Details of the Target

General Information of Target

Target ID LDTP11750
Target Name B-cell lymphoma/leukemia 11A (BCL11A)
Gene Name BCL11A
Gene ID 53335
Synonyms
CTIP1; EVI9; KIAA1809; ZNF856; B-cell lymphoma/leukemia 11A; BCL-11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein homolog; EVI-9; Zinc finger protein 856
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDA
KSRARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQP
HLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSLGEPELPPDSDTVGMDSSYL
SVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPD
VYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENY
AQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVG
QTHMGSLFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT
Target Type
Clinical trial
Target Bioclass
Transcription factor
Subcellular location
Cytoplasm; Nucleus matrix
Function
Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.
TTD ID
T26470
Uniprot ID
Q9H165
DrugMap ID
TTPLHYK
Ensemble ID
ENST00000335712.11
HGNC ID
HGNC:13221

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Deletion: p.L360SfsTer61 .
EFO27 Deletion: p.L360SfsTer61
SNV: p.S612L		 .
HCT116 Insertion: p.S763KfsTer9
SNV: p.R258C		 .
HCT15 SNV: p.A413T .
HEC1 SNV: p.P372S .
HEC1B SNV: p.P372S .
HS936T SNV: p.A468T .
LS513 SNV: p.E91Ter .
MEWO SNV: p.S528N .
MOLT4 Deletion: p.K821NfsTer8 .
NCIH2170 SNV: p.Q681K .
NCIH2172 SNV: p.G606C .
NCIH661 SNV: p.A95V .
OVK18 SNV: p.T791P .
RL952 Deletion: p.L265CfsTer15 .
SNGM SNV: p.C382Y .
U118MG SNV: p.D798N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C607(3.18)  LDD3339  [1]
AHL-Pu-1
 Probe Info  		C221(2.02)  LDD0168  [2]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [3]
IPM
 Probe Info  		C607(0.00); C76(0.00); C585(0.00)  LDD2156  [4]
Phosphinate-6
 Probe Info  		C407(0.00); C221(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C221(2.02)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C221(2.40)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C221(1.07); C754(1.18); C414(1.01)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C221(1.09); C754(1.22); C607(0.80); C414(1.52)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C221(1.20); C754(1.26); C414(1.07)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C221(1.00); C754(1.20); C414(0.94)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C221(1.02); C754(1.18); C607(1.28); C414(1.19)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C221(1.16); C754(1.22); C607(1.04); C414(1.90)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C221(0.98); C754(1.09); C414(0.98)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C221(0.94); C754(1.05); C607(1.04); C414(0.99)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C221(1.43); C754(1.11); C414(0.93)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C221(1.11); C754(1.25); C607(0.99); C414(0.73)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C221(1.02); C754(1.19); C414(0.98)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C221(1.07); C754(1.16); C414(0.97)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C221(0.96); C754(1.02); C607(1.76); C414(1.09)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C221(1.08); C754(1.19); C607(1.08); C414(1.04)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C221(1.00); C754(1.01); C414(1.14)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C221(0.98); C754(1.03); C414(1.20)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C221(1.08); C754(0.99); C607(0.80); C414(0.88)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C221(1.16); C754(0.95); C414(1.06)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C221(1.04); C754(1.04); C414(0.79)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C221(0.97); C754(0.99); C414(0.93)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C221(1.13); C754(1.11); C414(1.09)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C221(0.97); C754(1.02); C607(1.73); C414(0.95)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C221(1.05); C754(0.99); C607(1.07); C414(1.04)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C221(1.15); C754(0.97); C414(1.17)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C221(0.95); C754(1.17); C414(1.16)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C221(1.03); C754(1.18); C607(0.81); C414(1.13)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C221(1.48); C754(1.02); C414(1.06)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C221(1.07); C754(1.23); C414(0.96)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C221(1.11); C754(1.04); C414(1.08)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C221(0.88); C754(1.12); C607(1.18); C414(0.99)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C221(1.10); C754(1.08); C607(1.17); C414(1.12)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C221(1.00); C754(1.12); C414(0.82)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C221(1.14); C754(1.11); C414(1.03)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C221(0.99); C754(1.21); C414(1.04)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C221(1.07); C754(1.28); C607(0.86); C414(0.91)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C221(1.19); C754(1.08); C414(1.14)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C221(1.08); C754(1.19); C414(0.88)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C221(0.99); C754(1.11); C414(1.07)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C221(1.05); C754(1.22); C607(1.20); C414(1.12)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C221(1.25); C754(1.07); C607(0.85); C414(1.43)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C221(0.98); C754(1.16); C414(1.53)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C221(1.05); C754(1.13); C414(1.19)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C221(1.04); C754(1.06); C414(1.02)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C221(1.12); C754(1.08); C607(1.03); C414(1.01)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C221(1.09); C754(1.04); C414(1.28)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C221(1.09); C754(1.16); C414(0.81)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C221(1.04); C754(1.16); C414(1.37)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C221(1.02); C754(1.13); C607(1.41); C414(1.29)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C221(1.12); C754(1.11); C607(0.89); C414(1.41)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C221(1.02); C754(1.09); C414(1.17)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C221(0.97); C754(1.11); C414(0.87)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C221(0.96); C754(1.22); C607(0.84); C414(0.89)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C221(1.20); C754(1.09); C414(1.10)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C221(0.93); C754(1.06); C607(1.26); C414(1.07)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C221(1.00); C754(1.17); C414(0.89)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C221(1.08); C754(1.10); C414(1.13)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C221(1.04); C754(1.05); C607(1.21); C414(0.98)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C221(1.12); C754(1.05); C607(1.10); C414(1.03)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C221(1.04); C754(1.11); C414(1.12)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C221(1.30); C754(1.18); C607(1.09); C414(1.10)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C221(1.23); C754(1.08); C414(1.09)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C221(0.97); C754(1.14); C414(1.12)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C221(0.97); C754(1.16); C414(1.11)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C221(1.06); C754(1.10); C414(1.21)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C221(1.08); C754(1.15); C163(1.12)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C221(0.86); C754(0.80); C607(1.39); C414(0.82)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C221(1.03); C754(1.20)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C221(1.07); C754(1.15); C163(1.13)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C221(1.05); C754(1.08); C414(0.85)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C221(1.09); C754(1.10)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C221(1.16); C754(1.21)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C221(0.96); C754(1.09); C163(1.02)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C221(1.08); C754(1.10); C414(0.82)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C221(1.01); C754(1.07)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C221(1.09); C754(1.05)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C221(1.02); C754(0.85); C163(1.03)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C221(1.13); C754(1.06); C607(1.09); C414(0.91)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C221(0.97); C754(0.99); C414(0.68)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C221(0.98); C754(0.83)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C221(1.02); C754(0.94)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C221(1.11); C754(0.93); C163(0.95)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C221(1.15); C754(1.07); C414(0.90)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C221(1.11); C754(0.93)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C221(1.22); C754(1.02)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C221(1.02); C754(0.97); C163(1.01)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C221(1.07); C754(1.21); C414(1.11)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C221(1.15); C754(1.04)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C221(1.15); C754(0.90); C414(1.28)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C221(1.15); C754(1.25)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C221(0.96); C754(0.92); C163(0.96)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C221(1.05); C754(1.02); C414(0.92)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C221(0.98); C754(0.85)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C221(1.03); C754(1.02)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C221(1.00); C754(0.98); C163(0.77)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C221(1.00); C754(1.11); C414(0.80)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C221(1.10); C754(1.03)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C221(1.09); C754(1.23)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C221(1.10); C754(1.26); C163(0.92)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C221(1.17); C754(1.25); C414(1.36)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C221(1.11); C754(1.15)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C221(1.10); C754(1.22)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C221(1.05); C754(1.18); C414(1.09)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C221(0.95); C754(1.15); C607(1.01); C414(1.27)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C221(1.10); C754(1.27); C414(1.07)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C221(1.10); C754(1.23); C414(0.86)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C221(1.06); C754(1.06); C414(0.89)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C221(1.02); C754(0.88); C414(1.02)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C221(1.04); C754(0.98); C607(1.31); C414(1.07)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C221(1.14); C754(1.20); C607(0.82); C414(1.31)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C221(1.07); C754(0.91); C414(1.20)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C221(1.03); C754(1.21); C163(0.85)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C221(0.95); C754(1.26); C414(0.56)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C221(0.94); C754(1.18)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C221(1.07); C754(1.04)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C221(0.86); C754(1.15); C414(1.01)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C221(1.00); C754(1.15)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C221(0.95); C754(1.11); C607(0.89); C414(1.07)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C221(0.99); C754(1.13); C414(1.16)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C221(0.95); C754(1.00); C414(0.94)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C221(0.92); C754(0.87); C414(1.17)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C221(0.91); C754(0.85); C607(1.04); C414(1.33)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C221(1.09); C754(1.11); C607(0.82); C414(1.24)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C221(1.07); C754(0.82); C414(1.22)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C221(1.11); C754(1.11); C163(0.91)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C221(1.03); C754(1.14)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C221(1.05); C754(1.25)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C221(1.13); C754(1.13)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C221(0.62); C754(1.12); C414(0.99)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C221(1.04); C754(1.07); C607(0.68); C414(0.86)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C221(0.99); C754(1.12); C414(1.02)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C221(0.99); C754(0.99); C414(0.96)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C221(1.03); C754(0.93); C414(1.08)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C221(0.80); C754(0.85); C607(1.46); C414(1.48)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C221(1.10); C754(1.13); C607(0.95); C414(0.88)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C221(1.06); C754(0.83); C414(1.02)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C221(0.99); C754(1.31); C163(0.82)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C221(0.96); C754(1.15); C414(1.16)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C221(0.86); C754(1.34); C414(0.80)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C221(1.08); C754(1.19)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C221(0.91); C754(1.23); C414(1.15)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C221(1.00); C754(1.06); C607(0.75); C414(0.98)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C221(1.05); C754(1.11); C414(1.04)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C221(0.98); C754(1.19); C414(0.93)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C221(1.04); C754(0.93); C414(0.97)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C221(0.84); C754(1.02); C607(1.09); C414(1.15)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C221(1.09); C754(1.30); C607(0.80); C414(1.19)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C221(0.91); C754(1.07); C607(0.84); C414(0.76)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C221(0.98); C754(0.97); C414(1.36)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C221(1.06); C754(1.20); C163(0.97)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C221(0.98); C754(1.42); C414(1.01)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C221(1.09); C754(1.23)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C221(0.95); C754(1.24)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C221(1.06); C754(1.23); C414(1.25)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C221(1.00); C754(1.16); C607(0.90); C414(1.19)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C221(1.00); C754(1.22); C414(1.10)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C221(1.12); C754(1.10); C414(1.04)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C221(0.92); C754(0.99); C414(0.94)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C221(0.98); C754(1.15); C414(0.96)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C221(0.94); C754(0.92); C607(1.34); C414(1.25)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C221(1.01); C754(1.27); C607(0.78); C414(0.87)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C221(1.15); C754(0.99); C414(1.14)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C221(0.89); C754(1.16); C163(0.95)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C221(0.92); C754(1.29); C414(0.96)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C221(1.06); C754(1.22)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C221(0.99); C754(1.10); C414(1.19)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C221(0.91); C754(1.26); C607(0.95); C414(1.36)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C221(1.12); C754(1.16); C414(1.02)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C221(1.02); C754(0.90); C414(0.61)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C221(1.00); C754(1.10); C414(1.00)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C221(0.91); C754(0.97); C414(1.20)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C221(0.86); C754(0.96); C607(1.18); C414(1.26)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C221(1.05); C754(1.11); C607(1.09); C414(1.13)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C221(1.12); C754(0.92); C414(1.01)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C221(0.94); C754(1.20); C163(0.88)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C221(0.96); C754(1.37); C414(0.83)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C221(1.02); C754(1.15)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C221(1.27); C754(1.42)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C221(0.96); C754(1.43); C414(1.02)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C221(0.96); C754(0.85); C414(0.95)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C221(0.88); C754(1.12); C607(1.27); C414(0.84)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C221(1.12); C754(1.19); C414(1.07)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C221(0.66); C754(1.09); C414(0.90)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C221(1.06); C754(1.01); C414(1.27)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C221(0.88); C754(1.03); C607(1.08); C414(1.10)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C221(0.87); C754(1.10); C607(0.88); C414(0.92)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C221(1.02); C754(1.02); C414(0.98)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C221(1.01); C754(1.16); C163(0.85)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C221(1.00); C754(1.11); C414(0.76)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C221(0.94); C754(1.14)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C221(1.01); C754(1.15)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C221(0.96); C754(1.19)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C221(0.99); C754(1.20); C414(0.72)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C221(1.10); C163(1.26); C175(1.03)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C221(1.08); C163(1.19); C175(1.08)  LDD1497  [6]
 LDCM0024  KB05 NALM-6 C607(3.18)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Germ cell-less protein-like 2 (GMCL2) . Q8NEA9
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic protein NCK2 (NCK2) . O43639
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
NFAT activation molecule 1 (NFAM1) . Q8NET5
Rhombotin-1 (LMO1) . P25800

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ctx001 Gene therapy DVU2Y5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402