Details of the Target

General Information of Target

Target ID LDTP14194
Target Name Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2)
Gene Name LRRFIP2
Gene ID 9209
Synonyms
Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLQLRALLGAFGRWTLRLGPRPSCSPRMAGNAEPPPAGAACPQDRRSCSGRAGGDRVWE
DGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSAL
VRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRI
LGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYK
GTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGL
VVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQ
EEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAKVPSPLEGS
EGDGDTD
Target Bioclass
Transcription factor
Family
LRRFIP family
Function
May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Uniprot ID
Q9Y608
Ensemble ID
ENST00000336686.9
HGNC ID
HGNC:6703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.R46K DBIA    Probe Info 
FUOV1 SNV: p.A382D DBIA    Probe Info 
HCT15 SNV: p.L159I .
HSC3 Insertion: p.Y304CfsTer17 .
MFE296 SNV: p.A82P .
SUPT1 Deletion: p.I487LfsTer4 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.45  LDD0402  [1]
STPyne
 Probe Info  		K588(7.42); K705(1.05)  LDD0277  [2]
Probe 1
 Probe Info  		Y304(52.07)  LDD3495  [3]
DBIA
 Probe Info  		C435(0.98)  LDD3323  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
AOyne
 Probe Info  		14.50  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C435(0.97)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C435(0.93)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C435(1.03)  LDD1509  [7]
 LDCM0230  AC113 PaTu 8988t C435(1.05)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C435(1.09)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C435(0.84)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C435(1.06)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C435(0.96)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C435(0.92)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C435(1.05)  LDD1115  [8]
 LDCM0237  AC12 HEK-293T C435(0.93)  LDD1510  [7]
 LDCM0238  AC120 PaTu 8988t C435(1.18)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C435(1.10)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C435(1.02)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C435(1.11)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C435(1.05)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C435(0.84)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C435(0.96)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C435(1.09)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C435(0.78)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C435(0.89)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C435(0.81)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C435(0.95)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C435(0.95)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C435(0.89)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C435(0.89)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C435(0.92)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C435(0.88)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C435(0.89)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C435(0.80)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C435(0.95)  LDD1137  [8]
 LDCM0259  AC14 HEK-293T C435(1.10)  LDD1512  [7]
 LDCM0260  AC140 PaTu 8988t C435(0.89)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C435(0.94)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C435(0.88)  LDD1141  [8]
 LDCM0263  AC143 HEK-293T C435(1.11)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C435(0.83)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C435(0.99)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C435(1.05)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C435(1.19)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C435(0.78)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C435(0.87)  LDD0867  [8]
 LDCM0271  AC150 HEK-293T C435(1.28)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C435(0.80)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C435(0.88)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C435(0.75)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C435(0.77)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C435(0.87)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C435(1.00)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C435(1.44)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C435(0.99)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C435(0.92)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C435(0.88)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C435(0.99)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C435(1.00)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C435(0.99)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C435(1.00)  LDD1521  [7]
 LDCM0284  AC24 HEK-293T C435(1.11)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C435(0.77)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C435(1.08)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C435(1.06)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C435(2.27)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C435(1.07)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C435(1.00)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C435(1.01)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C435(0.94)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C435(0.98)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C435(1.17)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C435(1.07)  LDD0893  [8]
 LDCM0296  AC35 PaTu 8988t C435(0.92)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C435(0.87)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C435(0.88)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C435(0.90)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C435(0.98)  LDD1179  [8]
 LDCM0301  AC4 HEK-293T C435(0.94)  LDD1540  [7]
 LDCM0302  AC40 PaTu 8988t C435(0.82)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C435(1.06)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C435(0.92)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C435(0.92)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C435(0.88)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C435(0.99)  LDD1186  [8]
 LDCM0308  AC46 HEK-293T C435(0.92)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C435(0.99)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C435(0.89)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C435(0.95)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C435(1.04)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C435(0.82)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C435(1.02)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C435(1.18)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C435(1.02)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C435(0.98)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C435(1.01)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C435(0.75)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C435(1.30)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C435(1.12)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C435(1.28)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C435(1.03)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C435(0.78)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C435(1.66)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C435(1.64)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C435(1.31)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C435(1.47)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C435(1.50)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C435(1.38)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C435(1.69)  LDD0929  [8]
 LDCM0345  AC8 HEK-293T C435(1.05)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C435(1.00)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C435(0.97)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C435(1.11)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 14.25  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C435(1.03)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C435(0.95)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C435(1.07)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C435(0.99)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C435(1.06)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C435(1.08)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C435(0.96)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C435(0.93)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C435(1.09)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C435(1.06)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C435(0.99)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C435(0.95)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C435(0.86)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C435(1.09)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C435(0.88)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C435(1.34)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C435(1.10)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C435(1.20)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C435(1.08)  LDD0984  [8]
 LDCM0387  CL117 PaTu 8988t C435(1.24)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C435(1.10)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C435(0.99)  LDD1268  [8]
 LDCM0390  CL12 HEK-293T C435(0.92)  LDD1594  [7]
 LDCM0391  CL120 PaTu 8988t C435(0.95)  LDD1270  [8]
 LDCM0392  CL121 HEK-293T C435(0.91)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C435(0.96)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C435(0.87)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C435(0.95)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C435(1.07)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C435(1.08)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C435(1.41)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C435(1.34)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C435(0.92)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C435(1.10)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C435(0.99)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C435(1.08)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C435(0.86)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C435(0.93)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C435(0.99)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C435(1.27)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C435(0.92)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C435(0.97)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C435(0.97)  LDD1614  [7]
 LDCM0412  CL24 HEK-293T C435(1.00)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C435(0.88)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C435(0.98)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C435(1.07)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C435(1.00)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C435(0.91)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C435(0.97)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C435(1.01)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C435(1.01)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C435(0.91)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C435(0.82)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C435(0.98)  LDD1627  [7]
 LDCM0425  CL36 HEK-293T C435(1.01)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C435(0.96)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C435(1.04)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C435(1.07)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C435(0.98)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C435(0.91)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C435(0.92)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C435(1.03)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C435(0.88)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C435(0.90)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C435(0.95)  LDD1640  [7]
 LDCM0438  CL48 HEK-293T C435(0.98)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C435(0.94)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C435(0.97)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C435(1.15)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C435(0.97)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C435(0.85)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C435(0.82)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C435(1.06)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C435(0.88)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C435(0.95)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C435(0.96)  LDD1652  [7]
 LDCM0451  CL6 HEK-293T C435(0.85)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C435(1.05)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C435(0.94)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C435(1.23)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C435(1.16)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C435(1.06)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C435(1.02)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C435(0.93)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C435(1.06)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C435(0.89)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C435(0.98)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C435(0.95)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C435(1.00)  LDD1666  [7]
 LDCM0465  CL72 HEK-293T C435(1.00)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C435(0.93)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C435(1.12)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C435(0.76)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C435(0.76)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C435(1.19)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C435(1.08)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C435(0.66)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C435(0.91)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C435(1.13)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C435(0.61)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C435(0.59)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C435(0.86)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C435(0.97)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C435(1.33)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C435(1.79)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C435(1.07)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C435(0.94)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C435(0.98)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C435(0.55)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C435(0.95)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C435(0.88)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C435(0.90)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C435(0.96)  LDD1692  [7]
 LDCM0491  CL96 HEK-293T C435(0.76)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C435(0.96)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C435(0.99)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C435(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C435(1.12)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C435(1.02)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C435(1.24)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C435(1.02)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C435(0.92)  LDD1497  [7]
 LDCM0024  KB05 SKMEL24 C435(0.98)  LDD3323  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.