Details of the Target

General Information of Target

Target ID LDTP14950
Target Name HCLS1-binding protein 3 (HS1BP3)
Gene Name HS1BP3
Gene ID 64342
Synonyms
HCLS1-binding protein 3; HS1-binding protein 3; HSP1BP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPSSPRALFLLLLILACPEPRASQNCLSKQQLLSAIRQLQQLLKGQETRFAEGIRHMKS
RLAALQNSVGRVGPDALPVSCPALNTPADGRKFGSKYLVDHEVHFTCNPGFRLVGPSSVV
CLPNGTWTGEQPHCRGISECSSQPCQNGGTCVEGVNQYRCICPPGRTGNRCQHQAQTAAP
EGSVAGDSAFSRAPRCAQVERAQHCSCEAGFHLSGAAGDSVCQDVNECELYGQEGRPRLC
MHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECVGLQPVCPQGTTCINTGGSFQCVSPE
CPEGSGNVSYVKTSPFQCERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTPITLFRMATA
SAPGRAGPNSLRFGIVGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTLEVDVDMSEYLDR
SFQANHVSKVTIFVSPYDF
Target Bioclass
Other
Function May be a modulator of IL-2 signaling.
Uniprot ID
Q53T59
Ensemble ID
ENST00000304031.8
HGNC ID
HGNC:24979

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C287(3.02)  LDD2157  [1]
AHL-Pu-1
 Probe Info  		C287(2.42)  LDD0169  [2]
DBIA
 Probe Info  		C287(1.13)  LDD1492  [3]
m-APA
 Probe Info  		N.A.  LDD2232  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C287(2.42)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C287(1.16)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C287(0.99)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C287(1.17)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C287(0.99)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C287(1.07)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C287(1.21)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C287(0.98)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C287(1.01)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C287(0.86)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C287(1.07)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C287(0.96)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C287(1.10)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C287(1.42)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C287(1.60)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C287(1.15)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C287(1.19)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C287(1.14)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C287(1.09)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C287(1.00)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C287(1.10)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C287(1.17)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C287(1.41)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C287(1.00)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C287(0.95)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C287(0.91)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C287(1.06)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C287(0.94)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C287(0.99)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C287(1.15)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C287(0.78)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C287(1.13)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C287(0.87)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C287(1.05)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C287(1.26)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C287(1.33)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C287(1.10)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C287(1.10)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C287(1.19)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C287(1.12)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C287(0.96)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C287(1.14)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C287(1.05)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C287(0.94)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C287(0.98)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C287(1.08)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C287(0.84)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C287(0.98)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C287(1.21)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C287(0.89)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C287(0.86)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C287(0.92)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C287(0.99)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C287(1.21)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C287(1.19)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C287(1.02)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C287(1.02)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C287(1.08)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C287(0.88)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C287(1.00)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C287(1.00)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C287(0.96)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C287(1.07)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C287(0.95)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C287(1.05)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C287(0.96)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C287(1.03)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C287(0.98)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C287(1.06)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C287(1.23)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C287(0.95)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C287(1.13)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C287(1.13)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C287(0.94)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C287(0.97)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C287(1.04)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C287(1.32)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C287(1.13)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C287(1.00)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C287(1.01)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C287(1.02)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C287(1.21)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C287(1.00)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C287(1.12)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C287(1.08)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C287(1.07)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C287(0.98)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C287(0.87)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C287(0.92)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C287(0.98)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C287(1.09)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C287(1.20)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C287(1.08)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C287(1.15)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C287(1.03)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C287(1.59)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C287(0.98)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C287(1.17)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C287(0.85)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C287(0.91)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C287(1.01)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C287(1.06)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C287(0.98)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C287(1.15)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C287(1.13)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C287(0.86)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C287(0.99)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C287(1.09)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C287(1.17)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C287(1.04)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C287(0.85)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C287(0.89)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C287(1.05)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C287(1.02)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C287(1.01)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C287(1.27)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C287(1.26)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C287(1.46)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C287(1.00)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C287(1.19)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C287(0.93)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C287(0.99)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C287(1.09)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C287(1.02)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C287(0.95)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C287(1.01)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C287(1.08)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C287(0.97)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C287(1.60)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C287(0.97)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C287(0.83)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C287(1.18)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C287(0.91)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C287(0.86)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C287(1.11)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C287(0.93)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C287(1.13)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C287(1.11)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C287(1.15)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C287(0.83)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C287(0.91)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C287(1.35)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C287(0.91)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C287(0.85)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C287(1.10)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C287(0.89)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C287(1.02)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C287(1.13)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C287(0.93)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C287(1.01)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C287(1.06)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C287(0.98)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C287(1.38)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C287(0.69)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C287(1.00)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C287(1.07)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C287(1.00)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C287(1.02)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C287(0.91)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C287(1.03)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C287(0.74)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C287(0.92)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C287(1.18)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C287(0.91)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C287(0.93)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C287(1.03)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C287(0.96)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C287(1.01)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C287(1.05)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C287(0.94)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C287(0.86)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C287(0.97)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C287(1.02)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C287(1.14)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C287(1.11)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C287(1.14)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C287(0.98)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C287(1.13)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C287(0.92)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C287(1.10)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gelsolin (GSN) Villin/gelsolin family P06396
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.