Details of the Target

General Information of Target

Target ID LDTP13196
Target Name Serine/threonine-protein kinase 17A (STK17A)
Gene Name STK17A
Gene ID 9263
Synonyms
DRAK1; Serine/threonine-protein kinase 17A; EC 2.7.11.1; DAP kinase-related apoptosis-inducing protein kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
Subcellular location
Nucleus
Function Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
TTD ID
T91323
Uniprot ID
Q9UEE5
DrugMap ID
TTEYF03
Ensemble ID
ENST00000319357.6
HGNC ID
HGNC:11395
ChEMBL ID
CHEMBL4525

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C62(1.20)  LDD0078  [1]
IA-alkyne
 Probe Info  		C62(0.00); C101(0.00)  LDD0162  [2]
Lodoacetamide azide
 Probe Info  		C315(0.00); C31(0.00)  LDD0037  [3]
NAIA_4
 Probe Info  		C62(0.00); C315(0.00)  LDD2226  [4]
IPM
 Probe Info  		C62(0.00); C31(0.00)  LDD0147  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C62(2.32)  LDD0532  [1]
 LDCM0226  AC11 HCT 116 C62(2.25)  LDD0543  [1]
 LDCM0230  AC113 HCT 116 C62(1.10)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C62(1.02)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C62(1.03)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C62(0.97)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C62(1.06)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C62(1.13)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C62(1.04)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C62(1.19)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C62(1.08)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C62(1.05)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C62(1.18)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C62(1.15)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C62(1.09)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C62(1.05)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C62(0.98)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C62(1.25)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C62(0.82)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C62(0.87)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C62(0.99)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C62(0.85)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C62(1.01)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C62(0.93)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C62(1.20)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C62(0.96)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C62(1.11)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C62(1.00)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C62(1.07)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C62(1.13)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C62(1.63)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C62(1.08)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C62(1.01)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C62(1.04)  LDD0579  [1]
 LDCM0270  AC15 HCT 116 C62(1.90)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C62(1.61)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C62(0.93)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C62(1.42)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C62(1.32)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C62(1.56)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C62(1.15)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C62(1.53)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C62(1.18)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C62(1.38)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C62(0.68)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C62(1.03)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C62(1.24)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C62(1.77)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C62(1.10)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C62(1.29)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C62(1.23)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C62(1.75)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C62(1.28)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C62(0.90)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C62(0.91)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C62(0.93)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C62(1.25)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C62(1.13)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C62(1.10)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C62(0.87)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C62(0.86)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C62(1.18)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C62(1.04)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C62(0.97)  LDD0624  [1]
 LDCM0323  AC6 HCT 116 C62(2.41)  LDD0640  [1]
 LDCM0332  AC68 HCT 116 C62(1.08)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C62(1.04)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C62(1.11)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C62(1.03)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C62(0.98)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C62(1.01)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C62(1.03)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C62(0.97)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C62(0.91)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C62(0.94)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C62(1.01)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C62(1.04)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C62(1.06)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C62(2.37)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C62(0.96)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C62(1.00)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C62(1.03)  LDD0665  [1]
 LDCM0248  AKOS034007472 HCT 116 C62(1.60)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C62(1.35)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C62(1.69)  LDD0592  [1]
 LDCM0020  ARS-1620 HCC44 C62(1.20)  LDD0078  [1]
 LDCM0370  CL101 HCT 116 C62(1.63)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C62(1.22)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C62(1.85)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C62(1.29)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C62(1.99)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C62(1.35)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C62(2.46)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C62(1.84)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C62(1.65)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C62(1.45)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C62(1.11)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C62(1.02)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C62(1.43)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C62(0.94)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C62(0.98)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C62(1.87)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C62(1.18)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C62(1.07)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C62(1.09)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C62(1.21)  LDD0708  [1]
 LDCM0403  CL16 HCT 116 C62(1.30)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C62(1.13)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C62(1.03)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C62(0.92)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C62(1.17)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C62(0.98)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C62(1.05)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C62(1.27)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C62(1.19)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C62(1.10)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C62(1.36)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C62(1.17)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C62(1.15)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C62(1.18)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C62(1.00)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C62(1.00)  LDD0737  [1]
 LDCM0436  CL46 HCT 116 C62(1.22)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C62(0.99)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C62(0.89)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C62(0.97)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C62(1.05)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C62(1.32)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C62(0.87)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C62(0.91)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C62(0.93)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C62(0.83)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C62(1.17)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C62(1.06)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C62(1.19)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C62(1.03)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C62(1.13)  LDD0769  [1]
 LDCM0573  Fragment11 Ramos C315(3.54)  LDD2190  [6]
 LDCM0575  Fragment13 Ramos C315(0.40)  LDD2192  [6]
 LDCM0580  Fragment21 Ramos C315(0.59)  LDD2195  [6]
 LDCM0586  Fragment28 Ramos C315(1.05)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C315(0.55)  LDD2199  [6]
 LDCM0468  Fragment33 Ramos C315(1.07)  LDD2202  [6]
 LDCM0022  KB02 T cell-activated C31(9.26)  LDD1704  [7]
 LDCM0023  KB03 Jurkat C315(7.75)  LDD0209  [8]
 LDCM0024  KB05 SKMEL2 C315(1.72)  LDD3322  [9]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840