Details of the Target

General Information of Target

Target ID LDTP14049
Target Name WASH complex subunit 2C (WASHC2C)
Gene Name WASHC2C
Gene ID 253725
Synonyms
FAM21C; KIAA0592; VPEF; WASH complex subunit 2C; Vaccinia virus penetration factor; VPEF
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPANHLPIGSTMSTVHLSSDGTYFYWIWSPASLNEKTPKGHSVFMDIFELVVENGVFVAN
PLQERTILMRKEGESAKSINEMLLSRLSRYRASPSATLAALTGSTISNTLKEDQAANTSC
GLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFGGTSGLSSLKRACYDTVNNMLW
TCSNDYIDQWCNPGNQAFHYVCQRLGVSHIITEPKEEAITTNEVINQLLHHVGAMCIHQL
NLLATNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFF
SPQTERNRDIIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETEINNLLK
LVLTEGERNSGLSQLRDVILTNLAEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCI
LITKCQTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGET
LKVQELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLG
HLLPVLLTSLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAP
DQKCRLFPDERMLEEKEEPGFLTGLKIPAPWAAGKTVETVHPVRDNYKFKETVHIPGARC
LYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKCIS
PPSLNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLAL
GLSVLACSMLRILYNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLP
LTIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFRPSIKEVIQP
DVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDLLCKIMGETFKKLNAMERQLQS
VAELEQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENMV
LSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGLTRSISGTPAE
TPACKSASETKVISHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRANQRRRHVTSHRSSSF
TLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAAQTRWRRGNTRKQALV
HMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGETMTSVVSLCA
RYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSNQTESSSSEKQTKKQKVA
TMAWAAFQVLANRCVEWEKEEGGSTEAVHSGLARQVSSLLTNHLARATECCGNQAAGNDA
LQDVLSLLNDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRAALPLMSV
EDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASEPD
TTLTKTSPKNSLKGDKDPGEESEAVDGKLSIFIHKREDQSSHEVLQPLLSSSEGRPFRLG
TGANMEKVVKMDRDMTKGGCCEVITEEAAAALRKATKWAQSGLIVSIGPPVESINPETVS
GLSTGDKKKTAQTSICRERNSELARTDPVRPFISGHVANSMAAEVIALLHSLLMAPESNA
AQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGF
KETIKIGSEVQVLGRGISGSIGVVASINEQEGIATVRFPPIDCRKTSQASDTLTIPLSRL
CVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRLLAEI
RTRACLVMAQLLEDSLFCEEFIQQCPAAVEVLNLVAQECSAGERLAVVEVQCERLRMLYR
DCARPPPPPLQADRRQPKEITWSPSRVFPPVRACMFSSHLTSVTFLADPSAGGGLPRGTF
IYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFTTEAEKRDGAWTNPVGTCLFHN
NGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCGQR
LSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANF
EALPFAMASDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFI
TSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLD
QIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVT
RSPDSNNVASSAVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRY
WYPIDMLERPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKL
PHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSA
TDLFYQGNSQTVREWLNVAITRTLHQGEESLLELTKQICSFLQTAPEQFPSEEFPISESK
VNMDVNFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRNGQLNLIEAAC
YPRDASPANTGLAPPPTADQYPSVVLSTDRVHIKLGVSPPPGAVLVLHSLPLEFPLAMAF
AEQLLSWKSEDSEGKSEDEPDTIPTSVLLQVVELLGNFLWTTDMAACVKELVFHLLAELL
RTVHTLEQRRHPAGLSSSIALQLNPCLAMLMALQSELHKLYDEETQNWVSGGACGGSGGA
AAGDQGRFSTYFHALMEGCLAVAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSSSPGQT
PQSPSLLSKRKKVKMKREKASSSGKRQSSRTVDSDPTVLSIGGSKPEDMLWFHRALTLLI
ILRHLTRKDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEGVVRGAIRKACN
AHGGVFKDEIYIPLQEEDTKKPKDKAEGGDGKVEPEKTLAFPGTDSMEVSTSSSLTPAMS
ISASASTSQASICSSQGISQTVSDLSVDPLPAGLELPIPPGLLEPHAVSSQESLDISLCS
TGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPIKGFAVVEIRSRAKIEK
IRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFNDKSIK
GEKLVPGAREVLTEIFKSCAHSEQTLSLTPAKPIRVSDIYLSKEQINSQTPGNLLHLFFT
NVRPPKKVLEDQLTQILRKYGVPKPKFDKSKYSKAGKEQHPVKVVSTKRPITKPPAKDKA
VLNSVSRTALSEKKPTVKPKSPEKSKPDEKDPEKSPTKKQEVPEEKYLTLEGFHKFVIDR
ARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALVQYINQLCRHLAI
TPARLHPHEVYLDPADAADPRVACLLNVPIESLRLRFALLQSLNTTLETFFLPLVELRQT
PMYTHSIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRA
SENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCK
ELQSSSLSLLLLCPSSAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLD
LLPSFWKTLVGEPLDPEQDLQEADILTYNYVKKFESINDETELEALCAEIASQHLATESP
DSPNKPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAV
RAGLGSIIPLQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGAL
EMFTQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIR
VETCMFMIKLPQYSSLEIMLEKLRCAIHYREDPLSG
Target Bioclass
Transporter and channel
Family
FAM21 family
Subcellular location
Early endosome membrane
Function
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L.; (Microbial infection) Plays a role in fluid-phase endocytosis, a process exploited by vaccinia intracellular mature virus (IMV) to enter cells. As a result, may facilitate the penetration of IMV into cells.
Uniprot ID
Q9Y4E1
Ensemble ID
ENST00000374362.6
HGNC ID
HGNC:23414

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C828(1.41)  LDD3323  [2]
AHL-Pu-1
 Probe Info  		C826(3.12)  LDD0169  [3]
ATP probe
 Probe Info  		K926(0.00); K928(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
AOyne
 Probe Info  		12.50  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C826(3.12)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C828(1.03)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C828(1.00)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C828(1.00)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C828(1.01)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C828(1.13)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C828(1.02)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C828(0.98)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C828(1.15)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C828(1.08)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C828(1.06)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C828(1.02)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C828(1.01)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C828(0.98)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C828(1.04)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C828(0.96)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C828(1.01)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C828(1.09)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C828(0.98)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C828(0.95)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C828(0.96)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C828(1.03)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C828(1.03)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C828(0.96)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C828(0.98)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C828(1.00)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C828(1.05)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C828(0.95)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C828(1.09)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C828(0.94)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C828(1.08)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C828(0.95)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C828(1.07)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C828(0.98)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C828(0.97)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C828(1.18)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C828(0.99)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C828(1.06)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C828(0.92)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C828(1.13)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C828(1.12)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C828(0.97)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C828(0.98)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C828(0.95)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C828(1.16)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C828(0.97)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C828(0.98)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C828(0.97)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C828(1.12)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C828(1.18)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C828(1.01)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C828(0.98)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C828(1.09)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C828(0.97)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C828(1.10)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C828(0.96)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C828(0.98)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C828(1.07)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C828(1.07)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C828(0.97)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C828(1.03)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C828(1.01)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C828(0.97)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C828(0.94)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C828(0.96)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 14.07  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C828(2.82)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C828(0.93)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C828(1.00)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C828(0.95)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C828(1.01)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C828(0.89)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C828(0.97)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C828(1.00)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C828(1.00)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C828(0.96)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C828(0.99)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C828(1.00)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C828(0.97)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C828(0.95)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C828(0.91)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C828(0.96)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C828(1.00)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C828(1.02)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C828(0.91)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C828(0.99)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C828(0.94)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C828(1.02)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C828(0.99)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C828(0.95)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C828(0.94)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C828(0.95)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C828(0.97)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C828(0.99)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C828(0.87)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C828(0.96)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C828(0.97)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C828(0.94)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C828(0.96)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C828(0.95)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C828(1.07)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C828(0.92)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C828(0.81)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C828(0.95)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C828(0.90)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C828(1.10)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C828(0.96)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C828(0.93)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C828(1.01)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C828(0.92)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C828(1.14)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C828(1.02)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C828(1.00)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C828(0.91)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C828(0.98)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C828(0.97)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C828(1.00)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C828(0.98)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C828(0.90)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C828(1.02)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C828(0.96)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C828(1.08)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C828(0.78)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C828(0.96)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C828(1.17)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C828(0.98)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C828(0.94)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C828(0.96)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C828(0.94)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C828(0.99)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C828(0.90)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C828(1.07)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C828(0.96)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C828(1.02)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C828(0.97)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C828(1.09)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C828(1.24)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C828(0.97)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C828(0.94)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C828(0.97)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C828(0.92)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C828(0.97)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C828(0.95)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C828(0.97)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C828(0.91)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C828(1.05)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C828(0.93)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C828(1.20)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C828(1.05)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C828(0.99)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C828(0.97)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C828(1.00)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C828(0.98)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C828(0.95)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C828(0.95)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C828(1.02)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C828(1.15)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C828(0.98)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C828(1.02)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C828(0.96)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C828(0.92)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C828(1.10)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C828(1.05)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C828(1.02)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C828(0.92)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C828(0.97)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C828(0.94)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C828(0.87)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C828(1.09)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C828(0.98)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C828(0.73)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C828(1.02)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C828(1.04)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C828(1.11)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C828(1.06)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C828(0.94)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C828(0.95)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C828(0.95)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C828(0.97)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C828(0.95)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C828(1.00)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C828(0.95)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C828(0.91)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C828(0.95)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C828(0.99)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C828(0.94)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C828(1.26)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C828(0.98)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C828(0.91)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C828(0.95)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C828(0.96)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C828(0.99)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C828(1.00)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C828(0.95)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C828(0.96)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C828(0.99)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C828(1.06)  LDD1497  [10]
 LDCM0024  KB05 SKMEL24 C828(1.41)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 35 (VPS35) VPS35 family Q96QK1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402