Details of the Target

General Information of Target

Target ID LDTP15195
Target Name Tubulin polyglutamylase complex subunit 1 (TPGS1)
Gene Name TPGS1
Gene ID 91978
Synonyms
C19orf20; Tubulin polyglutamylase complex subunit 1; PGs1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNIVFSRDSQVRVMENTVANTEKYFGQFCSLLAAYTRKTARLRDKADQLVKQLIDFANSE
NPELRATMRGFAEDLAKVQDYRQAQVERLETKVVNPLKLYGAQIKQTRAEIKKFKHVQNH
EIKQLEKLEKLRQKSPSDQQMIGQAETRVQRAAVDSSRTTLQLEETVDGFQRQKLKDLQK
FFCDFVTIEMVFHAKAVEVYSSAFQTLEKYDLERDLLDFRAKMQGVYGHYDTRLLANTSP
PPSVLQSLASQGTLQVQLSRANEDPEHPHANHGRFSLCEWVVKGQPAHCVCGQGGHLMLP
GHSL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (Probable). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum.
Uniprot ID
Q6ZTW0
Ensemble ID
ENST00000359315.6
HGNC ID
HGNC:25058

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.C151Y .
CASKI SNV: p.P12L .
HCT15 SNV: p.P177S; p.R182C .
HT1197 SNV: p.R100S .
MKN45 SNV: p.G82S .
OVK18 SNV: p.Q230K .
SW1573 SNV: p.A279S .
TOV21G SNV: p.A209S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C126(0.88)  LDD0531  [1]
AOyne
 Probe Info  		12.40  LDD0443  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C126(0.88)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C126(0.82)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C126(0.83)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C126(0.82)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C126(0.79)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C126(0.93)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C126(0.92)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C126(0.92)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C126(0.80)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C126(0.88)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C126(0.78)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C126(0.81)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C126(0.91)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C126(0.79)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C126(1.07)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C126(0.89)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C126(0.81)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C126(0.88)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C126(0.88)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C126(0.81)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C126(1.23)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C126(1.15)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C126(1.23)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C126(1.15)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C126(0.90)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C126(1.71)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C126(1.47)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C126(0.90)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C126(0.90)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C126(1.12)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C126(1.22)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C126(1.93)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C126(1.01)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C126(1.11)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C126(1.17)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C126(1.36)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C126(1.33)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C126(1.19)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C126(1.04)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C126(0.88)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C126(1.20)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C126(1.37)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C126(1.40)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C126(1.14)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C126(1.11)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C126(1.24)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C126(1.13)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C126(1.33)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C126(1.28)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C126(1.14)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C126(0.81)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C126(1.11)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C126(1.11)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C126(1.35)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C126(1.23)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C126(1.26)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C126(1.20)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C126(1.35)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C126(0.76)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C126(1.03)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C126(0.89)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C126(0.88)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C126(1.19)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C126(1.19)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C126(1.01)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C126(1.11)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C126(1.15)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C126(1.03)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C126(1.08)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C126(1.16)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C126(1.10)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C126(1.22)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C126(0.84)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C126(1.24)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C126(1.05)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C126(1.01)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C126(1.28)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C126(1.18)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C126(1.29)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C126(1.54)  LDD0636  [1]
 LDCM0323  AC6 HCT 116 C126(0.93)  LDD0640  [1]
 LDCM0325  AC61 HEK-293T C126(1.04)  LDD1564  [3]
 LDCM0334  AC7 HCT 116 C126(0.99)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C126(1.02)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C126(0.94)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C126(1.04)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C126(0.91)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C126(0.77)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C126(1.03)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C126(0.68)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C126(0.89)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C126(0.85)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C126(1.00)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C126(0.88)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C126(0.79)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C126(0.84)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C126(0.72)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C126(0.90)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C126(0.87)  LDD0681  [1]
 LDCM0248  AKOS034007472 HCT 116 C126(0.87)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C126(0.94)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C126(1.16)  LDD0592  [1]
 LDCM0369  CL100 HCT 116 C126(0.75)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C126(0.81)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C126(0.75)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C126(0.92)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C126(0.76)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C126(1.21)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C126(1.22)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C126(1.19)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C126(1.37)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C126(1.34)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C126(1.34)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C126(1.21)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C126(1.07)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C126(1.26)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C126(1.25)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C126(1.22)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C126(1.15)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C126(1.09)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C126(1.02)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C126(1.10)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C126(1.30)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C126(1.10)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C126(1.06)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C126(1.24)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C126(1.20)  LDD0712  [1]
 LDCM0403  CL16 HCT 116 C126(0.64)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C126(1.11)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C126(1.22)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C126(1.10)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C126(0.93)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C126(1.13)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C126(1.48)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C126(1.43)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C126(1.40)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C126(1.13)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C126(0.78)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C126(1.10)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C126(1.29)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C126(1.18)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C126(1.21)  LDD0736  [1]
 LDCM0422  CL33 HEK-293T C126(1.03)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C126(0.93)  LDD1639  [3]
 LDCM0436  CL46 HCT 116 C126(1.03)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C126(1.11)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C126(0.92)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C126(1.07)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C126(1.05)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C126(0.90)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C126(1.01)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C126(1.20)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C126(1.30)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C126(1.06)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C126(1.03)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C126(1.29)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C126(1.15)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C126(1.08)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C126(1.07)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C126(1.16)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C126(1.15)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C126(1.13)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C126(1.25)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C126(1.14)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C126(1.43)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C126(1.36)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C126(1.16)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C126(1.18)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C126(1.20)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C126(1.18)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C126(1.35)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C126(1.22)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C126(1.19)  LDD0784  [1]
 LDCM0475  CL81 HEK-293T C126(1.00)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C126(0.95)  LDD1687  [3]
 LDCM0486  CL91 HCT 116 C126(0.77)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C126(0.71)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C126(0.81)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C126(0.79)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C126(0.87)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C126(0.97)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C126(0.80)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C126(0.80)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C126(0.81)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C126(1.34)  LDD0785  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402