136(0.89)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C113(0.94); C136(0.94)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C113(2.19); C136(2.19)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C113(1.72); C136(1.72)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C113(1.30); C136(1.30)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C113(1.36); C136(1.36)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C113(0.59); C136(0.59)  LDD0683  [1]
 LDCM0020  ARS-1620 HCC44 C113(1.14); C136(1.14)  LDD2171  [1]
 LDCM0374  CL105 HCT 116 C113(0.32); C136(0.32)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C113(0.35); C136(0.35)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C113(0.43); C136(0.43)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C113(0.39); C136(0.39)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C113(0.45); C136(0.45)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C113(0.38); C136(0.38)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C113(0.37); C136(0.37)  LDD0698  [1]
 LDCM0396  CL125 HCT 116 C113(0.97); C136(0.97)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C113(1.12); C136(1.12)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C113(1.23); C136(1.23)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C113(0.92); C136(0.92)  LDD0716  [1]
 LDCM0436  CL46 HCT 116 C113(1.59); C136(1.59)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C113(1.01); C136(1.01)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C113(1.24); C136(1.24)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C113(1.37); C136(1.37)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C113(1.18); C136(1.18)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C113(1.20); C136(1.20)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C113(1.74); C136(1.74)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C113(1.32); C136(1.32)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C113(1.53); C136(1.53)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C113(1.05); C136(1.05)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C113(1.11); C136(1.11)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C113(1.26); C136(1.26)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C113(1.45); C136(1.45)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C113(1.40); C136(1.40)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C113(1.13); C136(1.13)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C113(0.96); C136(0.96)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C113(1.05); C136(1.05)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C113(1.12); C136(1.12)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C113(0.72); C136(0.72)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C113(1.10); C136(1.10)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C113(1.43); C136(1.43)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C113(1.26); C136(1.26)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C113(0.93); C136(0.93)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C113(1.23); C136(1.23)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C113(0.99); C136(0.99)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C113(0.97); C136(0.97)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C113(1.17); C136(1.17)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C113(1.38); C136(1.38)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C113(1.25); C136(1.25)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C113(0.89); C136(0.89)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C113(1.00); C136(1.00)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C113(1.08); C136(1.08)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C113(0.92); C136(0.92)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C113(1.01); C136(1.01)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C113(0.92); C136(0.92)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C113(0.97); C136(0.97)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C113(0.83); C136(0.83)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C113(1.01); C136(1.01)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C113(0.94); C136(0.94)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C113(0.94); C136(0.94)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C113(0.83); C136(0.83)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C113(0.91); C136(0.91)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C113(0.91); C136(0.91)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C113(0.88); C136(0.88)  LDD0802  [1]
 LDCM0468  Fragment33 HCT 116 C113(1.11); C136(1.11)  LDD0785  [1]
 LDCM0021  THZ1 HCT 116 C113(1.14); C136(1.14)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060