Details of the Target

General Information of Target

Target ID LDTP12323
Target Name DNA-directed DNA/RNA polymerase mu (POLM)
Gene Name POLM
Gene ID 27434
Synonyms
polmu; DNA-directed DNA/RNA polymerase mu; Pol Mu; EC 2.7.7.7; Terminal transferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQFPMGPACIFLRKGIAEKQRERPLGQDEIEELREAFLEFDKDRDGFISCKDLGNLMRTM
GYMPTEMELIELGQQIRMNLGGRVDFDDFVELMTPKLLAETAGMIGVQEMRDAFKEFDTN
GDGEITLVELQQAMQRLLGERLTPREISEVVREADVNGDGTVDFEEFVKMMSR
Target Bioclass
Enzyme
Family
DNA polymerase type-X family
Subcellular location
Nucleus
Function Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.
Uniprot ID
Q9NP87
Ensemble ID
ENST00000242248.10
HGNC ID
HGNC:9185
ChEMBL ID
CHEMBL1914260

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.K339M DBIA    Probe Info 
LNCaP clone FGC SNV: p.E340K .
MCAS SNV: p.Q299Ter .
RCC10RGB SNV: p.G247S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C409(3.15)  LDD3373  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IA-alkyne
 Probe Info  		C390(0.00); C180(0.00)  LDD0166  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C119(0.91); C94(0.91)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C119(1.19); C94(1.19)  LDD1094  [6]
 LDCM0216  AC100 PaTu 8988t C119(1.02); C94(1.02)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C119(0.86); C94(0.86)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C119(0.89); C94(0.89)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C119(1.24); C94(1.24)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C119(1.00); C94(1.00)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C119(0.89); C94(0.89)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C119(1.07); C94(1.07)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C119(1.01); C94(1.01)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C119(0.94); C94(0.94)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C119(1.06); C94(1.06)  LDD1104  [6]
 LDCM0226  AC11 PaTu 8988t C119(1.27); C94(1.27)  LDD1105  [6]
 LDCM0227  AC110 PaTu 8988t C119(1.40); C94(1.40)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C119(1.09); C94(1.09)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C119(1.04); C94(1.04)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C119(0.86); C94(0.86)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C119(0.91); C94(0.91)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C119(1.10); C94(1.10)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C119(0.98); C94(0.98)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C119(0.98); C94(0.98)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C119(0.97); C94(0.97)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C119(0.95); C94(0.95)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C119(1.38); C94(1.38)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C119(0.88); C94(0.88)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C119(0.95); C94(0.95)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C119(0.74); C94(0.74)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C119(0.80); C94(0.80)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C119(0.98); C94(0.98)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C119(1.30); C94(1.30)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C119(0.81); C94(0.81)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C119(0.86); C94(0.86)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C119(1.27); C94(1.27)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C119(1.31); C94(1.31)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C119(0.86); C94(0.86)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C119(0.82); C94(0.82)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C119(1.26); C94(1.26)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C119(1.21); C94(1.21)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C119(1.28); C94(1.28)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C119(1.16); C94(1.16)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C119(1.42); C94(1.42)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C119(1.06); C94(1.06)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C119(1.49); C94(1.49)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C119(1.18); C94(1.18)  LDD1137  [6]
 LDCM0259  AC14 PaTu 8988t C119(0.98); C94(0.98)  LDD1138  [6]
 LDCM0260  AC140 PaTu 8988t C119(1.46); C94(1.46)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C119(1.16); C94(1.16)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C119(1.48); C94(1.48)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C119(1.33); C94(1.33)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C119(1.21); C94(1.21)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C119(1.20); C94(1.20)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C119(1.17); C94(1.17)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C119(1.03); C94(1.03)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C119(1.39); C94(1.39)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C119(1.44); C94(1.44)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C119(1.21); C94(1.21)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C119(1.00); C94(1.00)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C119(1.29); C94(1.29)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C119(1.18); C94(1.18)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C119(1.46); C94(1.46)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C119(1.46); C94(1.46)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C119(1.46); C94(1.46)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C119(1.10); C94(1.10)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C119(0.84); C94(0.84)  LDD2169  [6]
 LDCM0279  AC2 PaTu 8988t C119(0.77); C94(0.77)  LDD1158  [6]
 LDCM0285  AC25 PaTu 8988t C119(0.89); C94(0.89)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C119(0.98); C94(0.98)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C119(1.01); C94(1.01)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C119(1.20); C94(1.20)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C119(0.99); C94(0.99)  LDD1168  [6]
 LDCM0290  AC3 PaTu 8988t C119(0.75); C94(0.75)  LDD1169  [6]
 LDCM0291  AC30 PaTu 8988t C119(0.94); C94(0.94)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C119(0.83); C94(0.83)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C119(0.90); C94(0.90)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C119(1.17); C94(1.17)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C119(1.22); C94(1.22)  LDD1174  [6]
 LDCM0296  AC35 PaTu 8988t C119(1.10); C94(1.10)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C119(1.39); C94(1.39)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C119(1.47); C94(1.47)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C119(1.56); C94(1.56)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C119(1.51); C94(1.51)  LDD1179  [6]
 LDCM0301  AC4 PaTu 8988t C119(0.79); C94(0.79)  LDD1180  [6]
 LDCM0302  AC40 PaTu 8988t C119(1.96); C94(1.96)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C119(1.45); C94(1.45)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C119(1.71); C94(1.71)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C119(1.43); C94(1.43)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C119(2.38); C94(2.38)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C119(1.61); C94(1.61)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C119(1.04); C94(1.04)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C119(0.92); C94(0.92)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C119(1.25); C94(1.25)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C119(1.42); C94(1.42)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C119(0.89); C94(0.89)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C119(1.42); C94(1.42)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C119(0.98); C94(0.98)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C119(1.19); C94(1.19)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C119(1.67); C94(1.67)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C119(1.53); C94(1.53)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C119(1.03); C94(1.03)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C119(1.34); C94(1.34)  LDD1198  [6]
 LDCM0320  AC57 PaTu 8988t C119(1.16); C94(1.16)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C119(0.88); C94(0.88)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C119(0.95); C94(0.95)  LDD1201  [6]
 LDCM0323  AC6 PaTu 8988t C119(0.90); C94(0.90)  LDD1202  [6]
 LDCM0324  AC60 PaTu 8988t C119(0.95); C94(0.95)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C119(0.98); C94(0.98)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C119(1.16); C94(1.16)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C119(1.28); C94(1.28)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C119(1.10); C94(1.10)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C119(0.97); C94(0.97)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C119(1.03); C94(1.03)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C119(1.21); C94(1.21)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C119(0.84); C94(0.84)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C119(1.03); C94(1.03)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C119(1.06); C94(1.06)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C119(0.96); C94(0.96)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C119(0.95); C94(0.95)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C119(0.91); C94(0.91)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C119(0.90); C94(0.90)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C119(0.94); C94(0.94)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C119(1.04); C94(1.04)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C119(0.87); C94(0.87)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C119(0.89); C94(0.89)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C119(0.90); C94(0.90)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C119(1.16); C94(1.16)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C119(1.12); C94(1.12)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C119(0.98); C94(0.98)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C119(1.03); C94(1.03)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C119(1.09); C94(1.09)  LDD1227  [6]
 LDCM0365  AC98 PaTu 8988t C119(1.19); C94(1.19)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C119(0.84); C94(0.84)  LDD1245  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C119(0.92); C94(0.92)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C119(1.49); C94(1.49)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C119(1.37); C94(1.37)  LDD1154  [6]
 LDCM0369  CL100 PaTu 8988t C119(0.74); C94(0.74)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C119(1.40); C94(1.40)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C119(1.36); C94(1.36)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C119(1.53); C94(1.53)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C119(1.17); C94(1.17)  LDD1252  [6]
 LDCM0382  CL112 PaTu 8988t C119(1.03); C94(1.03)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C119(0.93); C94(0.93)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C119(1.31); C94(1.31)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C119(1.20); C94(1.20)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C119(0.90); C94(0.90)  LDD1265  [6]
 LDCM0387  CL117 PaTu 8988t C119(1.59); C94(1.59)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C119(1.38); C94(1.38)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C119(1.34); C94(1.34)  LDD1268  [6]
 LDCM0391  CL120 PaTu 8988t C119(1.19); C94(1.19)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C119(1.05); C94(1.05)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C119(1.13); C94(1.13)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C119(1.40); C94(1.40)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C119(1.62); C94(1.62)  LDD1274  [6]
 LDCM0396  CL125 PaTu 8988t C119(1.00); C94(1.00)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C119(1.11); C94(1.11)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C119(0.94); C94(0.94)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C119(1.14); C94(1.14)  LDD1278  [6]
 LDCM0420  CL31 PaTu 8988t C119(1.15); C94(1.15)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C119(1.35); C94(1.35)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C119(0.79); C94(0.79)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C119(1.39); C94(1.39)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C119(1.74); C94(1.74)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C119(0.39); C94(0.39)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C119(2.50); C94(2.50)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C119(1.62); C94(1.62)  LDD1307  [6]
 LDCM0430  CL40 PaTu 8988t C119(1.32); C94(1.32)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C119(1.58); C94(1.58)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C119(1.92); C94(1.92)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C119(1.52); C94(1.52)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C119(1.57); C94(1.57)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C119(1.66); C94(1.66)  LDD1314  [6]
 LDCM0486  CL91 PaTu 8988t C119(0.67); C94(0.67)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C119(0.92); C94(0.92)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C119(0.80); C94(0.80)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C119(0.97); C94(0.97)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C119(2.23); C94(2.23)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C119(0.83); C94(0.83)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C119(0.89); C94(0.89)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C119(1.12); C94(1.12)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C119(0.96); C94(0.96)  LDD1373  [6]
 LDCM0625  F8 Ramos C409(2.04)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C409(0.74)  LDD2190  [7]
 LDCM0576  Fragment14 Ramos C409(0.84)  LDD2193  [7]
 LDCM0566  Fragment4 Ramos C409(1.02)  LDD2184  [7]
 LDCM0427  Fragment51 PaTu 8988t C119(20.00); C94(20.00)  LDD1306  [6]
 LDCM0569  Fragment7 Ramos C409(1.02)  LDD2186  [7]
 LDCM0022  KB02 Ramos C409(1.94)  LDD2182  [7]
 LDCM0023  KB03 Ramos C409(0.73)  LDD2183  [7]
 LDCM0024  KB05 OCUG-1 C409(3.15)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578