Details of the Target

General Information of Target

Target ID LDTP16053
Target Name Tuftelin (TUFT1)
Gene Name TUFT1
Gene ID 7286
Synonyms
Tuftelin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILAGRAPSNTSTLMKFYSLLLYSLLFSFPFLYHPLPLPSYLHHTINLTHSLPAASNPSL
ANNCWLCISLSSSAYIAVPTLQTDRATSPVSLHLRTSFNSPHLYPPEELIYFLDRSSKTS
PDISHQPAAALLHIYLKNLSPYINSTPPIFGPLTTQTTIPVAAPLCISRQRPTGIPLGNI
SPSRCSFTLHLQSPTTHVTETIGVFQLHIIDKPSINTDKLKNVSSNYCLGRHLPYISLHP
WLPSPCSSDSPPRPSSCLLTPSPQNNSERLLVDTQRFLIHHENRTSSSMQLAHQSPLQPL
TAAALAGSLGVWVQDTPFSTPSHPFSLHLQFCLTQGLFFLCGSSTYMCLPANWTGTCTLV
FLTPKIQFANGTKELPVPLMTLTPQKRVIPLIPLMVGLGLSASTIALSTGIAGISTSVTT
FRSPSNDFSASITDISQTLSVLQAQVDSLAAVVLQNRRGLGLSILLNEECCFYLNQSGLV
YENIKKLKDRAQKLANQASNYAESPWALSNWMSWVLPILSPLIPIFLLLLFGPCIFHLVS
QFIQNRIQAITNHSI
Target Bioclass
Enzyme
Family
Tuftelin family
Subcellular location
Secreted
Function Involved in the structural organization of the epidermis. Involved in the mineralization and structural organization of enamel.
Uniprot ID
Q9NNX1
Ensemble ID
ENST00000368848.6
HGNC ID
HGNC:12422

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.H243D DBIA    Probe Info 
HCC44 SNV: p.R285W DBIA    Probe Info 
HT115 SNV: p.E209A .
HUH7 SNV: p.H290N .
MFE319 SNV: p.A265V DBIA    Probe Info 
SUDHL6 SNV: p.G129R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K182(10.00); K313(10.00); K350(10.00); K45(5.26)  LDD0277  [1]
Probe 1
 Probe Info  		Y105(9.13)  LDD3495  [2]
m-APA
 Probe Info  		12.82  LDD0403  [3]
DBIA
 Probe Info  		C8(1.17)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C267(1.01)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C267(1.42)  LDD1094  [4]
 LDCM0216  AC100 PaTu 8988t C267(1.13)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C267(1.06)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C267(1.11)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C267(1.16)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C267(1.15)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C267(0.88)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C267(0.98)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C267(1.09)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C267(1.16)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C267(1.23)  LDD1104  [4]
 LDCM0226  AC11 PaTu 8988t C267(1.35)  LDD1105  [4]
 LDCM0227  AC110 PaTu 8988t C267(0.99)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C267(1.64)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C267(1.04)  LDD1108  [4]
 LDCM0237  AC12 PaTu 8988t C267(1.29)  LDD1116  [4]
 LDCM0246  AC128 PaTu 8988t C267(1.01)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C267(1.06)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C267(1.17)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C267(0.81)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C267(0.77)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C267(1.11)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C267(1.00)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C267(1.37)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C267(1.33)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C267(1.16)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C267(1.18)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C267(1.12)  LDD1137  [4]
 LDCM0259  AC14 PaTu 8988t C267(1.72)  LDD1138  [4]
 LDCM0260  AC140 PaTu 8988t C267(0.85)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C267(1.04)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C267(1.33)  LDD1141  [4]
 LDCM0270  AC15 PaTu 8988t C267(2.30)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C267(2.59)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C267(1.30)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C267(1.26)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C267(1.11)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C267(1.14)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C267(1.44)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C267(1.51)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C267(1.80)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C267(1.00)  LDD1163  [4]
 LDCM0288  AC28 HEK-293T C267(1.09)  LDD1527  [9]
 LDCM0290  AC3 PaTu 8988t C267(0.85)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C267(0.89)  LDD1530  [9]
 LDCM0297  AC36 HEK-293T C267(1.17)  LDD1536  [9]
 LDCM0299  AC38 HEK-293T C267(1.12)  LDD1538  [9]
 LDCM0301  AC4 PaTu 8988t C267(0.94)  LDD1180  [4]
 LDCM0306  AC44 HEK-293T C267(0.74)  LDD1545  [9]
 LDCM0308  AC46 PaTu 8988t C267(0.94)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C267(1.14)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C267(1.24)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C267(1.07)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C267(1.07)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C267(1.58)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C267(0.61)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C267(1.01)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C267(1.36)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C267(1.49)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C267(1.38)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C267(1.56)  LDD1198  [4]
 LDCM0320  AC57 PaTu 8988t C267(1.15)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C267(1.36)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C267(1.40)  LDD1201  [4]
 LDCM0323  AC6 PaTu 8988t C267(1.21)  LDD1202  [4]
 LDCM0324  AC60 PaTu 8988t C267(1.50)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C267(1.41)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C267(1.32)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C267(1.21)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C267(1.19)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C267(1.13)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C267(1.04)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C267(1.02)  LDD1210  [4]
 LDCM0332  AC68 PaTu 8988t C267(0.90)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C267(1.39)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C267(0.87)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C267(1.40)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C267(1.27)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C267(1.58)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C267(0.98)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C267(0.81)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C267(1.75)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C267(0.88)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C267(0.94)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C267(1.17)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C267(1.61)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C267(0.86)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C267(1.70)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C267(1.31)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C267(1.68)  LDD1227  [4]
 LDCM0349  AC83 PaTu 8988t C267(1.03)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C267(1.18)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C267(1.25)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C267(1.24)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C267(1.08)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C267(1.05)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C267(1.11)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C267(1.45)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C267(1.02)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C267(1.07)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C267(1.05)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C267(1.02)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C267(1.11)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C267(1.06)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C267(1.03)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C267(1.05)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C267(1.12)  LDD1245  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C267(1.20)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C267(1.41)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C267(1.78)  LDD1154  [4]
 LDCM0156  Aniline NCI-H1299 12.82  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C8(1.17)  LDD0078  [4]
 LDCM0632  CL-Sc Hep-G2 C267(20.00)  LDD2227  [6]
 LDCM0368  CL10 HEK-293T C267(0.87)  LDD1572  [9]
 LDCM0369  CL100 PaTu 8988t C267(1.01)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C267(1.06)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C267(1.02)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C267(1.62)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C267(1.35)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C267(1.49)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C267(1.20)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C267(1.01)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C267(1.45)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C267(1.39)  LDD1257  [4]
 LDCM0380  CL110 PaTu 8988t C267(1.72)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C267(1.86)  LDD1260  [4]
 LDCM0392  CL121 PaTu 8988t C267(1.54)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C267(1.26)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C267(2.21)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C267(2.13)  LDD1274  [4]
 LDCM0396  CL125 PaTu 8988t C267(1.47)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C267(1.23)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C267(1.14)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C267(0.97)  LDD1278  [4]
 LDCM0403  CL16 PaTu 8988t C267(2.24)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C267(2.70)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C267(1.89)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C267(2.24)  LDD1285  [4]
 LDCM0408  CL20 PaTu 8988t C267(2.82)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C267(4.34)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C267(2.59)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C267(2.05)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C267(1.91)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C267(2.51)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C267(2.67)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C267(1.70)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C267(3.64)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C267(2.83)  LDD1296  [4]
 LDCM0419  CL30 PaTu 8988t C267(1.75)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C267(1.97)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C267(1.57)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C267(1.33)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C267(1.69)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C267(1.58)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C267(1.15)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C267(2.83)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C267(1.64)  LDD1307  [4]
 LDCM0430  CL40 PaTu 8988t C267(1.55)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C267(2.77)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C267(1.97)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C267(2.20)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C267(1.37)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C267(1.36)  LDD1314  [4]
 LDCM0436  CL46 PaTu 8988t C267(1.03)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C267(1.02)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C267(2.18)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C267(1.64)  LDD1318  [4]
 LDCM0441  CL50 PaTu 8988t C267(1.48)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C267(0.99)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C267(0.92)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C267(2.08)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C267(2.19)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C267(1.09)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C267(0.49)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C267(1.76)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C267(1.05)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C267(3.74)  LDD1329  [4]
 LDCM0452  CL60 PaTu 8988t C267(2.41)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C267(1.06)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C267(1.11)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C267(1.16)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C267(1.91)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C267(0.98)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C267(1.26)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C267(1.47)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C267(3.17)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C267(2.02)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C267(1.42)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C267(1.66)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C267(0.97)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C267(2.07)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C267(1.71)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C267(1.45)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C267(2.18)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C267(1.62)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C267(1.70)  LDD1351  [4]
 LDCM0473  CL8 HEK-293T C267(0.82)  LDD1676  [9]
 LDCM0474  CL80 PaTu 8988t C267(1.64)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C267(1.79)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C267(1.90)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C267(3.48)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C267(1.85)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C267(1.71)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C267(2.36)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C267(2.27)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C267(1.71)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C267(2.07)  LDD1362  [4]
 LDCM0485  CL90 PaTu 8988t C267(2.60)  LDD1364  [4]
 LDCM0486  CL91 PaTu 8988t C267(1.11)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C267(1.26)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C267(1.00)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C267(0.98)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C267(1.96)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C267(1.98)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C267(1.39)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C267(1.45)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C267(0.95)  LDD1373  [4]
 LDCM0468  Fragment33 PaTu 8988t C267(1.47)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C267(2.04)  LDD1306  [4]
 LDCM0022  KB02 HEK-293T C267(1.20)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C267(1.28)  LDD1497  [9]
 LDCM0024  KB05 HMCB C267(1.14)  LDD3312  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Rhombotin-2 (LMO2) . P25791

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840