Details of the Target

General Information of Target

Target ID LDTP14168
Target Name Sorting nexin-14 (SNX14)
Gene Name SNX14
Gene ID 57231
Synonyms
Sorting nexin-14
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQARVLIGFEEDILIVSE
GKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVN
VPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILQTPQNAIFFKTCQQA
ECPGGCRNGGFCNERRICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVN
CDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGY
QGDLCSKPVCEPGCGAHGTCHEPNKCQCQEGWHGRHCNKRYEASLIHALRPAGAQLRQHT
PSLKKAEERRDPPESNYIW
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Lysosome membrane
Function
Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)).
Uniprot ID
Q9Y5W7
Ensemble ID
ENST00000314673.8
HGNC ID
HGNC:14977

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.F350L .
CCK81 Deletion: p.E587KfsTer41 .
EFO21 SNV: p.F31L .
G402 SNV: p.C25Y .
HG3 SNV: p.T261A .
HT115 SNV: p.F728L .
LS180 Deletion: p.F173LfsTer5 .
MINO SNV: p.K13M .
PANC0403 SNV: p.S731F .
SUDHL4 SNV: p.L333Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C890(5.76)  LDD3319  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		13.20  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C401(1.08)  LDD1507  [5]
 LDCM0215  AC10 PaTu 8988t C833(1.46)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C833(1.30)  LDD1105  [6]
 LDCM0230  AC113 PaTu 8988t C833(0.75)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C833(0.77)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C833(0.72)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C833(0.71)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C833(0.82)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C833(0.89)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C833(0.92)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C833(1.39)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C833(0.94)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C833(0.97)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C833(0.87)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C833(0.85)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C833(1.04)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C833(0.80)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C833(0.94)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C833(1.03)  LDD1124  [6]
 LDCM0259  AC14 PaTu 8988t C833(1.17)  LDD1138  [6]
 LDCM0263  AC143 PaTu 8988t C857(0.77)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C857(1.28)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C857(0.83)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C857(1.40)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C857(0.94)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C857(1.05)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C857(1.45)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C833(1.19)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C857(1.38)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C857(2.30)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C857(1.23)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C857(1.72)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C857(2.60)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C857(1.20)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C857(1.63)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C857(1.50)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C833(1.00)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C833(1.09)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C833(0.90)  LDD1157  [6]
 LDCM0279  AC2 HEK-293T C401(1.12); C857(1.16)  LDD1518  [5]
 LDCM0280  AC20 PaTu 8988t C833(1.08)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C833(1.16)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C833(1.21)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C833(1.16)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C833(1.15)  LDD1163  [6]
 LDCM0285  AC25 PaTu 8988t C857(0.82)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C857(1.41)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C857(1.63)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C857(1.10)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C857(1.25)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C401(0.91); C857(1.03)  LDD1529  [5]
 LDCM0291  AC30 PaTu 8988t C857(1.48)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C857(1.53)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C857(1.07)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C857(1.20)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C857(1.75)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C401(0.96); C857(1.21)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C401(1.11)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C401(1.03); C857(1.18)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C401(1.02); C857(0.97)  LDD1538  [5]
 LDCM0301  AC4 HEK-293T C401(0.98)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C401(1.13); C732(1.02)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C401(1.05)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C401(1.07); C857(1.21)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C401(1.12); C857(1.07)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C401(1.06)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C401(0.99); C857(1.05)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C401(1.08); C857(1.06)  LDD1547  [5]
 LDCM0310  AC48 HEK-293T C401(1.18); C732(0.95)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C401(1.00)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C401(1.03); C857(0.97)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C401(1.12); C857(1.12)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C401(0.95); C857(1.24)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C401(1.02)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C401(1.02); C857(1.08)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C401(1.03); C857(1.05)  LDD1556  [5]
 LDCM0319  AC56 HEK-293T C401(1.18); C732(1.08)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C401(1.12)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C401(1.19); C857(1.23)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C401(0.97); C857(1.15)  LDD1561  [5]
 LDCM0323  AC6 PaTu 8988t C833(1.21)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C401(1.05)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C401(1.03); C857(0.96)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C401(1.07); C857(1.03)  LDD1565  [5]
 LDCM0328  AC64 HEK-293T C401(1.01); C732(1.30)  LDD1567  [5]
 LDCM0334  AC7 PaTu 8988t C833(1.12)  LDD1213  [6]
 LDCM0345  AC8 PaTu 8988t C833(1.16)  LDD1224  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C833(1.34)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C833(1.70)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C833(1.32)  LDD1154  [6]
 LDCM0367  CL1 PaTu 8988t C857(0.89)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C857(1.63)  LDD1247  [6]
 LDCM0369  CL100 HEK-293T C857(1.06)  LDD1573  [5]
 LDCM0370  CL101 PaTu 8988t C833(1.07)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C833(1.33)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C833(1.49)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C833(1.28)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C833(0.96)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C833(1.02)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C833(0.98)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C833(1.01)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C833(1.00)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C857(0.99)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C833(0.99)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C833(1.32)  LDD1260  [6]
 LDCM0382  CL112 PaTu 8988t C857(1.40)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C857(1.20)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C857(1.58)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C857(1.30)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C857(0.97)  LDD1265  [6]
 LDCM0387  CL117 HEK-293T C401(1.03)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C401(1.07); C857(0.93)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C401(1.11)  LDD1593  [5]
 LDCM0390  CL12 PaTu 8988t C857(1.29)  LDD1269  [6]
 LDCM0391  CL120 HEK-293T C857(1.10)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C401(0.99)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C401(1.09); C857(0.93)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C401(1.11)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C857(1.12)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C401(1.04)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C401(1.14); C857(1.30)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C401(1.15)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C857(1.11)  LDD1603  [5]
 LDCM0400  CL13 PaTu 8988t C857(1.65)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C857(1.34)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C857(1.02)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C857(1.09); C833(1.15)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C857(1.81); C833(1.42)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C857(1.47); C833(1.38)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C857(1.52); C833(1.39)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C857(0.83)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C857(1.10); C833(2.04)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C857(1.41); C833(1.75)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C857(1.32); C833(1.51)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C857(1.57); C833(1.74)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C857(1.60); C833(1.52)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C857(2.23); C833(1.31)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C857(1.66); C833(1.71)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C857(1.82); C833(1.59)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C857(1.87); C833(2.23)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C857(1.39); C833(1.87)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C857(1.22)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C857(1.33); C833(1.70)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C857(0.67); C833(0.92)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C857(0.65); C833(1.02)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C857(0.74); C833(1.47)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C857(0.67); C833(1.10)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C833(1.22); C857(0.69)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C857(0.83); C833(1.03)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C857(1.35); C833(1.22)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C857(0.84); C833(1.31)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C857(1.05)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C857(0.53); C833(0.93)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C857(0.59); C833(1.05)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C857(0.86); C833(1.57)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C857(1.17); C833(1.89)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C857(1.30); C833(1.31)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C857(0.71); C833(1.33)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C857(0.83); C833(1.15)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C857(1.19); C833(1.16)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C857(1.51); C833(1.02)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C857(1.11); C833(1.00)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C857(1.03)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C857(0.90); C833(1.01)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C857(1.04); C833(0.96)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C857(1.11); C833(1.15)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C857(1.30); C833(1.20)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C857(1.40); C833(0.91)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C857(1.39); C833(1.17)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C857(0.59); C833(1.06)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C857(1.69); C833(1.06)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C857(1.16); C833(1.10)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C857(2.18); C833(0.97)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C857(0.93)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C857(0.99); C833(1.08)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C833(0.94)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C833(0.76)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C833(0.65)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C833(1.03)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C833(0.81)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C833(0.90)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C833(1.07)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C833(1.01)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C833(1.30)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C857(1.11)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C833(1.09)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C833(0.65)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C833(0.91)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C833(0.92)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C833(0.89)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C857(1.50); C833(1.12)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C857(1.42); C833(1.19)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C857(2.34); C833(1.12)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C857(1.57); C833(1.19)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C857(1.37)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C857(1.48); C833(1.33)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C857(1.95); C833(1.21)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C857(2.54); C833(1.62)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C857(2.22); C833(1.34)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C857(1.44); C833(0.96)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C857(1.68); C833(1.32)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C857(1.76); C833(1.09)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C857(2.18); C833(1.41)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C857(1.84); C833(1.24)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C857(1.49); C833(1.07)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C857(1.34)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C857(1.85); C833(1.24)  LDD1364  [6]
 LDCM0486  CL91 HEK-293T C401(1.02); C857(1.14)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C401(1.11)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C401(1.02); C857(1.13)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C401(1.15); C857(1.05)  LDD1692  [5]
 LDCM0491  CL96 HEK-293T C401(1.06); C732(0.59)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C401(0.88)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C401(1.03); C857(1.14)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C401(1.14)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C401(1.05)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C833(0.99)  LDD1347  [6]
 LDCM0427  Fragment51 PaTu 8988t C857(0.80); C833(1.55)  LDD1306  [6]
 LDCM0022  KB02 HEK-293T C857(0.86); C401(1.03)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C857(0.86); C401(1.07)  LDD1497  [5]
 LDCM0024  KB05 MEWO C890(5.76)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.