Details of the Target

General Information of Target

Target ID LDTP12474
Target Name Endophilin-B2 (SH3GLB2)
Gene Name SH3GLB2
Gene ID 56904
Synonyms
KIAA1848; Endophilin-B2; SH3 domain-containing GRB2-like protein B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEF
KFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVE
FLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFC
FLQCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHIT
LDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVK
IPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS
Target Bioclass
Other
Family
Endophilin family
Subcellular location
Cytoplasm
Uniprot ID
Q9NR46
Ensemble ID
ENST00000372554.8
HGNC ID
HGNC:10834

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Substitution: p.T114S DBIA    Probe Info 
TOV21G SNV: p.F3L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y77(20.00)  LDD0257  [2]
TH216
 Probe Info  		Y77(13.46)  LDD0259  [2]
STPyne
 Probe Info  		K117(5.51); K185(4.73); K26(10.00); K55(6.25)  LDD0277  [3]
Probe 1
 Probe Info  		Y77(94.85)  LDD3495  [4]
DBIA
 Probe Info  		C271(4.83)  LDD3310  [5]
BTD
 Probe Info  		C172(0.57)  LDD1700  [6]
IPM
 Probe Info  		C172(2.42)  LDD1701  [6]
HHS-465
 Probe Info  		Y200(4.31)  LDD2237  [7]
5E-2FA
 Probe Info  		H134(0.00); H38(0.00)  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C252(0.00); C172(0.00); C267(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C252(0.00); C172(0.00); C267(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C252(0.00); C172(0.00); C267(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
1d-yne
 Probe Info  		N.A.  LDD0357  [12]
NAIA_5
 Probe Info  		C252(0.00); C172(0.00); C267(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C267(0.95); C252(1.04); C172(1.00)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C267(1.04); C252(1.01); C172(0.96)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C267(0.93); C252(1.04); C172(0.99)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C267(1.05); C252(0.87); C172(0.98)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C267(0.92); C252(1.03); C172(0.90)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C267(1.04); C252(1.13); C172(1.01)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C267(0.91); C252(0.99); C172(0.92)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C267(1.03); C252(1.10); C172(1.03)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C267(0.85); C252(0.99); C172(0.95)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C267(1.03); C252(1.03); C172(1.02)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C267(1.15); C252(1.03); C172(1.03)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C267(0.90); C252(1.02); C172(1.02)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C267(1.02); C252(1.03); C172(0.92)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C267(1.04); C252(1.01); C172(0.96)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C267(0.96); C252(1.02); C172(1.05)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C267(0.87); C252(1.05); C172(0.88)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C267(0.94); C252(1.01); C172(1.00)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C267(0.96); C252(1.06); C172(1.03)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C267(1.18); C252(1.11); C172(1.03)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C267(0.86); C252(0.99); C172(0.98)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C267(0.97); C252(1.06); C172(1.03)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C267(0.96); C252(1.06); C172(0.96)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C267(1.08); C252(1.05); C172(1.03)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C267(1.05); C252(1.00); C172(1.00)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C267(1.11); C252(1.00); C172(1.16)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C267(1.02); C252(0.99); C172(0.98)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C267(1.04); C252(1.02); C172(1.02)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C267(1.05); C252(1.08); C172(1.01)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C267(0.98); C252(0.94); C172(0.96)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C267(1.03); C252(1.03); C172(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C267(1.08); C252(0.95); C172(1.05)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C267(1.25); C252(1.01); C172(1.07)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C267(1.19); C252(1.07); C172(0.92)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C267(1.04); C252(0.99); C172(0.90)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C267(1.03); C252(1.04); C172(0.96)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C267(0.95); C252(1.05); C172(0.99)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C267(1.18); C252(0.96); C172(0.97)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C267(1.03); C252(0.97); C172(0.90)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C267(0.85); C252(1.05); C172(0.94)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C267(1.05); C252(1.02); C172(1.08)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C267(1.04); C252(0.96); C172(0.94)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C267(0.99); C252(1.04); C172(0.92)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C267(1.04); C252(0.99); C172(1.01)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C267(1.08); C252(1.00); C172(0.99)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C267(1.02); C252(0.99); C172(1.02)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C267(1.04); C252(0.97); C172(0.98)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C267(1.07); C252(0.96); C172(0.94)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C267(1.01); C252(1.04); C172(0.91)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C267(1.07); C252(0.99); C172(1.01)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C267(1.05); C252(1.00); C172(1.00)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C267(0.90); C252(1.00); C172(0.81)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C267(1.03); C252(1.02); C172(0.96)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C267(1.00); C252(1.03); C172(1.07)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C267(0.86); C252(1.07); C172(0.97)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C267(1.14); C252(1.04); C172(0.99)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C267(1.09); C252(0.98); C172(1.04)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C267(0.93); C252(1.03); C172(0.99)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C267(1.12); C252(0.92); C172(1.05)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C267(1.06); C252(1.00); C172(1.02)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C267(1.13); C252(1.02); C172(1.11)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C267(1.13); C252(0.98); C172(1.01)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C267(0.95); C252(0.95); C172(1.00)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C267(0.97); C252(1.03); C172(0.97)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C267(1.09); C252(1.00); C172(0.96)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 12.91  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C252(1.53); C267(1.47)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C267(1.10); C252(1.00); C172(0.98)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C267(0.89); C252(1.60); C172(0.62)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C267(1.03); C252(1.06); C172(1.05)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C267(0.95); C252(1.02); C172(1.08)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C267(1.04); C252(1.08); C172(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C267(1.00); C252(1.02); C172(0.93)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C267(0.94); C252(0.98); C172(1.04)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C267(0.99); C252(1.02); C172(1.00)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C267(0.94); C252(1.03); C172(0.94)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C267(1.02); C252(0.95); C172(0.96)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C267(1.04); C252(1.05); C172(1.02)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C267(1.10); C252(1.09); C172(0.94)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C267(1.01); C252(1.11); C172(0.86)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C267(1.03); C252(1.25); C172(0.90)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C267(0.95); C252(1.04); C172(0.90)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C267(0.92); C252(1.00); C172(0.99)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C267(0.90); C252(1.04); C172(1.05)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C267(1.01); C252(1.25); C172(0.94)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C267(0.76); C252(1.00); C172(0.96)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C267(0.95); C252(1.01); C172(1.05)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C267(1.09); C252(1.02); C172(1.11)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C267(1.07); C252(0.90); C172(0.99)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C267(0.81); C252(0.97); C172(1.01)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C267(1.11); C252(1.00); C172(0.74)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C267(1.12); C252(1.01); C172(1.07)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C267(1.03); C252(1.04); C172(0.99)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C267(0.98); C252(1.08); C172(1.01)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C267(0.96); C252(1.27); C172(0.86)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C267(1.13); C252(1.12); C172(1.00)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C267(1.01); C252(0.92); C172(1.19)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C267(1.01); C252(0.97); C172(1.09)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C267(1.09); C252(0.95); C172(1.03)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C267(1.00); C252(1.03); C172(1.12)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C267(0.91); C252(1.04); C172(1.07)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C267(1.03); C252(0.91); C172(0.97)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C267(0.81); C252(1.27); C172(0.78)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C267(0.94); C252(0.94); C172(1.05)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C267(0.86); C252(1.68); C172(0.76)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C267(0.99); C252(1.01); C172(0.87)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C267(0.89); C252(1.04); C172(0.94)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C267(0.99); C252(0.91); C172(0.99)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C267(0.98); C252(1.12); C172(0.88)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C267(0.79); C252(1.22); C172(0.75)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C267(0.88); C252(0.99); C172(0.76)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C267(1.04); C252(1.19); C172(0.86)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C267(1.03); C252(0.99); C172(0.77)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C267(1.11); C252(1.48); C172(1.06)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C267(1.07); C252(1.00); C172(1.05)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C267(0.97); C252(0.93); C172(1.06)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C267(1.03); C252(1.09); C172(1.01)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C267(1.05); C252(1.01); C172(0.95)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C267(0.92); C252(0.91); C172(0.99)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C267(1.08); C252(0.97); C172(1.02)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C267(0.92); C252(1.06); C172(0.91)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C267(1.12); C252(1.06); C172(0.95)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C267(0.93); C252(1.55); C172(0.72)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C267(0.92); C252(1.07); C172(0.85)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C267(1.04); C252(1.04); C172(0.91)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C267(0.98); C252(1.11); C172(0.80)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C267(1.26); C252(1.00); C172(1.26)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C267(1.00); C252(0.92); C172(1.07)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C267(0.90); C252(0.98); C172(0.99)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C267(1.02); C252(0.96); C172(1.07)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C267(0.78); C252(1.01); C172(0.95)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C267(1.17); C252(1.05); C172(1.03)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C267(1.06); C252(1.04); C172(0.99)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C267(0.89); C252(0.93); C172(0.96)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C267(0.96); C252(1.09); C172(0.84)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C267(0.97); C252(1.11); C172(0.80)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C267(0.97); C252(1.11); C172(0.85)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C267(1.10); C252(1.13); C172(0.85)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C267(0.85); C252(1.04); C172(1.22)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C267(1.08); C252(0.92); C172(0.92)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C267(0.98); C252(0.99); C172(1.06)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C267(0.94); C252(1.04); C172(1.10)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C267(0.87); C252(1.12); C172(0.65)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C267(1.08); C252(1.33); C172(0.80)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C267(1.00); C252(1.02); C172(0.96)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C267(1.12); C252(0.97); C172(0.92)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C267(0.87); C252(1.04); C172(0.76)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C267(0.91); C252(1.07); C172(0.82)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C267(0.99); C252(0.97); C172(0.90)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C267(1.34); C252(1.31); C172(0.85)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C267(1.01); C252(1.05); C172(0.78)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C267(1.14); C252(1.06); C172(1.30)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C267(1.01); C252(0.93); C172(1.12)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C267(0.84); C252(0.90); C172(1.02)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C267(0.91); C252(1.08); C172(0.99)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C267(1.12); C252(0.97); C172(1.08)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C267(1.10); C252(1.04); C172(0.98)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C267(0.91); C252(1.04); C172(0.97)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C267(1.12); C252(0.99); C172(0.92)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C267(1.05); C252(1.03); C172(0.83)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C267(0.90); C252(1.03); C172(0.98)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C267(0.87); C252(1.03); C172(0.85)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C267(1.11); C252(1.07); C172(0.91)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C267(1.12); C252(1.02); C172(0.79)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C267(1.01); C252(1.09); C172(1.19)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C267(1.11); C252(0.96); C172(1.15)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C267(0.97); C252(1.02); C172(1.10)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C267(0.95); C252(1.09); C172(1.03)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C267(1.07); C252(0.99); C172(0.98)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C267(1.00); C252(1.03); C172(1.04)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C267(1.47); C252(1.80); C172(0.66)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C267(1.13); C252(1.01); C172(0.99)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C267(1.02); C252(1.04); C172(0.87)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C267(0.79); C252(1.14); C172(0.83)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C267(1.01); C252(1.15); C172(0.91)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C267(1.01); C252(1.22); C172(0.80)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C267(0.96); C252(1.01); C172(1.45)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C267(1.05); C252(0.95); C172(1.28)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C267(0.95); C252(0.93); C172(1.14)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C267(1.03); C252(0.97); C172(1.19)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C267(1.05); C252(0.97); C172(1.38)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C267(0.93); C252(1.06); C172(0.84)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C267(1.05); C252(1.87); C172(0.74)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C267(0.98); C252(1.00); C172(1.07)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C267(1.16); C252(1.09); C172(0.87)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C267(0.94); C252(1.11); C172(0.81)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C267(0.96); C252(1.07); C172(0.83)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C267(1.04); C252(1.29); C172(0.82)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C267(1.00); C252(1.13); C172(0.88)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C267(0.98); C252(1.18); C172(1.02)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C267(1.03); C252(1.02); C172(0.96)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C267(0.93); C252(1.02); C172(0.99)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C267(1.10); C252(0.90); C172(1.00)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C252(3.03); C172(1.09)  LDD1702  [6]
 LDCM0625  F8 Ramos C252(0.89); C172(0.65); C267(1.01)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C252(1.22); C172(0.80); C267(0.77)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C252(0.12); C172(0.71); C267(0.55)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C252(1.27); C172(0.59); C267(0.74)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C252(1.67); C267(1.06)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C252(0.75); C172(1.43); C267(0.45)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C252(1.00); C172(0.66); C267(0.50)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C252(1.04); C172(0.59); C267(1.14)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C252(1.09); C172(0.56); C267(1.42)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C252(1.17); C172(1.09); C267(1.08)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C252(1.03); C267(0.68)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C252(1.62); C172(1.17); C267(1.48)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C252(1.36); C172(0.95); C267(1.50)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C252(1.07); C172(0.77); C267(0.71)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C267(0.95); C252(0.98); C172(1.09)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C252(2.02); C172(2.53); C267(0.99)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C252(0.94); C172(1.00); C267(0.65)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C267(1.03); C252(0.95); C172(1.05)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C252(1.26); C267(1.52)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C252(1.40); C172(1.28); C267(1.63)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C252(1.64); C172(0.85); C267(0.65)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C252(0.78); C172(0.67); C267(0.72)  LDD2188  [14]
 LDCM0022  KB02 HEK-293T C172(1.00)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C172(0.97)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C271(4.83)  LDD3310  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C172(1.05)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C172(0.46)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C172(1.02)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C172(0.75)  LDD2096  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C172(0.26)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C172(1.87)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C172(1.23)  LDD2119  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C172(0.52)  LDD2126  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C172(0.45)  LDD2134  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C172(0.57)  LDD1700  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C172(1.16)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C172(1.97)  LDD2153  [6]
 LDCM0131  RA190 MM1.R C267(1.90)  LDD0304  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin (HTT) Huntingtin family P42858
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B2 (SH3GLB2) Endophilin family Q9NR46
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Keratin-associated protein 5-11 (KRTAP5-11) KRTAP type 5 family Q6L8G4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Melanoma-associated antigen 1 (MAGEA1) . P43355
Placental protein 13-like (LGALS14) . Q8TCE9
PRKCA-binding protein (PICK1) . Q9NRD5
TBC1 domain family member 7 (TBC1D7) . Q9P0N9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.