Details of the Target

General Information of Target

Target ID LDTP11979
Target Name Coiled-coil domain-containing protein 134 (CCDC134)
Gene Name CCDC134
Gene ID 79879
Synonyms
Coiled-coil domain-containing protein 134
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGDFCSPGEGMEILQQVCSKQLPPCNLSKEDLLQNPYFSKLLLNLSQHVDESGLSLTL
AKEQAQAWKEVRLHKTTWLRSEILHRVIQELLVDYYVKIQDTNVTSEDKKFHETLEQRLL
VTELMRLLGPSQEREIPPLLGLEKADLLELMPLSEDFVWMRARLQQEVEEQLKKKCFTLL
CYYDPNSDADSETVKAAKVWKLAEVLVGEQQQCQDAKSQQKEQMLLLEKKSAAYSQVLLR
CLTLLQRLLQEHRLKTQSELDRINAQYLEVKCGAMILKLRMEELKILSDTYTVEKVEVHR
LIRDRLEGAIHLQEQDMENSRQVLNSYEVLGEEFDRLVKEYTVLKQATENKRWALQEFSK
VYR
Target Bioclass
Other
Family
CCDC134 family
Subcellular location
Nucleus
Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Has a critical role in the regulation of osteogenesis and bone development.; In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Uniprot ID
Q9H6E4
Ensemble ID
ENST00000255784.6
HGNC ID
HGNC:26185

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y63(20.00)  LDD0260  [1]
DBIA
 Probe Info  		C147(1.00)  LDD1509  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
m-APA
 Probe Info  		H132(0.00); H107(0.00)  LDD2231  [3]
STPyne
 Probe Info  		N.A.  LDD0009  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.23  LDD1725  [7]
C158
 Probe Info  		11.96  LDD1838  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C147(1.00)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C147(0.89)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C147(1.00)  LDD1513  [2]
 LDCM0278  AC19 HEK-293T C147(0.77)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C147(0.80)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C147(0.87)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C147(1.14)  LDD1523  [2]
 LDCM0287  AC27 HEK-293T C147(0.92)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C147(0.88)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C147(1.05)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C147(0.84)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C147(1.02)  LDD1532  [2]
 LDCM0296  AC35 HEK-293T C147(0.97)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C147(0.86)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C147(0.78)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C147(0.93)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C147(1.19)  LDD1541  [2]
 LDCM0305  AC43 HEK-293T C147(0.90)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C147(0.71)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C147(0.91)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C147(1.16)  LDD1549  [2]
 LDCM0314  AC51 HEK-293T C147(0.97)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C147(1.07)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C147(0.74)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C147(0.80)  LDD1558  [2]
 LDCM0322  AC59 HEK-293T C147(0.99)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C147(1.15)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C147(0.97)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C147(1.03)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C147(0.75)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C147(0.98)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C147(1.01)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C147(1.06)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C147(1.01)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C147(0.93)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C147(1.17)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C147(1.05)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C147(1.01)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C147(1.09)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C147(1.14)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C147(1.13)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C147(1.12)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C147(1.07)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C147(0.94)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C147(1.16)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C147(1.24)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C147(0.92)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C147(1.05)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C147(1.11)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C147(1.12)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C147(0.95)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C147(1.06)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C147(1.20)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C147(0.99)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C147(0.94)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C147(1.32)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C147(0.97)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C147(1.11)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C147(1.09)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C147(0.97)  LDD1607  [2]
 LDCM0406  CL19 HEK-293T C147(0.90)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C147(1.10)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C147(0.98)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C147(1.01)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C147(1.07)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C147(1.06)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C147(1.07)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C147(1.04)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C147(1.00)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C147(0.73)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C147(0.67)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C147(1.19)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C147(1.02)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C147(1.03)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C147(0.96)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C147(1.21)  LDD1634  [2]
 LDCM0433  CL43 HEK-293T C147(0.98)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C147(0.92)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C147(0.78)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C147(1.47)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C147(1.04)  LDD1643  [2]
 LDCM0443  CL52 HEK-293T C147(0.93)  LDD1646  [2]
 LDCM0446  CL55 HEK-293T C147(0.99)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C147(0.99)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C147(0.79)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C147(1.26)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C147(1.28)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C147(1.07)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C147(1.04)  LDD1659  [2]
 LDCM0459  CL67 HEK-293T C147(1.07)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C147(1.02)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C147(0.94)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C147(1.11)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C147(1.08)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C147(0.89)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C147(1.13)  LDD1672  [2]
 LDCM0472  CL79 HEK-293T C147(0.83)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C147(0.87)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C147(1.44)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C147(0.85)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C147(1.04)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C147(1.82)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C147(1.02)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C147(0.89)  LDD1685  [2]
 LDCM0486  CL91 HEK-293T C147(0.88)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C147(0.78)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C147(0.92)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C147(0.89)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C147(1.15)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C147(1.08)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C147(1.11)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C147(1.05)  LDD1671  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional adapter 2-alpha (TADA2A) . O75478

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587