Details of the Target

General Information of Target

Target ID LDTP12072
Target Name tRNA endonuclease ANKZF1 (ANKZF1)
Gene Name ANKZF1
Gene ID 55139
Synonyms
ZNF744; tRNA endonuclease ANKZF1; EC 3.1.-.-; Ankyrin repeat and zinc finger domain-containing protein 1; Zinc finger protein 744
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTRSGSQCSVTPEAILNNEKLVLPPRISRVNGWSLPLHYFQVVTWAVFVGLSSATFGIF
IPFLPHAWKYIAYVVTGGIFSFHLVVHLIASCIDPADSNVRLMKNYSQPMPLFDRSKHAH
VIQNQFCHLCKVTVNKKTKHCISCNKCVSGFDHHCKWINNCVGSRNYWFFFSTVASATAG
MLCLIAILLYVLVQYLVNPGVLRTDPRYEDVKNMNTWLLFLPLFPVQVQTLIVVIIGMLV
LLLDFLGLVHLGQLLIFHIYLKAKKMTTFEYLINNRKEESSKHQAVRKDPYVQMDKGVLQ
QGAGALGSSAQGVKAKSSLLIHKHLCHFCTSVNQDGDSTAREGDEDPCPSALGAKARNSR
LICRRLCQFSTRVHPDGGSMAQEADDAPSISTLGLQQETTEPMKTDSAESED
Target Bioclass
Enzyme
Family
ANKZF1/VMS1 family
Subcellular location
Cytoplasm
Function
Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress.
Uniprot ID
Q9H8Y5
Ensemble ID
ENST00000323348.10
HGNC ID
HGNC:25527

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C385(20.00)  LDD2227  [1]
DA-P3
 Probe Info  		7.76  LDD0183  [2]
DBIA
 Probe Info  		C48(9.03)  LDD0209  [3]
IA-alkyne
 Probe Info  		C48(0.00); C713(0.00); C502(0.00)  LDD0162  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C77(3.30)  LDD0812  [7]
 LDCM0216  AC100 HEK-293T C48(1.29); C74(0.75)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C48(1.13); C74(0.81)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C48(1.21); C74(0.60)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C48(1.25); C74(0.49)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C48(1.29); C74(0.66)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C48(1.00); C74(1.15)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C48(1.00); C74(1.63)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C48(1.08); C74(0.52)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C48(0.98); C74(1.04)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C48(1.13); C74(0.88)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C48(1.21)  LDD1509  [8]
 LDCM0227  AC110 HEK-293T C48(1.50); C74(0.48)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C48(2.00); C74(0.53)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C48(1.53); C74(0.51)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C48(1.09); C77(0.83)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C48(0.88); C77(0.65)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C48(0.97); C77(0.78)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C48(0.95); C77(0.80)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C48(1.19); C77(0.51)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C48(1.22); C77(0.51)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C48(1.20); C77(0.42)  LDD0834  [7]
 LDCM0238  AC120 HEK-293T C48(1.14); C77(0.57)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C48(1.14); C77(0.51)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C48(1.23); C77(0.32)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C48(1.43); C77(0.33)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C48(1.12); C77(0.48)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C48(1.30); C77(0.36)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C48(1.44); C77(0.41)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C48(1.63); C77(0.46)  LDD0843  [7]
 LDCM0246  AC128 HEK-293T C74(1.04)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C74(1.13)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C74(1.11)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C74(1.14)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C74(1.22)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C74(0.60)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C74(0.76)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C74(1.28)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C74(0.95)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C74(0.50)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C74(0.64)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C74(0.54)  LDD0856  [7]
 LDCM0260  AC140 HEK-293T C74(0.81)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C74(0.54)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C74(0.72)  LDD0860  [7]
 LDCM0276  AC17 HEK-293T C74(0.88)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C74(1.15)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C74(1.10)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C77(1.13)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C74(1.26)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C74(1.12)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C74(0.99)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C74(0.69)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C74(1.14)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C74(0.71); C77(1.03)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C74(0.71); C77(0.99)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C74(0.94); C77(1.14)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C74(0.71); C77(1.01)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C74(0.72); C77(1.30)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C77(1.04)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C74(0.85); C77(1.21)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C74(0.70); C77(0.98)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C74(0.59); C77(1.15)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C74(0.63); C77(1.21)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C74(0.73); C77(1.16)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C48(1.04)  LDD1535  [8]
 LDCM0301  AC4 HEK-293T C77(0.99)  LDD0899  [7]
 LDCM0303  AC41 HEK-293T C48(0.84)  LDD1542  [8]
 LDCM0305  AC43 HEK-293T C48(1.09)  LDD1544  [8]
 LDCM0308  AC46 HEK-293T C48(0.91)  LDD0906  [7]
 LDCM0309  AC47 HEK-293T C48(1.35)  LDD0907  [7]
 LDCM0310  AC48 HEK-293T C48(1.22)  LDD0908  [7]
 LDCM0311  AC49 HEK-293T C48(1.13)  LDD0909  [7]
 LDCM0312  AC5 HEK-293T C77(0.87)  LDD0910  [7]
 LDCM0313  AC50 HEK-293T C48(1.20)  LDD0911  [7]
 LDCM0314  AC51 HEK-293T C48(1.20)  LDD0912  [7]
 LDCM0315  AC52 HEK-293T C48(1.06)  LDD0913  [7]
 LDCM0316  AC53 HEK-293T C48(1.02)  LDD0914  [7]
 LDCM0317  AC54 HEK-293T C48(1.10)  LDD0915  [7]
 LDCM0318  AC55 HEK-293T C48(1.36)  LDD0916  [7]
 LDCM0319  AC56 HEK-293T C48(1.03)  LDD0917  [7]
 LDCM0320  AC57 HEK-293T C74(1.10); C77(0.87)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C74(0.96); C77(0.97)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C74(0.79); C77(1.08)  LDD0920  [7]
 LDCM0324  AC60 HEK-293T C74(0.97); C77(1.56)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C74(0.88); C77(1.01)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C74(0.91); C77(1.06)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C74(0.86); C77(0.99)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C74(0.93); C77(0.97)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C74(0.85); C77(1.04)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C74(1.04); C77(1.04)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C74(1.05); C77(1.09)  LDD0929  [7]
 LDCM0332  AC68 HEK-293T C74(1.07); C77(0.95)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C74(1.12); C77(1.02)  LDD0931  [7]
 LDCM0335  AC70 HEK-293T C74(1.11); C77(1.18)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C74(1.04); C77(1.10)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C74(1.10); C77(1.12)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C74(1.13); C77(1.37)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C74(1.63); C77(2.95)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C74(1.17); C77(1.18)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C74(1.14); C77(1.22)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C74(1.22); C77(1.11)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C74(1.23); C77(1.06)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C74(1.06); C77(1.13)  LDD0942  [7]
 LDCM0346  AC80 HEK-293T C74(1.25); C77(1.34)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C74(1.17); C77(1.21)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C74(1.18); C77(1.10)  LDD0946  [7]
 LDCM0349  AC83 HEK-293T C48(0.89); C74(1.19); C77(1.02)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C48(0.97); C74(0.85); C77(0.81)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C48(0.87); C74(1.08); C77(0.98)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C48(1.04); C74(1.10); C77(0.99)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C48(1.03); C74(1.68); C77(1.01)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C48(1.03); C74(0.95); C77(0.65)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C48(1.26); C74(0.72); C77(0.51)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C48(1.15); C74(0.83); C77(0.55)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C48(1.04); C74(1.05); C77(0.84)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C48(0.99); C74(1.09); C77(0.89)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C48(1.13); C74(1.12); C77(0.94)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C48(1.09); C74(0.65); C77(0.42)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C48(1.01); C74(1.04); C77(0.67)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C48(1.09); C74(1.40); C77(1.21)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C48(1.44); C74(0.74); C77(0.36)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C48(1.19); C74(1.09)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C48(1.01); C74(1.26)  LDD0964  [7]
 LDCM0356  AKOS034007680 HEK-293T C48(0.80)  LDD1570  [8]
 LDCM0108  Chloroacetamide HeLa C74(0.00); H347(0.00)  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C385(20.00)  LDD2227  [1]
 LDCM0369  CL100 HEK-293T C77(1.07)  LDD0967  [7]
 LDCM0373  CL104 HEK-293T C48(1.06)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C74(0.99)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C74(0.95)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C74(1.30)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C74(1.05)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C74(0.92)  LDD0976  [7]
 LDCM0380  CL110 HEK-293T C74(1.33)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C74(1.04)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C74(0.75); C77(1.17)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C74(0.77); C77(0.98)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C74(0.76); C77(0.99)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C74(0.77); C77(1.17)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C74(0.90); C77(1.18)  LDD0984  [7]
 LDCM0391  CL120 HEK-293T C48(0.88)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C48(1.25)  LDD0990  [7]
 LDCM0393  CL122 HEK-293T C48(1.08)  LDD0991  [7]
 LDCM0394  CL123 HEK-293T C48(1.52)  LDD0992  [7]
 LDCM0395  CL124 HEK-293T C48(1.13)  LDD0993  [7]
 LDCM0396  CL125 HEK-293T C74(0.91); C77(1.01)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C74(1.12); C77(0.88)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C74(0.93); C77(1.11)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C74(0.95); C77(0.98)  LDD0997  [7]
 LDCM0403  CL16 HEK-293T C48(0.73); C74(0.90)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C48(0.84); C74(1.28)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C48(0.77); C74(0.61)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C48(1.02); C74(0.86)  LDD1004  [7]
 LDCM0408  CL20 HEK-293T C48(0.82); C74(0.80)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C48(1.09); C74(0.62)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C48(1.12); C74(0.49)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C48(0.84); C74(0.90)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C48(0.84); C74(0.76)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C48(1.00); C74(0.82)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C48(0.91); C74(0.94)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C48(0.98); C74(0.85)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C48(0.93); C74(0.94)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C48(0.91); C74(0.88)  LDD1015  [7]
 LDCM0419  CL30 HEK-293T C48(1.09); C74(0.29)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C48(1.18)  LDD1624  [8]
 LDCM0429  CL4 HEK-293T C48(1.11)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C48(1.06)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C48(1.02)  LDD1635  [8]
 LDCM0433  CL43 HEK-293T C48(1.21)  LDD1637  [8]
 LDCM0436  CL46 HEK-293T C48(1.09); C77(0.70)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C48(0.97); C77(1.02)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C48(0.93); C77(0.94)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C48(1.09); C77(0.80)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C48(0.80)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C48(1.34); C77(0.36)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C48(1.18); C77(0.85)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C48(0.92); C77(1.05)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C48(1.04); C77(0.87)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C48(1.08); C77(0.91)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C48(1.06); C77(0.76)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C48(0.93); C77(1.16)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C48(1.32); C77(1.07)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C48(1.25); C77(0.80)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C48(1.13); C77(0.53)  LDD1048  [7]
 LDCM0452  CL60 HEK-293T C48(1.31); C77(0.33)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C48(0.94); C77(1.14)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C48(0.97); C77(1.18)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C48(1.02); C77(1.07)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C48(1.08); C77(1.44)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C48(1.02); C77(1.19)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C48(1.05); C77(1.47)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C48(1.03); C77(1.24)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C48(1.20); C77(1.47)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C48(1.00); C77(1.13)  LDD1059  [7]
 LDCM0462  CL7 HEK-293T C48(1.13)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C48(1.02); C77(1.10)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C48(1.08); C77(1.03)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C48(1.01); C77(1.04)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C48(1.13); C77(1.37)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C48(1.41); C77(0.38)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C74(1.10)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C74(1.17)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C74(0.73)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C74(0.97)  LDD1070  [7]
 LDCM0474  CL80 HEK-293T C74(1.04)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C74(0.89)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C74(1.29)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C74(1.38)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C74(1.13)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C74(0.71)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C74(0.76)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C74(1.11)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C74(0.95)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C74(0.87)  LDD1081  [7]
 LDCM0485  CL90 HEK-293T C74(1.55)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C77(0.94)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C77(1.06)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C77(1.12)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C77(1.04)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C77(0.83)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C77(1.24)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C77(1.12)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C77(1.05)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C77(1.15)  LDD1092  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.76  LDD0183  [2]
 LDCM0468  Fragment33 HEK-293T C48(1.54); C77(1.52)  LDD1066  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 Caov-3 C48(1.85)  LDD2295  [9]
 LDCM0023  KB03 Jurkat C48(9.03)  LDD0209  [3]
 LDCM0024  KB05 NUGC-3 C48(2.58)  LDD3367  [9]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840