Details of the Target

General Information of Target

Target ID LDTP15220
Target Name Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)
Gene Name EEPD1
Gene ID 80820
Synonyms
KIAA1706; Endonuclease/exonuclease/phosphatase family domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDELDSYMYQTVGHHAIDL
YAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVEDLYELLKLVKEKEEVEGISVGAILSD
YQRIRVENVCKRLNLQPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDPDKHLGKTL
DQMEPYLIELSKKYGVHVCGEGGEYETFTLDCPLFKKKIIVDSSEVVIHSADAFAPVAYL
RFLELHLEDKVSSVPDNYRTSNYIYNF
Target Bioclass
Other
Uniprot ID
Q7L9B9
Ensemble ID
ENST00000242108.9
HGNC ID
HGNC:22223

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(0.77)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C28(0.77)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C28(1.07)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C28(0.89)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C28(1.07)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C28(1.09)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C28(1.29)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C28(1.09)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C28(1.06)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C28(1.14)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C28(1.21)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C28(1.09)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C28(1.18)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C28(1.47)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C28(1.08)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C28(1.47)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C28(1.26)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C28(0.87)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C28(1.09)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C28(0.81)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C28(1.33)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C28(1.02)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C28(1.04)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C28(1.06)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C28(1.12)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C28(0.96)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C28(0.76)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C28(1.01)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C28(0.91)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C28(0.75)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C28(0.94)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C28(0.90)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C28(0.90)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C28(1.35)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C28(1.12)  LDD0587  [1]
 LDCM0276  AC17 HEK-293T C99(0.95)  LDD1515  [5]
 LDCM0279  AC2 HCT 116 C28(0.90)  LDD0596  [1]
 LDCM0285  AC25 HCT 116 C28(0.87)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C28(0.90)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C28(0.72)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C28(0.78)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C28(0.81)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C28(0.74)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C28(0.86)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C28(0.85)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C28(0.99)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C28(1.09)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C28(0.97)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C28(0.72)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C28(0.89)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C28(0.89)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C28(0.78)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C28(0.90)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C28(0.75)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C28(1.06)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C28(1.60)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C28(1.38)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C28(1.47)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C28(1.77)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C28(1.12)  LDD0624  [1]
 LDCM0311  AC49 HEK-293T C99(0.92)  LDD1550  [5]
 LDCM0312  AC5 HCT 116 C28(0.76)  LDD0629  [1]
 LDCM0320  AC57 HEK-293T C99(1.10)  LDD1559  [5]
 LDCM0323  AC6 HCT 116 C28(1.05)  LDD0640  [1]
 LDCM0332  AC68 HCT 116 C28(1.13)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C28(0.95)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C28(1.17)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C28(0.93)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C28(0.74)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C28(0.83)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C28(1.08)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C28(0.90)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C28(0.91)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C28(0.99)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C28(1.09)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C28(0.96)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C28(0.98)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C28(1.27)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C28(1.00)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C28(0.82)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C28(0.88)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C28(1.15)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C28(1.12)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C28(1.17)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C28(1.40)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C28(1.20)  LDD0592  [1]
 LDCM0369  CL100 HCT 116 C28(0.79)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C28(1.10)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C28(1.38)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C28(1.36)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C28(1.32)  LDD0690  [1]
 LDCM0375  CL106 HEK-293T C99(1.09)  LDD1579  [5]
 LDCM0380  CL110 HEK-293T C99(0.97)  LDD1584  [5]
 LDCM0382  CL112 HCT 116 C28(0.88)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C28(1.05)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C28(0.72)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C28(0.85)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C28(0.96)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C28(0.81)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C28(0.86)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C28(0.93)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C28(0.83)  LDD0708  [1]
 LDCM0393  CL122 HEK-293T C99(1.03)  LDD1597  [5]
 LDCM0397  CL126 HEK-293T C99(1.00)  LDD1601  [5]
 LDCM0401  CL14 HEK-293T C99(1.10)  LDD1605  [5]
 LDCM0404  CL17 HCT 116 C28(1.06)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C28(1.03)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C28(1.19)  LDD0723  [1]
 LDCM0407  CL2 HEK-293T C99(1.35)  LDD1611  [5]
 LDCM0408  CL20 HCT 116 C28(1.21)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C28(1.06)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C28(0.86)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C28(1.08)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C28(1.08)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C28(1.13)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C28(1.09)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C28(0.96)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C28(1.01)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C28(1.02)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C28(1.21)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C28(1.03)  LDD0737  [1]
 LDCM0431  CL41 HEK-293T C99(0.96)  LDD1635  [5]
 LDCM0436  CL46 HCT 116 C28(1.08)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C28(1.27)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C28(1.32)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C28(1.09)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C99(1.10)  LDD1644  [5]
 LDCM0441  CL50 HCT 116 C28(1.35)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C28(1.16)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C28(1.36)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C28(1.33)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C28(1.58)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C28(1.12)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C28(1.10)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C28(1.18)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C28(1.16)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C28(1.17)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C28(1.23)  LDD0769  [1]
 LDCM0454  CL62 HEK-293T C99(1.00)  LDD1657  [5]
 LDCM0457  CL65 HEK-293T C99(1.14)  LDD1660  [5]
 LDCM0467  CL74 HEK-293T C99(1.04)  LDD1670  [5]
 LDCM0470  CL77 HEK-293T C99(1.00)  LDD1673  [5]
 LDCM0480  CL86 HEK-293T C99(1.20)  LDD1683  [5]
 LDCM0483  CL89 HEK-293T C99(1.08)  LDD1686  [5]
 LDCM0486  CL91 HCT 116 C28(1.15)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C28(0.89)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C28(0.64)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C28(0.90)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C28(0.82)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C28(0.75)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C28(0.88)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C28(0.77)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C28(0.78)  LDD0811  [1]
 LDCM0427  Fragment51 HEK-293T C99(0.97)  LDD1631  [5]
 LDCM0022  KB02 ECC2 C99(1.66)  LDD2320  [6]
 LDCM0023  KB03 ECC2 C99(1.91)  LDD2737  [6]
 LDCM0024  KB05 MEWO C99(2.64)  LDD3319  [6]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840