Details of the Target

General Information of Target

Target ID LDTP10708
Target Name Serine/threonine-protein kinase Nek1 (NEK1)
Gene Name NEK1
Gene ID 4750
Synonyms
KIAA1901; Serine/threonine-protein kinase Nek1; EC 2.7.11.1; Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKK
WELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIG
WVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVESSVDKSKPWSRSIEDLHRGSN
LPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKKDDVHVCIMCLRAIMNYQYGFNM
VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRF
EKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTE
SDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKI
VELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGT
IKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPSSDTP
ETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT
SSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDE
FEEIFKTKAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAI
HVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQ
KMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAV
YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVL
LDVKELQRGMDLTKREYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGE
NPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHK
SKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITVLKTVPFTARTAKRGSRFFCEPVL
TEEYHY
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Subcellular location
Nucleus
Function
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly.
TTD ID
T43031
Uniprot ID
Q96PY6
DrugMap ID
TTO5QT2
Ensemble ID
ENST00000439128.6
HGNC ID
HGNC:7744
ChEMBL ID
CHEMBL5855

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C1223(2.14); C276(3.05)  LDD0168  [1]
DBIA
 Probe Info  		C1223(154.18)  LDD0209  [2]
ATP probe
 Probe Info  		K130(0.00); K17(0.00)  LDD0199  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_4
 Probe Info  		C276(0.00); C1007(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C1223(2.14); C276(3.05)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C276(2.02); C1223(2.34)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C1223(1.00); C1051(1.03); C855(0.99); C917(1.03)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C1223(0.94); C1051(0.98); C855(0.91); C917(0.91)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C1223(1.02); C1051(1.04); C855(0.86); C917(1.00)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C1223(0.98); C1051(0.98); C855(1.06); C917(0.96)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C1223(0.87); C1051(0.94); C855(0.88); C917(1.04)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C1223(1.02); C1051(1.00); C855(0.99); C917(1.05)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C1223(1.12); C1051(1.03); C855(1.05); C917(1.02)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C1223(0.93); C1051(1.05); C855(1.03); C917(0.92)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C1223(1.08); C1051(1.15); C855(1.07); C917(1.09)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C1223(0.91); C1051(0.96); C855(1.04); C917(0.87)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C1223(0.99); C1051(1.05); C855(1.01); C917(0.91)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C1223(1.09); C1051(0.96); C855(1.04); C917(1.03)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C1223(0.98); C1051(0.97); C855(0.91); C917(1.01)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C1223(1.02); C1051(0.89); C855(0.88); C917(1.03)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C1223(0.98); C1051(0.90); C855(0.97); C917(0.88)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C1223(1.03); C1051(1.05); C855(0.93); C917(0.95)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C1223(0.92); C1051(1.08); C855(1.03); C917(0.96)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C1223(0.97); C1051(1.01); C855(0.99); C917(0.99)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C1223(0.99); C1051(1.03); C855(0.99); C917(0.90)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C1223(0.95); C1051(0.99); C855(1.05); C917(1.05)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C1223(0.99); C1051(0.99); C855(0.96); C917(0.98)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C1223(0.93); C1051(1.03); C855(0.88); C917(0.98)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C1223(1.02); C1051(0.95); C855(0.97); C917(1.07)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C1223(1.02); C1051(0.96); C855(0.93); C917(0.95)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C1223(1.04); C1051(1.09); C855(0.99); C917(1.02)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C1223(1.02); C1051(1.07); C855(1.05); C917(0.91)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C1223(1.02); C1051(1.03); C855(0.91); C917(0.98)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C1223(0.97); C1051(0.97); C855(1.01); C917(0.92)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C1223(1.03); C1051(0.93); C855(0.96); C917(1.07)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C1223(0.94); C1051(1.03); C855(0.91); C917(0.96)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C1223(1.05); C1051(0.99); C855(1.10); C917(1.11)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C1223(1.04); C1051(1.01); C855(0.95); C917(0.92)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C1223(0.96); C1051(0.88); C855(1.06); C917(1.04)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C1223(1.02); C1051(1.05); C855(0.98); C917(0.99)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C1223(0.92); C1051(1.06); C855(0.96); C917(0.91)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C1223(1.09); C1051(1.00); C855(1.02); C917(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C1223(0.95); C1051(0.99); C855(0.99); C917(0.96)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C1223(0.95); C1051(0.89); C855(1.02); C917(0.97)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C1223(0.92); C1051(1.03); C855(1.01); C917(1.08)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C1223(1.02); C1051(0.99); C855(1.05); C917(1.06)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C1223(0.94); C1051(0.89); C855(0.94); C917(1.08)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C1223(1.01); C1051(1.06); C855(0.98); C917(1.02)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C1223(1.06); C1051(0.94); C855(0.91); C917(0.95)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C1223(0.90); C1051(1.03); C855(0.98); C917(0.94)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C1223(0.98); C1051(1.01); C855(0.90); C917(1.01)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C1223(1.00); C1051(0.97); C855(0.99); C917(0.97)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C1223(0.89); C1051(0.95); C855(1.04); C917(0.92)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C1223(0.89); C1051(1.02); C855(0.92); C917(1.05)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C1223(1.03); C1051(0.93); C855(0.93); C917(1.01)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C1223(1.02); C1051(0.98); C855(0.94); C917(1.02)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C1223(1.03); C1051(1.07); C855(0.94); C917(0.99)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C1223(0.90); C1051(0.98); C855(0.95); C917(0.94)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C1223(1.05); C1051(0.95); C855(0.92); C917(0.99)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C1223(0.90); C1051(1.02); C855(0.93); C917(1.00)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C1223(0.94); C1051(1.02); C855(0.97); C917(0.95)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C1223(0.88); C1051(0.98); C855(0.94); C917(0.93)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C1223(0.97); C1051(1.06); C855(0.84); C917(0.97)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C1223(0.99); C1051(1.02); C855(0.96); C917(1.04)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C1223(0.96); C1051(0.96); C855(0.98); C917(0.92)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C1223(0.97); C1051(0.97); C855(0.87); C917(1.08)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C1223(0.96); C1051(0.94); C855(0.82); C917(1.08)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C1223(0.90); C1051(1.05); C855(1.01); C917(1.02)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C1223(1.00); C1051(1.04); C855(0.98); C917(1.03)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C1223(1.02); C1051(0.93); C855(0.90); C917(1.02)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C1223(0.86); C1051(0.98); C855(0.84); C917(0.98)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C1223(1.01); C1051(1.30); C855(1.30); C917(0.89)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C1223(0.96); C1051(0.99); C855(0.90); C917(1.06)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C1223(0.95); C1051(0.96); C855(0.91); C917(1.07)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C1223(1.01); C1051(1.19); C855(0.95); C917(0.86)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C1223(1.06); C1051(1.00); C855(0.98); C917(0.90)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C1223(0.93); C1051(1.01); C855(0.84); C917(1.00)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C1223(1.00); C1051(1.00); C855(0.91); C917(0.97)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C1223(0.92); C1051(1.14); C855(0.95); C917(0.95)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C1223(1.15); C1051(1.03); C855(0.82); C917(0.87)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C1223(0.95); C1051(1.02); C855(0.97); C917(0.90)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C1223(0.93); C1051(0.99); C855(0.85); C917(1.01)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C1223(1.16); C1051(1.07); C855(1.39); C917(1.17)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C1223(0.98); C1051(1.38); C855(0.86); C917(0.95)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C1223(0.93); C1051(1.09); C855(0.85); C917(0.90)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C1223(0.93); C1051(1.06); C855(0.97); C917(0.95)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C1223(1.03); C1051(0.93); C855(0.96); C917(1.03)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C1223(0.99); C1051(1.23); C855(0.93); C917(0.89)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C1223(1.02); C1051(1.01); C855(1.01); C917(0.89)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C1223(1.05); C1051(1.01); C855(0.97); C917(1.02)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C1223(0.96); C1051(0.99); C855(0.96); C917(0.96)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C1223(1.02); C1051(1.08); C855(0.96); C917(1.04)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C1223(0.92); C1051(1.01); C855(0.90); C917(0.97)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C1223(1.09); C1051(1.07); C855(1.33); C917(1.12)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C1223(0.93); C1051(1.07); C855(0.93); C917(1.05)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C1223(0.93); C1051(1.00); C855(0.90); C917(1.07)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C1223(1.03); C1051(1.03); C855(0.88); C917(1.03)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C1223(1.02); C1051(1.18); C855(0.75); C917(0.80)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C1223(0.92); C1051(1.08); C855(0.90); C917(0.96)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C1223(0.89); C1051(0.96); C855(0.81); C917(1.04)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C1223(1.01); C1051(1.05); C855(0.94); C917(0.97)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C1223(0.94); C1051(1.02); C855(0.91); C917(0.81)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C1223(0.93); C1051(1.03); C855(0.98); C917(0.97)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C1223(0.93); C1051(1.00); C855(0.90); C917(1.03)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C1223(1.11); C1051(1.00); C855(0.97); C917(1.05)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C1223(0.99); C1051(1.44); C855(0.84); C917(0.89)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C1223(0.86); C1051(1.04); C855(0.98); C917(0.99)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C1223(1.09); C1051(1.35); C855(0.92); C917(0.98)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C1223(1.04); C1051(1.06); C855(1.15); C917(1.03)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C1223(1.05); C1051(1.02); C855(1.26); C917(1.10)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C1223(1.08); C1051(1.03); C855(0.99); C917(1.04)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C1223(1.08); C1051(1.01); C855(1.17); C917(1.21)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C1223(0.91); C1051(1.48); C855(1.29); C917(1.14)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C1223(1.01); C1051(1.06); C855(1.17); C917(1.10)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C1223(1.14); C1051(1.06); C855(1.45); C917(1.29)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C1223(1.13); C1051(1.02); C855(1.30); C917(1.24)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C1223(0.89); C1051(1.06); C855(0.85); C917(0.86)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C1223(1.12); C1051(1.01); C855(0.97); C917(0.97)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C1223(1.01); C1051(0.98); C855(0.85); C917(0.92)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C1223(0.94); C1051(1.10); C855(0.97); C917(1.02)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C1223(0.98); C1051(1.02); C855(1.01); C917(1.03)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C1223(1.08); C1051(1.05); C855(0.90); C917(0.93)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C1223(0.96); C1051(1.05); C855(1.14); C917(1.01)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C1223(1.11); C1051(1.07); C855(1.13); C917(1.09)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C1223(1.05); C1051(1.02); C855(1.17); C917(1.11)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C1223(0.99); C1051(1.34); C855(1.23); C917(1.00)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C1223(0.95); C1051(1.05); C855(1.27); C917(0.98)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C1223(1.07); C1051(1.02); C855(1.62); C917(1.27)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C1223(1.10); C1051(1.07); C855(1.36); C917(1.22)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C1223(0.92); C1051(0.99); C855(0.83); C917(0.93)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C1223(1.09); C1051(0.97); C855(0.96); C917(0.89)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C1223(1.00); C1051(1.03); C855(0.88); C917(0.91)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C1223(1.15); C1051(0.97); C855(1.03); C917(1.05)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C1223(0.92); C1051(1.11); C855(0.95); C917(0.99)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C1223(1.02); C1051(1.14); C855(1.15); C917(1.06)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C1223(1.01); C1051(1.03); C855(0.99); C917(1.06)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C1223(1.04); C1051(1.03); C855(1.14); C917(1.07)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C1223(1.03); C1051(0.99); C855(1.39); C917(1.01)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C1223(0.93); C1051(1.08); C855(1.48); C917(0.99)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C1223(1.19); C1051(0.96); C855(1.37); C917(1.16)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C1223(1.07); C1051(0.97); C855(1.22); C917(1.18)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C1223(0.91); C1051(0.94); C855(0.77); C917(0.88)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C1223(1.11); C1051(1.07); C855(1.00); C917(1.12)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C1223(1.10); C1051(1.16); C855(0.96); C917(0.96)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C1223(1.07); C1051(1.08); C855(0.97); C917(0.89)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C1223(0.92); C1051(1.28); C855(1.05); C917(0.93)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C1223(1.07); C1051(1.30); C855(1.02); C917(0.96)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C1223(1.11); C1051(0.99); C855(1.12); C917(1.06)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C1223(1.07); C1051(0.99); C855(1.10); C917(1.10)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C1223(0.98); C1051(1.11); C855(1.26); C917(1.02)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C1223(0.88); C1051(1.08); C855(1.23); C917(1.04)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C1223(1.19); C1051(1.05); C855(1.27); C917(1.17)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C1223(0.96); C1051(1.26); C855(1.02); C917(1.00)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C1223(1.04); C1051(1.07); C855(1.47); C917(1.23)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C1223(0.91); C1051(0.90); C855(0.83); C917(0.99)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C1223(1.01); C1051(1.04); C855(0.92); C917(0.96)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C1223(1.19); C1051(0.98); C855(0.91); C917(1.03)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C1223(1.00); C1051(1.31); C855(0.91); C917(0.82)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C1223(1.08); C1051(1.06); C855(0.84); C917(1.03)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C1223(1.00); C1051(1.01); C855(1.12); C917(1.10)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C1223(1.01); C1051(0.99); C855(1.15); C917(1.11)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C1223(1.06); C1051(1.05); C855(1.12); C917(1.08)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C1223(0.98); C1051(0.96); C855(1.18); C917(1.19)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C1223(0.98); C1051(1.09); C855(1.37); C917(1.12)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C1223(0.92); C1051(1.04); C855(1.13); C917(0.99)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C1223(1.09); C1051(1.03); C855(1.49); C917(1.19)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C1223(1.13); C1051(1.00); C855(1.13); C917(1.33)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C1223(0.94); C1051(0.98); C855(0.80); C917(0.95)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C1223(0.99); C1051(0.97); C855(0.90); C917(1.07)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C1223(0.94); C1051(1.11); C855(0.87); C917(0.97)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C1223(1.13); C1051(1.20); C855(1.03); C917(0.91)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C1223(0.97); C1051(1.02); C855(1.09); C917(0.92)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C1223(0.96); C1051(1.04); C855(1.06); C917(1.04)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C1223(1.16); C1051(1.58); C855(0.87); C917(0.96)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C1223(0.99); C1051(0.95); C855(1.11); C917(1.06)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C1223(1.00); C1051(0.94); C855(1.35); C917(1.12)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C1223(0.94); C1051(1.04); C855(1.28); C917(1.04)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C1223(1.06); C1051(0.98); C855(1.49); C917(1.16)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C1223(1.05); C1051(1.01); C855(1.13); C917(1.10)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C1223(0.99); C1051(0.98); C855(0.81); C917(0.95)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C1223(0.97); C1051(1.00); C855(0.84); C917(0.91)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C1223(0.93); C1051(1.02); C855(0.83); C917(0.93)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C1223(0.90); C1051(0.98); C855(0.84); C917(0.94)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C1223(1.11); C1051(1.05); C855(1.05); C917(0.95)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C1223(0.99); C1051(1.04); C855(1.32); C917(1.09)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C1223(1.15); C1051(1.59); C855(0.94); C917(0.75)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C1223(0.95); C1051(1.00); C855(1.02); C917(1.06)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C1223(1.07); C1051(1.12); C855(1.06); C917(0.98)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C1223(0.99); C1051(1.03); C855(1.06); C917(1.07)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C1223(1.00); C1051(0.96); C855(0.94); C917(1.05)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C1223(1.17); C1051(1.51); C855(1.02); C917(1.08)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C1223(1.04); C1051(1.15); C855(0.94); C917(0.96)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C1223(0.91); C1051(1.04); C855(0.89); C917(1.00)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C1223(1.01); C1051(1.03); C855(0.99); C917(1.11)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C1223(0.88); C1051(0.92); C855(0.89); C917(0.95)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C1223(1.25); C1051(1.00); C855(0.79); C917(0.95)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C1223(1.02); C1051(0.99); C855(0.87); C917(0.98)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C1223(1.07); C1051(1.08); C855(0.86); C917(1.03)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C1223(0.89); C1051(0.92); C1007(1.06); C855(0.96)  LDD1492  [8]
 LDCM0023  KB03 Jurkat C1223(154.18)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C276(1.66)  LDD3310  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fasciculation and elongation protein zeta-1 (FEZ1) Zygin family Q99689
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid20936789c31 Small molecular drug D0K0UJ

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840