Details of the Target

General Information of Target

Target ID LDTP12760
Target Name Ras-related protein Rab-20 (RAB20)
Gene Name RAB20
Gene ID 55647
Synonyms
Ras-related protein Rab-20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIG
DRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALT
N
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Golgi apparatus
Function
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
Uniprot ID
Q9NX57
Ensemble ID
ENST00000267328.5
HGNC ID
HGNC:18260

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C106(0.97)  LDD0532  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C106(0.97)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C106(0.79)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C106(0.71)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C106(0.75)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C106(0.78)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C106(0.76)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C106(0.68)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C106(0.71)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C106(0.43)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C106(0.63)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C106(0.51)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C106(0.95)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C106(0.56)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C106(0.55)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C106(0.43)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C106(0.84)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C106(0.89)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C106(0.99)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C106(1.22)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C106(0.86)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C106(1.01)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C106(1.12)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C106(0.97)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C106(0.98)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C106(0.87)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C106(1.32)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C106(0.89)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C106(1.16)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C106(1.32)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C106(1.09)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C106(1.09)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C106(0.99)  LDD0576  [1]
 LDCM0270  AC15 HCT 116 C106(0.96)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C106(1.08)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C106(0.95)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C106(0.93)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C106(0.93)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C106(0.91)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C106(0.99)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C106(0.96)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C106(1.08)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C106(0.99)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C106(1.01)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C106(1.01)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C106(0.99)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C106(0.99)  LDD0606  [1]
 LDCM0291  AC30 HCT 116 C106(1.02)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C106(1.02)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C106(0.97)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C106(0.95)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C106(0.95)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C106(1.10)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C106(1.03)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C106(1.06)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C106(1.02)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C106(1.02)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C106(0.96)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C106(1.05)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C106(0.98)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C106(1.05)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C106(0.97)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C106(0.95)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C106(1.01)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C106(0.91)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C106(1.29)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C106(0.94)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C106(0.99)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C106(1.12)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C106(1.00)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C106(0.92)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C106(0.91)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C106(0.95)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C106(1.04)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C106(1.01)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C106(1.09)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C106(0.94)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C106(0.97)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C106(1.08)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C106(1.40)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C106(0.96)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C106(1.03)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C106(1.05)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C106(1.46)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C106(1.55)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C106(1.09)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C106(1.03)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C106(1.06)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C106(0.90)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C106(0.75)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C106(1.01)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C106(1.06)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C106(0.97)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C106(0.98)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C106(0.91)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C106(0.99)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C106(0.94)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C106(1.06)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C106(0.98)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C106(0.90)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C106(0.91)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C106(0.80)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C106(0.76)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C106(0.98)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C106(0.97)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C106(1.08)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C106(1.07)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C106(1.10)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C106(1.07)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C106(1.04)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C106(1.20)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C106(0.99)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C106(0.95)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C106(1.02)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C106(0.94)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C106(1.16)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C106(0.93)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C106(1.08)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C106(0.61)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C106(0.82)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C106(1.13)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C106(0.93)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C106(0.96)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C106(1.10)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C106(1.93)  LDD1572  [3]
 LDCM0370  CL101 HCT 116 C106(0.99)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C106(1.04)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C106(0.98)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C106(0.99)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C106(0.85)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C106(1.00)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C106(0.91)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C106(0.98)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C106(0.86)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C106(0.83)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C106(0.94)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C106(0.98)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C106(0.95)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C106(1.01)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C106(0.94)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C106(1.00)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C106(0.97)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C106(1.04)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C106(1.00)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C106(1.28)  LDD1594  [3]
 LDCM0391  CL120 HCT 116 C106(0.98)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C106(0.70)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C106(1.06)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C106(0.97)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C106(0.99)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C106(1.11)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C106(0.88)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C106(1.09)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C106(0.94)  LDD0716  [1]
 LDCM0400  CL13 HEK-293T C106(1.21)  LDD1604  [3]
 LDCM0403  CL16 HCT 116 C106(1.01)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C106(1.05)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C106(0.94)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C106(1.03)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C106(1.15)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C106(1.17)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C106(1.24)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C106(1.02)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C106(1.04)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C106(1.03)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C106(1.17)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C106(1.07)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C106(1.28)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C106(1.32)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C106(1.36)  LDD0736  [1]
 LDCM0423  CL34 HEK-293T C106(1.13)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C106(1.31)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C106(1.09)  LDD1630  [3]
 LDCM0436  CL46 HEK-293T C106(1.17)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C106(1.28)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C106(1.01)  LDD1643  [3]
 LDCM0449  CL58 HEK-293T C106(1.24)  LDD1652  [3]
 LDCM0452  CL60 HEK-293T C106(1.40)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C106(1.09)  LDD1656  [3]
 LDCM0463  CL70 HEK-293T C106(1.60)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C106(1.20)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C106(1.05)  LDD1669  [3]
 LDCM0476  CL82 HEK-293T C106(0.82)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C106(1.06)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C106(1.02)  LDD1682  [3]
 LDCM0489  CL94 HEK-293T C106(0.90)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C106(1.09)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C106(1.02)  LDD1695  [3]
 LDCM0022  KB02 22RV1 C106(3.83)  LDD2243  [4]
 LDCM0023  KB03 22RV1 C106(6.17)  LDD2660  [4]
 LDCM0024  KB05 IGR37 C106(4.52)  LDD3314  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840