Details of the Target

General Information of Target

Target ID LDTP12787
Target Name Ankyrin repeat domain-containing protein 10 (ANKRD10)
Gene Name ANKRD10
Gene ID 55608
Synonyms
Ankyrin repeat domain-containing protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETR
NRDLLSENNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQA
NDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQEL
AVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDST
GGTPLTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRTGGPASGRSSKNRDG
GERRPSSTSVPLGDKGLDTSCRWLSKSTTRSSSSC
Target Bioclass
Other
Uniprot ID
Q9NXR5
Ensemble ID
ENST00000267339.6
HGNC ID
HGNC:20265

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.K70Ter DBIA    Probe Info 
DU145 SNV: p.M252I DBIA    Probe Info 
HCT15 SNV: p.T337P .
MOLT4 SNV: p.L22P; p.N204I IA-alkyne    Probe Info 
SG231 SNV: p.G33R DBIA    Probe Info 
TE4 SNV: p.A4T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C73(6.53)  LDD0209  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
IPM
 Probe Info  		N.A.  LDD0147  [5]
NAIA_5
 Probe Info  		C107(0.00); C140(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C73(1.04)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C215(0.92)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C73(0.98)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C73(1.06); C215(1.05)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C73(1.02); C215(0.85)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C73(1.00)  LDD1513  [9]
 LDCM0276  AC17 HCT 116 C73(0.98)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C73(0.84)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C73(0.91)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C73(1.32)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C73(1.10)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C73(1.08)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C73(0.93)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C73(0.90)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C73(1.11)  LDD0601  [8]
 LDCM0286  AC26 HEK-293T C215(1.03)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C73(1.31)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C73(1.21); C215(1.10)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C73(0.96); C215(1.00)  LDD1528  [9]
 LDCM0290  AC3 HCT 116 C73(1.07)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C73(1.09); C215(1.29)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C73(1.01)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C73(1.19); C215(0.92)  LDD1532  [9]
 LDCM0295  AC34 HEK-293T C215(0.92)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C73(1.23)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C73(1.57); C215(1.14)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C73(1.01); C215(1.05)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C73(1.08); C215(1.08)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C73(1.12)  LDD1539  [9]
 LDCM0301  AC4 HCT 116 C73(1.34)  LDD0618  [8]
 LDCM0302  AC40 HEK-293T C73(1.15); C215(1.46)  LDD1541  [9]
 LDCM0304  AC42 HEK-293T C215(0.88)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C73(1.28)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C73(1.41); C215(1.21)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C73(1.00); C215(1.08)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C73(1.14); C215(0.93)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C73(0.95)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C73(0.86); C215(1.39)  LDD1549  [9]
 LDCM0312  AC5 HCT 116 C73(1.07)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C215(0.96)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C73(1.02)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C73(1.34); C215(1.11)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C73(1.08); C215(1.06)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C73(1.31); C215(1.08)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C73(1.20)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C73(1.19); C215(1.16)  LDD1558  [9]
 LDCM0321  AC58 HEK-293T C215(0.99)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C73(1.22)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C73(1.14); C215(0.97)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C73(1.23); C215(1.09)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C73(1.09); C215(1.20)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C73(1.26); C215(1.26)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C73(1.00)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C73(1.04); C215(1.11)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C73(0.89)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C73(0.74); C215(0.85)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C73(1.06); C215(1.00)  LDD1511  [9]
 LDCM0275  AKOS034007705 HEK-293T C73(1.03); C215(1.17)  LDD1514  [9]
 LDCM0020  ARS-1620 HCC44 C302(1.12); C327(1.12)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HCT 116 C73(0.84)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C73(0.81)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C73(1.10)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C73(1.15); C215(1.03)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C73(0.85)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C73(0.98); C215(0.99)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C215(1.02)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C73(0.96)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C73(0.95)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C73(0.83)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C73(0.89)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C73(0.89)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C73(0.72)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C73(0.92)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C73(0.85)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C215(1.36)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C73(1.19); C215(1.07)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C73(0.95)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C73(1.26); C215(1.19)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C215(1.07)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C73(1.14); C215(1.07)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C73(1.32)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C73(0.87); C215(1.02)  LDD1593  [9]
 LDCM0390  CL12 HCT 116 C73(1.27)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C215(0.99)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C73(1.09); C215(1.12)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C73(1.10)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C73(1.14); C215(0.94)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C215(1.15)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C73(1.19); C215(1.01)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C73(0.98)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C73(1.52); C215(1.05)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C215(1.04)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C73(0.92)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C73(0.88)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C73(0.85)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C215(1.55)  LDD1607  [9]
 LDCM0405  CL18 HEK-293T C215(0.87)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C73(1.08)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C73(0.82)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C73(1.74); C215(1.32)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C73(1.11); C215(1.41)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C73(1.17); C215(1.07)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C73(1.16)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C73(0.94); C215(1.31)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C73(1.12); C215(1.04)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C73(0.92)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C73(1.01); C215(1.14)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C215(0.99)  LDD1620  [9]
 LDCM0418  CL3 HCT 116 C73(0.84)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C215(0.88)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C73(1.06)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C73(1.31); C215(1.47)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C73(1.17); C215(1.01)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C73(1.35); C215(1.54)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C73(1.25)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C73(1.17); C215(1.35)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C73(1.17); C215(1.04)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C73(0.90); C215(1.14)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C73(0.86)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C215(1.20)  LDD1634  [9]
 LDCM0432  CL42 HEK-293T C215(0.80)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C73(1.40)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C73(1.50); C215(1.25)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C73(1.08); C215(1.36)  LDD1639  [9]
 LDCM0436  CL46 HCT 116 C73(0.78)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C73(0.80)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C73(0.74)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C73(0.79)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C73(0.82)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C73(0.86)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C73(0.74)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C73(0.90)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C73(0.96)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C73(0.69)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C73(0.69)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C73(0.96)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C73(0.93)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C73(0.83)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C73(0.90)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C73(0.93)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C73(0.77)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C73(1.26); C215(1.07)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C73(1.00)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C73(1.03); C215(1.10)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C215(1.08)  LDD1659  [9]
 LDCM0458  CL66 HEK-293T C215(1.11)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C73(1.13)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C73(1.21); C215(1.21)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C73(1.20); C215(1.34)  LDD1664  [9]
 LDCM0462  CL7 HCT 116 C73(1.09)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C73(1.19); C215(1.21)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C73(1.13)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C73(1.21); C215(1.39)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C73(1.07); C215(1.01)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C73(1.26)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C215(1.18)  LDD1672  [9]
 LDCM0471  CL78 HEK-293T C215(1.18)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C73(0.77)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C73(1.38)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C73(1.19); C215(1.35)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C73(1.07); C215(1.44)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C73(1.12); C215(1.20)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C73(1.04)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C73(0.88); C215(1.26)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C73(1.19); C215(1.00)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C73(1.25)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C73(0.95); C215(1.03)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C215(1.03)  LDD1685  [9]
 LDCM0484  CL9 HCT 116 C73(0.93)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C215(1.05)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C73(1.08)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C73(0.94)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C73(0.91)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C73(0.83)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C73(0.96)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C73(0.98)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C73(1.16)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C73(1.23)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C73(1.16)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C73(1.01); C215(1.08)  LDD1698  [9]
 LDCM0625  F8 Ramos C73(0.92); C140(0.41)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C73(3.39); C215(1.52)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C73(2.09); C215(2.83); C140(0.34)  LDD2190  [10]
 LDCM0575  Fragment13 Ramos C73(1.00)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C73(6.70); C215(0.75); C140(1.42)  LDD2193  [10]
 LDCM0580  Fragment21 Ramos C73(1.20); C215(1.05)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C73(1.27); C215(1.85)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C73(0.96); C215(0.78)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C73(0.83); C215(0.63)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C73(0.96); C215(0.75)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C73(1.63); C215(1.09)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C73(2.22)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C73(0.92); C215(1.05)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C73(0.84); C215(1.12)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C73(2.61)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C73(1.11)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C73(1.21); C215(0.77)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C73(0.90); C215(0.50)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C73(4.07); C215(0.73); C140(0.43)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C215(1.18)  LDD2188  [10]
 LDCM0022  KB02 Ramos C140(0.24)  LDD2182  [10]
 LDCM0023  KB03 Jurkat C73(6.53)  LDD0209  [1]
 LDCM0024  KB05 G361 C73(2.28)  LDD3311  [11]
 LDCM0021  THZ1 HCT 116 C302(1.12); C327(1.12)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM222B (FAM222B) FAM222 family Q8WU58
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Peflin (PEF1) . Q9UBV8
SHC-transforming protein 3 (SHC3) . Q92529

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840