Details of the Target

General Information of Target

Target ID LDTP12435
Target Name Kinesin-like protein KIF13B (KIF13B)
Gene Name KIF13B
Gene ID 23303
Synonyms
GAKIN; KIAA0639; Kinesin-like protein KIF13B; Kinesin-like protein GAKIN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARAC
SRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGI
VTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVC
IDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVK
AKTIQQTLILANILEACEHMTSDQRKQIFSRLAES
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes.
Uniprot ID
Q9NQT8
Ensemble ID
ENST00000524189.6
HGNC ID
HGNC:14405

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL62 SNV: p.V1720L DBIA    Probe Info 
CCK81 SNV: p.L1249P DBIA    Probe Info 
DU145 SNV: p.A212T DBIA    Probe Info 
HCT116 SNV: p.G745R; p.A1564T .
HCT15 SNV: p.G115D; p.I995T .
HUPT3 SNV: p.A1605V DBIA    Probe Info 
IGROV1 Deletion: p.P1611HfsTer18 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.M151I DBIA    Probe Info 
MEWO SNV: p.R1092C DBIA    Probe Info 
MONOMAC6 SNV: p.K1749E DBIA    Probe Info 
NALM6 SNV: p.V1516M; p.H1609P DBIA    Probe Info 
NCIH1155 SNV: p.C26Y; p.A1694V DBIA    Probe Info 
NCIH2170 SNV: p.H635Q DBIA    Probe Info 
NCIH2286 SNV: p.Y305Ter DBIA    Probe Info 
RKO SNV: p.A260T DBIA    Probe Info 
RL952 SNV: p.M113V DBIA    Probe Info 
SKMEL28 SNV: p.P1551L DBIA    Probe Info 
SW1573 SNV: p.H1276Q DBIA    Probe Info 
TOV21G SNV: p.S475L DBIA    Probe Info 
TYKNU SNV: p.H926Y DBIA    Probe Info 
UACC257 Substitution: p.P1698Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1466(10.00); K1713(10.00); K248(9.53); K351(0.81)  LDD0277  [1]
Probe 1
 Probe Info  		Y702(9.00)  LDD3495  [2]
BTD
 Probe Info  		C1529(1.31)  LDD2098  [3]
NAIA_5
 Probe Info  		C1754(3.03)  LDD2227  [4]
AHL-Pu-1
 Probe Info  		C773(5.33)  LDD0170  [5]
DBIA
 Probe Info  		C127(5.52)  LDD0209  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1234(0.00); C26(0.00); C1272(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C1234(0.00); C26(0.00); C1272(0.00); C773(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C26(0.00); C1272(0.00); C1234(0.00); C127(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C773(5.33)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C1669(2.37); C773(2.89)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C127(0.78); C1234(1.09); C1272(0.98)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C82(0.83); C98(0.83)  LDD1094  [11]
 LDCM0226  AC11 PaTu 8988t C82(0.88); C98(0.88)  LDD1105  [11]
 LDCM0237  AC12 PaTu 8988t C82(1.28); C98(1.28)  LDD1116  [11]
 LDCM0259  AC14 PaTu 8988t C82(1.06); C98(1.06)  LDD1138  [11]
 LDCM0270  AC15 PaTu 8988t C82(1.02); C98(1.02)  LDD1149  [11]
 LDCM0276  AC17 HEK-293T C127(1.06); C1234(1.06); C1272(1.07)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C127(1.01); C773(1.39); C1234(0.90)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C127(0.88)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C127(1.05); C773(1.07); C1234(1.07)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C127(0.93); C773(0.93); C1234(1.04); C61(0.86)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C127(1.08); C26(0.99)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C127(1.30); C773(0.93)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C127(0.96); C773(1.02); C1234(0.91); C61(1.05)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C127(1.15); C773(1.22); C26(1.03)  LDD1523  [10]
 LDCM0285  AC25 PaTu 8988t C82(1.06); C98(1.06)  LDD1164  [11]
 LDCM0286  AC26 PaTu 8988t C82(0.81); C98(0.81)  LDD1165  [11]
 LDCM0287  AC27 PaTu 8988t C82(0.68); C98(0.68)  LDD1166  [11]
 LDCM0288  AC28 PaTu 8988t C82(0.70); C98(0.70)  LDD1167  [11]
 LDCM0289  AC29 PaTu 8988t C82(0.73); C98(0.73)  LDD1168  [11]
 LDCM0290  AC3 HEK-293T C127(0.91)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C82(0.92); C98(0.92)  LDD1170  [11]
 LDCM0292  AC31 PaTu 8988t C82(1.30); C98(1.30)  LDD1171  [11]
 LDCM0293  AC32 PaTu 8988t C82(0.95); C98(0.95)  LDD1172  [11]
 LDCM0294  AC33 PaTu 8988t C82(0.84); C98(0.84)  LDD1173  [11]
 LDCM0295  AC34 PaTu 8988t C82(1.00); C98(1.00)  LDD1174  [11]
 LDCM0296  AC35 HEK-293T C127(0.70)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C127(1.11); C773(1.06); C1234(1.01); C61(0.89)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C127(1.39); C26(1.04)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C127(1.03); C773(0.91)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C127(0.85); C773(0.94); C1234(1.20); C61(0.94)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C127(1.01); C773(0.97); C1234(0.89); C61(0.82)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C127(0.87); C773(0.88); C26(1.03)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C127(1.10); C1234(1.10); C1272(1.06)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C127(0.99); C773(1.29); C1234(1.05)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C127(0.90)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C127(0.93); C773(0.99); C1234(1.19); C61(0.98)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C127(1.00); C26(1.24)  LDD1546  [10]
 LDCM0308  AC46 PaTu 8988t C82(1.49); C98(1.49)  LDD1187  [11]
 LDCM0309  AC47 PaTu 8988t C82(1.48); C98(1.48)  LDD1188  [11]
 LDCM0310  AC48 PaTu 8988t C82(1.12); C98(1.12)  LDD1189  [11]
 LDCM0311  AC49 PaTu 8988t C82(1.15); C98(1.15)  LDD1190  [11]
 LDCM0312  AC5 HEK-293T C127(1.05); C26(1.07)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C82(0.99); C98(0.99)  LDD1192  [11]
 LDCM0314  AC51 PaTu 8988t C82(1.06); C98(1.06)  LDD1193  [11]
 LDCM0315  AC52 PaTu 8988t C82(1.18); C98(1.18)  LDD1194  [11]
 LDCM0316  AC53 PaTu 8988t C82(1.41); C98(1.41)  LDD1195  [11]
 LDCM0317  AC54 PaTu 8988t C82(1.39); C98(1.39)  LDD1196  [11]
 LDCM0318  AC55 PaTu 8988t C82(1.35); C98(1.35)  LDD1197  [11]
 LDCM0319  AC56 PaTu 8988t C82(1.94); C98(1.94)  LDD1198  [11]
 LDCM0320  AC57 PaTu 8988t C82(0.87); C98(0.87)  LDD1199  [11]
 LDCM0321  AC58 PaTu 8988t C82(1.05); C98(1.05)  LDD1200  [11]
 LDCM0322  AC59 PaTu 8988t C82(1.10); C98(1.10)  LDD1201  [11]
 LDCM0323  AC6 PaTu 8988t C82(1.20); C98(1.20)  LDD1202  [11]
 LDCM0324  AC60 PaTu 8988t C82(1.39); C98(1.39)  LDD1203  [11]
 LDCM0325  AC61 PaTu 8988t C82(1.13); C98(1.13)  LDD1204  [11]
 LDCM0326  AC62 PaTu 8988t C82(0.88); C98(0.88)  LDD1205  [11]
 LDCM0327  AC63 PaTu 8988t C82(1.06); C98(1.06)  LDD1206  [11]
 LDCM0328  AC64 PaTu 8988t C82(0.98); C98(0.98)  LDD1207  [11]
 LDCM0329  AC65 PaTu 8988t C82(1.13); C98(1.13)  LDD1208  [11]
 LDCM0330  AC66 PaTu 8988t C82(1.05); C98(1.05)  LDD1209  [11]
 LDCM0331  AC67 PaTu 8988t C82(1.02); C98(1.02)  LDD1210  [11]
 LDCM0334  AC7 PaTu 8988t C82(0.84); C98(0.84)  LDD1213  [11]
 LDCM0345  AC8 PaTu 8988t C82(0.78); C98(0.78)  LDD1224  [11]
 LDCM0248  AKOS034007472 PaTu 8988t C82(1.53); C98(1.53)  LDD1127  [11]
 LDCM0356  AKOS034007680 PaTu 8988t C82(1.17); C98(1.17)  LDD1235  [11]
 LDCM0275  AKOS034007705 PaTu 8988t C82(0.72); C98(0.72)  LDD1154  [11]
 LDCM0632  CL-Sc Hep-G2 C1754(3.03)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C127(1.10); C773(0.90)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C127(0.91); C773(0.90)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C127(0.95); C1234(1.01); C61(0.87)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C82(0.79); C98(0.79)  LDD1249  [11]
 LDCM0371  CL102 PaTu 8988t C82(1.13); C98(1.13)  LDD1250  [11]
 LDCM0372  CL103 PaTu 8988t C82(0.82); C98(0.82)  LDD1251  [11]
 LDCM0373  CL104 PaTu 8988t C82(0.79); C98(0.79)  LDD1252  [11]
 LDCM0374  CL105 HEK-293T C127(1.17); C773(0.95)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C127(1.51); C773(0.95); C1234(0.93); C61(0.88)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C127(1.17); C1234(1.03); C82(1.08)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C127(0.86); C1234(0.99); C61(0.94)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C127(0.99); C773(1.06)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C127(0.85); C773(1.09); C1234(1.22); C61(1.10)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C127(1.19); C773(0.81); C1234(1.01); C61(0.95)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C127(1.09); C1234(0.95); C82(0.97)  LDD1585  [10]
 LDCM0382  CL112 PaTu 8988t C82(0.93); C98(0.93)  LDD1261  [11]
 LDCM0383  CL113 PaTu 8988t C82(0.96); C98(0.96)  LDD1262  [11]
 LDCM0384  CL114 PaTu 8988t C82(1.00); C98(1.00)  LDD1263  [11]
 LDCM0385  CL115 PaTu 8988t C82(0.81); C98(0.81)  LDD1264  [11]
 LDCM0386  CL116 PaTu 8988t C82(1.14); C98(1.14)  LDD1265  [11]
 LDCM0387  CL117 HEK-293T C127(1.17); C773(1.08)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C127(0.98); C773(1.06); C1234(1.05); C61(0.89)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C127(0.99); C1234(1.33); C82(1.11)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C127(0.84); C773(0.83); C26(1.06)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C127(0.98); C1234(1.11); C61(0.91)  LDD1595  [10]
 LDCM0392  CL121 PaTu 8988t C82(1.19); C98(1.19)  LDD1271  [11]
 LDCM0393  CL122 PaTu 8988t C82(2.30); C98(2.30)  LDD1272  [11]
 LDCM0394  CL123 PaTu 8988t C82(0.97); C98(0.97)  LDD1273  [11]
 LDCM0395  CL124 PaTu 8988t C82(0.87); C98(0.87)  LDD1274  [11]
 LDCM0396  CL125 PaTu 8988t C82(1.10); C98(1.10)  LDD1275  [11]
 LDCM0397  CL126 PaTu 8988t C82(1.16); C98(1.16)  LDD1276  [11]
 LDCM0398  CL127 PaTu 8988t C82(1.32); C98(1.32)  LDD1277  [11]
 LDCM0399  CL128 PaTu 8988t C82(0.93); C98(0.93)  LDD1278  [11]
 LDCM0400  CL13 HEK-293T C127(0.93); C773(1.01)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C127(0.94); C773(0.95); C1234(0.95); C61(0.95)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C127(0.93); C1234(1.09); C82(0.92)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C127(0.99); C1234(0.99); C61(1.07)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C127(1.10); C1234(1.03); C1272(1.16)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C127(0.96); C773(1.53); C1234(1.04)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C127(0.64)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C127(1.09); C773(0.95); C1234(1.10); C61(0.87)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C127(1.08); C773(0.98); C1234(1.02); C61(0.95)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C127(1.05); C26(0.92)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C127(1.07); C773(1.05)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C127(0.79); C773(1.22); C1234(1.06); C61(0.95)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C127(0.87); C773(0.99); C26(1.05)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C127(0.86); C773(0.82)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C127(1.01); C773(0.95); C1234(1.04); C61(1.17)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C127(1.08); C1234(1.19); C82(0.92)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C127(1.05); C1234(0.94); C61(1.18)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C127(1.37); C1234(1.11); C1272(1.04)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C127(0.94); C1234(1.03); C82(1.04)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C127(1.12); C773(1.02); C1234(0.96)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C127(0.81)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C127(1.28); C773(0.93); C1234(0.94); C61(0.88)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C127(0.99); C26(0.89)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C127(1.21); C773(1.12)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C127(0.81); C773(1.15); C1234(1.10); C61(0.89)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C127(0.99); C773(1.28); C26(1.15)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C127(1.28); C773(1.01)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C127(1.09); C1234(1.14); C82(0.86)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C127(1.10); C1234(0.96); C61(0.89)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C127(1.00); C1234(1.04); C61(0.88)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C127(0.97); C1234(1.00); C1272(0.94)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C127(0.97); C773(1.54); C1234(1.07)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C127(0.87)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C127(1.14); C773(0.92); C1234(0.86); C61(0.84)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C127(0.94); C26(0.94)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C127(1.39); C773(1.02)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C127(0.93); C773(1.26); C1234(0.97); C61(0.95)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C127(1.12); C773(0.98); C26(1.07)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C127(1.15); C773(0.80)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C127(1.03); C1234(1.10); C1272(1.20)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C127(0.97); C773(0.94); C1234(1.09); C61(1.06)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C127(1.06); C1234(0.90); C61(1.02)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C127(0.91); C1234(1.36); C1272(1.32)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C127(1.15); C773(0.87); C1234(1.06)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C127(0.78)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C127(1.21); C773(1.06); C1234(0.99); C61(0.90)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C127(1.16); C26(1.05)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C127(1.04); C773(1.04)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C127(0.86); C773(1.14); C1234(1.17); C61(1.06)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C127(1.12); C773(1.14); C1234(1.02)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C127(0.69); C773(1.04); C26(1.03)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C127(1.15); C773(0.97)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C127(1.12); C773(0.94); C1234(0.99); C61(1.18)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C127(1.24); C1234(1.15); C82(1.14)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C127(1.14); C1234(1.00); C61(1.20)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C127(1.00); C1234(1.12); C1272(1.18)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C127(1.18); C773(1.51); C1234(1.06)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C127(0.80)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C127(0.87); C773(1.04); C1234(0.97); C61(0.81)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C127(0.95); C26(1.09)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C127(0.87)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C127(1.27); C773(0.92)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C127(0.88); C773(1.26); C1234(1.03); C61(0.99)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C127(0.80); C773(1.06); C26(1.11)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C127(1.27); C773(0.88)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C127(1.11); C773(0.89); C1234(0.94); C61(1.07)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C127(0.99); C1234(1.04); C61(1.49)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C127(1.02); C1234(1.08); C1272(0.94)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C127(1.01); C773(1.59); C1234(1.10)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C127(0.85)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C127(1.52); C773(1.00); C1234(0.99); C61(1.32)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C127(1.16); C773(1.07); C1234(0.89); C61(1.00)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C127(0.99); C26(0.95)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C127(0.84); C773(0.89)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C127(0.82); C773(1.12); C1234(1.17); C61(0.98)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C127(0.90); C773(1.30); C26(1.07)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C127(1.10); C773(1.04)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C127(1.35); C773(0.86); C1234(0.96); C61(1.00)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C127(1.41); C1234(0.84); C82(0.96)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C127(1.08); C1234(0.96); C61(1.06)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C127(0.90); C1234(1.04); C1272(1.15)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C127(0.99); C26(0.95)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C127(1.04); C773(1.45); C1234(0.97)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C127(0.87)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C127(1.19); C773(1.10); C1234(1.02); C61(1.05)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C127(0.94); C26(1.02)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C127(1.27); C773(0.87)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C127(0.97); C773(0.85); C1234(1.08); C61(0.69)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C127(1.01); C773(1.26); C26(0.95)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C127(0.94); C773(0.95)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C127(0.92); C773(0.91); C1234(1.13); C61(1.03)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C127(0.96); C1234(1.24); C82(1.03)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C127(1.00); C1234(1.11); C82(0.97)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C127(2.13); C1529(1.14)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C127(1.05); C1234(0.94); C82(0.82)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C127(1.28); C773(0.93); C1234(0.91); C61(1.28)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C26(1.09)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C127(5.52)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C127(3.40)  LDD3310  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1529(1.31)  LDD2098  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1529(1.44)  LDD2105  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1529(1.16)  LDD2120  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arf-GAP with dual PH domain-containing protein 1 (ADAP1) . O75689

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840