Details of the Target

General Information of Target

Target ID LDTP15180
Target Name Metastasis-associated in colon cancer protein 1 (MACC1)
Gene Name MACC1
Gene ID 346389
Synonyms
Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIP
RKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQ
VSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRR
SPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSV
GDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP
CGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD
QEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSK
GTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP
VIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSP
SGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQE
KPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYK
TKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNII
EQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQ
HDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPT
EPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTV
IRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLAS
VEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGL
PDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAP
RGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFH
RDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSL
GPTDEAGSECPFPRKA
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Uniprot ID
Q6ZN28
Ensemble ID
ENST00000332878.8
HGNC ID
HGNC:30215

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C104(0.97)  LDD0531  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]
IA-alkyne
 Probe Info  		C310(0.00); C35(0.00); C104(0.00); C704(0.00)  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C104(0.97)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C104(1.13)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C104(1.20)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C104(1.25)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C104(1.26)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C104(1.22)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C104(1.30)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C104(1.21)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C104(1.12)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C104(1.06)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C104(0.98)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C104(1.38)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C104(1.14)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C104(1.14)  LDD0546  [1]
 LDCM0246  AC128 HCT 116 C326(1.27)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C326(1.13)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C326(1.08)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C326(1.17)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C326(1.17)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C326(1.09)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C326(1.07)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C326(1.06)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C326(1.09)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C326(1.00)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C326(1.10)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C326(1.15)  LDD0575  [1]
 LDCM0260  AC140 HCT 116 C326(1.10)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C326(1.19)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C326(1.08)  LDD0579  [1]
 LDCM0276  AC17 HCT 116 C326(1.07)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C326(1.27)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C326(1.13)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C104(0.89)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C326(1.09)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C326(1.06)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C326(0.97)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C326(1.10)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C326(1.07)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C104(0.85)  LDD0607  [1]
 LDCM0296  AC35 HCT 116 C326(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C326(0.97)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C326(1.17)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C326(1.03)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C326(1.00)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C104(0.85)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C326(1.06)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C326(0.97)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C326(1.01)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C326(1.02)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C326(1.10)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C326(1.23)  LDD0624  [1]
 LDCM0312  AC5 HCT 116 C104(0.86)  LDD0629  [1]
 LDCM0349  AC83 HCT 116 C326(0.83)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C326(0.83)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C326(0.79)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C326(0.93)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C326(0.88)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C326(0.92)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C326(0.85)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C326(0.78)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C326(0.87)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C326(0.85)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C326(0.82)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C326(1.07)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C326(0.79)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C326(1.10)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C326(0.82)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C104(1.13)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C104(1.27)  LDD0683  [1]
 LDCM0369  CL100 HCT 116 C104(1.07)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C326(1.14)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C326(1.24)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C326(1.13)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C326(1.18)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C326(0.94)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C326(1.24)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C326(1.15)  LDD0698  [1]
 LDCM0387  CL117 HCT 116 C326(0.98)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C326(0.90)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C326(0.98)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C326(1.09)  LDD0708  [1]
 LDCM0436  CL46 HCT 116 C104(0.95)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C104(0.79)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C104(0.79)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C104(0.68)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C104(0.80)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C104(0.84)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C104(1.00)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C104(1.04)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C104(0.84)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C104(0.88)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C104(0.86)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C104(0.78)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C104(0.99)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C104(0.85)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C104(0.83)  LDD0769  [1]
 LDCM0469  CL76 HCT 116 C104(1.30)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C104(1.05)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C104(0.94)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C104(1.19)  LDD0789  [1]
 LDCM0474  CL80 HCT 116 C104(0.91)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C104(1.03)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C104(0.77)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C104(0.93)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C104(1.13)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C104(1.05)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C104(1.09)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C104(1.02)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C104(0.85)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C104(0.96)  LDD0800  [1]
 LDCM0485  CL90 HCT 116 C104(1.18)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C104(1.06)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C104(1.09)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C104(1.07)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C104(0.90)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C104(0.95)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C104(0.84)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C104(0.89)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C104(1.20)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C104(1.17)  LDD0811  [1]
 LDCM0022  KB02 769-P C326(1.89)  LDD2246  [4]
 LDCM0023  KB03 769-P C326(2.85)  LDD2663  [4]
 LDCM0024  KB05 COLO792 C611(1.13); C326(2.16)  LDD3310  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840