Details of the Target

General Information of Target

Target ID LDTP11754
Target Name Nucleotide exchange factor SIL1 (SIL1)
Gene Name SIL1
Gene ID 64374
Synonyms
Nucleotide exchange factor SIL1; BiP-associated protein; BAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVD
IEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE
SGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKEL
VTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVV
SLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCP
TYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDP
IESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKV
FNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQV
VCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPV
TAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFR
EPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
Target Bioclass
Other
Family
SIL1 family
Subcellular location
Endoplasmic reticulum lumen
Function Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
Uniprot ID
Q9H173
Ensemble ID
ENST00000265195.9
HGNC ID
HGNC:24624

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K109(0.13)  LDD0277  [1]
DBIA
 Probe Info  		C408(3.94)  LDD3310  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
ATP probe
 Probe Info  		N.A.  LDD0035  [5]
NAIA_5
 Probe Info  		C379(0.00); C408(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C408(0.84)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C408(1.04)  LDD0813  [7]
 LDCM0216  AC100 PaTu 8988t C294(0.78)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C294(1.15)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C294(0.99)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C294(0.98)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C294(0.98)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C294(1.04)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C294(1.05)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C294(1.03)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C294(0.99)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C294(0.94)  LDD1104  [7]
 LDCM0226  AC11 HEK-293T C408(1.02)  LDD0824  [7]
 LDCM0227  AC110 PaTu 8988t C294(1.09)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C294(0.96)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C294(0.85)  LDD1108  [7]
 LDCM0230  AC113 PaTu 8988t C294(0.92)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C294(1.18)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C294(1.19)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C294(1.10)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C294(1.00)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C294(0.92)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C294(1.20)  LDD1115  [7]
 LDCM0237  AC12 HEK-293T C408(1.14)  LDD0835  [7]
 LDCM0238  AC120 PaTu 8988t C294(0.96)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C294(1.00)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C294(1.21)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C294(1.17)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C294(1.41)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C294(0.88)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C294(0.90)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C294(1.01)  LDD1124  [7]
 LDCM0259  AC14 HEK-293T C408(1.01)  LDD0857  [7]
 LDCM0270  AC15 HEK-293T C408(1.42)  LDD0868  [7]
 LDCM0276  AC17 PaTu 8988t C408(0.80); C294(0.93)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C408(0.67); C294(0.88)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C408(0.86); C294(0.99)  LDD1157  [7]
 LDCM0279  AC2 HEK-293T C408(1.56)  LDD0877  [7]
 LDCM0280  AC20 PaTu 8988t C408(0.70); C294(1.01)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C408(0.65); C294(0.97)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C408(0.70); C294(0.87)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C408(0.67); C294(0.96)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C408(0.86); C294(1.01)  LDD1163  [7]
 LDCM0285  AC25 HEK-293T C408(0.94)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C408(1.24)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C408(1.34)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C408(1.21)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C408(1.28)  LDD0887  [7]
 LDCM0290  AC3 HEK-293T C408(1.04)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C408(1.19)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C408(0.95)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C408(0.96)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C408(1.14)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C408(0.97)  LDD0893  [7]
 LDCM0296  AC35 PaTu 8988t C408(0.82); C294(0.96)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C408(0.75); C294(0.66)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C408(0.68); C294(0.93)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C408(0.71); C294(0.82)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C408(0.67); C294(0.67)  LDD1179  [7]
 LDCM0301  AC4 HEK-293T C408(0.90)  LDD0899  [7]
 LDCM0302  AC40 PaTu 8988t C408(0.67); C294(0.87)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C408(0.71); C294(0.72)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C408(0.72); C294(0.72)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C408(0.70); C294(0.99)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C408(0.54); C294(0.67)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C408(0.71); C294(0.78)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C408(0.67); C294(0.70)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C408(0.69); C294(0.69)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C408(0.61); C294(0.58)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C408(0.66); C294(0.64)  LDD1190  [7]
 LDCM0312  AC5 HEK-293T C408(0.98)  LDD0910  [7]
 LDCM0313  AC50 PaTu 8988t C408(0.66); C294(0.67)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C408(0.90); C294(0.66)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C408(0.65); C294(0.81)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C408(0.53); C294(0.61)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C408(0.56); C294(0.75)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C408(0.66); C294(0.77)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C408(0.90); C294(0.75)  LDD1198  [7]
 LDCM0320  AC57 PaTu 8988t C408(0.69); C294(0.88)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C408(0.64); C294(0.87)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C408(0.76); C294(0.85)  LDD1201  [7]
 LDCM0323  AC6 HEK-293T C408(0.75)  LDD0921  [7]
 LDCM0324  AC60 PaTu 8988t C408(0.64); C294(0.81)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C408(0.86); C294(0.76)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C408(0.78); C294(0.81)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C408(0.75); C294(0.91)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C408(0.85); C294(0.85)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C408(0.86); C294(0.84)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C408(0.78); C294(0.89)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C408(0.81); C294(0.87)  LDD1210  [7]
 LDCM0332  AC68 HEK-293T C408(0.96)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C408(1.19)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C408(1.14)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C408(1.24)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C408(1.06)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C408(1.15)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C408(1.12)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C408(1.07)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C408(1.19)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C408(1.07)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C408(1.47)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C408(1.14)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C408(1.26)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C408(1.43)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C408(1.39)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C408(1.18)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C408(1.47)  LDD0946  [7]
 LDCM0365  AC98 PaTu 8988t C294(0.99)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C294(1.10)  LDD1245  [7]
 LDCM0248  AKOS034007472 HEK-293T C408(1.00)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C408(1.50)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C408(1.19)  LDD0873  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C408(0.88)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C408(2.74)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C408(1.11)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C408(1.22)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C408(1.22)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C408(1.30)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C408(1.01)  LDD0971  [7]
 LDCM0374  CL105 PaTu 8988t C408(0.80); C294(0.90)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C408(0.84); C294(1.07)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C408(0.81); C294(0.92)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C408(0.72); C294(0.98)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C408(0.74); C294(1.00)  LDD1257  [7]
 LDCM0379  CL11 HEK-293T C408(2.61)  LDD0977  [7]
 LDCM0380  CL110 PaTu 8988t C408(0.74); C294(0.83)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C408(0.69); C294(0.99)  LDD1260  [7]
 LDCM0382  CL112 HEK-293T C408(1.22)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C408(1.25)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C408(1.57)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C408(0.96)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C408(1.13)  LDD0984  [7]
 LDCM0387  CL117 PaTu 8988t C408(0.69); C294(0.76)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C408(0.81); C294(0.84)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C408(0.62); C294(0.82)  LDD1268  [7]
 LDCM0390  CL12 HEK-293T C408(1.33)  LDD0988  [7]
 LDCM0391  CL120 PaTu 8988t C408(0.62); C294(0.83)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C408(0.76); C294(0.69)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C408(1.02); C294(0.78)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C408(0.54); C294(0.65)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C408(0.61); C294(0.64)  LDD1274  [7]
 LDCM0396  CL125 PaTu 8988t C408(0.76); C294(0.77)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C408(0.88); C294(0.77)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C408(0.82); C294(0.85)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C408(0.78); C294(0.96)  LDD1278  [7]
 LDCM0400  CL13 HEK-293T C408(1.41)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C408(1.24)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C408(1.98)  LDD1000  [7]
 LDCM0403  CL16 PaTu 8988t C294(1.18)  LDD1282  [7]
 LDCM0404  CL17 PaTu 8988t C294(0.96)  LDD1283  [7]
 LDCM0405  CL18 PaTu 8988t C294(1.36)  LDD1284  [7]
 LDCM0406  CL19 PaTu 8988t C294(1.55)  LDD1285  [7]
 LDCM0407  CL2 HEK-293T C408(1.37)  LDD1005  [7]
 LDCM0408  CL20 PaTu 8988t C294(1.19)  LDD1287  [7]
 LDCM0409  CL21 PaTu 8988t C294(1.48)  LDD1288  [7]
 LDCM0410  CL22 PaTu 8988t C294(1.35)  LDD1289  [7]
 LDCM0411  CL23 PaTu 8988t C294(1.20)  LDD1290  [7]
 LDCM0412  CL24 PaTu 8988t C294(1.18)  LDD1291  [7]
 LDCM0413  CL25 PaTu 8988t C294(1.00)  LDD1292  [7]
 LDCM0414  CL26 PaTu 8988t C294(1.18)  LDD1293  [7]
 LDCM0415  CL27 PaTu 8988t C294(1.23)  LDD1294  [7]
 LDCM0416  CL28 PaTu 8988t C294(1.49)  LDD1295  [7]
 LDCM0417  CL29 PaTu 8988t C294(1.75)  LDD1296  [7]
 LDCM0418  CL3 HEK-293T C408(1.02)  LDD1016  [7]
 LDCM0419  CL30 PaTu 8988t C294(1.08)  LDD1298  [7]
 LDCM0420  CL31 HEK-293T C408(0.83)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C408(1.25)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C408(1.27)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C408(1.32)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C408(1.38)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C408(1.37)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C408(1.34)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C408(2.45)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C408(1.17)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C408(1.76)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C408(2.03)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C408(2.33)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C408(2.29)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C408(1.51)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C408(2.15)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C408(0.87)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C408(0.87)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C408(1.01)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C408(1.08)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C408(1.19)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C408(1.41)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C408(1.11)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C408(0.71)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C408(0.68)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C408(1.79)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C408(0.77)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C408(1.00)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C408(0.67)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C408(0.76)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C408(1.00)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C408(1.37)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C408(1.23)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C408(1.02)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C408(0.94); C294(0.93)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C408(1.03); C294(0.92)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C408(1.08); C294(1.17)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C408(1.05); C294(1.00)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C408(1.12); C294(0.83)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C408(1.05); C294(1.09)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C408(1.26); C294(0.82)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C408(1.13); C294(1.02)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C408(1.61)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C408(0.88); C294(0.98)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C408(1.04); C294(0.98)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C408(0.93); C294(0.87)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C408(1.18)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C408(0.90); C294(0.94)  LDD1670  [8]
 LDCM0469  CL76 PaTu 8988t C408(0.88); C294(0.83)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C408(0.69); C294(0.89)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C408(0.56); C294(0.75)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C408(0.67); C294(0.81)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C408(1.77)  LDD1071  [7]
 LDCM0474  CL80 PaTu 8988t C408(0.63); C294(0.73)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C408(0.57); C294(0.74)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C408(0.58); C294(0.65)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C408(0.55); C294(0.75)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C408(0.77); C294(0.83)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C408(0.67); C294(1.09)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C408(0.58); C294(0.82)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C408(0.66); C294(0.82)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C408(0.57); C294(0.76)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C408(0.76); C294(0.98)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C408(1.48)  LDD1082  [7]
 LDCM0485  CL90 PaTu 8988t C408(0.67); C294(0.99)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C408(0.73)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C408(0.81)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C408(0.88)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C408(1.03)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C408(1.31)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C408(0.92)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C408(0.90)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C408(0.96)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C408(0.84)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C408(0.91); C294(0.88)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C408(0.89); C294(0.81)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C408(1.39)  LDD1025  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C294(1.22)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C294(0.91)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C408(3.94)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Nucleotide exchange factor SIL1 (SIL1) SIL1 family Q9H173
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402