Details of the Target

General Information of Target

Target ID LDTP10629
Target Name Sodium channel and clathrin linker 1 (SCLT1)
Gene Name SCLT1
Gene ID 132320
Synonyms
SAP1; Sodium channel and clathrin linker 1; Sodium channel-associated protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLAD
NFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFS
GLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDH
NMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN
PLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLE
GQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIAS
NPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDK
IVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGT
MYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVAS
VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENA
QCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAV
TNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization.
Uniprot ID
Q96NL6
Ensemble ID
ENST00000281142.10
HGNC ID
HGNC:26406

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.L580F .
COLO792 SNV: p.S459L .
KELLY SNV: p.R269T .
KMS11 SNV: p.I377V .
KNS81FD Deletion: p.K420NfsTer11 .
MEWO SNV: p.S573F .
OVISE SNV: p.L581I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C292(2.51)  LDD3410  [1]
VSF
 Probe Info  		N.A.  LDD0007  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C292(1.07)  LDD1508  [3]
 LDCM0216  AC100 HEK-293T C390(0.85)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C390(0.84)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C390(0.79)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C390(1.24)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C390(0.76)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C390(0.73)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C390(0.86)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C390(0.98)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C390(0.98)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C390(0.75)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C292(1.14)  LDD1509  [3]
 LDCM0227  AC110 HEK-293T C390(1.36)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C390(1.15)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C390(0.68)  LDD0827  [4]
 LDCM0237  AC12 HEK-293T C292(1.10)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C292(1.09)  LDD1512  [3]
 LDCM0263  AC143 HEK-293T C390(0.90)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C390(0.83)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C390(0.90)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C390(0.84)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C390(0.82)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C390(0.77)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C390(0.80)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C292(1.03)  LDD1513  [3]
 LDCM0271  AC150 HEK-293T C390(0.70)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C390(0.86)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C390(0.87)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C390(0.86)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C390(1.00)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C390(0.85)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C390(0.98)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C390(0.74)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C390(0.94)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C390(0.93)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C390(1.12)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C292(1.00)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C390(1.08)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C390(0.93)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C390(1.18)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C390(1.63)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C390(0.98)  LDD0882  [4]
 LDCM0286  AC26 HEK-293T C292(0.99)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C292(1.16)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C292(1.04)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C292(1.09)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C292(1.17)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C292(0.94)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C292(0.94)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C292(0.85)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C292(0.96)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C292(0.89)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C292(1.04)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C292(1.16)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C292(0.99)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C292(1.14)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C292(1.05)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C292(0.93)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C292(0.99)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C292(1.14)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C292(1.01)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C292(1.13)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C292(1.06)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C292(1.13)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C292(0.97)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C292(1.06)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C292(0.95)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C292(1.11)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C292(1.00)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C292(1.02)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C292(1.00)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C292(1.08)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C292(0.95)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C292(0.84)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C292(0.91)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C292(1.06)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C292(1.24)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C292(1.01)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C292(1.14)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C292(0.93)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C292(0.94)  LDD1567  [3]
 LDCM0332  AC68 HEK-293T C390(0.75)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C390(0.90)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C292(1.01)  LDD1568  [3]
 LDCM0335  AC70 HEK-293T C390(1.00)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C390(0.81)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C390(0.94)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C390(1.00)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C390(1.13)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C390(0.76)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C390(0.63)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C390(0.72)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C390(1.02)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C390(0.71)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C292(0.92)  LDD1569  [3]
 LDCM0346  AC80 HEK-293T C390(0.82)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C390(0.88)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C390(0.96)  LDD0946  [4]
 LDCM0365  AC98 HEK-293T C390(1.46)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C390(0.75)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C292(1.10)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C292(0.95)  LDD1514  [3]
 LDCM0368  CL10 HEK-293T C292(0.59)  LDD1572  [3]
 LDCM0374  CL105 HEK-293T C390(0.98)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C390(1.14)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C390(1.03)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C390(0.89)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C390(1.06)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C292(1.15)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C390(1.10)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C390(0.93)  LDD0979  [4]
 LDCM0390  CL12 HEK-293T C292(0.93)  LDD1594  [3]
 LDCM0405  CL18 HEK-293T C292(0.98)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C292(1.22)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C292(1.08)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C292(1.07)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C292(0.86)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C292(1.16)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C292(1.00)  LDD1616  [3]
 LDCM0419  CL30 HEK-293T C292(0.88)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C390(1.21)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C390(1.65)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C390(1.15)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C390(1.47)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C390(2.70)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C390(1.18)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C390(1.11)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C390(1.61)  LDD1026  [4]
 LDCM0430  CL40 HEK-293T C390(1.58)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C390(1.31)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C390(1.25)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C390(1.31)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C390(1.30)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C390(1.67)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C292(0.89)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C292(0.97)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C292(0.89)  LDD1642  [3]
 LDCM0445  CL54 HEK-293T C292(1.10)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C292(1.22)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C292(1.24)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C292(1.27)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C292(0.95)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C292(1.18)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C292(1.07)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C292(0.97)  LDD1655  [3]
 LDCM0458  CL66 HEK-293T C292(0.97)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C292(1.11)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C292(1.14)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C292(1.19)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C292(1.04)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C292(0.87)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C292(1.13)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C292(1.07)  LDD1668  [3]
 LDCM0471  CL78 HEK-293T C292(0.92)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C292(1.05)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C292(1.25)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C292(1.10)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C292(1.13)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C292(0.89)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C292(1.01)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C292(0.96)  LDD1681  [3]
 LDCM0484  CL9 HEK-293T C292(1.05)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C292(1.05)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C292(0.93)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C292(1.09)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C292(1.12)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C292(0.81)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C292(1.32)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C292(1.04)  LDD1694  [3]
 LDCM0427  Fragment51 HEK-293T C390(1.20)  LDD1025  [4]
 LDCM0022  KB02 A-375 C292(1.55)  LDD2255  [1]
 LDCM0023  KB03 A-375 C292(1.82)  LDD2672  [1]
 LDCM0024  KB05 RPMI-7951 C292(2.51)  LDD3410  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.