Details of the Target

General Information of Target

Target ID LDTP12705
Target Name E3 ubiquitin-protein ligase FANCL (FANCL)
Gene Name FANCL
Gene ID 55120
Synonyms
PHF9; E3 ubiquitin-protein ligase FANCL; EC 2.3.2.27; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43; RING-type E3 ubiquitin transferase FANCL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYE
QETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLT
MAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALK
KLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDY
DKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGK
EEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLY
VPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIA
FVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYE
QVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRV
FKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEH
ALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Uniprot ID
Q9NW38
Ensemble ID
ENST00000233741.9
HGNC ID
HGNC:20748

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.I136V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C55(0.51)  LDD2189  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
DBIA
 Probe Info  		C12(1.11)  LDD1507  [3]
CY-1
 Probe Info  		N.A.  LDD0246  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C12(1.11)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C132(0.96)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C132(1.10)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C12(1.03); C132(1.01); C55(1.00)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C12(1.02); C55(0.97)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C12(1.03); C132(1.12); C55(0.98)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C12(0.99)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C132(1.19)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C132(0.98)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C132(1.33)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C12(0.98); C132(0.99); C55(0.97)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C12(0.97); C55(0.84)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C12(1.01); C55(0.92)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C12(1.06); C132(1.05); C55(0.99)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C12(1.02); C55(0.99)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C12(1.17)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C132(1.30)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C132(0.86)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C12(1.04); C132(0.97); C55(1.02)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C12(1.01); C55(0.95)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C132(1.19)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C12(1.05); C55(1.09)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C12(1.07); C132(1.00); C55(0.81)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C12(0.97); C55(0.91)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C12(1.32)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C132(1.03)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C132(0.85)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C12(1.09); C132(1.13); C55(1.09)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C12(0.99); C55(1.06)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C12(0.97); C55(0.97)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C12(0.97); C132(1.13); C55(0.91)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C12(1.00); C132(1.02); C55(0.91)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C12(1.08); C55(0.94)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C12(1.21)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C132(1.08)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C132(1.01)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C12(0.86); C132(1.13); C55(1.24)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C12(1.10); C55(1.05)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C12(1.16); C55(1.09)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C12(1.17); C132(1.13); C55(0.95)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C12(1.12); C55(0.91)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C12(1.19)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C12(0.93); C55(1.04)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C132(1.19)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C132(0.97)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C12(0.96); C132(0.99); C55(1.10)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C12(1.08); C55(0.93)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C12(1.09); C55(1.06)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C12(1.02); C132(1.02); C55(0.97)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C12(1.20); C55(0.96)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C12(1.31)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C132(1.23)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C132(1.15)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C12(1.00); C55(1.06)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C12(1.07); C132(1.04); C55(1.06)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C12(1.07); C55(0.82)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C12(0.94); C55(1.04)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C12(1.03); C132(1.06); C55(0.96)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C12(1.07); C55(0.88)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C12(0.87); C132(1.18); C55(0.75)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C12(1.04); C55(0.81)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C12(1.01); C55(0.97)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C12(1.26)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C12(1.10); C55(1.10)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C12(1.20); C132(1.15); C55(1.15)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C12(1.13); C55(1.31)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C132(1.04)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C12(1.05); C132(1.09); C55(0.91)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C12(1.15); C132(0.85); C251(1.18)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C12(0.95); C55(1.21)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C132(1.13)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C12(1.01); C132(0.85); C55(1.14)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C12(1.07); C132(0.87); C251(1.06)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C12(1.04); C55(0.93)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C132(1.02)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C12(1.21); C132(1.16); C55(0.89)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C12(1.09); C132(1.19); C55(1.24)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C12(1.07); C132(1.01); C251(1.34)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C12(1.09); C55(1.02)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C132(0.95)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C12(1.00); C132(1.21); C55(0.87)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C12(1.04); C132(0.86); C251(1.11)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C12(1.00); C55(1.09)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C132(0.99)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C12(0.99); C132(1.38); C55(0.87)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C12(0.99); C132(0.90); C251(1.13)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C12(1.02); C55(1.03)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C12(1.01); C55(1.16)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C132(1.08)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C12(1.02); C132(1.24); C55(0.90)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C12(1.08); C132(0.88); C251(1.07)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C12(1.17); C55(1.06)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C132(0.94)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C12(0.95); C132(1.18); C55(0.93)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C12(0.96); C132(0.95); C251(1.06)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C12(1.02); C55(1.00)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C132(1.15)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C12(1.05); C132(1.03); C55(0.96)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C12(1.10); C132(0.88); C251(1.20)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C12(1.45); C55(1.14)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C132(1.09)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C12(1.14)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C132(1.17)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C132(1.05)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C12(1.08); C132(0.89); C251(1.05)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C12(1.09); C132(1.05); C55(0.99)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C12(1.48); C55(1.13)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C12(1.12); C55(1.28)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C12(0.97); C132(1.28); C55(1.14)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C12(1.17); C55(1.27)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C12(1.17); C132(1.01); C55(1.28)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C12(0.99); C132(0.95); C251(1.16)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C12(1.08); C55(1.14)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C132(0.94)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C12(1.23)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C12(1.04); C55(0.90)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C132(1.07)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C132(1.20)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C12(1.01); C132(1.08); C55(0.81)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C12(1.44); C55(1.04)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C12(1.23); C55(1.06)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C12(0.97); C132(1.15); C55(0.91)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C12(1.16); C55(1.14)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C12(1.10); C132(1.31); C55(0.91)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C12(0.94); C55(1.14)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C132(1.06)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C132(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C12(1.33)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C132(1.11)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C132(0.93)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C12(0.97); C132(1.06); C55(1.03)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C12(1.24); C55(1.33)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C12(1.06); C55(1.14)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C12(1.06); C132(1.22); C55(0.92)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C12(1.17); C55(1.26)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C12(1.04); C132(1.12); C55(1.03)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C12(1.29)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C12(1.08); C132(0.92); C251(1.17)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C132(1.01)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C12(1.18)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C132(1.40)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C132(1.01)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C12(0.98); C132(1.07); C55(0.97)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C12(1.38); C55(1.22)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C12(0.99); C55(1.17)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C12(1.01); C132(1.24); C55(1.09)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C132(1.08)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C12(1.15); C55(1.04)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C12(1.05); C132(1.05); C55(0.76)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C12(1.18); C132(0.91); C251(1.36)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C12(1.07); C55(1.01)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C132(1.11)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C12(1.10)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C132(1.46)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C132(0.94)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C12(1.14); C132(1.07); C55(1.15)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C12(1.16); C55(0.97)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C132(1.12)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C12(1.01); C55(1.31)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C12(1.08); C132(1.08); C55(0.98)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C12(1.19); C55(1.24)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C12(1.02); C132(1.34); C55(0.91)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C12(0.97); C132(0.94); C251(1.04)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C132(1.02)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C12(1.28)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C132(1.32)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C132(0.92)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C12(1.76); C132(1.16); C55(1.53)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C12(0.94); C132(1.07); C55(0.95)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C12(1.04); C55(0.93)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C12(0.93); C55(1.07)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C12(1.11); C132(1.12); C55(1.04)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C12(1.24); C55(1.28)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C12(1.15); C132(1.33); C55(0.94)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C12(1.15); C132(1.04); C251(1.03)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C12(1.04); C55(1.19)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C132(0.97)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C12(1.18)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C12(1.06); C55(1.14)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C132(1.18)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C132(0.97)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C12(1.14); C132(1.04); C55(1.04)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C12(1.16); C55(1.05)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C12(1.09); C55(1.29)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C12(1.44); C132(1.43); C55(1.07)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C12(1.17); C55(1.00)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C12(1.18); C132(1.36); C55(1.03)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C12(1.03); C132(0.85); C251(1.17)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C12(0.91); C55(1.36)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C12(1.08); C55(0.79)  LDD1698  [3]
 LDCM0572  Fragment10 Ramos C55(0.51)  LDD2189  [1]
 LDCM0574  Fragment12 Ramos C55(0.61)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C55(3.52)  LDD2192  [1]
 LDCM0579  Fragment20 Ramos C55(0.25)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C55(0.95)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C55(0.66)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C55(9.99)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C55(1.13)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C55(1.05)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C55(0.67)  LDD2200  [1]
 LDCM0468  Fragment33 HEK-293T C12(1.02); C55(0.93)  LDD1671  [3]
 LDCM0596  Fragment38 Ramos C55(0.87)  LDD2203  [1]
 LDCM0427  Fragment51 HEK-293T C12(1.01); C132(0.93); C251(1.17)  LDD1631  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
Putative hydrolase DDAH2 (DDAH2) DDAH family O95865
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) HAD-like hydrolase superfamily Q9BSH5
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Proteasome subunit beta type-3 (PSMB3) Peptidase T1B family P49720
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Ubiquitin-conjugating enzyme E2 T (UBE2T) Ubiquitin-conjugating enzyme family Q9NPD8
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D4 (HOXD4) Antp homeobox family P09016
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 224 (ZNF224) Krueppel C2H2-type zinc-finger protein family Q9NZL3
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Rho guanine nucleotide exchange factor 9 (ARHGEF9) . O43307
RING finger protein 11 (RNF11) . Q9Y3C5
RNA-binding protein 45 (RBM45) . Q8IUH3
Zinc finger matrin-type protein 5 (ZMAT5) . Q9UDW3

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.