General Information of Target

Target ID LDTP13990
Target Name Charged multivesicular body protein 3 (CHMP3)
Gene Name CHMP3
Gene ID 100526767
Synonyms
CGI149; NEDF; VPS24; Charged multivesicular body protein 3; Chromatin-modifying protein 3; Neuroendocrine differentiation factor; Vacuolar protein sorting-associated protein 24; hVps24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSKSLVMEYLAHPSTLGLAVGVACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILG
DSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCGQPKVVVKA
PDEETLIALLAHAKMLGLTVSLIQDAGRTQIAPGSQTVLGIGPGPADLIDKVTGHLKLY
Target Bioclass
Other
Family
SNF7 family
Subcellular location
Cytoplasm, cytosol
Function
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
Uniprot ID
Q9Y3E7
Ensemble ID
ENST00000263856.9
HGNC ID
HGNC:29865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info 
K49(5.26); K76(9.09)  LDD0277  [1]
DBIA
 Probe Info 
C89(2.42)  LDD3314  [2]
BTD
 Probe Info 
C60(2.24)  LDD1700  [3]
IA-alkyne
 Probe Info 
N.A.  LDD0162  [4]
TFBX
 Probe Info 
N.A.  LDD0148  [5]
Acrolein
 Probe Info 
N.A.  LDD0217  [6]
NAIA_5
 Probe Info 
N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info 
57.28  LDD1948  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C60(0.52)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C60(0.75)  LDD2112  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C60(1.03)  LDD2152  [3]
 LDCM0214  AC1 HEK-293T C60(0.93)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C60(0.94)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C60(0.96)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C60(0.91)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C60(0.93)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C60(0.92)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C60(0.91)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C60(0.95)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C60(0.83)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C60(1.05)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C60(0.88)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C60(0.95)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C60(1.02)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C60(1.06)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C60(1.12)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C60(1.08)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C60(0.97)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C60(0.99)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C60(0.97)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C60(0.92)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C60(1.01)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C60(0.97)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C60(0.98)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C60(1.01)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C60(0.91)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C60(1.01)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C60(0.95)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C60(0.92)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C60(0.96)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C60(0.88)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C60(0.90)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C60(0.94)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C60(0.97)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C60(0.79)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C60(0.95)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C60(0.93)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C60(0.91)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C60(0.88)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C60(0.87)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C60(0.91)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C60(0.92)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C60(0.74)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C60(1.05)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C60(1.01)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C60(0.93)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C60(0.86)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C60(0.89)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C60(1.00)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C60(0.83)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C60(0.97)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C60(0.92)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C60(0.98)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C60(1.08)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C60(0.89)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C60(0.96)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C60(0.93)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C60(0.86)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C60(0.98)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C60(0.94)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C60(1.09)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C60(0.95)  LDD1569  [9]
 LDCM0545  Acetamide MDA-MB-231 C60(0.82)  LDD2138  [3]
 LDCM0248  AKOS034007472 HEK-293T C60(0.90)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C60(0.82)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C60(0.95)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C60(0.94)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C60(1.01)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C60(0.85)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C60(0.89)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C60(0.77)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C60(0.84)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C60(0.92)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C60(1.03)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C60(0.81)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C60(0.87)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C60(0.93)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C60(0.89)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C60(1.06)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C60(0.85)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C60(0.91)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C60(0.84)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C60(0.99)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C60(0.84)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C60(0.86)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C60(0.87)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C60(0.94)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C60(0.73)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C60(0.89)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C60(1.09)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C60(0.91)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C60(0.87)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C60(0.74)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C60(0.74)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C60(0.81)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C60(0.97)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C60(0.97)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C60(0.96)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C60(0.90)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C60(0.89)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C60(0.81)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C60(0.81)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C60(0.89)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C60(0.78)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C60(0.99)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C60(0.91)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C60(1.01)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C60(0.89)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C60(0.94)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C60(1.19)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C60(1.09)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C60(1.11)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C60(1.17)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C60(0.94)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C60(0.84)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C60(0.85)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C60(0.89)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C60(0.98)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C60(1.03)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C60(0.95)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C60(0.90)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C60(0.90)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C60(0.80)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C60(1.08)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C60(1.22)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C60(1.09)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C60(0.96)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C60(0.93)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C60(0.95)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C60(0.96)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C60(1.06)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C60(1.07)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C60(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C60(0.94)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C60(1.05)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C60(1.05)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C60(1.13)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C60(1.01)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C60(1.02)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C60(0.86)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C60(0.92)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C60(0.85)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C60(0.88)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C60(1.01)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C60(0.90)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C60(0.89)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C60(0.91)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C60(1.05)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C60(0.91)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C60(1.04)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C60(0.95)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C60(0.96)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C60(0.83)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C60(0.87)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C60(0.94)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C60(1.05)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C60(1.04)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C60(1.04)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C60(0.92)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C60(1.06)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C60(1.04)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C60(0.95)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C60(1.14)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C60(0.89)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C60(0.83)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C60(0.88)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C60(0.93)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C60(0.93)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C60(1.09)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C60(0.83)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C60(1.03)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C60(0.87)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C60(0.90)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C60(0.99)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C60(1.20)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C60(1.05)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C60(1.10)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C60(0.92)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C60(0.89)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C60(0.91)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C60(1.04)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C60(0.86)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C60(1.14)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C60(0.89)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C60(0.91)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C60(0.89)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C60(0.93)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C60(1.06)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C60(0.98)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C60(0.97)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C60(1.05)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C60(0.98)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C60(0.85)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C60(0.97)  LDD1631  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C60(1.03)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C60(0.99)  LDD1497  [9]
 LDCM0024  KB05 IGR37 C89(2.42)  LDD3314  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C60(1.02)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C60(1.12)  LDD2093  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C60(0.27)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C60(0.79)  LDD2104  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C60(0.60)  LDD2108  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C60(1.03)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C60(1.79)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C60(0.34)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C60(0.23)  LDD2124  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C60(1.17)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C60(0.86)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C60(2.24)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C60(0.86)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C60(0.56)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C60(0.82)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C60(0.47)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
STAM-binding protein (STAMBP) Peptidase M67C family O95630
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Charged multivesicular body protein 2a (CHMP2A) SNF7 family O43633
Charged multivesicular body protein 2b (CHMP2B) SNF7 family Q9UQN3
Charged multivesicular body protein 4b (CHMP4B) SNF7 family Q9H444

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402