Details of the Target

General Information of Target

Target ID LDTP12184
Target Name Beta-parvin (PARVB)
Gene Name PARVB
Gene ID 29780
Synonyms
Beta-parvin; Affixin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPEFLYDLLQLPKGVEPPAEEELSKGGKKKYLPPTSRKDPKFEELQKVLMEWINATLLP
EHIVVRSLEEDMFDGLILHHLFQRLAALKLEAEDIALTATSQKHKLTVVLEAVNRSLQLE
EWQAKWSVESIFNKDLLSTLHLLVALAKRFQPDLSLPTNVQVEVITIESTKSGLKSEKLV
EQLTEYSTDKDEPPKDVFDELFKLAPEKVNAVKEAIVNFVNQKLDRLGLSVQNLDTQFAD
GVILLLLIGQLEGFFLHLKEFYLTPNSPAEMLHNVTLALELLKDEGLLSCPVSPEDIVNK
DAKSTLRVLYGLFCKHTQKAHRDRTPHGAPN
Target Bioclass
Other
Family
Parvin family
Subcellular location
Cell junction, focal adhesion
Function
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Uniprot ID
Q9HBI1
Ensemble ID
ENST00000338758.12
HGNC ID
HGNC:14653

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
OCILY3 SNV: p.N318H .
PC9 SNV: p.R236L .
SKN SNV: p.E104G .
TGBC1TKB SNV: p.L115M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-482
 Probe Info  		Y354(1.27)  LDD0285  [1]
HHS-475
 Probe Info  		Y354(0.89)  LDD0264  [2]
ATP probe
 Probe Info  		K359(0.00); K361(0.00)  LDD0199  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]
HHS-465
 Probe Info  		N.A.  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y354(0.89)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y354(0.87)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y354(0.82)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y354(0.80)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y354(0.93)  LDD0268  [2]
 LDCM0123  JWB131 DM93 Y354(1.27)  LDD0285  [1]
 LDCM0124  JWB142 DM93 Y354(2.38)  LDD0286  [1]
 LDCM0126  JWB150 DM93 Y354(3.64)  LDD0288  [1]
 LDCM0127  JWB152 DM93 Y354(0.34)  LDD0289  [1]
 LDCM0128  JWB198 DM93 Y354(0.22)  LDD0290  [1]
 LDCM0129  JWB202 DM93 Y354(1.81)  LDD0291  [1]
 LDCM0130  JWB211 DM93 Y354(0.69)  LDD0292  [1]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010