Details of the Target

General Information of Target

Target ID LDTP13005
Target Name Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3)
Gene Name CAMSAP3
Gene ID 57662
Synonyms
KIAA1543; Calmodulin-regulated spectrin-associated protein 3; Protein Nezha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
Target Bioclass
Other
Family
CAMSAP1 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In addition, it also reduces the velocity of microtubule polymerization. Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation. Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo. Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration. Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome. Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes. Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal. Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia.
Uniprot ID
Q9P1Y5
Ensemble ID
ENST00000160298.9
HGNC ID
HGNC:29307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A340T DBIA    Probe Info 
CCSW1 SNV: p.E698D .
COLO792 SNV: p.V551M .
EGI1 Substitution: p.F684T .
HCT116 Deletion: p.L160WfsTer3 .
HCT15 SNV: p.A765V .
ICC10 Substitution: p.E648R .
ICC106 Substitution: p.E648R .
ICC108 Substitution: p.E648R .
IPC298 Substitution: p.S658F .
Ishikawa (Heraklio) 02 ER SNV: p.S597R DBIA    Probe Info 
JURKAT SNV: p.A308V; p.T447I; p.V820M .
LS123 SNV: p.E788A DBIA    Probe Info 
MELHO SNV: p.G10W .
MONOMAC6 SNV: p.M600T .
NALM6 SNV: p.A605T; p.G862R .
NCIH1155 SNV: p.A236V DBIA    Probe Info 
NCIH2170 SNV: p.R882Q .
NCIH2291 SNV: p.P662S .
OAW28 SNV: p.A103V DBIA    Probe Info 
PEO1 Substitution: p.F684T DBIA    Probe Info 
PF382 SNV: p.A87V .
SKMEL2 SNV: p.P513L .
SNGM Deletion: p.N100TfsTer28 DBIA    Probe Info 
SNU1079 SNV: p.R14K; p.I21F .
TOV21G SNV: p.E561K .
U937 Substitution: p.F684T .
WM1552C SNV: p.G664W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C1022(0.00); C1023(0.00)  LDD0241  [1]
DA-P3
 Probe Info  		7.01  LDD0183  [2]
DBIA
 Probe Info  		C1023(13.88); C1167(33.20)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
AOyne
 Probe Info  		11.80  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C532(1.14); C256(0.92); C1167(0.92); C285(1.04)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C532(1.01); C256(1.01); C1167(1.03); C285(1.20)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C532(1.01); C256(0.98); C1167(1.10); C285(1.15)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C532(0.98); C256(0.99); C1167(1.00); C285(1.03)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C532(0.94); C256(0.97); C1167(0.98); C285(0.86)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C532(1.05); C256(0.98); C1167(1.01); C285(0.99)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C532(0.98); C256(0.99); C1167(0.87); C285(1.02)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C532(1.05); C256(0.96); C1167(1.01); C285(0.93)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C532(0.99); C256(0.98); C1167(1.35); C285(1.02)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C532(0.99); C256(0.93); C1167(1.07); C285(0.95)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C532(0.97); C256(0.99); C1167(0.98); C285(1.09)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C532(1.03); C256(0.99); C1167(0.94); C285(1.62)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C532(0.96); C256(1.04); C1167(0.97); C285(0.75)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C532(0.95); C256(1.06); C1167(1.05); C285(1.00)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C532(0.98); C256(1.08); C1167(1.11); C285(1.41)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C532(1.10); C256(1.01); C1167(0.87); C285(0.71)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C532(1.08); C256(1.00); C1167(0.96); C285(0.97)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C532(1.02); C256(1.00); C1167(1.03); C285(0.96)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C532(1.04); C256(0.92); C1167(1.00); C285(1.04)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C532(1.00); C256(1.15); C1167(0.93); C285(0.91)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C532(1.04); C256(0.95); C1167(1.08); C285(0.91)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C532(0.99); C256(1.02); C1167(1.00); C285(0.82)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C532(0.98); C256(1.03); C1167(1.08); C285(1.37)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C532(1.01); C256(1.01); C1167(1.01); C285(0.92)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C532(1.15); C256(0.95); C1167(1.01); C285(1.02)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C532(1.07); C256(0.86); C1167(1.10); C285(1.14)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C532(1.01); C256(0.94); C1167(1.10); C285(1.07)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C532(1.05); C256(1.01); C1167(0.93); C285(0.96)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C532(1.01); C256(1.00); C1167(1.11); C285(0.75)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C532(0.84); C256(0.94); C1167(1.06); C285(0.70)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C532(1.00); C256(1.02); C1167(1.04); C285(0.73)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C532(0.93); C256(0.99); C1167(1.10); C285(1.07)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C532(1.06); C256(0.99); C1167(1.03); C285(1.01)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C532(1.05); C256(0.98); C1167(0.99); C285(0.99)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C532(1.03); C256(0.95); C1167(1.09); C285(1.20)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C532(0.98); C256(0.99); C1167(1.01); C285(1.07)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C532(0.94); C256(0.94); C1167(1.12); C285(1.12)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C532(1.06); C256(1.09); C1167(1.06); C285(1.18)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C532(0.92); C256(0.99); C1167(1.06); C285(0.92)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C532(0.98); C256(0.98); C1167(1.10); C285(0.90)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C532(1.06); C256(1.04); C1167(1.17); C285(0.97)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C532(1.15); C256(1.01); C1167(0.92); C285(0.94)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C532(1.01); C256(1.09); C1167(0.98); C285(0.89)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C532(1.10); C256(0.97); C1167(1.05); C285(1.11)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C532(1.05); C256(0.93); C1167(1.04); C285(1.00)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C532(1.02); C256(1.00); C1167(1.09); C285(1.06)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C532(1.00); C256(1.01); C1167(1.14); C285(0.97)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C532(0.98); C256(0.95); C1167(1.03); C285(0.92)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C532(1.02); C256(0.98); C1167(1.03); C285(0.96)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C532(1.06); C256(1.03); C1167(1.14); C285(1.14)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C532(1.05); C256(0.99); C1167(1.03); C285(0.96)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C532(0.93); C256(0.97); C1167(1.10); C285(1.10)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C532(0.96); C256(0.95); C1167(1.05); C285(1.14)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C532(1.00); C256(0.96); C1167(0.98); C285(0.76)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C532(0.97); C256(0.98); C1167(1.12); C285(1.19)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C532(0.97); C256(0.98); C1167(0.96); C285(1.37)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C532(0.91); C256(0.95); C1167(1.03); C285(1.02)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C532(0.92); C256(0.98); C1167(0.95); C285(1.15)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C532(1.05); C256(0.99); C1167(1.10); C285(1.04)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C532(1.04); C256(0.93); C1167(1.07); C285(0.86)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C532(1.01); C256(1.00); C1167(1.09); C285(1.06)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C532(1.04); C256(0.98); C1167(1.10); C285(1.20)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C532(1.06); C256(1.01); C1167(0.95); C285(1.03)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C532(1.05); C256(1.05); C1167(1.08); C285(1.06)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C532(1.00); C256(0.95); C1167(1.08); C285(0.55)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C532(0.99); C256(0.99); C1167(0.91); C285(0.98)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C532(1.01); C256(0.98); C1167(0.96); C222(1.10)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C532(1.10); C256(0.98); C1167(1.10); C285(0.85)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C532(1.00); C256(0.99); C285(1.16); C85(0.97)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C532(1.04); C256(1.00); C285(1.01); C222(1.00)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C532(0.98); C256(0.95); C1167(1.06); C222(1.06)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C532(0.99); C256(0.94); C1167(1.03); C285(1.15)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C532(0.99); C256(0.91); C285(0.97); C85(0.92)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C532(1.04); C256(0.98); C285(1.03); C222(0.97)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C532(1.01); C256(1.00); C1167(0.94); C222(1.06)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C532(0.94); C256(0.96); C1167(1.00); C285(1.05)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C532(1.01); C256(1.00); C1167(1.22); C285(1.11)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C532(1.01); C256(1.00); C285(1.01); C85(1.01)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C532(0.99); C256(0.99); C285(0.82); C222(1.02)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C532(1.05); C256(1.05); C1167(1.02); C222(1.28)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C532(0.99); C256(0.99); C1167(1.24); C285(0.89)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C532(0.98); C256(0.88); C285(1.39); C85(0.94)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C532(1.07); C256(1.10); C285(0.86); C222(1.10)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C532(1.03); C256(0.98); C1167(0.96); C222(1.02)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C532(0.96); C256(1.03); C1167(1.03); C285(1.09)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C532(0.99); C256(0.96); C285(1.06); C85(0.90)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C532(1.01); C256(1.08); C285(1.18); C222(1.05)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C532(1.02); C256(0.95); C1167(1.04); C285(1.14)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C532(1.01); C256(0.98); C1167(1.06); C222(1.14)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C532(1.03); C256(1.01); C1167(1.03); C285(0.93)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C532(0.98); C256(0.93); C285(1.24); C85(1.01)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C532(0.96); C256(1.05); C285(1.27); C222(0.92)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C532(1.06); C256(1.03); C1167(1.03); C222(0.94)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C532(0.99); C256(0.96); C1167(1.00); C285(0.98)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C532(0.95); C256(0.94); C285(1.16); C85(1.08)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C532(1.00); C256(1.00); C285(1.22); C222(1.19)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C532(0.98); C256(0.97); C1167(1.02); C222(1.66)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C532(1.25); C256(0.99); C1167(1.12); C285(0.96)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C532(1.09); C256(0.90); C285(1.04); C85(0.94)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C532(1.03); C256(1.10); C285(0.90); C222(0.90)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C532(1.15); C256(1.02); C1167(0.97); C222(1.26)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C532(1.25); C256(1.04); C1167(0.82); C285(1.19)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C532(1.30); C256(0.95); C1167(1.06); C285(1.09)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C532(1.29); C256(0.95); C1167(1.04); C285(1.27)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C532(1.04); C256(0.93); C285(1.25); C85(0.96)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C532(1.26); C256(0.98); C1167(1.17); C285(1.04)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C532(1.16); C256(1.08); C1167(0.93); C285(1.16)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C532(1.14); C256(0.90); C1167(0.97); C285(0.82)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C532(1.26); C256(1.01); C1167(1.24); C285(1.02)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C532(1.20); C256(0.99); C1167(1.08); C285(1.14)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C532(0.95); C256(0.98); C1167(0.91); C285(0.67)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C532(1.02); C256(0.97); C285(1.29); C85(1.15)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C532(1.13); C256(1.02); C285(1.02); C222(0.98)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C532(1.04); C256(1.03); C1167(0.98); C222(1.18)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C532(1.06); C256(1.04); C1167(0.92); C285(0.82)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C532(1.13); C256(1.05); C285(1.14); C222(0.86)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C532(1.03); C256(1.08); C1167(1.06); C285(1.05)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C532(1.10); C256(1.02); C1167(1.04); C285(0.98)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C532(1.03); C256(1.00); C1167(1.10); C285(1.16)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C532(0.88); C256(1.12); C1167(0.93); C285(0.81)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C532(1.15); C256(0.99); C1167(1.02); C285(0.74)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C532(1.03); C256(1.05); C1167(1.26); C285(0.77)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C532(1.06); C256(1.00); C1167(1.08); C285(1.22)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C532(0.93); C256(0.96); C1167(1.05); C285(1.05)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C532(0.92); C256(0.93); C285(0.86); C222(0.95)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C532(0.99); C256(1.11); C1167(1.02); C222(1.25)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C532(1.00); C256(0.98); C1167(1.08); C222(0.91)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C532(1.12); C256(0.98); C1167(0.96); C285(0.90)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C532(0.97); C256(1.00); C1167(1.03); C285(1.13)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C532(1.05); C256(0.98); C1167(1.04); C285(1.00)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C532(0.94); C256(0.93); C1167(1.11); C285(1.15)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C532(1.16); C256(1.03); C1167(0.94); C285(1.07)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C532(1.09); C256(1.01); C1167(1.04); C285(1.07)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C532(1.08); C256(1.04); C1167(1.14); C285(1.04)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C532(1.11); C256(1.04); C1167(1.05); C285(1.14)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C532(0.93); C256(0.97); C1167(1.07); C285(1.02)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C532(1.21); C256(1.01); C1167(0.93); C285(1.03)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C532(0.97); C256(0.95); C285(1.05); C85(0.95)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C532(0.97); C256(1.02); C1167(1.05); C222(1.01)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C532(1.03); C256(0.99); C1167(1.00); C285(1.12)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C532(0.97); C256(1.15); C1167(0.98); C285(1.44)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C532(1.07); C256(0.97); C1167(1.10); C285(1.29)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C532(1.04); C256(0.92); C1167(1.06); C285(1.10)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C532(0.96); C256(1.10); C1167(0.95); C285(1.04)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C532(0.93); C256(0.95); C1167(1.08); C285(0.76)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C532(1.01); C256(0.98); C1167(1.32); C285(1.28)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C532(1.00); C256(1.01); C1167(1.02); C285(1.40)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C532(1.12); C256(1.00); C1167(1.10); C285(1.02)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C532(0.96); C256(0.97); C1167(1.23); C285(0.81)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C532(0.93); C256(0.96); C285(1.33); C85(0.94)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C532(1.01); C256(1.08); C285(1.10); C222(1.07)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C532(0.97); C256(1.03); C1167(0.99); C222(1.09)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C532(1.08); C256(0.96); C1167(0.94); C285(0.88)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C532(1.06); C256(0.92); C1167(1.06); C285(1.17)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C532(1.02); C256(0.96); C1167(1.07); C285(1.20)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C532(1.00); C256(1.03); C1167(1.13); C285(0.97)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C532(1.04); C256(0.96); C1167(0.96); C285(0.78)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C532(1.12); C256(0.95); C1167(1.07); C285(1.05)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C532(0.99); C256(0.96); C1167(1.03); C285(1.07)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C532(1.07); C256(1.02); C1167(1.28); C285(0.98)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C532(1.08); C256(1.00); C1167(1.07); C285(1.04)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C532(0.93); C256(0.99); C1167(1.08); C285(1.01)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C532(1.02); C256(0.92); C285(1.16); C85(1.02)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C532(0.97); C256(0.96); C1167(1.02); C222(1.24)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C532(1.15); C256(0.93); C1167(0.89); C285(1.01)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C532(1.11); C256(0.94); C1167(1.07); C285(1.14)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C532(0.99); C256(0.93); C1167(1.01); C285(1.14)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C532(0.81); C256(0.97); C1167(1.08); C285(1.31)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C532(1.06); C256(1.02); C1167(1.14); C285(1.17)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C532(1.11); C256(1.01); C1167(1.04); C285(0.81)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C532(1.01); C256(1.01); C1167(1.01); C285(0.74)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C532(1.09); C256(0.98); C1167(1.18); C285(1.10)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C532(1.02); C256(0.98); C1167(1.03); C285(1.32)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C532(0.95); C256(0.92); C1167(1.06); C285(1.35)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C532(1.02); C256(0.95); C285(1.14); C85(1.01)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C532(1.21); C256(1.04); C285(1.01); C222(1.19)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C532(1.03); C256(1.00); C1167(1.08); C222(0.99)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C532(1.25); C256(0.95); C1167(1.04); C285(1.00)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C532(1.10); C256(1.11); C1167(1.05); C285(1.16)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C532(0.94); C256(1.18); C1167(0.95); C285(0.99)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C532(1.14); C256(1.00); C1167(1.06); C285(1.26)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C532(1.08); C256(0.92); C1167(0.98); C285(1.24)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C532(1.10); C256(1.06); C1167(0.98); C285(1.02)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C532(1.12); C256(0.98); C1167(1.07); C285(0.90)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C532(1.04); C256(0.89); C1167(1.19); C285(1.01)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C532(1.09); C256(0.89); C1167(1.01); C285(1.23)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C532(0.99); C256(1.01); C1167(0.93); C285(0.81)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C532(1.03); C256(0.88); C285(1.07); C85(0.99)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C532(1.10); C256(1.03); C285(0.89); C222(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C532(1.06); C256(1.08); C285(1.00); C222(0.92)  LDD1698  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.01  LDD0183  [2]
 LDCM0468  Fragment33 HEK-293T C532(1.02); C256(1.05); C285(1.10); C222(1.00)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C532(1.03); C256(1.00); C285(1.04); C85(0.95)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C1167(0.89); C532(1.05); C256(0.94); C1133(0.96)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C1023(13.88); C1167(33.20)  LDD0209  [3]
 LDCM0024  KB05 NCI-H1155 C1194(3.91)  LDD3342  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DHX15 (DHX15) DEAD box helicase family O43143
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840