Details of the Target

General Information of Target

Target ID LDTP12257
Target Name Band 4.1-like protein 5 (EPB41L5)
Gene Name EPB41L5
Gene ID 57669
Synonyms
KIAA1548; Band 4.1-like protein 5; Erythrocyte membrane protein band 4.1-like 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASC
APDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDT
AFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITV
SPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSE
GIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIP
LPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSP
LLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTW
CAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQV
FNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGS
LSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVES
SLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTS
QSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWS
SFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDIL
TAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLIT
DAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTL
MGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTV
LARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINS
KLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVR
KHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEF
SFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLL
SEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLI
NKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILY
WKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGP
LKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDG
RSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQ
RPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKE
RHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLI
TTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSI
EEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSP
AQTANNPCSRYEDYGMTPPTGPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIY
SEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPPSRGSQYGGPGWPSYGEDE
AGRREATHMLGHQEYSSSPLFQVPRTSGREPSAPSGNLPHRGLQGPGLGYPTSSTEDLQP
GHSSASLIKAIREELLRLSQKQSTVQNFHS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells.
Uniprot ID
Q9HCM4
Ensemble ID
ENST00000263713.10
HGNC ID
HGNC:19819

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.S103AfsTer6 DBIA    Probe Info 
HCC1954 Deletion: p.E296DfsTer46 DBIA    Probe Info 
NCIH196 SNV: p.F323Y DBIA    Probe Info 
NCIH2291 SNV: p.D77Y DBIA    Probe Info 
NUGC3 SNV: p.R12L DBIA    Probe Info 
OVISE SNV: p.K102R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C357(1.52)  LDD3311  [3]
IA-alkyne
 Probe Info  		C115(0.00); C315(0.00)  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NPM
 Probe Info  		N.A.  LDD0016  [7]
TFBX
 Probe Info  		C315(0.00); C115(0.00)  LDD0148  [8]
AOyne
 Probe Info  		13.00  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C315(0.72)  LDD1093  [10]
 LDCM0215  AC10 PaTu 8988t C315(0.94)  LDD1094  [10]
 LDCM0226  AC11 PaTu 8988t C315(0.98)  LDD1105  [10]
 LDCM0237  AC12 PaTu 8988t C315(0.82)  LDD1116  [10]
 LDCM0259  AC14 PaTu 8988t C315(1.02)  LDD1138  [10]
 LDCM0263  AC143 PaTu 8988t C315(1.00)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C315(1.04)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C315(0.97)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C315(0.90)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C315(0.95)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C315(1.07)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C315(1.04)  LDD1148  [10]
 LDCM0270  AC15 PaTu 8988t C315(1.02)  LDD1149  [10]
 LDCM0271  AC150 PaTu 8988t C315(1.02)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C315(1.01)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C315(0.96)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C315(1.09)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C315(0.92)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C315(0.93)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C315(0.99)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C315(0.90)  LDD2169  [10]
 LDCM0276  AC17 HEK-293T C543(1.03); C385(0.89)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C543(0.96); C385(1.23); C727(1.03)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C543(1.13); C385(1.10); C727(1.07); C680(1.26)  LDD1517  [11]
 LDCM0279  AC2 PaTu 8988t C315(0.94)  LDD1158  [10]
 LDCM0280  AC20 HEK-293T C543(1.04)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C543(1.07); C680(0.99)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C543(0.98); C385(0.91); C727(1.09)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C543(1.09)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C543(0.87); C385(1.10); C680(0.72)  LDD1523  [11]
 LDCM0285  AC25 PaTu 8988t C315(0.75)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C315(0.96)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C315(0.96)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C315(1.06)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C315(1.01)  LDD1168  [10]
 LDCM0290  AC3 PaTu 8988t C315(0.83)  LDD1169  [10]
 LDCM0291  AC30 PaTu 8988t C315(0.70)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C315(0.99)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C315(0.89)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C315(0.82)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C315(0.89)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C315(1.20)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C315(1.19)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C315(1.07)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C315(1.28)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C315(1.08)  LDD1179  [10]
 LDCM0301  AC4 PaTu 8988t C315(1.06)  LDD1180  [10]
 LDCM0302  AC40 PaTu 8988t C315(1.30)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C315(0.94)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C315(1.01)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C315(1.18)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C315(1.11)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C315(0.95)  LDD1186  [10]
 LDCM0308  AC46 HEK-293T C543(1.11); C385(1.08); C727(1.21)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C543(1.09)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C543(1.04); C385(0.88); C680(0.86)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C543(1.13); C385(0.81)  LDD1550  [11]
 LDCM0312  AC5 PaTu 8988t C315(0.83)  LDD1191  [10]
 LDCM0313  AC50 HEK-293T C543(0.98); C385(0.94); C727(1.07)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C543(1.11); C385(1.02); C727(1.03); C680(0.93)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C543(1.05)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C543(1.11); C680(0.87)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C543(1.00); C385(0.97); C727(1.02)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C543(1.07)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C543(1.05); C385(0.86); C680(1.07)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C543(1.15); C385(0.80)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C543(1.00); C385(0.78); C727(1.07)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C543(1.09); C385(0.74); C727(1.02); C680(1.27)  LDD1561  [11]
 LDCM0323  AC6 PaTu 8988t C315(0.86)  LDD1202  [10]
 LDCM0324  AC60 HEK-293T C543(1.09)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C543(1.03); C680(1.23)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C543(1.15); C385(1.14); C727(0.96)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C543(1.04)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C543(1.03); C385(0.87); C680(0.80)  LDD1567  [11]
 LDCM0332  AC68 PaTu 8988t C315(1.11)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C315(1.14)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C315(0.86)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C315(1.18)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C315(1.15)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C315(1.07)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C315(1.20)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C315(1.25)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C315(1.70)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C315(1.11)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C315(1.10)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C315(1.14)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C315(1.43)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C315(0.81)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C315(1.35)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C315(1.06)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C315(1.11)  LDD1227  [10]
 LDCM0349  AC83 PaTu 8988t C315(0.99)  LDD1228  [10]
 LDCM0350  AC84 PaTu 8988t C315(1.04)  LDD1229  [10]
 LDCM0351  AC85 PaTu 8988t C315(1.03)  LDD1230  [10]
 LDCM0352  AC86 PaTu 8988t C315(0.98)  LDD1231  [10]
 LDCM0353  AC87 PaTu 8988t C315(1.37)  LDD1232  [10]
 LDCM0354  AC88 PaTu 8988t C315(1.11)  LDD1233  [10]
 LDCM0355  AC89 PaTu 8988t C315(0.92)  LDD1234  [10]
 LDCM0357  AC90 PaTu 8988t C315(0.89)  LDD1236  [10]
 LDCM0358  AC91 PaTu 8988t C315(0.96)  LDD1237  [10]
 LDCM0359  AC92 PaTu 8988t C315(1.07)  LDD1238  [10]
 LDCM0360  AC93 PaTu 8988t C315(1.01)  LDD1239  [10]
 LDCM0361  AC94 PaTu 8988t C315(1.03)  LDD1240  [10]
 LDCM0362  AC95 PaTu 8988t C315(1.08)  LDD1241  [10]
 LDCM0363  AC96 PaTu 8988t C315(0.91)  LDD1242  [10]
 LDCM0364  AC97 PaTu 8988t C315(0.74)  LDD1243  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C315(1.13)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C315(0.92)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C315(0.85)  LDD1154  [10]
 LDCM0367  CL1 HEK-293T C543(1.12); C385(0.95)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C543(1.03); C385(0.98); C727(0.32)  LDD1572  [11]
 LDCM0369  CL100 PaTu 8988t C315(0.86)  LDD1248  [10]
 LDCM0370  CL101 PaTu 8988t C315(0.83)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C315(0.75)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C315(0.86)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C315(0.92)  LDD1252  [10]
 LDCM0374  CL105 HEK-293T C543(1.13); C385(0.92)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C543(0.94); C727(1.11)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C543(1.01); C385(0.70); C680(0.85)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C543(1.03); C385(0.84)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C543(1.03); C385(0.81)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C543(1.07)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C543(0.92); C727(1.03)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C543(1.13); C385(0.83); C680(1.27)  LDD1585  [11]
 LDCM0382  CL112 PaTu 8988t C315(0.87)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C315(0.87)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C315(0.84)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C315(0.94)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C315(0.94)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C315(0.93)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C315(0.96)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C315(0.96)  LDD1268  [10]
 LDCM0390  CL12 HEK-293T C543(0.93); C385(1.13); C680(0.81)  LDD1594  [11]
 LDCM0391  CL120 PaTu 8988t C315(1.00)  LDD1270  [10]
 LDCM0392  CL121 HEK-293T C543(1.14); C385(1.25)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C543(1.07); C727(0.95)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C543(0.93); C385(0.67); C680(1.29)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C543(0.96); C385(0.70)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C543(1.17); C385(0.77)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C543(1.12); C727(0.95)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C543(1.22); C385(0.75); C680(1.34)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C543(1.00); C385(0.83)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C543(1.09); C385(1.02)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C543(1.09); C727(1.03)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C543(1.09); C385(0.82); C680(0.91)  LDD1606  [11]
 LDCM0403  CL16 PaTu 8988t C315(0.82)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C315(0.93)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C315(0.87)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C315(0.98)  LDD1285  [10]
 LDCM0407  CL2 HEK-293T C543(1.01); C727(1.00)  LDD1611  [11]
 LDCM0408  CL20 PaTu 8988t C315(1.09)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C315(1.08)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C315(0.99)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C315(1.25)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C315(1.05)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C315(0.80)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C315(1.00)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C315(0.90)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C315(1.21)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C315(1.33)  LDD1296  [10]
 LDCM0418  CL3 HEK-293T C543(1.18); C385(0.85); C680(0.99)  LDD1622  [11]
 LDCM0419  CL30 PaTu 8988t C315(0.98)  LDD1298  [10]
 LDCM0420  CL31 HEK-293T C543(0.97); C385(0.75); C727(1.11); C680(0.93)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C543(1.04)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C543(0.90); C680(1.06)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C543(1.11); C385(0.77); C727(1.04)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C543(1.01)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C543(0.99); C385(0.64); C680(0.80)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C543(1.03); C385(0.85)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C543(1.10); C385(0.84); C680(1.12)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C543(1.00); C385(0.77)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C543(0.93); C385(0.66)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C543(0.98); C385(0.82)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C543(0.96); C385(0.87); C727(1.14)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C543(1.08); C385(0.79); C727(1.01); C680(0.83)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C543(0.94)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C543(1.11); C680(1.01)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C543(1.10); C385(0.83); C727(1.14)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C543(1.14)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C543(0.95); C385(0.67); C680(0.63)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C543(1.14); C385(0.76)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C543(1.05); C385(0.77)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C543(1.00); C727(1.08)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C543(0.99); C385(0.86)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C543(1.00); C385(1.15)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C543(1.14); C385(0.94); C727(1.34)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C543(1.21); C385(0.91); C727(1.11); C680(0.87)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C543(0.95)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C543(1.04); C680(1.41)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C543(1.13); C385(0.94); C727(1.32)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C543(1.13)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C543(0.98); C385(0.76); C727(1.00)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C543(0.98); C385(0.83); C680(0.76)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C543(1.24); C385(0.90)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C543(1.01); C727(0.95)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C543(1.17); C385(0.73); C680(1.02)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C543(0.92); C385(0.91)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C543(1.08); C385(0.90)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C543(0.97); C385(0.80); C727(1.07)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C543(1.17); C385(1.00); C727(1.06); C680(0.99)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C543(1.05)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C543(1.10); C680(1.04)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C543(1.21); C385(0.86); C727(1.02); C680(0.96)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C543(0.97); C385(1.20); C727(1.15)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C543(1.02)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C543(1.01); C385(1.02); C680(0.76)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C543(1.00); C385(0.69)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C543(1.05); C727(1.06)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C543(0.98); C385(0.77)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C543(1.08); C385(0.75)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C543(0.95); C385(0.87); C727(1.03)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C543(1.07); C385(0.75); C727(1.15); C680(0.93)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C543(0.89)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C543(0.97)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C543(1.05); C680(0.99)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C543(1.03); C385(1.00); C727(1.06)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C543(1.05)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C543(1.03); C385(0.69); C680(0.74)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C543(1.01); C385(0.86)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C543(1.09); C727(0.97)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C543(0.95); C385(0.67); C680(1.16)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C543(1.19); C385(0.73)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C543(1.18); C385(0.80)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C543(0.98); C680(0.70)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C543(0.91); C385(0.70); C727(1.09)  LDD1688  [11]
 LDCM0486  CL91 PaTu 8988t C315(0.81)  LDD1365  [10]
 LDCM0487  CL92 PaTu 8988t C315(0.97)  LDD1366  [10]
 LDCM0488  CL93 PaTu 8988t C315(0.75)  LDD1367  [10]
 LDCM0489  CL94 PaTu 8988t C315(0.85)  LDD1368  [10]
 LDCM0490  CL95 PaTu 8988t C315(0.90)  LDD1369  [10]
 LDCM0491  CL96 PaTu 8988t C315(0.72)  LDD1370  [10]
 LDCM0492  CL97 PaTu 8988t C315(0.95)  LDD1371  [10]
 LDCM0493  CL98 PaTu 8988t C315(0.89)  LDD1372  [10]
 LDCM0494  CL99 PaTu 8988t C315(0.85)  LDD1373  [10]
 LDCM0495  E2913 HEK-293T C543(1.10); C385(0.66); C680(1.18)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C543(1.13); C385(1.07); C680(0.91)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C543(0.99); C727(0.95)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C315(1.00); C385(1.29); C543(1.02)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C315(1.06); C385(0.98); C543(0.98)  LDD1497  [11]
 LDCM0024  KB05 G361 C357(1.52)  LDD3311  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C543(0.93)  LDD2207  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein crumbs homolog 1 (CRB1) Crumbs protein family P82279
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein PALS1 (PALS1) MAGUK family Q8N3R9
Protein crumbs homolog 3 (CRB3) . Q9BUF7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.