Details of the Target

General Information of Target

Target ID LDTP12555
Target Name Glutaredoxin-2, mitochondrial (GLRX2)
Gene Name GLRX2
Gene ID 51022
Synonyms
GRX2; Glutaredoxin-2, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS
QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
Target Type
Literature-reported
Target Bioclass
Other
Family
Glutaredoxin family
Subcellular location
Nucleus; Mitochondrion
Function
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
TTD ID
T74425
Uniprot ID
Q9NS18
DrugMap ID
TTESHRV
Ensemble ID
ENST00000367439.8
HGNC ID
HGNC:16065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NUGC3 Deletion: p.S158VfsTer22 .
SW837 SNV: p.G29A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K142(6.76)  LDD0277  [1]
DBIA
 Probe Info  		C77(61.81)  LDD0209  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C153(1.05); C77(1.02)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C77(1.02)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C77(0.93)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C77(0.96)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C77(0.96)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C77(1.05)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C153(1.00); C77(1.01)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C77(0.91)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C77(0.62)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C77(0.92)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C77(0.94)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C77(0.86)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C77(0.85)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C77(0.95)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C77(1.00)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C153(1.11); C77(0.94)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C77(1.10)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C77(0.94)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C77(0.95)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C77(1.01)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C77(0.92)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C77(1.08)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C77(1.01)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C77(0.89)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C153(1.04); C77(0.90)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C77(1.00)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C77(0.93)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C77(0.92)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C77(0.77)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C77(0.96)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C77(1.03)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C77(1.02)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C77(1.01)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C153(1.07); C77(0.98)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C77(0.90)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C77(1.01)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C77(1.01)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C77(0.77)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C77(0.94)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C77(0.91)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C77(0.94)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C153(1.06); C77(1.02)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C77(0.78)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C77(0.99)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C77(0.88)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C77(0.90)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C77(0.95)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C77(0.82)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C77(0.98)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C77(0.98)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C153(1.14); C77(1.05)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C77(0.87)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C77(1.00)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C77(0.92)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C77(0.93)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C77(0.91)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C77(0.96)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C77(1.01)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C77(1.17)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C77(1.05)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C77(0.90)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C77(0.98)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C153(1.06); C77(0.92)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C77(1.02)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C77(0.95)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C77(1.60)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C77(1.03)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C77(0.82)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C77(1.37)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C77(0.97)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C77(0.94)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C77(0.81)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C77(0.83)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C77(0.89)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C77(1.04)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C77(1.07)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C77(1.38)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C77(0.81)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C77(0.97)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C77(2.21)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C77(0.96)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C77(0.92)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C77(1.13)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C77(0.96)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C77(1.00)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C77(0.90)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C77(0.99)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C77(0.81)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C77(1.19)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C77(0.91)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C77(1.10)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C77(1.86)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C77(0.94)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C77(1.22)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C77(1.12)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C77(1.20)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C77(1.26)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C77(0.66)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C77(2.03)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C77(0.75)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C77(1.06)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C153(1.14); C77(0.92)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C77(0.97)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C77(0.91)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C77(1.85)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C77(0.89)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C77(0.87)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C77(1.46)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C77(1.09)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C77(1.04)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C77(1.14)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C77(1.03)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C77(1.01)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C77(1.00)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C153(1.12); C77(0.90)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C77(0.98)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C77(0.96)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C77(1.47)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C77(0.92)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C77(1.01)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C77(0.79)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C77(1.04)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C77(1.11)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C77(0.84)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C77(11.02)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C77(1.04)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C77(0.90)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C153(1.05); C77(1.22)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C77(1.11)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C77(2.07)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C77(1.02)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C77(2.54)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C77(1.28)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C77(2.54)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C77(0.99)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C77(0.81)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C153(1.06); C77(1.13)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C77(1.26)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C77(0.91)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C153(1.06); C77(1.08)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C77(2.54)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C77(1.04)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C77(1.98)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C77(0.91)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C77(1.10)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C77(0.89)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C77(0.78)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C77(1.12)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C77(1.31)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C77(1.40)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C77(1.26)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C77(0.92)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C153(0.96); C77(1.39)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C77(2.33)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C77(0.94)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C77(1.27)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C77(1.86)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C77(0.92)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C77(1.01)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C77(1.07)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C77(0.98)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C77(1.13)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C77(0.98)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C77(1.03)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C153(0.97); C77(1.03)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C77(0.97)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C77(0.89)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C77(0.64)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C77(0.91)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C77(1.07)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C77(0.89)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C77(1.05)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C77(1.08)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C77(0.92)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C77(0.95)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C77(1.19)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C77(1.04)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C153(1.05); C77(1.13)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C77(0.89)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C77(0.85)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C77(1.06)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C77(1.44)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C77(0.88)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C77(2.35)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C77(1.14)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C77(0.94)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C77(1.39)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C77(1.95)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C77(5.39)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C77(2.56)  LDD1698  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C77(0.84)  LDD1702  [8]
 LDCM0625  F8 Ramos 1.57  LDD2187  [9]
 LDCM0572  Fragment10 Ramos 1.11  LDD2189  [9]
 LDCM0573  Fragment11 Ramos 1.46  LDD2190  [9]
 LDCM0574  Fragment12 Ramos 1.46  LDD2191  [9]
 LDCM0575  Fragment13 Ramos 1.89  LDD2192  [9]
 LDCM0576  Fragment14 Ramos 1.15  LDD2193  [9]
 LDCM0579  Fragment20 Ramos 0.92  LDD2194  [9]
 LDCM0580  Fragment21 Ramos 1.04  LDD2195  [9]
 LDCM0582  Fragment23 Ramos 1.54  LDD2196  [9]
 LDCM0578  Fragment27 Ramos 1.32  LDD2197  [9]
 LDCM0586  Fragment28 Ramos 1.56  LDD2198  [9]
 LDCM0588  Fragment30 Ramos 1.56  LDD2199  [9]
 LDCM0589  Fragment31 Ramos 1.31  LDD2200  [9]
 LDCM0590  Fragment32 Ramos 0.74  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C77(2.17)  LDD1671  [7]
 LDCM0596  Fragment38 Ramos 0.91  LDD2203  [9]
 LDCM0566  Fragment4 Ramos 0.95  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C77(0.78)  LDD1631  [7]
 LDCM0610  Fragment52 Ramos 1.22  LDD2204  [9]
 LDCM0614  Fragment56 Ramos 1.32  LDD2205  [9]
 LDCM0569  Fragment7 Ramos 0.99  LDD2186  [9]
 LDCM0571  Fragment9 Ramos 3.52  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C77(1.05)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C77(61.81)  LDD0209  [2]
 LDCM0024  KB05 HEK-293T C77(1.12)  LDD1502  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C77(0.42)  LDD2206  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C77(0.93)  LDD2207  [10]
 LDCM0131  RA190 MM1.R C77(1.35)  LDD0304  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
L-xylulose reductase (DCXR) Short-chain dehydrogenases/reductases (SDR) family Q7Z4W1
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ETS-related transcription factor Elf-5 (ELF5) ETS family Q9UKW6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutathione Small molecular drug DB00143

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.