Details of the Target

General Information of Target

Target ID LDTP13880
Target Name Zinc finger and BTB domain-containing protein 1 (ZBTB1)
Gene Name ZBTB1
Gene ID 22890
Synonyms
KIAA0997; Zinc finger and BTB domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.
Uniprot ID
Q9Y2K1
Ensemble ID
ENST00000358738.3
HGNC ID
HGNC:20259
ChEMBL ID
CHEMBL5069370

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.F587I DBIA    Probe Info 
CCK81 Deletion: p.K524SfsTer25 .
FTC133 SNV: p.A37T .
KASUMI2 Insertion: p.S196KfsTer24 DBIA    Probe Info 
MDAMB231 SNV: p.D351V .
MFE319 Deletion: p.S383VfsTer6 .
SNU1 SNV: p.C26R DBIA    Probe Info 
TOV21G Deletion: p.K524SfsTer25 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C160(2.21)  LDD0168  [1]
DBIA
 Probe Info  		C448(1.02); C580(0.94); C583(0.94); C532(0.91)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		C160(0.00); C193(0.00)  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		13.00  LDD0443  [7]
NAIA_5
 Probe Info  		C126(0.00); C193(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C160(2.21)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C160(2.44)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C126(0.95)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C126(1.63)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C126(1.60)  LDD1105  [2]
 LDCM0230  AC113 HEK-293T C532(1.19)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C532(1.18)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C532(1.27)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C532(1.10)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C532(1.46)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C532(1.07)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C532(1.07)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C126(1.50)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C532(1.19)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C532(1.47)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C532(1.36)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C532(1.04)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C532(1.21)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C532(1.20)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C532(1.38)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C532(1.14)  LDD0843  [2]
 LDCM0259  AC14 PaTu 8988t C126(1.28)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C126(1.32)  LDD1149  [2]
 LDCM0276  AC17 HEK-293T C238(1.02)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C160(1.06); C532(1.01); C238(1.04); C193(1.05)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C532(1.13); C227(1.16)  LDD1517  [8]
 LDCM0279  AC2 HCT 116 C126(1.67)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C238(0.98)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C227(1.05); C448(0.98)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C238(0.93); C227(1.00); C448(0.94)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C532(1.09); C238(1.00); C453(0.92); C448(0.84)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C238(0.96); C193(1.16); C126(1.10); C448(0.95)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C238(1.02)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C160(0.99); C532(0.96); C238(1.09); C193(1.05)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C532(1.10); C227(1.05)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C238(1.04)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C227(0.97); C448(0.95)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C126(1.06)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C238(0.87); C227(0.96); C448(0.97)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C532(0.98); C238(1.08); C453(1.20); C448(0.93)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C238(1.01); C193(1.18); C126(1.05); C448(0.94)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C238(1.05)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C160(1.06); C532(1.07); C238(1.18); C193(0.94)  LDD1534  [8]
 LDCM0296  AC35 PaTu 8988t C126(1.26)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C126(1.03)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C126(1.32)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C126(1.06)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C126(1.48)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C126(1.20)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C126(1.93)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C126(1.20)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C126(1.43)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C126(1.45)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C126(1.98)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C126(1.30)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C532(0.95)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C532(0.88)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C532(1.11)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C532(1.14)  LDD0909  [2]
 LDCM0312  AC5 HCT 116 C126(0.98)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C532(0.97)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C532(1.14)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C532(0.93)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C532(0.83)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C532(0.97)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C532(1.23)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C532(0.96)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C532(1.06)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C532(1.07)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C532(0.90)  LDD0920  [2]
 LDCM0323  AC6 PaTu 8988t C126(1.47)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C532(1.16)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C532(0.98)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C532(0.98)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C532(0.95)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C532(0.97)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C532(0.88)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C532(0.91)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C532(0.79)  LDD0929  [2]
 LDCM0334  AC7 PaTu 8988t C126(1.99)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C126(1.20)  LDD1224  [2]
 LDCM0349  AC83 HCT 116 C126(1.30)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C126(1.46)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C126(1.33)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C126(1.43)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C126(0.95)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C126(2.02)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C126(1.15)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C126(1.56)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C126(1.08)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C126(1.17)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C126(1.07)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C126(0.85)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C126(1.42)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C126(1.12)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C126(1.40)  LDD0681  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C126(1.71)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C126(1.72)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C126(2.43)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C448(1.02); C580(0.94); C583(0.94); C532(0.91)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C193(1.57)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C160(1.32); C532(1.09); C238(1.05); C227(1.13)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C238(1.04); C227(1.24); C448(0.83)  LDD1572  [8]
 LDCM0369  CL100 HCT 116 C126(1.10)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C126(1.65)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C126(2.11)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C126(1.65)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C126(1.70)  LDD1252  [2]
 LDCM0374  CL105 HEK-293T C160(1.09); C532(1.02); C238(0.92); C227(0.97)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C160(1.59); C532(0.92); C238(0.94); C227(0.97)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C227(1.03); C448(0.97)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C532(0.95); C193(1.38); C448(1.02)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C160(1.19); C532(1.02); C238(1.01); C227(0.98)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C532(1.08); C238(0.99); C453(1.18); C448(1.02)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C160(1.47); C532(0.95); C238(0.92); C227(0.95)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C227(0.93); C448(0.86)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C532(1.02); C193(1.17); C448(0.98)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C160(0.79); C532(0.99); C238(0.99); C227(1.04)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C160(1.33); C532(0.99); C238(1.01); C227(1.10)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C227(1.07); C448(1.15)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C532(0.96); C193(0.89); C448(1.00)  LDD1590  [8]
 LDCM0387  CL117 PaTu 8988t C126(1.40)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C126(0.95)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C126(1.53)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C238(0.98); C193(1.06); C126(0.98); C448(1.03)  LDD1594  [8]
 LDCM0391  CL120 PaTu 8988t C126(1.16)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C532(1.12)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C532(0.98)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C532(1.06)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C532(0.97)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C532(0.94)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C532(1.10)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C532(1.06)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C532(1.14)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C160(1.06); C532(1.22); C238(1.07); C227(1.28)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C160(1.32); C532(0.95); C238(1.11); C227(1.10)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C227(1.08); C448(0.88)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C532(1.09); C193(0.92); C448(1.06)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C238(0.97)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C160(1.04); C532(1.15); C238(1.26); C193(0.94)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C532(1.08); C227(1.06)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C160(1.20); C532(0.99); C238(1.12); C227(1.31)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C238(1.15)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C227(1.33); C448(0.82)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C238(1.07); C227(1.25); C448(1.04)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C532(0.96); C238(1.07); C453(1.20); C448(0.86)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C238(1.05); C193(0.98); C126(0.88); C448(1.08)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C160(1.15); C532(1.07); C238(1.09); C227(0.93)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C160(1.44); C532(0.98); C238(1.01); C227(1.10)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C227(0.93); C448(0.97)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C532(0.92); C193(1.13); C448(0.97)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C238(0.93)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C227(0.98); C448(1.03)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C160(1.10); C532(1.04); C238(1.14); C193(1.05)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C532(1.09); C227(1.04)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C238(1.16)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C227(1.04); C448(0.82)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C238(1.07); C227(1.00); C448(0.99)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C532(0.91); C238(1.18); C453(1.09); C448(0.76)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C238(0.94); C193(1.20); C126(1.09); C448(0.96)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C160(1.16); C532(1.01); C238(1.00); C227(1.06)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C227(0.94); C448(0.93)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C532(1.10); C193(0.90); C448(1.03)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C532(0.88); C193(1.29); C448(0.99)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C238(1.00)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C160(0.92); C532(0.99); C238(1.29); C193(0.92)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C532(0.96); C227(1.01)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C238(1.06)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C227(1.34); C448(1.09)  LDD1639  [8]
 LDCM0436  CL46 HCT 116 C126(0.68)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C126(0.66)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C126(0.65)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C126(0.68)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C238(1.02)  LDD1644  [8]
 LDCM0441  CL50 HCT 116 C126(0.98)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C126(1.18)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C126(1.28)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C126(0.95)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C126(0.62)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C126(0.51)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C126(0.60)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C126(0.86)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C126(0.87)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C126(0.79)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C160(1.17); C532(1.08); C238(1.45); C193(0.88)  LDD1654  [8]
 LDCM0452  CL60 HCT 116 C126(0.88)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C126(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C126(1.25)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C126(1.10)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C126(1.31)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C126(0.93)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C126(1.03)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C126(1.41)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C126(1.24)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C126(0.96)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C532(1.00); C227(1.24)  LDD1665  [8]
 LDCM0463  CL70 HCT 116 C126(0.91)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C126(1.12)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C126(1.07)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C126(0.90)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C126(1.09)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C532(1.12)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C532(1.12)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C532(1.11)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C532(1.23)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C238(1.26)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C532(1.18)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C532(0.92)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C532(1.10)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C532(0.81)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C532(1.20)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C532(1.25)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C532(1.17)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C532(1.08)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C532(1.36)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C532(1.20)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C227(1.15); C448(0.93)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C532(0.96)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C126(0.87)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C126(1.14)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C126(0.74)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C126(1.03)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C126(1.27)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C126(1.07)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C126(1.33)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C126(1.36)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C126(1.14)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C227(1.20); C448(1.03)  LDD1698  [8]
 LDCM0468  Fragment33 HCT 116 C126(1.09)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C160(1.13); C532(0.89); C238(0.93); C227(0.95)  LDD1631  [8]
 LDCM0022  KB02 HCT 116 C532(1.94)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C532(1.53)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C532(1.51)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Aldo/keto reductase family O43488
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Serine/threonine-protein kinase pim-1 (PIM1) CAMK Ser/Thr protein kinase family P11309
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger and BTB domain-containing protein 25 (ZBTB25) . P24278
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161A (FAM161A) FAM161 family Q3B820
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402