Details of the Target

General Information of Target

Target ID LDTP12650
Target Name Protection of telomeres protein 1 (POT1)
Gene Name POT1
Gene ID 25913
Synonyms
Protection of telomeres protein 1; hPot1; POT1-like telomere end-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
Target Bioclass
Other
Family
Telombin family
Subcellular location
Nucleus
Function
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
Uniprot ID
Q9NUX5
Ensemble ID
ENST00000357628.8
HGNC ID
HGNC:17284
ChEMBL ID
CHEMBL5908

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.D482G .
HELA SNV: p.L454F .
KYSE30 SNV: p.K564Ter DBIA    Probe Info 
MCC13 SNV: p.Q87Ter .
MFE319 SNV: p.Q94R .
MOLT4 SNV: p.Q287K IA-alkyne    Probe Info 
MV411 SNV: p.K39E .
NCIH1793 SNV: p.G186V .
NCIH358 SNV: p.K521R .
OVK18 SNV: p.Q341L .
SKMEL30 SNV: p.H264Y .
SKMEL5 SNV: p.F566C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y419(8.32)  LDD3495  [1]
DBIA
 Probe Info  		C349(2.06)  LDD3342  [2]
IA-alkyne
 Probe Info  		C385(0.00); C349(0.00)  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C605(0.55)  LDD1093  [9]
 LDCM0237  AC12 HEK-293T C59(0.88); C329(1.03)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C59(0.82)  LDD1512  [10]
 LDCM0263  AC143 PaTu 8988t C154(0.55); C166(0.55)  LDD1142  [9]
 LDCM0264  AC144 PaTu 8988t C154(0.77); C166(0.77)  LDD1143  [9]
 LDCM0265  AC145 PaTu 8988t C154(0.71); C166(0.71)  LDD1144  [9]
 LDCM0266  AC146 PaTu 8988t C154(0.45); C166(0.45)  LDD1145  [9]
 LDCM0267  AC147 PaTu 8988t C154(0.81); C166(0.81)  LDD1146  [9]
 LDCM0268  AC148 PaTu 8988t C154(0.77); C166(0.77)  LDD1147  [9]
 LDCM0269  AC149 PaTu 8988t C154(0.47); C166(0.47)  LDD1148  [9]
 LDCM0270  AC15 HEK-293T C59(0.85)  LDD1513  [10]
 LDCM0271  AC150 PaTu 8988t C154(0.64); C166(0.64)  LDD1150  [9]
 LDCM0272  AC151 PaTu 8988t C154(0.46); C166(0.46)  LDD1151  [9]
 LDCM0273  AC152 PaTu 8988t C154(0.60); C166(0.60)  LDD1152  [9]
 LDCM0274  AC153 PaTu 8988t C154(0.47); C166(0.47)  LDD1153  [9]
 LDCM0621  AC154 PaTu 8988t C154(0.50); C166(0.50)  LDD2166  [9]
 LDCM0622  AC155 PaTu 8988t C154(0.43); C166(0.43)  LDD2167  [9]
 LDCM0623  AC156 PaTu 8988t C154(0.41); C166(0.41)  LDD2168  [9]
 LDCM0624  AC157 PaTu 8988t C154(0.63); C166(0.63)  LDD2169  [9]
 LDCM0279  AC2 PaTu 8988t C605(0.73)  LDD1158  [9]
 LDCM0280  AC20 HEK-293T C59(1.04); C329(1.22)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C59(1.14); C464(0.83)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C59(1.30)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C59(1.18)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C329(1.05)  LDD1523  [10]
 LDCM0285  AC25 PaTu 8988t C154(1.04); C166(1.04)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C154(0.34); C166(0.34)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C154(0.41); C166(0.41)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C154(0.32); C166(0.32)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C154(0.42); C166(0.42)  LDD1168  [9]
 LDCM0290  AC3 PaTu 8988t C605(0.83)  LDD1169  [9]
 LDCM0291  AC30 PaTu 8988t C154(0.82); C166(0.82)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C154(0.82); C166(0.82)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C154(2.20); C166(2.20)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C154(0.40); C166(0.40)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C154(0.58); C166(0.58)  LDD1174  [9]
 LDCM0297  AC36 HEK-293T C59(1.23); C329(0.96)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C59(1.23); C464(1.03)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C59(1.15)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C59(0.88)  LDD1539  [10]
 LDCM0301  AC4 PaTu 8988t C605(0.84)  LDD1180  [9]
 LDCM0302  AC40 HEK-293T C329(1.09)  LDD1541  [10]
 LDCM0306  AC44 HEK-293T C59(1.13); C329(1.19)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C59(0.88); C464(0.92)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C464(1.18)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C464(1.27)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C464(1.16)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C464(1.07)  LDD0909  [9]
 LDCM0312  AC5 PaTu 8988t C605(0.65)  LDD1191  [9]
 LDCM0313  AC50 HEK-293T C464(1.22)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C464(1.44)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C464(1.37)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C464(1.09)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C464(1.53)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C464(1.28)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C464(1.23)  LDD0917  [9]
 LDCM0323  AC6 HEK-293T C59(1.17)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C59(1.02); C329(0.96)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C59(1.20); C464(0.96)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C59(1.21)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C59(0.84)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C329(1.01)  LDD1567  [10]
 LDCM0332  AC68 HEK-293T C464(1.14)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C464(1.00)  LDD0931  [9]
 LDCM0334  AC7 HEK-293T C59(0.92)  LDD1568  [10]
 LDCM0335  AC70 HEK-293T C464(1.21)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C464(1.07)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C464(1.12)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C464(1.18)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C464(1.36)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C464(1.12)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C464(1.20)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C464(1.18)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C464(1.26)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C464(1.07)  LDD0942  [9]
 LDCM0345  AC8 HEK-293T C329(1.06)  LDD1569  [10]
 LDCM0346  AC80 HEK-293T C464(1.28)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C464(1.11)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C464(1.48)  LDD0946  [9]
 LDCM0248  AKOS034007472 HEK-293T C59(0.94); C464(1.08)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C329(1.02)  LDD1514  [10]
 LDCM0632  CL-Sc Hep-G2 C329(0.77)  LDD2227  [5]
 LDCM0367  CL1 PaTu 8988t C154(1.17); C166(1.17)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C154(0.58); C166(0.58)  LDD1247  [9]
 LDCM0369  CL100 PaTu 8988t C605(0.77)  LDD1248  [9]
 LDCM0371  CL102 HEK-293T C59(0.77)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C329(1.09)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C464(0.97)  LDD1577  [10]
 LDCM0375  CL106 HEK-293T C59(0.65)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C329(1.24)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C464(0.88)  LDD1581  [10]
 LDCM0379  CL11 PaTu 8988t C154(1.02); C166(1.02)  LDD1258  [9]
 LDCM0380  CL110 HEK-293T C59(0.81)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C329(1.11)  LDD1585  [10]
 LDCM0382  CL112 PaTu 8988t C154(0.82); C166(0.82)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C154(0.86); C166(0.86)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C154(0.62); C166(0.62)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C154(1.07); C166(1.07)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C154(0.39); C166(0.39)  LDD1265  [9]
 LDCM0388  CL118 HEK-293T C59(0.93)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C329(1.36)  LDD1593  [10]
 LDCM0390  CL12 PaTu 8988t C154(0.87); C166(0.87)  LDD1269  [9]
 LDCM0391  CL120 HEK-293T C464(0.76)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C464(1.29)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C464(1.29)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C464(1.06)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C464(1.16)  LDD0993  [9]
 LDCM0397  CL126 HEK-293T C59(0.90)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C329(1.01)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C464(0.92)  LDD1603  [10]
 LDCM0400  CL13 PaTu 8988t C154(0.48); C166(0.48)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C154(0.52); C166(0.52)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C154(0.88); C166(0.88)  LDD1281  [9]
 LDCM0403  CL16 HEK-293T C464(0.95)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C464(0.90)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C464(1.04)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C464(1.09)  LDD1004  [9]
 LDCM0407  CL2 PaTu 8988t C154(0.87); C166(0.87)  LDD1286  [9]
 LDCM0408  CL20 HEK-293T C464(1.10)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C464(1.11)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C464(1.33)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C464(1.03)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C464(0.89)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C464(1.06)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C464(1.12)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C464(1.07)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C464(1.05)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C464(1.04)  LDD1015  [9]
 LDCM0418  CL3 PaTu 8988t C154(0.39); C166(0.39)  LDD1297  [9]
 LDCM0419  CL30 HEK-293T C464(1.35)  LDD1017  [9]
 LDCM0420  CL31 PaTu 8988t C605(0.87)  LDD1299  [9]
 LDCM0421  CL32 PaTu 8988t C605(0.86)  LDD1300  [9]
 LDCM0422  CL33 PaTu 8988t C605(0.66)  LDD1301  [9]
 LDCM0423  CL34 PaTu 8988t C605(0.73)  LDD1302  [9]
 LDCM0424  CL35 PaTu 8988t C605(0.69)  LDD1303  [9]
 LDCM0425  CL36 PaTu 8988t C605(0.42)  LDD1304  [9]
 LDCM0426  CL37 PaTu 8988t C605(0.69)  LDD1305  [9]
 LDCM0428  CL39 PaTu 8988t C605(0.71)  LDD1307  [9]
 LDCM0429  CL4 PaTu 8988t C154(0.48); C166(0.48)  LDD1308  [9]
 LDCM0430  CL40 PaTu 8988t C605(0.82)  LDD1309  [9]
 LDCM0431  CL41 PaTu 8988t C605(0.68)  LDD1310  [9]
 LDCM0432  CL42 PaTu 8988t C605(0.72)  LDD1311  [9]
 LDCM0433  CL43 PaTu 8988t C605(0.62)  LDD1312  [9]
 LDCM0434  CL44 PaTu 8988t C605(0.64)  LDD1313  [9]
 LDCM0435  CL45 PaTu 8988t C605(0.69)  LDD1314  [9]
 LDCM0436  CL46 PaTu 8988t C154(0.76); C166(0.76)  LDD1315  [9]
 LDCM0437  CL47 PaTu 8988t C154(0.95); C166(0.95)  LDD1316  [9]
 LDCM0438  CL48 PaTu 8988t C154(0.75); C166(0.75)  LDD1317  [9]
 LDCM0439  CL49 PaTu 8988t C154(0.67); C166(0.67)  LDD1318  [9]
 LDCM0440  CL5 PaTu 8988t C154(0.63); C166(0.63)  LDD1319  [9]
 LDCM0441  CL50 PaTu 8988t C154(0.97); C166(0.97)  LDD1320  [9]
 LDCM0442  CL51 PaTu 8988t C154(0.71); C166(0.71)  LDD1321  [9]
 LDCM0443  CL52 PaTu 8988t C154(0.66); C166(0.66)  LDD1322  [9]
 LDCM0444  CL53 PaTu 8988t C154(0.68); C166(0.68)  LDD1323  [9]
 LDCM0445  CL54 PaTu 8988t C154(0.58); C166(0.58)  LDD1324  [9]
 LDCM0446  CL55 PaTu 8988t C154(0.59); C166(0.59)  LDD1325  [9]
 LDCM0447  CL56 PaTu 8988t C154(0.51); C166(0.51)  LDD1326  [9]
 LDCM0448  CL57 PaTu 8988t C154(0.56); C166(0.56)  LDD1327  [9]
 LDCM0449  CL58 PaTu 8988t C154(0.65); C166(0.65)  LDD1328  [9]
 LDCM0450  CL59 PaTu 8988t C154(0.63); C166(0.63)  LDD1329  [9]
 LDCM0451  CL6 PaTu 8988t C154(0.74); C166(0.74)  LDD1330  [9]
 LDCM0452  CL60 PaTu 8988t C154(0.69); C166(0.69)  LDD1331  [9]
 LDCM0453  CL61 HEK-293T C464(1.02)  LDD1051  [9]
 LDCM0454  CL62 HEK-293T C464(1.04)  LDD1052  [9]
 LDCM0455  CL63 HEK-293T C464(0.97)  LDD1053  [9]
 LDCM0456  CL64 HEK-293T C464(0.94)  LDD1054  [9]
 LDCM0457  CL65 HEK-293T C464(1.10)  LDD1055  [9]
 LDCM0458  CL66 HEK-293T C464(1.09)  LDD1056  [9]
 LDCM0459  CL67 HEK-293T C464(1.16)  LDD1057  [9]
 LDCM0460  CL68 HEK-293T C464(1.27)  LDD1058  [9]
 LDCM0461  CL69 HEK-293T C464(1.03)  LDD1059  [9]
 LDCM0462  CL7 PaTu 8988t C154(0.58); C166(0.58)  LDD1341  [9]
 LDCM0463  CL70 HEK-293T C464(1.08)  LDD1061  [9]
 LDCM0464  CL71 HEK-293T C464(1.15)  LDD1062  [9]
 LDCM0465  CL72 HEK-293T C464(1.01)  LDD1063  [9]
 LDCM0466  CL73 HEK-293T C464(1.16)  LDD1064  [9]
 LDCM0467  CL74 HEK-293T C464(1.65)  LDD1065  [9]
 LDCM0469  CL76 PaTu 8988t C605(0.88)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C605(0.91)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C605(0.82)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C605(0.99)  LDD1351  [9]
 LDCM0473  CL8 PaTu 8988t C154(0.48); C166(0.48)  LDD1352  [9]
 LDCM0474  CL80 PaTu 8988t C605(0.78)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C605(0.95)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C605(0.88)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C605(0.70)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C605(0.74)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C605(1.11)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C605(0.79)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C605(0.77)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C605(0.74)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C605(0.92)  LDD1362  [9]
 LDCM0484  CL9 PaTu 8988t C154(0.55); C166(0.55)  LDD1363  [9]
 LDCM0485  CL90 PaTu 8988t C605(0.94)  LDD1364  [9]
 LDCM0486  CL91 PaTu 8988t C605(0.85)  LDD1365  [9]
 LDCM0487  CL92 PaTu 8988t C605(0.76)  LDD1366  [9]
 LDCM0488  CL93 PaTu 8988t C605(0.78)  LDD1367  [9]
 LDCM0489  CL94 PaTu 8988t C605(0.64)  LDD1368  [9]
 LDCM0490  CL95 PaTu 8988t C605(0.52)  LDD1369  [9]
 LDCM0491  CL96 PaTu 8988t C605(0.70)  LDD1370  [9]
 LDCM0492  CL97 PaTu 8988t C605(0.72)  LDD1371  [9]
 LDCM0493  CL98 PaTu 8988t C605(0.57)  LDD1372  [9]
 LDCM0494  CL99 PaTu 8988t C605(0.71)  LDD1373  [9]
 LDCM0495  E2913 HEK-293T C329(1.06)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C349(1.55); C329(1.01)  LDD1702  [11]
 LDCM0468  Fragment33 HEK-293T C464(1.40)  LDD1066  [9]
 LDCM0427  Fragment51 PaTu 8988t C605(0.60)  LDD1306  [9]
 LDCM0022  KB02 A2058 C349(2.02)  LDD2253  [2]
 LDCM0023  KB03 MDA-MB-231 C349(3.87)  LDD1701  [11]
 LDCM0024  KB05 NCI-H1155 C349(2.06)  LDD3342  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-hydroxyanthranilate 3,4-dioxygenase (HAAO) 3-HAO family P46952
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) Aldehyde dehydrogenase family P30838
Biotin--protein ligase (HLCS) Biotin--protein ligase family P50747
5-phosphohydroxy-L-lysine phospho-lyase (PHYKPL) Class-III pyridoxal-phosphate-dependent aminotransferase family Q8IUZ5
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B) Cyclic nucleotide phosphodiesterase family Q01064
Mevalonate kinase (MVK) GHMP kinase family Q03426
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Peroxisomal sarcosine oxidase (PIPOX) MSOX/MTOX family Q9P0Z9
Inositol-3-phosphate synthase 1 (ISYNA1) Myo-inositol 1-phosphate synthase family Q9NPH2
Putative monooxygenase p33MONOX (KIAA1191) P33MONOX family Q96A73
Phytanoyl-CoA dioxygenase domain-containing protein 1 (PHYHD1) PhyH family Q5SRE7
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) STE Ser/Thr protein kinase family Q12851
Sulfotransferase 1B1 (SULT1B1) Sulfotransferase 1 family O43704
Sulfotransferase 4A1 (SULT4A1) Sulfotransferase 1 family Q9BR01
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (GFPT2) . O94808
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A2 (ANXA2) Annexin family P07355
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell surface A33 antigen (GPA33) . Q99795
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Consortin (CNST) CNST family Q6PJW8
Docking protein 2 (DOK2) DOK family O60496
P antigen family member 5 (PAGE5) GAGE family Q96GU1
Heat shock 70 kDa protein 1A (HSPA1A) Heat shock protein 70 family P0DMV8
MAP kinase-activating death domain protein (MADD) MADD family Q8WXG6
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) PACSIN family Q9BY11
Partner of Y14 and mago (PYM1) Pym family Q9BRP8
RNA polymerase II-associated protein 1 (RPAP1) RPAP1 family Q9BWH6
Thymosin beta-10 (TMSB10) Thymosin beta family P63313
WD repeat domain phosphoinositide-interacting protein 2 (WIPI2) WD repeat PROPPIN family Q9Y4P8
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0
Coiled-coil domain-containing protein 32 (CCDC32) . Q9BV29
Melanoma-associated antigen 4 (MAGEA4) . P43358
Proline and serine-rich protein 2 (PROSER2) . Q86WR7
Synapse-associated protein 1 (SYAP1) . Q96A49
Telomeric repeat-binding factor 2 (TERF2) . Q15554
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761