Details of the Target

General Information of Target

Target ID LDTP12371
Target Name mRNA-decapping enzyme 1A (DCP1A)
Gene Name DCP1A
Gene ID 55802
Synonyms
SMIF; mRNA-decapping enzyme 1A; EC 3.6.1.62; Smad4-interacting transcriptional co-activator; Transcription factor SMIF
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESL
DMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFL
TVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELF
REVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM
Target Bioclass
Enzyme
Family
DCP1 family
Subcellular location
Cytoplasm, P-body
Function
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
Uniprot ID
Q9NPI6
Ensemble ID
ENST00000294241.10
HGNC ID
HGNC:18714

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.C149W .
JURKAT SNV: p.R337Ter .
L428 SNV: p.R170K .
MEWO SNV: p.P40S .
NCIH358 SNV: p.A442G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.59  LDD0402  [1]
DA-P3
 Probe Info  		4.69  LDD0183  [2]
HHS-475
 Probe Info  		Y64(0.48)  LDD0264  [3]
HHS-465
 Probe Info  		Y64(4.54)  LDD2237  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C39(1.02); C149(1.01)  LDD1492  [6]
5E-2FA
 Probe Info  		H404(0.00); H365(0.00)  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		C115(0.00); C39(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C115(0.00); C39(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
AOyne
 Probe Info  		13.90  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C149(1.18); C39(0.95)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C149(1.13); C39(1.09)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C149(1.08); C39(1.01)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C149(1.05); C39(1.07)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C149(0.99); C39(1.00)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C149(1.05); C39(1.10)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C149(1.16); C39(0.92)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C149(1.25); C39(1.05)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C149(1.33); C39(0.98)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C149(1.08); C39(1.08)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C149(1.24); C39(1.06)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C149(1.08); C39(1.02)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C149(1.07); C39(1.02)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C149(1.02); C39(1.20)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C149(1.00); C39(0.94); C115(1.19)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C149(1.50); C39(1.05)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C149(1.18); C39(1.01)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C149(1.18); C39(1.03)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C149(1.03); C39(1.01)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C149(0.97); C39(1.07)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C149(1.08); C39(0.99)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C149(1.02); C39(1.00)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C149(0.95); C39(1.05)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C149(0.93); C39(0.99); C115(1.13)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C149(1.29); C39(0.96)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C149(1.19); C39(0.97)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C149(1.00); C39(1.06)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C149(0.95); C39(1.05)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C149(1.19); C39(1.14)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C149(1.05); C39(1.06)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C149(1.07); C39(0.91)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C149(1.00); C39(0.96)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C149(1.05); C39(0.95); C115(1.04)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C149(1.11); C39(0.93)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C149(1.26); C39(1.13)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C149(1.12); C39(1.04)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C149(1.16); C39(0.96)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C149(1.23); C39(1.12)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C149(1.01); C39(1.05)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C149(1.10); C39(0.94)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C149(0.93); C39(1.01); C115(1.24)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C149(1.30); C39(0.98)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C149(1.14); C39(1.16)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C149(1.15); C39(1.07)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C149(1.09); C39(1.02)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C149(1.04); C39(0.99)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C149(0.99); C39(1.03)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C149(0.89); C39(0.96)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C149(1.02); C39(1.03)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C149(0.91); C39(1.04); C115(1.19)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C149(1.31); C39(1.06)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C149(1.23); C39(1.11)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C149(0.89); C39(1.18)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C149(1.06); C39(1.09)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C149(1.12); C39(1.03)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C149(1.04); C39(1.14)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C149(1.02); C39(1.00)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C149(1.05); C39(1.09)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C149(1.00); C39(0.98); C115(1.15)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C149(1.13); C39(0.84)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C149(1.07); C39(0.91); C115(1.01)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C149(1.01); C39(0.98)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C149(1.33); C39(0.95)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C149(0.94); C39(0.93); C115(1.10)  LDD1514  [6]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C149(0.95); C39(1.20)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C149(0.95); C39(1.16)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C149(1.11); C39(1.05)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C149(1.03); C39(1.08)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C149(1.15); C39(1.04)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C149(1.07); C39(1.02)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C149(1.11); C39(0.93)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C149(1.07); C39(1.07)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C149(1.24); C39(1.00)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C149(0.97); C39(1.02)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C149(1.25); C39(1.01)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C149(1.02); C39(0.99)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C149(0.99); C39(1.00)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C149(1.12); C39(1.03)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C149(1.06); C39(1.17)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C149(1.21); C39(1.08)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C149(1.08); C39(1.03)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C149(1.16); C39(1.03)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C149(1.13); C39(1.13)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C149(1.19); C39(1.04)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C149(0.98); C39(1.09)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C149(1.31); C39(1.06)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C149(1.10); C39(0.99)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C149(0.83); C39(0.98); C115(1.13)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C149(1.19); C39(1.04)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C149(1.02); C39(1.05)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C149(0.95); C39(0.98)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C149(1.01); C39(0.79)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C149(1.01); C39(0.96)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C149(1.13); C39(1.18)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C149(0.91); C39(1.28)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C149(0.89); C39(1.04)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C149(0.96); C39(1.05)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C149(1.18); C39(1.16)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C149(1.26); C39(1.17)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C149(0.93); C39(1.06)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C149(1.20); C39(1.11)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C149(1.38); C39(1.00)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C149(1.29); C39(1.08)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C149(0.98); C39(1.02)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C149(1.11); C39(1.22)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C149(0.95); C39(1.00)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C149(0.89); C39(1.05)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C149(0.90); C39(1.03)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C149(1.05); C39(1.02)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C149(0.81); C39(0.90); C115(1.34)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C149(1.07); C39(1.12)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C149(1.22); C39(1.12)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C149(1.08); C39(1.04)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C149(1.08); C39(1.08)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C149(1.21); C39(0.94)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C149(1.04); C39(0.98)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C149(1.11); C39(0.93)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C149(0.92); C39(1.09)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C149(0.90); C39(1.11)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C149(0.87); C39(1.13)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C149(0.79); C39(0.93)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C149(1.00); C39(0.98)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C149(0.71); C39(0.99); C115(1.09)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C149(1.02); C39(1.13)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C149(0.99); C39(1.20)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C149(1.23); C39(1.08)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C149(1.16); C39(1.12)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C149(1.34); C39(1.11)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C149(1.16); C39(1.02)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C149(1.02); C39(1.06)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C149(1.09); C39(0.96)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C149(0.96); C39(1.64)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C149(0.86); C39(0.99)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C149(1.03); C39(0.81)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C149(0.72); C39(0.90); C115(1.00)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C149(1.01); C39(1.05)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C149(1.31); C39(1.15)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C149(1.29); C39(1.13)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C149(1.27); C39(1.16)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C149(1.12); C39(0.85)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C149(1.20); C39(1.06)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C149(0.87); C39(1.04)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C149(0.93); C39(1.09)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C149(0.76); C39(1.24)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C149(0.81); C39(0.90)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C149(1.13); C39(0.87)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C149(1.23); C39(1.06)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C149(0.72); C39(0.88); C115(1.19)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C149(1.01); C39(1.20)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C149(1.23); C39(1.06)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C149(0.98); C39(1.07)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C149(1.22); C39(1.10)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C149(1.38); C39(0.96)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C149(1.16); C39(1.15)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C149(1.00); C39(1.06)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C149(0.93); C39(1.06)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C149(0.77); C39(1.10)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C149(0.90); C39(1.16)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C149(0.89); C39(0.93)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C149(1.01); C39(0.96)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C149(0.70); C39(0.91); C115(1.26)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C149(1.02); C39(1.15)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C149(0.89); C39(1.04)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C149(1.31); C39(1.00)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C149(1.13); C39(1.09)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C149(1.20); C39(1.14)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C149(1.00); C39(0.99)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C149(0.99); C39(0.98)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C149(0.86); C39(1.02)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C149(0.82); C39(1.01)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C149(0.84); C39(1.09)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C149(0.94); C39(0.98)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C149(0.78); C39(0.92); C115(1.12)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C149(1.05); C39(1.07)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C149(0.82); C39(1.21)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C149(1.03); C39(1.17)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C149(0.99); C39(1.06)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C149(1.03); C39(1.15)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C149(0.94); C39(1.13)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C149(1.19); C39(1.30)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C149(0.57); C39(1.15)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C149(1.01); C39(0.99)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C149(0.92); C39(0.50)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C149(0.84); C39(1.01)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C149(1.01); C39(1.07)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C149(0.65); C39(0.90); C115(1.02)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C149(1.13); C39(1.04)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C149(0.98); C39(1.13)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C149(1.14); C39(1.27)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C149(1.07); C39(1.28)  LDD1698  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.69  LDD0183  [2]
 LDCM0468  Fragment33 HEK-293T C149(0.97); C39(1.00)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C149(1.20); C39(1.25)  LDD1631  [6]
 LDCM0116  HHS-0101 DM93 Y64(0.48)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y64(0.45)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y64(0.38)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y64(0.38)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y64(1.00)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C39(1.02); C149(1.01)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C39(0.97); C149(1.01)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C39(0.93); C149(1.07)  LDD1502  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C39(0.22)  LDD2207  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
mRNA-decapping enzyme 1B (DCP1B) DCP1 family Q8IZD4
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Regulator of nonsense transcripts 1 (UPF1) DNA2/NAM7 helicase family Q92900
m7GpppN-mRNA hydrolase (DCP2) Nudix hydrolase family Q8IU60
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of mRNA-decapping protein 3 (EDC3) EDC3 family Q96F86
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
Proline-rich nuclear receptor coactivator 2 (PNRC2) PNRC family Q9NPJ4
DNA repair protein RAD52 homolog (RAD52) RAD52 family P43351
RBPJ-interacting and tubulin-associated protein 1 (RITA1) RITA family Q96K30
Enhancer of mRNA-decapping protein 4 (EDC4) WD repeat EDC4 family Q6P2E9
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Four and a half LIM domains protein 2 (FHL2) . Q14192
mRNA decay activator protein ZFP36 (ZFP36) . P26651
Negative regulator of P-body association (NBDY) . A0A0U1RRE5
Protein FAN (NSMAF) . Q92636

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.