Details of the Target

General Information of Target

Target ID LDTP15184
Target Name GDP-D-glucose phosphorylase 1 (GDPGP1)
Gene Name GDPGP1
Gene ID 390637
Synonyms
C15orf58; GDP-D-glucose phosphorylase 1; EC 2.7.7.78
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEASWRQVAGGRGRSRGRATAAPSGNGVHLRGAGGGREKGSVGAVPSGTSPGGVATTAAA
GSRHSPAGSQALQTTAASELMSQKKFEEIKKANQAAARKLVEEQFSSSSEEGDEDFEGKQ
GKILANTFITYTTQTDGDTRELERTKQYVNEAFQAGAMTCLICIASVKRNQAVWSCSGCF
CIFHMPCIQKWAKDSQFLVSSVTDDDFGKKDCPWPCPKCRFEYKRSETPSRYYCYCGKVE
DPPLDPWLVPHSCGQVCEREFKPPCGHKCLLLCHPGPCPPCPKMVTTTCYCKKAKPIPRR
CSAKEWSCQLPCGQKLLCGQHKCENPCHAGSCQPCPRVSRQKCVCGKKVAERSCASPLWH
CDQVCGKTLPCGNHTCEQVCHVGACGECPRSGKRFCPCQKSKFSLPCTEDVPTCGDSCDK
VLECGIHRCSQRCHRGPCETCRQEVEKHCRCGKHTKRMPCHKPYLCETKCVKMRDCQKHQ
CRRKCCPGNCPPCDQNCGRTLGCRNHKCPSVCHRGSCYPCPETVDVKCNCGNTKVTVPCG
RERTTRPPKCKEQCSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQ
ALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLGKHEVSPLPCHAVGPYSC
KRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILR
CHPGECPPCVQMLRIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCK
EMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIECDTTCKEMKRKASEIKEA
EAKAALEEEKRRQQAELEAFENRLKGRRKKNRKRDEVAVELSLWQKHKYYLISVCGVVVV
VFAWYITHDVN
Target Bioclass
Enzyme
Family
GDPGP1 family
Subcellular location
Cytoplasm
Function Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
Uniprot ID
Q6ZNW5
Ensemble ID
ENST00000329600.8
HGNC ID
HGNC:34360

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C64(1.53)  LDD3319  [1]
AHL-Pu-1
 Probe Info  		C64(2.49)  LDD0169  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C64(2.49)  LDD0169  [2]
 LDCM0214  AC1 PaTu 8988t C64(1.26)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C64(1.06)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C64(1.11)  LDD1105  [6]
 LDCM0237  AC12 PaTu 8988t C64(1.26)  LDD1116  [6]
 LDCM0259  AC14 PaTu 8988t C64(0.94)  LDD1138  [6]
 LDCM0270  AC15 PaTu 8988t C64(1.11)  LDD1149  [6]
 LDCM0276  AC17 HEK-293T C64(0.94)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C64(0.88)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C64(1.07)  LDD1517  [7]
 LDCM0279  AC2 PaTu 8988t C64(1.29)  LDD1158  [6]
 LDCM0280  AC20 HEK-293T C64(1.00); C333(0.94)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C64(1.04)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C64(1.01)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C64(1.01); C333(1.08)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C64(1.13)  LDD1523  [7]
 LDCM0285  AC25 PaTu 8988t C64(1.03)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C64(0.94)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C64(1.13)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C64(1.27)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C64(1.06)  LDD1168  [6]
 LDCM0290  AC3 PaTu 8988t C64(1.00)  LDD1169  [6]
 LDCM0291  AC30 PaTu 8988t C64(1.14)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C64(0.95)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C64(1.05)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C64(1.14)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C64(1.26)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C64(0.82)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C64(0.84)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C64(0.96)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C64(0.85)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C64(0.93)  LDD1179  [6]
 LDCM0301  AC4 PaTu 8988t C64(1.59)  LDD1180  [6]
 LDCM0302  AC40 PaTu 8988t C64(0.91)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C64(1.29)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C64(1.05)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C64(1.00)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C64(1.10)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C64(0.93)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C64(0.80)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C64(0.76)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C64(0.87)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C64(1.01)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C64(1.19)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C64(1.11)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C64(0.60)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C64(0.86)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C64(1.04)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C64(1.09)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C64(0.85)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C64(0.84)  LDD1198  [6]
 LDCM0320  AC57 HEK-293T C64(1.03)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C64(0.93)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C64(1.09)  LDD1561  [7]
 LDCM0323  AC6 PaTu 8988t C64(0.97)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C64(0.95); C333(1.08)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C64(0.95)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C64(0.99)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C64(0.93); C333(1.13)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C64(1.05)  LDD1567  [7]
 LDCM0334  AC7 PaTu 8988t C64(0.90)  LDD1213  [6]
 LDCM0345  AC8 PaTu 8988t C64(0.96)  LDD1224  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C64(0.85)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C64(1.28)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C64(1.20)  LDD1154  [6]
 LDCM0632  CL-Sc Hep-G2 C333(20.00); C64(1.21)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C64(0.98)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C64(0.82)  LDD1572  [7]
 LDCM0369  CL100 PaTu 8988t C64(0.99)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C64(0.93)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C64(0.92)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C64(0.99)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C64(1.16)  LDD1252  [6]
 LDCM0374  CL105 HEK-293T C64(0.95)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C64(1.06); C333(1.19)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C64(1.03)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C64(1.05)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C64(0.92)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C64(0.96); C333(1.17)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C64(0.87); C333(1.32)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C64(0.79)  LDD1585  [7]
 LDCM0382  CL112 PaTu 8988t C64(1.20)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C64(0.96)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C64(1.07)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C64(1.14)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C64(0.82)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C64(1.02)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C64(0.86)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C64(0.85)  LDD1268  [6]
 LDCM0390  CL12 HEK-293T C64(1.01)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C64(0.83)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C64(1.25)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C64(0.93)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C64(0.92)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C64(0.85)  LDD1274  [6]
 LDCM0396  CL125 HEK-293T C64(0.96)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C64(0.94); C333(0.54)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C64(1.08)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C64(1.02)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C64(1.19)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C64(1.14); C333(1.17)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C64(0.88)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C64(1.00)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C64(0.99)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C64(1.04)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C64(1.15)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C64(1.06); C333(1.03)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C64(1.02); C333(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C64(1.01)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C64(1.04)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C64(1.03); C333(1.18)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C64(0.99)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C64(1.00)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C64(1.14); C333(1.20)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C64(1.04)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C64(1.07)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C64(0.90)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C64(1.05)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C64(0.92)  LDD1623  [7]
 LDCM0420  CL31 PaTu 8988t C64(0.94)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C64(1.11)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C64(0.84)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C64(1.12)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C64(1.35)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C64(0.62)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C64(1.00)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C64(1.48)  LDD1307  [6]
 LDCM0429  CL4 HEK-293T C64(0.95)  LDD1633  [7]
 LDCM0430  CL40 PaTu 8988t C64(1.13)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C64(1.22)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C64(1.08)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C64(1.30)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C64(0.86)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C64(0.94)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C64(0.99)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C64(0.82)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C64(0.59)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C64(1.16)  LDD1318  [6]
 LDCM0440  CL5 HEK-293T C64(1.01)  LDD1644  [7]
 LDCM0441  CL50 PaTu 8988t C64(0.88)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C64(0.78)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C64(1.02)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C64(1.13)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C64(0.77)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C64(0.94)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C64(1.52)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C64(0.90)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C64(0.76)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C64(0.95)  LDD1329  [6]
 LDCM0451  CL6 HEK-293T C64(0.87)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C64(0.70)  LDD1331  [6]
 LDCM0453  CL61 HEK-293T C64(0.96)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C64(1.05); C333(1.19)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C64(0.94)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C64(0.99)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C64(1.07)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C64(1.03)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C64(1.06)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C64(0.94); C333(0.96)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C64(0.99)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C64(1.17)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C64(0.95)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C64(1.22); C333(1.11)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C64(0.98)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C64(0.89)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C64(0.86); C333(0.88)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C64(1.12)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C64(0.97)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C64(0.97)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C64(1.25)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C64(0.82); C333(0.97)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C64(1.02); C333(1.08)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C64(0.95)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C64(1.04)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C64(0.87); C333(1.30)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C64(1.01)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C64(0.94)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C64(0.99); C333(1.93)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C64(0.97)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C64(0.96)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C64(0.91)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C64(0.95)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C64(0.79)  LDD1688  [7]
 LDCM0486  CL91 PaTu 8988t C64(1.32)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C64(0.91)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C64(0.93)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C64(1.61)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C64(1.71)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C64(1.07)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C64(1.26)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C64(0.94)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C64(0.95)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C64(0.89)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C64(0.87)  LDD1671  [7]
 LDCM0427  Fragment51 PaTu 8988t C64(1.04)  LDD1306  [6]
 LDCM0022  KB02 HEK-293T C64(1.05)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C64(1.10)  LDD1497  [7]
 LDCM0024  KB05 MEWO C64(1.53)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402