Details of the Target

General Information of Target

Target ID LDTP11863
Target Name Tumor protein 63 (TP63)
Gene Name TP63
Gene ID 8626
Synonyms
KET; P63; P73H; P73L; TP73L; Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ
HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS
AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE
AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN
LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPS
QIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTS
TQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETL
TASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRS
KVDEAVAVLQAHQAKEATQKAVNSATGVPTV
Target Bioclass
Transcription factor
Family
P53 family
Subcellular location
Nucleus
Function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Uniprot ID
Q9H3D4
Ensemble ID
ENST00000264731.8
HGNC ID
HGNC:15979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R343Q .
A2058 SNV: p.R379C .
AN3CA SNV: p.E248A .
COLO679 SNV: p.P148L .
COLO800 SNV: p.S395F .
COLO829 SNV: p.M499I .
CORL23 SNV: p.V240L .
HCT116 SNV: p.N470S .
HCT15 SNV: p.P279H .
HEL SNV: p.E636Q .
HEL9217 SNV: p.E636Q .
HT29 SNV: p.P504S .
IM95 SNV: p.R243W .
JURKAT SNV: p.R674C .
JVM3 SNV: p.E63Ter .
LOXIMVI SNV: p.P539L .
MEWO SNV: p.S162L .
MOLT4 SNV: p.T217P; p.A354V .
NCIH2172 SNV: p.S310G .
NCIH358 SNV: p.V364I .
SKN SNV: p.A513T .
SKOV3 SNV: p.E33Q; p.S560A .
SNGM SNV: p.E255K .
SW1271 Insertion: p.G349RfsTer8 .
YSCCC SNV: p.D397N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C347(1.34)  LDD0532  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C347(1.34)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C347(1.16)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C347(1.04)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C347(1.04)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C347(1.00)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C347(0.99)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C347(1.02)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C347(0.99)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C347(1.35)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C347(1.19)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C347(1.00)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C347(1.21)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C347(0.68)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C347(0.45)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C347(0.63)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C347(1.15)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C347(1.06)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C347(1.15)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C347(1.04)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C347(1.09)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C347(0.96)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C347(0.90)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C347(1.03)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C347(1.01)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C347(0.90)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C347(0.82)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C347(0.71)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C347(0.97)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C347(0.85)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C347(0.63)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C347(0.46)  LDD0843  [1]
 LDCM0246  AC128 HCT 116 C347(0.89)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C347(1.51)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C347(1.44)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C347(1.13)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C347(2.00)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C347(1.48)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C347(1.45)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C347(1.52)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C347(1.62)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C347(1.32)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C347(1.09)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C347(1.94)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C347(0.81)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C347(1.40)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C347(1.40)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C347(1.60)  LDD0579  [1]
 LDCM0263  AC143 PaTu 8988t C347(1.18)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C347(1.17)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C347(1.10)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C347(1.82)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C347(1.16)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C347(1.09)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C347(1.06)  LDD1148  [1]
 LDCM0270  AC15 HCT 116 C347(0.73)  LDD0587  [1]
 LDCM0271  AC150 PaTu 8988t C347(0.84)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C347(0.76)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C347(0.94)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C347(0.73)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C347(0.81)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C347(0.83)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C347(1.44)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C347(0.82)  LDD2169  [1]
 LDCM0276  AC17 HCT 116 C347(1.20)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C347(0.86)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C347(1.07)  LDD0595  [1]
 LDCM0280  AC20 HCT 116 C347(1.06)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C347(0.74)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C347(0.95)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C347(0.83)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C347(1.28)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C347(0.49)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C347(0.56)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C347(0.73)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C347(0.87)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C347(0.63)  LDD0887  [1]
 LDCM0291  AC30 HEK-293T C347(0.60)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C347(0.62)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C347(0.67)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C347(0.80)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C347(0.68)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C347(1.03)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C347(0.82)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C347(0.90)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C347(1.19)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C347(1.58)  LDD0617  [1]
 LDCM0302  AC40 HCT 116 C347(1.24)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C347(1.09)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C347(1.27)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C347(1.06)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C347(0.99)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C347(0.73)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C347(1.38)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C347(1.21)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C347(1.26)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C347(1.23)  LDD0628  [1]
 LDCM0313  AC50 HCT 116 C347(1.11)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C347(1.31)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C347(1.48)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C347(1.08)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C347(1.34)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C347(1.20)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C347(1.26)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C347(1.35)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C347(1.31)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C347(1.58)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C347(1.42)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C347(1.53)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C347(1.14)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C347(1.34)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C347(1.21)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C347(1.54)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C347(1.23)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C347(1.45)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C347(1.49)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C347(0.94)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C347(0.61)  LDD0650  [1]
 LDCM0334  AC7 HCT 116 C347(1.15)  LDD0651  [1]
 LDCM0335  AC70 HCT 116 C347(0.89)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C347(1.06)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C347(1.44)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C347(1.23)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C347(0.88)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C347(0.70)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C347(0.81)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C347(0.70)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C347(0.83)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C347(0.85)  LDD0661  [1]
 LDCM0345  AC8 HCT 116 C347(1.00)  LDD0662  [1]
 LDCM0346  AC80 HCT 116 C347(0.76)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C347(0.93)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C347(0.55)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C347(0.95)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C347(0.93)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C347(0.77)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C347(1.13)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C347(0.93)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C347(1.03)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C347(0.74)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C347(1.44)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C347(0.88)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C347(0.83)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C347(0.99)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C347(0.93)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C347(0.74)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C347(0.67)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C347(0.51)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C347(1.32)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C347(1.38)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C347(1.10)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C347(1.07)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C347(1.22)  LDD0592  [1]
 LDCM0370  CL101 HCT 116 C347(1.13)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C347(1.16)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C347(1.25)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C347(0.90)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C347(0.84)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C347(0.84)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C347(0.79)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C347(1.33)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C347(0.86)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C347(0.83)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C347(1.26)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C347(0.57)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C347(0.61)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C347(0.65)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C347(0.57)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C347(0.74)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C347(1.33)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C347(1.15)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C347(0.97)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C347(0.97)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C347(1.23)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C347(1.14)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C347(1.03)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C347(1.43)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C347(1.54)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C347(1.47)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C347(1.91)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C347(1.17)  LDD0716  [1]
 LDCM0403  CL16 PaTu 8988t C347(0.84)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C347(0.92)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C347(0.97)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C347(0.71)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C347(0.89)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C347(0.90)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C347(0.82)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C347(0.87)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C347(1.17)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C347(1.44)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C347(0.64)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C347(0.73)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C347(0.87)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C347(0.86)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C347(1.35)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C347(0.64)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C347(0.44)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C347(0.43)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C347(0.73)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C347(0.65)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C347(0.60)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C347(0.71)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C347(0.86)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C347(0.76)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C347(0.75)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C347(0.84)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C347(0.98)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C347(0.53)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C347(0.78)  LDD1033  [1]
 LDCM0469  CL76 PaTu 8988t C347(1.05)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C347(1.56)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C347(1.81)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C347(1.82)  LDD1351  [1]
 LDCM0474  CL80 PaTu 8988t C347(1.96)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C347(1.55)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C347(1.20)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C347(1.66)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C347(1.90)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C347(1.61)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C347(1.43)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C347(1.69)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C347(1.50)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C347(1.58)  LDD1362  [1]
 LDCM0485  CL90 PaTu 8988t C347(0.98)  LDD1364  [1]
 LDCM0427  Fragment51 HEK-293T C347(0.77)  LDD1025  [1]
 LDCM0022  KB02 CAL-51 C65(2.12)  LDD2288  [2]
 LDCM0023  KB03 CC-SW-1 C65(1.84)  LDD2716  [2]
 LDCM0024  KB05 NCI-H1975 C65(1.33)  LDD3352  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
E3 ubiquitin-protein ligase pellino homolog 2 (PELI2) Pellino family Q9HAT8
Protein kinase C delta type (PRKCD) AGC Ser/Thr protein kinase family Q05655
Homeodomain-interacting protein kinase 2 (HIPK2) CMGC Ser/Thr protein kinase family Q9H2X6
E3 ubiquitin-protein ligase Itchy homolog (ITCH) . Q96J02
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein SATB2 (SATB2) CUT homeobox family Q9UPW6
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Tumor protein 63 (TP63) P53 family Q9H3D4
Tumor protein p73 (TP73) P53 family O15350
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
CDK5 and ABL1 enzyme substrate 1 (CABLES1) Cyclin family Q8TDN4
Protein NipSnap homolog 3A (NIPSNAP3A) NipSnap family Q9UFN0
RNA-binding protein FUS (FUS) RRM TET family P35637
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937
Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) . Q99729
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840