Details of the Target

General Information of Target

Target ID LDTP13075
Target Name Rabankyrin-5 (ANKFY1)
Gene Name ANKFY1
Gene ID 51479
Synonyms
ANKHZN; KIAA1255; Rabankyrin-5; Rank-5; Ankyrin repeat and FYVE domain-containing protein 1; Ankyrin repeats hooked to a zinc finger motif
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEY
FGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATIELFFL
NAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSL
AYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGI
FQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYAC
PALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK
IISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELT
GKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAAR
RLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIAS
EDSSLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRND
YDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIR
GLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLG
SENDTGSPDFYTPRTRSSNGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKAR
QRQRQRQRAAGALGSASSGSMPNLAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLY
IEGGATPVVVRSLESDQEGHYSVKAQFKTSNSYTAGGLFKESWRGGGGDEGDTGRLTPSR
SQILRTPSLGREGAHDKGAGRAAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYS
TSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSSEIGATPPSSPHHILTWQTGEAT
ENSPILDGSESPPHQSTDE
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
Uniprot ID
Q9P2R3
Ensemble ID
ENST00000341657.9
HGNC ID
HGNC:20763

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.A704P DBIA    Probe Info 
ETK1 SNV: p.E865K DBIA    Probe Info 
HEC1B SNV: p.D253G .
IGROV1 SNV: p.D454N DBIA    Probe Info 
JHH6 Deletion: p.D195AfsTer3 DBIA    Probe Info 
LS180 SNV: p.P1143L DBIA    Probe Info 
MCC13 SNV: p.T599I DBIA    Probe Info 
MFE319 SNV: p.E735K; p.P773L DBIA    Probe Info 
MOLT4 SNV: p.V1064A IA-alkyne    Probe Info 
PC9 SNV: p.S206R .
SSP25 SNV: p.E865K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1016(7.29)  LDD0257  [1]
STPyne
 Probe Info  		K1151(5.56); K26(0.36); K32(10.00); K931(9.09)  LDD0277  [2]
DBIA
 Probe Info  		C1102(3.83); C791(3.41); C541(3.74)  LDD3310  [3]
BTD
 Probe Info  		C460(1.10)  LDD1700  [4]
HHS-475
 Probe Info  		Y1016(1.33)  LDD0264  [5]
HHS-465
 Probe Info  		Y1016(10.00)  LDD2237  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
m-APA
 Probe Info  		H571(0.00); H644(0.00)  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C742(0.00); C34(0.00); C186(0.00); C1060(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C34(0.00); C1060(0.00); C460(0.00); C675(0.00)  LDD0037  [10]
TFBX
 Probe Info  		C460(0.00); C675(0.00); C34(0.00); C742(0.00)  LDD0027  [12]
WYneN
 Probe Info  		C675(0.00); C499(0.00); C34(0.00)  LDD0021  [13]
WYneO
 Probe Info  		C34(0.00); C499(0.00); C460(0.00)  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C460(0.00); C675(0.00); C34(0.00)  LDD0147  [12]
SF
 Probe Info  		N.A.  LDD0028  [15]
VSF
 Probe Info  		C34(0.00); C460(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Methacrolein
 Probe Info  		C460(0.00); C675(0.00); C499(0.00); C749(0.00)  LDD0218  [7]
W1
 Probe Info  		C460(0.00); C742(0.00); C499(0.00); C675(0.00)  LDD0236  [17]
AOyne
 Probe Info  		5.90  LDD0443  [18]
NAIA_5
 Probe Info  		C34(0.00); C460(0.00); C499(0.00); C675(0.00)  LDD2223  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C460(0.92)  LDD2142  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1060(1.09); C460(1.59)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C1060(0.91); C460(1.11); C499(1.07); C34(0.98)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C1060(0.81); C460(1.06); C499(1.05); C34(1.03)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C1060(1.02); C460(0.96); C499(0.96); C34(0.98)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C1060(0.99); C460(1.15); C499(0.92); C34(1.03)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C1060(1.06); C460(1.01); C499(1.02); C34(1.04)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C1060(0.99); C460(0.93); C499(1.03); C34(1.10)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C1060(0.94); C460(1.00); C499(1.01); C34(1.09)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C1060(0.90); C460(1.26); C499(0.99); C34(0.98)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C1060(0.85); C460(0.88); C499(1.03); C34(1.10)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C1060(0.82); C460(1.11); C499(1.00); C34(0.91)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C1060(0.98); C460(1.09); C499(0.91); C34(1.07)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C1060(1.00); C460(0.96); C499(1.03); C34(0.99)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C1060(0.98); C460(1.04); C499(0.96); C34(1.03)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C1060(1.03); C460(0.87); C499(0.99); C34(1.09)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C1060(1.05); C460(1.05); C499(1.06); C34(1.03)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C1060(0.91); C460(1.00); C499(1.01); C34(1.10)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C1060(0.93); C460(1.21); C499(1.04); C34(1.06)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C1060(1.02); C460(0.95); C499(0.98); C34(1.03)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C1060(1.01); C460(1.10); C499(0.91); C34(1.06)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C1060(1.01); C460(1.05); C499(0.92); C34(1.07)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C1060(0.97); C460(1.00); C499(0.96); C34(0.84)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C1060(1.02); C460(1.03); C499(1.00); C34(1.04)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C1060(0.97); C460(1.00); C499(1.03); C34(1.06)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C1060(1.06); C460(0.94); C499(1.05); C34(0.96)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C1060(0.91); C460(1.03); C499(1.03); C34(0.97)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C1060(0.86); C460(1.06); C499(1.04); C34(0.95)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C1060(1.05); C460(0.92); C499(1.01); C34(0.92)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C1060(0.95); C460(1.01); C499(1.05); C34(1.02)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C1060(1.01); C460(1.07); C499(0.96); C34(0.96)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C1060(1.00); C460(1.20); C499(1.00); C34(1.05)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C1060(0.98); C460(0.83); C499(0.99); C34(0.98)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C1060(0.97); C460(1.17); C499(0.87); C34(0.97)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C1060(1.04); C460(1.02); C499(1.11); C34(0.94)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C1060(0.94); C460(0.99); C499(1.07); C34(1.06)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C1060(0.87); C460(1.29); C499(1.00); C34(1.00)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C1060(1.02); C460(0.87); C499(0.97); C34(0.98)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C1060(0.96); C460(0.99); C499(1.04); C34(1.07)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C1060(1.00); C460(1.02); C499(1.04); C34(1.04)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C1060(0.99); C460(1.17); C499(1.00); C34(1.05)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C1060(0.96); C460(0.88); C499(0.99); C34(1.01)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C1060(1.03); C460(1.12); C499(1.17); C34(0.97)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C1060(0.90); C460(1.09); C499(1.03); C34(1.12)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C1060(1.03); C460(1.07); C499(0.96); C34(0.95)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C1060(0.97); C460(1.02); C499(0.97); C34(1.02)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C1060(0.99); C460(1.00); C499(1.03); C34(1.00)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C1060(1.02); C460(1.06); C499(0.92); C34(1.07)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C1060(0.95); C460(1.01); C499(1.02); C34(1.03)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C1060(0.97); C460(1.10); C499(1.01); C34(1.05)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C1060(0.95); C460(0.98); C499(1.00); C34(1.08)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C1060(1.04); C460(1.06); C499(1.05); C34(1.01)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C1060(0.87); C460(1.09); C499(1.05); C34(0.97)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C1060(0.86); C460(1.19); C499(0.99); C34(0.93)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C1060(1.01); C460(1.01); C499(1.08); C34(0.87)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C1060(0.97); C460(1.21); C499(1.01); C34(0.92)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C1060(0.92); C460(1.10); C499(0.96); C34(0.95)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C1060(0.96); C460(1.09); C499(0.99); C34(0.94)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C1060(0.96); C460(1.19); C499(0.99); C34(0.98)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C1060(1.02); C460(1.18); C499(1.03); C34(0.97)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C1060(1.07); C460(1.06); C499(1.06); C34(0.96)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C1060(1.01); C460(0.93); C499(1.02); C34(0.96)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C1060(1.01); C460(0.91); C499(1.02); C34(0.87)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C1060(1.02); C460(1.03); C499(1.01); C34(1.00)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C1060(0.93); C460(0.92); C499(1.09); C34(1.07)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C1060(1.00); C460(1.09); C499(1.04); C34(1.05)  LDD1514  [20]
 LDCM0108  Chloroacetamide HeLa C675(0.00); C1060(0.00); H278(0.00); C460(0.00)  LDD0222  [7]
 LDCM0632  CL-Sc Hep-G2 C34(1.14); C675(0.73)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C1060(1.00); C460(1.29); C499(1.09); C34(0.88)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C1060(1.03); C460(1.93); C499(1.05); C34(1.14)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C1060(0.88); C460(1.19); C499(1.03); C34(0.97)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C1060(1.02); C460(1.11); C499(1.00); C34(0.93)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C1060(1.01); C460(1.25); C34(1.02); C742(1.04)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C1060(0.83); C460(1.12); C499(1.04); C34(1.16)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C1060(0.87); C460(0.97); C499(1.01); C34(1.06)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C1060(0.99); C460(1.14); C499(0.98); C34(1.04)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C1060(0.92); C460(1.27); C34(1.11); C742(0.94)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C1060(0.86); C460(1.06); C499(0.88); C34(1.03)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C1060(0.94); C460(1.01); C499(0.98); C34(1.05)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C1060(1.00); C460(1.30); C499(1.00); C34(1.13)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C1060(0.91); C460(0.87); C499(1.09); C34(1.05)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C1060(0.95); C460(1.09); C34(1.21); C742(0.96)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C1060(0.86); C460(1.16); C499(0.95); C34(0.98)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C1060(0.90); C460(1.12); C499(1.05); C34(1.10)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C1060(1.00); C460(1.01); C499(1.05); C34(0.99)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C1060(0.96); C460(1.05); C34(1.05); C742(1.06)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C1060(0.80); C460(1.13); C499(1.10); C34(0.99)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C1060(0.83); C460(0.98); C499(1.05); C34(1.02)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C1060(0.98); C460(1.28); C499(1.05); C34(0.92)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C1060(1.00); C460(1.02); C34(0.98); C742(0.98)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C1060(0.82); C460(1.00); C499(1.04); C34(0.97)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C1060(1.05); C460(1.19); C499(1.12); C34(0.97)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C1060(0.95); C460(0.97); C499(1.05); C34(0.96)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C1060(0.97); C460(1.16); C499(1.02); C34(1.06)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C1060(0.90); C460(1.27); C34(0.99); C742(1.05)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C1060(0.77); C460(1.69); C499(0.86); C34(1.11)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C1060(0.91); C460(1.20); C499(1.01); C34(1.18)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C1060(1.06); C460(1.18); C499(1.11); C34(0.89)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C1060(0.97); C460(1.18); C34(0.94); C742(1.12)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C1060(0.84); C460(1.19); C499(1.15); C34(0.89)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C1060(0.97); C460(1.13); C499(1.04); C34(0.92)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C1060(0.92); C460(1.09); C499(1.06); C34(0.94)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C1060(0.97); C460(1.01); C34(1.03); C742(1.00)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C1060(0.81); C460(1.34); C499(1.08); C34(1.16)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C1060(0.91); C460(1.12); C499(1.07); C34(0.97)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C1060(0.92); C460(1.33); C499(1.04); C34(1.16)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C1060(0.93); C460(1.22); C499(1.04); C34(1.07)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C1060(0.98); C460(0.88); C499(0.96); C34(1.02)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C1060(0.94); C460(1.06); C34(0.92); C742(1.04)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C1060(0.95); C460(0.99); C499(0.96); C34(1.13)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C1060(0.96); C460(1.43); C499(1.05); C34(1.39)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C1060(1.04); C460(1.19); C499(1.09); C34(1.02)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C1060(0.97); C460(0.90); C499(1.07); C34(1.04)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C1060(1.07); C460(0.72); C499(1.11); C34(0.97)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C1060(1.08); C460(1.39); C499(0.96); C34(0.86)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C1060(0.96); C460(1.12); C34(0.94); C742(1.04)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C1060(0.80); C460(1.03); C499(0.91); C34(1.09)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C1060(1.00); C460(1.28); C499(1.04); C34(1.06)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C1060(0.99); C460(1.06); C499(1.00); C34(1.03)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C1060(0.81); C460(1.10); C499(1.06); C34(0.96)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C1060(0.96); C460(1.01); C499(1.03); C34(1.02)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C1060(1.01); C460(0.93); C499(0.95); C34(1.09)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C1060(1.01); C460(1.09); C499(0.96); C34(1.23)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C1060(1.10); C460(1.67); C499(1.01); C34(1.33)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C1060(1.04); C460(1.13); C499(1.01); C34(1.17)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C1060(1.00); C460(0.98); C499(1.05); C34(1.14)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C1060(1.02); C460(1.03); C499(0.97); C34(1.04)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C1060(1.11); C460(1.05); C499(0.98); C34(0.88)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C1060(0.85); C460(1.36); C499(0.94); C34(0.87)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C1060(0.99); C460(1.29); C499(1.08); C34(0.90)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C1060(0.93); C460(1.12); C499(1.07); C34(1.01)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C1060(1.01); C460(1.22); C499(1.08); C34(1.04)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C1060(0.95); C460(1.11); C499(0.97); C34(0.97)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C1060(1.09); C460(0.96); C499(1.07); C34(0.99)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C1060(0.98); C460(1.04); C499(0.91); C34(1.06)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C1060(0.95); C460(1.20); C499(1.00); C34(1.10)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C1060(1.08); C460(1.06); C499(0.98); C34(1.19)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C1060(1.03); C460(0.82); C499(1.08); C34(1.17)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C1060(1.09); C460(0.88); C499(1.09); C34(0.99)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C1060(1.12); C460(1.00); C499(1.05); C34(0.81)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C1060(0.87); C460(0.97); C499(0.98); C34(0.90)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C1060(0.96); C460(1.18); C34(1.01); C742(1.07)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C1060(0.95); C460(0.99); C499(1.06); C34(0.98)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C1060(0.91); C460(1.23); C499(1.07); C34(1.11)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C1060(0.90); C460(2.14); C499(1.06); C34(1.28)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C1060(1.00); C460(0.97); C499(1.03); C34(0.97)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C1060(0.95); C460(1.10); C499(0.93); C34(1.05)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C1060(1.00); C460(1.32); C499(1.06); C34(1.11)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C1060(0.97); C460(1.31); C499(1.04); C34(1.18)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C1060(1.03); C460(1.00); C499(1.08); C34(1.16)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C1060(0.92); C460(1.30); C499(0.99); C34(1.05)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C1060(1.10); C460(0.98); C499(1.11); C34(1.03)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C1060(1.04); C460(1.23); C499(1.05); C34(0.79)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C1060(1.04); C460(1.04); C34(1.02); C742(1.14)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C1060(0.86); C460(1.14); C499(1.22); C34(1.05)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C1060(0.95); C460(1.12); C499(0.95); C34(1.18)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C1060(0.95); C460(1.02); C499(1.02); C34(0.95)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C1060(0.95); C460(1.09); C499(1.09); C34(0.99)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C1060(1.06); C460(0.92); C499(0.96); C34(0.95)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C1060(1.06); C460(1.15); C499(1.02); C34(1.12)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C1060(1.01); C460(1.10); C499(1.03); C34(1.07)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C1060(0.98); C460(0.83); C499(0.96); C34(0.91)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C1060(1.02); C460(1.10); C499(1.05); C34(1.07)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C1060(1.01); C460(0.90); C499(1.07); C34(1.16)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C1060(1.06); C460(1.29); C499(1.00); C34(0.97)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C1060(1.00); C460(1.37); C499(0.97); C34(0.94)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C1060(0.99); C460(1.16); C34(0.99); C742(1.02)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C1060(0.98); C460(0.98); C499(1.02); C34(0.94)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C1060(0.93); C460(1.55); C499(1.07); C34(1.16)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C1060(0.92); C460(0.96); C499(1.01); C34(1.02)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C1060(1.04); C460(0.93); C499(1.04); C34(1.00)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C1060(0.96); C460(2.18); C499(1.02); C34(1.45)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C1060(1.01); C460(1.13); C499(1.01); C34(1.05)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C1060(1.04); C460(0.98); C499(1.01); C34(1.13)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C1060(1.03); C460(1.06); C499(1.03); C34(1.06)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C1060(1.02); C460(0.99); C499(1.04); C34(1.09)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C1060(1.07); C460(1.05); C499(1.11); C34(1.04)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C1060(1.06); C460(1.01); C499(1.00); C34(0.79)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C1060(0.99); C460(1.33); C34(0.85); C742(0.99)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C1060(0.84); C460(1.15); C499(0.97); C34(0.93)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C1060(0.92); C460(0.96); C499(1.06); C34(0.92)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C1060(1.04); C460(1.02); C499(1.06); C34(0.92)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C1060(0.98); C460(0.96); C499(0.97); C34(1.02)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C1060(0.93); C460(2.01); C499(1.05); C34(1.32)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C1060(1.04); C460(0.99); C499(1.04); C34(0.90)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C1060(0.97); C460(1.44); C499(0.95); C34(1.05)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C1060(0.98); C460(1.25); C499(0.99); C34(1.08)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C1060(0.98); C460(1.12); C499(1.02); C34(0.91)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C1060(1.01); C460(1.33); C499(1.07); C34(1.15)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C1060(1.06); C460(1.23); C499(1.21); C34(0.94)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C1060(1.04); C460(1.49); C499(1.03); C34(0.96)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C1060(0.99); C460(1.21); C34(0.93); C742(0.98)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C1060(0.78); C460(1.17); C499(1.02); C34(0.84)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C1060(0.86); C460(1.31); C499(0.96); C34(1.01)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C460(3.84); C499(1.61); C1060(1.39)  LDD1702  [4]
 LDCM0625  F8 Ramos C460(1.13); C34(0.77)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C460(1.05); C34(1.13)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C460(2.24)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C460(1.25); C34(1.13)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C460(0.98)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C460(2.05)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C460(0.99)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C460(0.99); C34(0.74)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C460(0.13); C34(0.67)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C460(0.79); C34(0.81)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C460(1.00)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C460(1.25); C34(0.78)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C460(0.96)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C460(1.29); C34(0.67)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C1060(0.86); C460(1.17); C499(0.92); C34(1.10)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C460(1.22); C34(1.64)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C460(2.15)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C1060(0.98); C460(0.92); C34(0.91); C742(0.85)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C460(1.73)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C460(1.23); C34(0.68)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C460(1.56)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C460(1.13); C34(1.05)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y1016(1.33)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y1016(1.48)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y1016(0.72)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y1016(0.70)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y1016(1.16)  LDD0268  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C749(0.88); C1060(1.00); C460(0.70); C499(1.01)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C749(0.91); C1060(0.99); C460(0.92); C499(0.95)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C1102(3.83); C791(3.41); C541(3.74)  LDD3310  [3]
 LDCM0109  NEM HeLa H449(0.00); H12(0.00)  LDD0223  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C460(0.64)  LDD2089  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C460(1.12)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C460(1.03)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C460(1.42)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C460(1.20)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C460(0.74)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1060(0.73); C460(1.00)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C460(1.21)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C460(0.85); C34(1.12)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C34(0.77)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1060(1.40)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C460(1.26)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C499(2.24)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C460(1.18); C499(1.36); C34(0.83)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C460(1.10)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C460(1.00)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C460(0.63)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C460(1.20)  LDD2143  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C460(0.95)  LDD2146  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C460(0.43)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C460(1.09)  LDD2206  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-5A (RAB5A) Rab family P20339
EH domain-containing protein 3 (EHD3) Dynamin/Fzo/YdjA family Q9NZN3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EH domain-containing protein 1 (EHD1) Dynamin/Fzo/YdjA family Q9H4M9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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