Details of the Target

General Information of Target

Target ID LDTP16893
Target Name Putative dehydrogenase/reductase SDR family member 4-like 1 (DHRS4L1)
Gene Name DHRS4L1
Synonyms
SDR25C4; Putative dehydrogenase/reductase SDR family member 4-like 1; EC 1.1.-.-; Short chain dehydrogenase/reductase family 25C member 4; Protein SDR25C4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKEPRIFPRERPTPWTRAPLPPRGRLDGSLGPQGGPVLNTGHPLGVNSDPFLMAAGSLGG
NLTPFPRNPSPFPASSGSLASNPAPFPAGARDPSMASFPRGMNPTGTGAVSFPRPGGLLG
PGPGPGPTLNPRTGALPGPGPLSNPRLGGLPGPGPMSNPRAGGLLGAGPDPRGGGPMGPG
SGPNLRAGVLLTSGNGPPNPRPVGLGPGPNPNLRSGFLGTNPAPRSGVFPGPGLGPNPRP
SGLGPGPNLDARAGGLLGTGSGLNLRMAGPQGLDLAPILRAAGLLGANSASFSQASGNMG
TSPSSMARVPGPMGPNSGPSSRGIGLPGPNPSPMSRAPGPIGPNSAHFSRPVGPMGVNAN
PFPRGAGSSAFSQSSGTLASNPATFQRSAGLQGSNPTIFPRASGPLGPNPANFPRATGLQ
GPSPTTFPRSTGPLGPGQVTFPRPAAGHLGPSPAGPVGINPAPFTRPTGTLGLNPASFPR
MNGPAGKSFVPFPRVGSLPGTNPAAFPRPGGPMAAMYPNGMLPP
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Function Putative oxidoreductase.
Uniprot ID
P0CG22
HGNC ID
HGNC:19732

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K15(0.30)  LDD0274  [1]
DBIA
 Probe Info  		C212(0.98)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C212(0.98)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C212(0.93)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C212(1.21)  LDD1509  [6]
 LDCM0230  AC113 HEK-293T C212(0.95)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C212(1.09)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C212(1.06)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C212(1.35)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C212(0.92)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C212(1.19)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C212(1.09)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C212(0.92)  LDD1510  [6]
 LDCM0238  AC120 HEK-293T C212(1.08)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C212(0.97)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C212(1.01)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C212(0.98)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C212(1.07)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C212(1.06)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C212(1.07)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C212(1.05)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C212(1.18)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C212(0.74)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C212(0.85)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C212(1.01)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C212(0.81)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C212(0.82)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C212(0.94)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C212(0.90)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C212(1.14)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C212(0.96)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C212(0.68)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C212(0.94)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C212(0.93)  LDD1512  [6]
 LDCM0260  AC140 HCT 116 C212(0.92)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C212(0.84)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C212(0.93)  LDD0579  [2]
 LDCM0270  AC15 HEK-293T C212(0.99); C259(1.43)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C212(1.03)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C212(0.98)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C212(0.98)  LDD1517  [6]
 LDCM0279  AC2 HCT 116 C212(1.12)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C212(1.03)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C212(1.05)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C212(0.98)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C212(1.00); C259(1.62)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C212(0.98); C259(0.95)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C212(1.28)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C212(0.94)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C212(1.15)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C212(1.06)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C212(1.16)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C212(1.02)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C212(1.10)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C212(1.07)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C212(0.95)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C212(1.10)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C212(1.01)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C212(1.20)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C212(1.09)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C212(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C212(1.14)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C212(1.30)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C212(1.04)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C212(1.21)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C212(1.12)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C212(1.34)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C212(1.22)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C212(1.28)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C212(1.28)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C212(0.93)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C212(0.98); C259(1.18)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C212(0.87); C259(1.15)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C212(0.93)  LDD1550  [6]
 LDCM0312  AC5 HCT 116 C212(1.00)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C212(0.93)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C212(0.99)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C212(0.91)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C212(0.96)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C212(0.92)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C212(1.04); C259(1.06)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C212(0.94); C259(1.31)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C212(1.13)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C212(1.03)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C212(1.06)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C212(0.92)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C212(1.15)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C212(0.91)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C212(1.05)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C212(0.96)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C212(0.99)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C212(1.00)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C212(1.05)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C212(1.14)  LDD0929  [2]
 LDCM0334  AC7 HEK-293T C212(0.97); C259(1.61)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C212(1.00); C259(1.38)  LDD1569  [6]
 LDCM0349  AC83 HCT 116 C212(0.90)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C212(0.84)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C212(0.97)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C212(0.96)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C212(0.99)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C212(0.97)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C212(0.99)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C212(0.99)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C212(0.80)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C212(1.06)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C212(0.86)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C212(0.93)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C212(1.07)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C212(0.87)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C212(0.89)  LDD0681  [2]
 LDCM0248  AKOS034007472 HEK-293T C212(0.93)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C212(0.90)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C212(0.91); C259(1.19)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C212(1.09); C259(1.25)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C212(0.89)  LDD1572  [6]
 LDCM0369  CL100 HCT 116 C212(0.98)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C212(0.95); C259(1.14)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C212(0.87)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C212(1.03)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C212(1.02)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C212(1.03); C259(0.97)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C212(1.00)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C212(1.10)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C212(0.94)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C212(0.93); C259(0.90)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C212(0.83); C259(0.90)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C212(0.93)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C212(1.05)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C212(0.89)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C212(1.05)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C212(1.07)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C212(1.07)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C212(1.38)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C212(1.25)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C212(0.94)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C212(0.99)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C212(0.85); C259(1.29)  LDD1594  [6]
 LDCM0391  CL120 HCT 116 C212(1.03)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C212(0.95); C259(1.49)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C212(0.85)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C212(1.02)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C212(0.93)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C212(1.12)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C212(1.09)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C212(0.78)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C212(1.17)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C212(0.91); C259(1.51)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C212(0.91)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C212(0.93)  LDD1606  [6]
 LDCM0403  CL16 HCT 116 C212(0.89)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C212(0.91)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C212(0.87)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C212(0.96)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C212(0.87)  LDD1611  [6]
 LDCM0408  CL20 HCT 116 C212(0.86)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C212(0.97)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C212(0.84)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C212(0.90)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C212(0.89)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C212(0.94)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C212(0.95)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C212(0.94)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C212(0.86)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C212(0.83)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C212(1.05)  LDD1622  [6]
 LDCM0419  CL30 HCT 116 C212(0.90)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C212(1.05)  LDD0737  [2]
 LDCM0421  CL32 HEK-293T C212(0.96)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C212(0.91)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C212(1.00)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C212(0.87); C259(1.21)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C212(0.93); C259(1.45)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C212(0.93); C259(1.20)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C212(1.03)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C212(1.02)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C212(0.98)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C212(0.92)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C212(1.00)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C212(1.03)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C212(1.01)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C212(1.02)  LDD1639  [6]
 LDCM0436  CL46 HCT 116 C212(0.84)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C212(0.73)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C212(0.75)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C212(0.93)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C212(0.97)  LDD1644  [6]
 LDCM0441  CL50 HCT 116 C212(0.82)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C212(0.82)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C212(0.88)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C212(0.80)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C212(0.91)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C212(0.87)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C212(0.76)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C212(0.79)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C212(0.83)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C212(0.85)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C212(0.85)  LDD1654  [6]
 LDCM0452  CL60 HCT 116 C212(0.82)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C212(0.94)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C212(1.08)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C212(1.08)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C212(0.89)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C212(1.05)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C212(1.03)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C212(0.94)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C212(0.95)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C212(0.77)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C212(1.15)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C212(0.84)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C212(1.09)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C212(1.25)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C212(0.81)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C212(0.93)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C212(0.82)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C212(0.62)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C212(0.80)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C212(0.84)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C212(0.92)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C212(0.89)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C212(0.83)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C212(0.81)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C212(0.88)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C212(0.69)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C212(0.74)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C212(0.71)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C212(0.77)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C212(0.90)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C212(0.71)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C212(1.05)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C212(0.70)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C212(0.99)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C212(0.98)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C212(0.99)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C212(1.03)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C212(0.93)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C212(0.97)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C212(1.01)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C212(1.07)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C212(0.97)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C212(1.06)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C212(0.88)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C212(0.96)  LDD1631  [6]
 LDCM0022  KB02 22RV1 C212(1.66)  LDD2243  [7]
 LDCM0023  KB03 22RV1 C212(2.31)  LDD2660  [7]
 LDCM0024  KB05 COLO792 C212(2.36)  LDD3310  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
10-propargyl-58-dideazafolic Acid Small molecular drug DB03541
246-triaminoquinazoline . DB02532
Methyl 1-(4-{[(24-diaminopteridin-6-yl)Methyl](Methyl)Amino}Benzoyl)Piperidine-4-carboxylate . DB07765
Methyl 1-(4-{[(24-diaminopteridin-6-yl)Methyl]Amino}Benzoyl)Piperidine-4-carboxylate . DB07689
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840