Details of the Target

General Information of Target

Target ID LDTP10689
Target Name Transcriptional-regulating factor 1 (TRERF1)
Gene Name TRERF1
Gene ID 55809
Synonyms
BCAR2; RAPA; TREP132; Transcriptional-regulating factor 1; Breast cancer anti-estrogen resistance 2; Transcriptional-regulating protein 132; Zinc finger protein rapa; Zinc finger transcription factor TReP-132
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSS
AMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVI
KCSLEIHGLFETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQN
MAQMNDVILSPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYY
PSGEHKNLLRLACTLKPDPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLM
FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELT
HALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMY
YPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNR
KEDYPLLGRNKEINYFMYTMKKFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRI
IAISLNKISFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIF
HVQFPISREISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKL
IRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISK
ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLN
MVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTF
TTELLFEILPCWNMKMMIKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRSLSLK
PSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYELWLKDQRKAMHLKCARFLEED
AHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHGFKTEEKLILSNSEIPETSAF
FPENRSPEEIREKILNFFDHVLTKMKTSDEDIIPLESCQCEEILEIVILPLAHHFLALGE
NDKALYYFLEIASAYLIFCDNYMAYMYLNEGQKLLKTLKKDKSWSQTFESATFYSLKGEV
CFNMGQIVLAKKMLRKALKLLNRIFPYNLISLFLHIHVEKNRHFHYVNRQAQESPPPGKK
RLAQLYRQTVCLSLLWRIYSYSYLFHCKYYAHLAVMMQMNTALETQNCFQIIKAYLDYSL
YHHLAGYKGVWFKYEVMAMEHIFNLPLKGEGIEIVAYVAETLVFNKLIMGHLDLAIELGS
RALQMWALLQNPNRHYQSLCRLSRCLLLNSRYPQLIQVLGRLWELSVTQEHIFSKAFFYF
VCLDILLYSGFVYRTFEECLEFIHQYENNRILKFHSGLLLGLYSSVAIWYARLQEWDNFY
KFSNRAKNLLPRRTMTLTYYDGISRYMEGQVLHLQKQIKEQSENAQASGEELLKNLENLV
AQNTTGPVFCPRLYHLMAYVCILMGDGQKCGLFLNTALRLSETQGNILEKCWLNMNKESW
YSTSELKEDQWLQTILSLPSWEKIVAGRVNIQDLQKNKFLMRANTVDNHF
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.
Uniprot ID
Q96PN7
Ensemble ID
ENST00000340840.6
HGNC ID
HGNC:18273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1106(10.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C876(2.15)  LDD2157  [2]
DBIA
 Probe Info  		C1065(1.36)  LDD0532  [3]
N1
 Probe Info  		K914(0.00); K917(0.00); K919(0.00)  LDD0245  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C1065(1.36)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1065(0.93)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1065(1.06)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1065(1.15)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1065(1.20)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1065(1.17)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1065(1.14)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1065(1.00)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1065(1.41)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1065(1.00)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1065(1.01)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C1065(1.78)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1065(0.90)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1065(0.95)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1065(1.04)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C1065(0.98)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C1065(1.11)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C1065(0.87)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C1065(2.08)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C1065(0.87)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C1065(1.02)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C1065(1.49)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C1065(1.20)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C1065(1.32)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C1065(0.77)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C1065(0.90)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C1065(1.09)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C1065(0.92)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C1065(1.24)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C1065(1.48)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C1065(1.05)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C1065(1.05)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C1065(0.82)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C1065(0.89)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C1065(0.77)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C1065(0.88)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C1065(0.98)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C1065(0.86)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C1065(0.92)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C1065(0.95)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C1065(1.02)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C1065(1.16)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C1065(0.97)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C1065(1.36)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C1065(1.11)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C1065(1.09)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C1065(0.82)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C1065(1.30)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C1065(2.59)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C1065(1.71)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C1065(1.26)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C1065(1.75)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C1065(2.22)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C1065(1.91)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C1065(1.44)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C1065(1.38)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C1065(1.72)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C1065(2.10)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C1065(3.60)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C1065(2.24)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C1065(1.56)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C1065(1.37)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C1065(1.60)  LDD2161  [3]
 LDCM0285  AC25 HCT 116 C1065(1.30)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C1065(1.58)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C1065(1.61)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C1065(1.50)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C1065(1.65)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C1065(1.30)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C1065(1.35)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C1065(1.68)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C1065(1.65)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C1065(1.74)  LDD0612  [3]
 LDCM0296  AC35 PaTu 8988t C1065(1.55)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C1065(2.09)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C1065(1.28)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C1065(1.21)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C1065(1.48)  LDD1179  [3]
 LDCM0302  AC40 PaTu 8988t C1065(1.82)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C1065(1.45)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C1065(1.63)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C1065(1.31)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C1065(1.35)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C1065(1.51)  LDD1186  [3]
 LDCM0323  AC6 HCT 116 C1065(1.36)  LDD0640  [3]
 LDCM0332  AC68 HCT 116 C1065(1.03)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C1065(1.17)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C1065(1.21)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C1065(1.21)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C1065(1.13)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C1065(1.19)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C1065(1.82)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C1065(1.90)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C1065(2.02)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C1065(1.20)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C1065(1.49)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C1065(1.13)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C1065(1.11)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C1065(1.33)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C1065(1.49)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C1065(1.16)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C1065(2.38)  LDD0665  [3]
 LDCM0365  AC98 HCT 116 C1065(1.77)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1065(0.89)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C1065(1.23)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C1065(1.57)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C1065(2.02)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C1065(0.93)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C1065(1.75)  LDD1247  [3]
 LDCM0370  CL101 HCT 116 C1065(1.63)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C1065(1.19)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C1065(1.44)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C1065(1.38)  LDD0690  [3]
 LDCM0379  CL11 PaTu 8988t C1065(1.22)  LDD1258  [3]
 LDCM0382  CL112 HCT 116 C1065(1.10)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C1065(1.53)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C1065(1.11)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C1065(1.36)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C1065(1.22)  LDD0703  [3]
 LDCM0387  CL117 PaTu 8988t C1065(1.28)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C1065(1.12)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C1065(1.60)  LDD1268  [3]
 LDCM0390  CL12 PaTu 8988t C1065(0.91)  LDD1269  [3]
 LDCM0391  CL120 PaTu 8988t C1065(2.03)  LDD1270  [3]
 LDCM0400  CL13 PaTu 8988t C1065(2.57)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C1065(2.49)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C1065(1.55)  LDD1281  [3]
 LDCM0403  CL16 PaTu 8988t C1065(1.33)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C1065(0.89)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C1065(0.94)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C1065(0.82)  LDD1285  [3]
 LDCM0407  CL2 PaTu 8988t C1065(1.13)  LDD1286  [3]
 LDCM0408  CL20 PaTu 8988t C1065(0.96)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C1065(1.13)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C1065(1.45)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C1065(1.02)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C1065(1.13)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C1065(0.97)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C1065(1.04)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C1065(1.12)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C1065(1.14)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C1065(1.19)  LDD1296  [3]
 LDCM0418  CL3 PaTu 8988t C1065(1.00)  LDD1297  [3]
 LDCM0419  CL30 PaTu 8988t C1065(1.03)  LDD1298  [3]
 LDCM0429  CL4 PaTu 8988t C1065(1.17)  LDD1308  [3]
 LDCM0440  CL5 PaTu 8988t C1065(1.62)  LDD1319  [3]
 LDCM0451  CL6 PaTu 8988t C1065(1.42)  LDD1330  [3]
 LDCM0462  CL7 PaTu 8988t C1065(1.69)  LDD1341  [3]
 LDCM0473  CL8 PaTu 8988t C1065(1.60)  LDD1352  [3]
 LDCM0484  CL9 PaTu 8988t C1065(1.78)  LDD1363  [3]
 LDCM0022  KB02 A2780 C994(2.71)  LDD2254  [5]
 LDCM0023  KB03 A2780 C994(2.11)  LDD2671  [5]
 LDCM0024  KB05 OV-90 C994(2.26)  LDD3380  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Transcriptional coactivator YAP1 (YAP1) YAP1 family P46937

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840