Details of the Target

General Information of Target

Target ID LDTP11158
Target Name TERF1-interacting nuclear factor 2 (TINF2)
Gene Name TINF2
Gene ID 26277
Synonyms
TIN2; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAWAAASLSRAAARCLLARGPGVRAAPPRDPRPSHPEPRGCGAAPGRTLHFTAAVPAGH
NKWSKVRHIKGPKDVERSRIFSKLCLNIRLAVKEGGPNPEHNSNLANILEVCRSKHMPKS
TIETALKMEKSKDTYLLYEGRGPGGSSLLIEALSNSSHKCQADIRHILNKNGGVMAVGAR
HSFDKKGVIVVEVEDREKKAVNLERALEMAIEAGAEDVKETEDEEERNVFKFICDASSLH
QVRKKLDSLGLCSVSCALEFIPNSKVQLAEPDLEQAAHLIQALSNHEDVIHVYDNIE
Target Bioclass
Other
Subcellular location
Nucleus; Nucleus matrix
Function
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Uniprot ID
Q9BSI4
Ensemble ID
ENST00000267415.12
HGNC ID
HGNC:11824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P450H .
IM95 SNV: p.D96G .
SUPT1 SNV: p.P32T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C332(3.32)  LDD3311  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C156(1.03)  LDD1093  [7]
 LDCM0215  AC10 PaTu 8988t C27(1.15)  LDD1094  [7]
 LDCM0226  AC11 PaTu 8988t C27(1.06)  LDD1105  [7]
 LDCM0237  AC12 PaTu 8988t C27(1.07)  LDD1116  [7]
 LDCM0259  AC14 PaTu 8988t C27(1.03)  LDD1138  [7]
 LDCM0263  AC143 PaTu 8988t C156(0.89)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C156(0.89)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C156(0.85)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C156(0.99)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C156(0.87)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C156(0.98)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C156(1.11)  LDD1148  [7]
 LDCM0270  AC15 PaTu 8988t C27(1.06)  LDD1149  [7]
 LDCM0271  AC150 PaTu 8988t C156(0.91)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C156(1.20)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C156(1.00)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C156(1.03)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C156(1.21)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C156(1.06)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C156(1.08)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C156(1.11)  LDD2169  [7]
 LDCM0277  AC18 HEK-293T C332(0.99)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C27(0.98); C156(0.83)  LDD1517  [8]
 LDCM0279  AC2 PaTu 8988t C156(0.98)  LDD1158  [7]
 LDCM0280  AC20 HEK-293T C332(1.00); C27(0.95)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C332(1.10)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C332(1.02); C27(1.05)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C332(1.06); C27(0.93)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C332(1.02); C27(1.05); C156(0.99)  LDD1523  [8]
 LDCM0285  AC25 PaTu 8988t C156(0.97)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C156(1.02)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C156(1.02)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C156(1.06)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C156(1.00)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C156(0.94)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C156(1.05)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C156(0.93)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C156(1.00)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C156(0.98)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C156(1.17)  LDD1174  [7]
 LDCM0296  AC35 PaTu 8988t C156(0.88)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C156(0.90)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C156(0.90)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C156(0.86)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C156(0.98)  LDD1179  [7]
 LDCM0301  AC4 PaTu 8988t C156(0.91)  LDD1180  [7]
 LDCM0302  AC40 PaTu 8988t C156(0.85)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C156(0.91)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C156(0.85)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C156(0.91)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C156(0.85)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C156(0.75)  LDD1186  [7]
 LDCM0308  AC46 PaTu 8988t C27(1.10)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C27(1.06)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C27(1.18)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C27(1.38)  LDD1190  [7]
 LDCM0312  AC5 PaTu 8988t C156(1.08)  LDD1191  [7]
 LDCM0313  AC50 PaTu 8988t C27(1.22)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C27(0.27)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C27(0.99)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C27(1.31)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C27(1.29)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C27(1.19)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C27(1.02)  LDD1198  [7]
 LDCM0321  AC58 HEK-293T C332(0.93)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C27(1.06); C156(0.90)  LDD1561  [8]
 LDCM0323  AC6 PaTu 8988t C27(0.96)  LDD1202  [7]
 LDCM0324  AC60 HEK-293T C332(1.01); C27(0.97)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C332(1.01)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C332(1.02); C27(1.02)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C332(1.08); C27(1.00)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C332(0.99); C27(1.03); C156(1.01)  LDD1567  [8]
 LDCM0334  AC7 PaTu 8988t C27(0.94)  LDD1213  [7]
 LDCM0345  AC8 PaTu 8988t C27(1.02)  LDD1224  [7]
 LDCM0349  AC83 PaTu 8988t C27(1.12)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C27(1.04)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C27(1.25)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C27(1.12)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C27(0.93)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C27(0.95)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C27(1.09)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C27(1.06)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C27(0.84)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C27(1.04)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C27(0.91)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C27(0.93)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C27(0.96)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C27(0.96)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C27(0.90)  LDD1243  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C27(1.23)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C27(1.30)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C27(1.13)  LDD1154  [7]
 LDCM0367  CL1 PaTu 8988t C27(1.45)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C27(1.05)  LDD1247  [7]
 LDCM0369  CL100 PaTu 8988t C156(0.90)  LDD1248  [7]
 LDCM0370  CL101 PaTu 8988t C27(1.04)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C27(1.07)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C27(1.04)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C27(1.16)  LDD1252  [7]
 LDCM0374  CL105 HEK-293T C332(1.23)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C332(0.89)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C332(0.85); C27(1.09)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C332(1.05); C27(0.94)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C332(1.19)  LDD1582  [8]
 LDCM0379  CL11 PaTu 8988t C27(1.12)  LDD1258  [7]
 LDCM0380  CL110 HEK-293T C332(1.12)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C332(1.01); C27(1.10)  LDD1585  [8]
 LDCM0382  CL112 PaTu 8988t C156(1.02)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C156(0.93)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C156(0.92)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C156(1.05)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C156(1.03)  LDD1265  [7]
 LDCM0387  CL117 PaTu 8988t C156(0.89)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C156(0.90)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C156(0.81)  LDD1268  [7]
 LDCM0390  CL12 PaTu 8988t C27(1.23)  LDD1269  [7]
 LDCM0391  CL120 PaTu 8988t C156(0.81)  LDD1270  [7]
 LDCM0392  CL121 PaTu 8988t C27(1.20)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C27(1.02)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C27(1.09)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C27(1.13)  LDD1274  [7]
 LDCM0396  CL125 HEK-293T C332(1.10)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C332(0.95)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C332(0.90); C27(1.08)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C332(0.99); C27(0.94)  LDD1603  [8]
 LDCM0400  CL13 PaTu 8988t C27(1.13)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C27(1.21)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C27(1.31)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C332(0.98); C27(0.97)  LDD1607  [8]
 LDCM0405  CL18 HEK-293T C332(1.08)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C27(1.09); C156(0.99)  LDD1610  [8]
 LDCM0407  CL2 PaTu 8988t C27(1.25)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C332(1.02); C27(1.10)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C332(0.99)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C332(1.14); C27(1.07)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C332(1.21); C27(1.15)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C332(1.01); C27(1.17); C156(0.97)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C332(1.19)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C332(0.91)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C332(0.91); C27(1.09)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C332(0.97); C27(0.92)  LDD1620  [8]
 LDCM0418  CL3 PaTu 8988t C27(1.35)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C332(1.00)  LDD1623  [8]
 LDCM0420  CL31 PaTu 8988t C156(0.89)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C156(0.79)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C156(0.69)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C156(0.73)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C156(0.81)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C156(0.24)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C156(0.85)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C156(0.78)  LDD1307  [7]
 LDCM0429  CL4 PaTu 8988t C27(1.13)  LDD1308  [7]
 LDCM0430  CL40 PaTu 8988t C156(0.78)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C156(0.75)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C156(0.80)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C156(0.78)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C156(0.69)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C156(0.69)  LDD1314  [7]
 LDCM0436  CL46 HEK-293T C332(1.13); C27(1.09)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C332(1.25); C27(1.14)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C332(1.09); C27(1.09); C156(0.86)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C332(1.10)  LDD1643  [8]
 LDCM0440  CL5 PaTu 8988t C27(1.12)  LDD1319  [7]
 LDCM0441  CL50 HEK-293T C332(1.02)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C332(0.98); C27(0.91)  LDD1646  [8]
 LDCM0445  CL54 HEK-293T C332(1.04)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C27(1.02); C156(1.06)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C332(1.15); C27(1.08)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C332(1.08)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C332(1.12); C27(1.18)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C332(1.31); C27(1.13)  LDD1653  [8]
 LDCM0451  CL6 PaTu 8988t C27(0.98)  LDD1330  [7]
 LDCM0452  CL60 HEK-293T C332(1.06); C27(1.06); C156(0.93)  LDD1655  [8]
 LDCM0453  CL61 PaTu 8988t C27(1.09)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C27(1.14)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C27(0.76)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C27(0.97)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C27(1.06)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C27(1.09)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C27(0.92)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C27(1.51)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C27(1.17)  LDD1340  [7]
 LDCM0462  CL7 PaTu 8988t C27(1.20)  LDD1341  [7]
 LDCM0463  CL70 PaTu 8988t C27(1.00)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C27(0.79)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C27(0.84)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C27(1.13)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C27(1.10)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C156(0.99)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C156(1.01)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C156(1.05)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C156(1.15)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C27(1.28)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C156(1.07)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C156(1.06)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C156(1.13)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C156(1.11)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C156(1.04)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C156(0.88)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C156(0.89)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C156(0.96)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C156(1.11)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C156(0.99)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C27(1.08)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C156(0.95)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C156(0.93)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C156(0.89)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C156(0.95)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C156(0.98)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C156(0.94)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C156(0.93)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C156(0.95)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C156(0.97)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C156(0.93)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C332(0.96); C27(1.22)  LDD1698  [8]
 LDCM0468  Fragment33 PaTu 8988t C27(0.77)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C156(0.74)  LDD1306  [7]
 LDCM0022  KB02 HEK-293T C27(0.90); C332(0.95); C156(0.88)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C27(1.02); C332(1.06); C156(0.98)  LDD1497  [8]
 LDCM0024  KB05 G361 C332(3.32)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Gamma-enolase (ENO2) Enolase family P09104
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Secernin-2 (SCRN2) Peptidase C69 family Q96FV2
Leukotriene A-4 hydrolase (LTA4H) Peptidase M1 family P09960
Phosphoglucomutase-1 (PGM1) Phosphohexose mutase family P36871
Phosphopentomutase (PGM2) Phosphohexose mutase family Q96G03
Protein kinase C beta type (PRKCB) AGC Ser/Thr protein kinase family P05771
Dual specificity protein kinase CLK3 (CLK3) CMGC Ser/Thr protein kinase family P49761
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) STE Ser/Thr protein kinase family P46734
Protein phosphatase inhibitor 2 (PPP1R2) Protein phosphatase inhibitor 2 family P41236
Pyruvate kinase PKM (PKM) Pyruvate kinase family P14618
Sulfotransferase 1C2 (SULT1C2) Sulfotransferase 1 family O00338
Tripartite motif-containing protein 16 (TRIM16) TRIM/RBCC family O95361
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Annexin A5 (ANXA5) Annexin family P08758
Copine-3 (CPNE3) Copine family O75131
Thioredoxin domain-containing protein 17 (TXNDC17) Thioredoxin family Q9BRA2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
AT-rich interactive domain-containing protein 3B (ARID3B) . Q8IVW6
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A4 (ANXA4) Annexin family P09525
Caldesmon (CALD1) Caldesmon family Q05682
Transgelin (TAGLN) Calponin family Q01995
Coiled-coil domain-containing protein 43 (CCDC43) CCDC43 family Q96MW1
Protein FAM131B (FAM131B) FAM131 family Q86XD5
Cdc42-interacting protein 4 (TRIP10) FNBP1 family Q15642
P antigen family member 2 (PAGE2) GAGE family Q7Z2X7
Neurochondrin (NCDN) Neurochondrin family Q9UBB6
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542
Rho GDP-dissociation inhibitor 1 (ARHGDIA) Rho GDI family P52565
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5
Mitochondrial import receptor subunit TOM34 (TOMM34) Tom34 family Q15785
Tubulin beta chain (TUBB) Tubulin family P07437
Small ribosomal subunit protein uS2 (RPSA) Universal ribosomal protein uS2 family P08865
F-box-like/WD repeat-containing protein TBL1X (TBL1X) WD repeat EBI family O60907
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0
Ankyrin repeat and MYND domain-containing protein 2 (ANKMY2) . Q8IV38
Aryl-hydrocarbon-interacting protein-like 1 (AIPL1) . Q9NZN9
BAG family molecular chaperone regulator 3 (BAG3) . O95817
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Coiled-coil domain-containing protein 9 (CCDC9) . Q9Y3X0
Drebrin (DBN1) . Q16643
Eukaryotic translation initiation factor 4B (EIF4B) . P23588
Galectin-related protein (LGALSL) . Q3ZCW2
Neuronal migration protein doublecortin (DCX) . O43602
Nucleolar protein 3 (NOL3) . O60936
Regulator of G-protein signaling 14 (RGS14) . O43566
Telomeric repeat-binding factor 1 (TERF1) . P54274
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402