Details of the Target

General Information of Target

Target ID LDTP13458
Target Name Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2)
Gene Name CHIC2
Gene ID 26511
Synonyms
BTL; Cysteine-rich hydrophobic domain-containing protein 2; BrX-like translocated in leukemia
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWE
LATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQ
SVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRV
TQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQ
NTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSV
LKA
Target Bioclass
Other
Family
CHIC family
Subcellular location
Cell membrane
Uniprot ID
Q9UKJ5
Ensemble ID
ENST00000263921.8
HGNC ID
HGNC:1935

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C131(1.66)  LDD3315  [1]
BTD
 Probe Info  		C74(1.61)  LDD2090  [2]
IPM
 Probe Info  		C131(8.84)  LDD1701  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(1.14)  LDD2103  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C74(0.67)  LDD2132  [2]
 LDCM0214  AC1 HEK-293T C141(1.04)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C141(1.09)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C141(1.09)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C141(1.30)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C141(1.05)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C141(1.15)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C141(1.08)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C141(1.00)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C141(0.98)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C141(0.95)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C141(1.03)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C141(1.04)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C141(0.98)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C141(0.97)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C141(1.28)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C141(1.19)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C141(1.10)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C141(0.86)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C141(1.08)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C141(1.01)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C141(0.96)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C141(0.95)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C141(0.67)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C141(1.24)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C141(1.13)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C141(1.18)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C141(1.13)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C141(1.18)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C141(1.25)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C141(1.08)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C141(0.95)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C141(1.05)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C141(0.94)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C141(1.21)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C141(1.24)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C141(1.01)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C141(1.19)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C141(1.27)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C141(0.94)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C141(1.24)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C141(1.18)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C141(1.14)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C141(1.12)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C141(1.05)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C141(0.95)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C141(1.32)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C141(1.31)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C141(1.10)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C141(0.88)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C141(1.17)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C141(0.99)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C141(0.97)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C141(1.04)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C141(1.10)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C141(1.12)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C141(1.19)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C141(0.98)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C141(0.78)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C141(1.18)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C141(0.80)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C141(1.11)  LDD1569  [3]
 LDCM0545  Acetamide MDA-MB-231 C74(0.29)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C141(1.20)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C141(1.03)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C141(1.19)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C141(0.73)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C141(1.04)  LDD1575  [3]
 LDCM0375  CL106 HEK-293T C141(1.15)  LDD1579  [3]
 LDCM0379  CL11 HEK-293T C141(0.99)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C141(0.97)  LDD1584  [3]
 LDCM0384  CL114 HEK-293T C141(0.93)  LDD1588  [3]
 LDCM0388  CL118 HEK-293T C141(1.19)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C141(1.19)  LDD1594  [3]
 LDCM0393  CL122 HEK-293T C141(0.97)  LDD1597  [3]
 LDCM0397  CL126 HEK-293T C141(0.91)  LDD1601  [3]
 LDCM0401  CL14 HEK-293T C141(1.03)  LDD1605  [3]
 LDCM0404  CL17 HEK-293T C141(1.07)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C141(1.15)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C141(1.14)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C141(1.02)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C141(1.07)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C141(1.20)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C141(0.91)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C141(0.93)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C141(1.53)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C141(0.92)  LDD1618  [3]
 LDCM0417  CL29 HEK-293T C141(0.94)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C141(1.37)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C141(1.11)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C141(1.28)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C141(1.35)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C141(1.02)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C141(1.06)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C141(1.36)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C141(1.19)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C141(1.01)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C141(1.04)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C141(1.24)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C141(1.32)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C141(1.18)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C141(1.40)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C141(1.22)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C141(1.13)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C141(1.15)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C141(1.23)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C141(1.06)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C141(1.01)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C141(1.28)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C141(1.00)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C141(1.09)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C141(1.09)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C141(1.07)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C141(1.38)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C141(0.95)  LDD1657  [3]
 LDCM0457  CL65 HEK-293T C141(1.02)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C141(1.29)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C141(1.03)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C141(1.24)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C141(1.17)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C141(1.03)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C141(1.20)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C141(0.71)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C141(1.36)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C141(0.95)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C141(1.21)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C141(1.19)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C141(1.07)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C141(1.02)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C141(1.37)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C141(1.22)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C141(0.94)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C141(0.85)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C141(1.40)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C141(1.07)  LDD1683  [3]
 LDCM0483  CL89 HEK-293T C141(0.98)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C141(1.15)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C141(1.08)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C141(1.06)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C141(1.16)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C141(1.06)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C141(1.18)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C141(0.87)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C141(1.23)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C141(0.92)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C141(1.04)  LDD1631  [3]
 LDCM0022  KB02 42-MG-BA C74(1.43)  LDD2244  [1]
 LDCM0023  KB03 MDA-MB-231 C131(8.84)  LDD1701  [2]
 LDCM0024  KB05 IGR39 C131(1.66)  LDD3315  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C74(1.61)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C74(1.30)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C74(1.23)  LDD2093  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C74(1.04)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C74(1.94)  LDD2105  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(0.73)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C74(0.45)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(4.12)  LDD2119  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C74(0.87)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(1.31)  LDD2127  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C74(0.66)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C74(1.25)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C74(0.87)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C74(2.68)  LDD2144  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C74(3.26)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Pleckstrin homology domain-containing family F member 1 (PLEKHF1) . Q96S99
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
POU domain, class 4, transcription factor 2 (POU4F2) POU transcription factor family Q12837
Homeobox protein MOX-2 (MEOX2) . P50222
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Myogenic factor 5 (MYF5) . P13349
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Dynein axonemal light chain 4 (DNAL4) Dynein light chain family O96015
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 3A (LCE3A) LCE family Q5TA76
Late cornified envelope protein 3C (LCE3C) LCE family Q5T5A8
Late cornified envelope protein 3D (LCE3D) LCE family Q9BYE3
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Axin-2 (AXIN2) . Q9Y2T1
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2) . Q9BXJ5
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402